CLODREL PLUS TABLET 15'S

How CLODREL PLUS TABLET 15'S Works

• CLODREL PLUS TABLET 15'S is a combination medication containing clopidogrel and aspirin. These two antiplatelet agents work synergistically to prevent blood clot formation, reducing the risk of serious cardiovascular events like heart attack and stroke. Understanding how each component functions is crucial to appreciating the overall effectiveness of this medication.
• Clopidogrel belongs to a class of drugs called thienopyridines. It works by selectively inhibiting the binding of adenosine diphosphate (ADP) to its platelet receptor, P2Y12. ADP is a chemical that stimulates platelet activation and aggregation. By blocking ADP from binding, clopidogrel prevents platelets from becoming activated and sticking together. This inhibition is irreversible, meaning that the platelet is affected for its entire lifespan (approximately 7-10 days). Therefore, the antiplatelet effect lasts until new platelets are produced.
• Aspirin, or acetylsalicylic acid, is a nonsteroidal anti-inflammatory drug (NSAID) that also possesses antiplatelet properties. Aspirin inhibits the production of thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. It achieves this by irreversibly acetylating cyclooxygenase-1 (COX-1), an enzyme responsible for TXA2 synthesis in platelets. By blocking COX-1, aspirin reduces the formation of TXA2, thereby preventing platelets from clumping together. Similar to clopidogrel, aspirin's effect on platelets is irreversible, lasting for the lifespan of the platelet.
• When combined, clopidogrel and aspirin offer a dual antiplatelet effect. Clopidogrel blocks ADP-mediated platelet activation, while aspirin inhibits TXA2-mediated platelet aggregation. This dual action provides a more comprehensive approach to preventing blood clot formation compared to using either agent alone. The combination is particularly beneficial in patients who have undergone percutaneous coronary intervention (PCI), such as stent placement, or who are at high risk of developing atherothrombotic events.
• In summary, CLODREL PLUS TABLET 15'S works by inhibiting two key pathways involved in platelet activation and aggregation: the ADP pathway (via clopidogrel) and the TXA2 pathway (via aspirin). This dual antiplatelet action effectively reduces the risk of blood clot formation and subsequent cardiovascular events. It's important to use this medication as directed by your healthcare provider, considering the potential risks and benefits.

The following side effects may occur while using Clodrel Plus Tablet: * Increased risk of bleeding: This is the most common side effect. It can manifest as nosebleeds, easy bruising, prolonged bleeding from cuts, blood in the urine or stool, or bleeding gums. * Stomach upset: Heartburn, indigestion, abdominal pain, nausea, vomiting, diarrhea, or constipation may occur. * Allergic reactions: Rash, itching, hives, swelling of the face, lips, or tongue, and difficulty breathing are possible. * Dizziness or lightheadedness * Headache * Weakness or fatigue * Chest pain * Shortness of breath * Swelling in the legs or ankles * Serious side effects (less common): These require immediate medical attention and include: * Severe bleeding (e.g., stroke, intracranial hemorrhage) * Thrombotic Thrombocytopenic Purpura (TTP): A rare blood disorder characterized by blood clots in small blood vessels. * Liver problems: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, and abdominal pain. * Kidney problems * Severe skin reactions: Stevens-Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN)

• If you forget to take a dose of Clodrel Plus Tablet 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Keep CLODREL PLUS TAB 1X15 away from the reach of children and pets.
• Store CLODREL PLUS TAB 1X15 at room temperature.

• Take CLODREL PLUS TABLET 15'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your physician, as this can increase your risk of serious cardiovascular events like heart attack or stroke. This medication is usually taken once daily, with or without food, but consistency in timing is key for optimal effectiveness. If you miss a dose, take it as soon as you remember unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
• Inform your doctor about all other medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins. CLODREL PLUS TABLET 15'S can interact with other drugs, potentially leading to increased bleeding risk or reduced effectiveness. Pay special attention to medications like NSAIDs (e.g., ibuprofen, naproxen), other antiplatelet drugs (e.g., aspirin), anticoagulants (e.g., warfarin), and certain antidepressants. Your doctor may need to adjust your dosage or monitor you more closely for side effects.
• Be aware of the potential side effects of CLODREL PLUS TABLET 15'S, particularly the risk of bleeding. Report any unusual or prolonged bleeding to your doctor immediately, such as nosebleeds, bleeding gums, blood in your urine or stool, or unusual bruising. Avoid activities that may increase your risk of injury or bleeding while taking this medication. If you need to undergo any surgery or dental procedure, inform your doctor and dentist that you are taking CLODREL PLUS TABLET 15'S, as they may need to temporarily discontinue the medication.
• Monitor yourself for signs of allergic reactions, such as rash, itching, swelling, dizziness, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms. It's also important to be aware of other potential side effects, such as stomach upset, nausea, diarrhea, or headache. If these side effects persist or become bothersome, consult your doctor. Do not drive or operate heavy machinery if you experience dizziness or drowsiness while taking CLODREL PLUS TABLET 15'S.
• Store CLODREL PLUS TABLET 15'S in a cool, dry place, away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Properly dispose of any unused or expired medication according to your local regulations. If you have any questions or concerns about taking CLODREL PLUS TABLET 15'S, do not hesitate to ask your doctor or pharmacist. It's crucial to follow their instructions carefully and attend all scheduled follow-up appointments to ensure the medication is working effectively and safely for you.

• Clopidogrel, one of the active ingredients in CLODREL PLUS TABLET 15'S, can be taken with or without food. Food does not significantly affect the absorption of clopidogrel. However, it is advisable to take the medicine at the same time each day to maintain consistent blood levels. Always follow your doctor's instructions regarding dosage and timing.