ACITROM 3.5 TABLET 30'S

How ACITROM 3.5 TABLET 30'S Works

• ACITROM 3.5 Tablet contains Acitretin, a retinoid (a vitamin A derivative). It is primarily used to manage severe psoriasis and other skin disorders characterized by abnormal skin cell growth and inflammation. Acitretin works by modulating the growth and differentiation of skin cells, reducing inflammation, and normalizing the skin's structure and function. It is crucial to understand the mechanism of action to appreciate its therapeutic benefits.
• Acitretin exerts its effects through several key mechanisms at the cellular level. Firstly, it binds to retinoid receptors in the nucleus of skin cells. These receptors, known as retinoic acid receptors (RARs) and retinoid X receptors (RXRs), regulate gene expression. When Acitretin binds to these receptors, it alters the transcription of genes involved in cell proliferation, differentiation, and inflammation. This leads to a decrease in the rapid and excessive growth of skin cells that is characteristic of psoriasis.
• Secondly, Acitretin helps to normalize the differentiation of skin cells. In psoriasis, skin cells mature too quickly, resulting in the formation of thick, scaly plaques. Acitretin slows down this process, allowing skin cells to mature properly and reducing the build-up of scales. This helps to restore the normal structure and function of the skin.
• Thirdly, Acitretin possesses anti-inflammatory properties. It inhibits the production of inflammatory mediators, such as cytokines, that contribute to the redness, swelling, and itching associated with psoriasis. By reducing inflammation, Acitretin helps to alleviate the symptoms of skin disorders and improve the overall condition of the skin.
• In summary, ACITROM 3.5 Tablet works by binding to retinoid receptors, modulating gene expression, normalizing skin cell differentiation, and reducing inflammation. These actions collectively help to control the excessive growth and abnormal behavior of skin cells in psoriasis and other skin disorders, leading to improved skin condition and reduced symptoms. It is important to use this medication under the guidance of a healthcare professional to ensure safe and effective treatment.

Common side effects of ACITROM 3.5 Tablet may include: Increased risk of bleeding, easy bruising, nosebleeds, heavy menstrual periods, blood in urine or stool, red or black stools, headache, dizziness, weakness. Less common but serious side effects include: Severe bleeding (internal bleeding), allergic reactions (rash, itching, swelling), skin necrosis (skin damage due to blood clots), liver problems (jaundice, dark urine, abdominal pain), purple toes syndrome. This is not an exhaustive list, and other side effects may occur. Contact your doctor immediately if you experience any unusual or severe symptoms.

• If you miss a dose of Acitrom 3.5 Tablet, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

• Keep ACITROM 3.5MG TAB 1X30 away from the reach of children and pets.
• Store ACITROM 3.5MG TAB 1X30 at room temperature.

• **Take ACITROM 3.5 TABLET 30'S exactly as prescribed by your doctor.** Do not change the dosage or stop taking the medicine without consulting them, as this could affect your INR (International Normalized Ratio) levels and increase the risk of blood clots or bleeding. Regular monitoring of your INR is essential while on this medication. This ensures the medicine is working effectively and the dosage is appropriate for you.
• **Maintain a consistent diet, especially regarding Vitamin K intake.** Vitamin K can interfere with the effectiveness of ACITROM 3.5 TABLET 30'S. Avoid drastic changes in your consumption of green leafy vegetables (like spinach and kale), broccoli, and other foods rich in Vitamin K. Consistency helps stabilize your INR levels and makes managing your medication easier.
• **Be aware of potential drug interactions.** Inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. Certain medications can significantly affect how ACITROM 3.5 TABLET 30'S works. For example, some antibiotics, antifungals, and pain relievers can interact with warfarin and alter your INR. Always consult your doctor or pharmacist before starting any new medication.
• **Monitor yourself for signs of bleeding.** While taking ACITROM 3.5 TABLET 30'S, be vigilant for any unusual bleeding, such as nosebleeds, bleeding gums, blood in urine or stool, excessive bruising, or prolonged bleeding from cuts. These could be signs that your blood is too thin. Report any such symptoms to your doctor immediately. Early detection and management are crucial to prevent serious complications.
• **Avoid activities that may lead to injury.** Because ACITROM 3.5 TABLET 30'S thins your blood, you are more prone to bleeding. Take precautions to avoid falls, cuts, and other injuries. Use caution when shaving, using sharp objects, or participating in contact sports. If you do get injured, apply pressure to the wound immediately and seek medical attention if bleeding is excessive or does not stop quickly.

• ACITROM 3.5 TABLET 30'S can be taken with or without food. However, it is important to maintain a consistent dietary intake of vitamin K-rich foods (e.g., green leafy vegetables) as significant changes in vitamin K intake can affect the drug's efficacy. Consult your doctor or pharmacist for specific dietary advice while taking this medication.