DAPAVEL GM 10/1/1000 TABLET 10'S

How DAPAVEL GM 10/1/1000 TABLET 10'S Works

• DAPAVEL GM 10/1/1000 Tablet is a combination medicine used to treat type 2 diabetes mellitus when diet and exercise alone are not sufficient to control blood sugar levels. It contains three active ingredients: Dapagliflozin, Glimepiride, and Metformin. Each of these components works through different mechanisms to lower blood glucose and improve glycemic control.
• **Dapagliflozin:** This belongs to a class of drugs called Sodium-Glucose Co-transporter 2 (SGLT2) inhibitors. SGLT2 is a protein in the kidneys that helps reabsorb glucose back into the bloodstream. Dapagliflozin blocks the action of SGLT2, preventing the kidneys from reabsorbing glucose. As a result, excess glucose is excreted in the urine, leading to a reduction in blood sugar levels. This mechanism is insulin-independent, meaning it works even if the body's insulin production or sensitivity is impaired.
• **Glimepiride:** This is a sulfonylurea, a class of drugs that stimulate the pancreas to release more insulin. Insulin is a hormone that helps glucose move from the bloodstream into cells, where it can be used for energy. Glimepiride works by binding to specific receptors on pancreatic beta cells, triggering the release of insulin. This increased insulin secretion helps lower blood sugar levels. However, it's important to note that Glimepiride's effectiveness depends on the pancreas's ability to produce insulin. Therefore, it is most effective in the early stages of type 2 diabetes.
• **Metformin:** This is a biguanide, and it works primarily by reducing glucose production in the liver. The liver is a major source of glucose in the body, especially during fasting periods. Metformin inhibits gluconeogenesis, the process by which the liver converts non-carbohydrate sources (like amino acids and glycerol) into glucose. Additionally, Metformin improves insulin sensitivity in peripheral tissues, such as muscles. This means that the body's cells are better able to respond to insulin and take up glucose from the bloodstream. Metformin may also have a modest effect on reducing glucose absorption from the intestines.
• In combination, these three medications provide a multi-pronged approach to managing blood sugar levels in type 2 diabetes. Dapagliflozin helps remove excess glucose from the body through the urine. Glimepiride stimulates the pancreas to release more insulin. Metformin reduces glucose production in the liver and improves insulin sensitivity. By targeting different pathways involved in glucose metabolism, DAPAVEL GM 10/1/1000 Tablet can effectively lower blood sugar levels and improve overall glycemic control in individuals with type 2 diabetes. It is crucial to take this medication as prescribed by your doctor and to follow a healthy diet and exercise plan to maximize its benefits.

The common side effects of DAPAVEL GM 10/1/1000 Tablet may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, hypoglycemia (low blood sugar), headache, dizziness, and skin rash. Less common but potentially serious side effects include urinary tract infections (UTIs), genital infections (such as yeast infections), kidney problems, dehydration, ketoacidosis (increased ketones in blood or urine), pancreatitis, allergic reactions (rash, itching, swelling), and vitamin B12 deficiency. In rare cases, it can lead to lactic acidosis (a buildup of lactic acid in the body), which is a medical emergency. Muscle pain and weakness can also occur. Consult your doctor immediately if you experience any severe or persistent side effects.

• If you miss a dose of DAPAVEL GM 10/1/1000 Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep DAPAVEL GM 10/1/1000MG TAB 1X10 away from the reach of children and pets.
• Store DAPAVEL GM 10/1/1000MG TAB 1X10 at room temperature.

• **Maintain a Consistent Diet:** Pair DAPAVEL GM 10/1/1000 Tablet with a balanced diet rich in fiber, whole grains, and lean protein. Consistent meal timings can help regulate blood sugar levels and maximize the medication's effectiveness. Avoid sugary drinks and processed foods, as these can lead to blood sugar spikes. Incorporate plenty of non-starchy vegetables like spinach, broccoli, and kale into your meals.
• **Monitor Blood Sugar Regularly:** Frequent monitoring of your blood sugar levels is crucial while taking DAPAVEL GM 10/1/1000 Tablet. This helps you understand how your body responds to the medication and allows your doctor to adjust the dosage if needed. Keep a log of your blood sugar readings, noting the time of day and any relevant factors like meals or exercise. Share this log with your healthcare provider during your regular check-ups.
• **Stay Hydrated:** Drink plenty of water throughout the day. Adequate hydration helps your kidneys function properly and can aid in the elimination of excess glucose through urine, which is one of the mechanisms of action of dapagliflozin (one of the components of DAPAVEL GM 10/1/1000 Tablet). Aim for at least 8 glasses of water per day, adjusting for activity level and climate.
• **Engage in Regular Physical Activity:** Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Physical activity helps improve insulin sensitivity, lower blood sugar levels, and promote weight loss. Choose activities you enjoy, such as brisk walking, swimming, or cycling. Remember to check your blood sugar before, during, and after exercise, especially when you first start, as exercise can affect blood sugar levels differently for each individual.
• **Be Aware of Potential Side Effects:** While DAPAVEL GM 10/1/1000 Tablet is generally well-tolerated, it's essential to be aware of potential side effects. These can include urinary tract infections, genital infections, and dehydration. Report any unusual symptoms or concerns to your doctor promptly. Also, inform your doctor about all other medications and supplements you are taking, as drug interactions can occur.

• DAPAVEL GM 10/1/1000 TABLET 10'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent blood sugar levels. If you experience stomach upset, taking it with food may help. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of low blood sugar (hypoglycemia).