GLICLATUS XR 60MG TABLET 10'S

How GLICLATUS XR 60MG TABLET 10'S Works

• GLICLATUS XR 60MG TABLET 10'S is an oral hypoglycemic medication primarily used to manage type 2 diabetes. Its active ingredient, gliclazide, belongs to a class of drugs called sulfonylureas. Understanding how GLICLATUS XR works involves understanding its mechanism of action at the cellular level.
• The primary action of GLICLATUS XR is to stimulate the release of insulin from the beta cells of the pancreas. Beta cells are specialized cells in the pancreas responsible for producing and secreting insulin in response to rising blood glucose levels. Gliclazide binds to specific receptors on the beta cell membrane. This binding inhibits ATP-sensitive potassium channels (KATP channels). These channels normally regulate the flow of potassium ions in and out of the cell. When KATP channels are inhibited, the beta cell membrane depolarizes. This depolarization opens voltage-gated calcium channels, allowing calcium ions to enter the beta cell.
• The influx of calcium ions triggers a cascade of events that leads to the exocytosis (release) of insulin-containing granules. Insulin is then released into the bloodstream. Released insulin then lowers blood glucose levels by facilitating the uptake of glucose into cells (muscle and fat), suppressing hepatic glucose production (glucose production by the liver), and promoting glycogen synthesis (storage of glucose as glycogen).
• GLICLATUS XR is formulated as an extended-release tablet, meaning the gliclazide is released slowly over a prolonged period. This extended release helps to maintain a more stable concentration of the drug in the bloodstream, providing better control of blood sugar levels throughout the day. This sustained release mechanism reduces the risk of sudden spikes and drops in blood glucose, offering a more consistent therapeutic effect compared to immediate-release formulations. Therefore, it is important to take the medicine regularly, as prescribed by the doctor.
• In summary, GLICLATUS XR 60MG TABLET 10'S works by stimulating insulin release from pancreatic beta cells through the inhibition of KATP channels, leading to membrane depolarization, calcium influx, and ultimately, insulin secretion. The extended-release formulation provides a sustained and consistent blood glucose control throughout the day.

Like all medicines, GLICLATUS XR 60MG TABLET 10'S can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms may include sweating, paleness, hunger, shakiness, anxiety, rapid heartbeat, headache, confusion, and difficulty concentrating. Severe hypoglycemia can lead to loss of consciousness and even seizures. * Gastrointestinal disturbances: Abdominal pain, nausea, vomiting, indigestion, diarrhea, and constipation. **Uncommon side effects (may affect up to 1 in 100 people):** * Visual disturbances: Blurred vision may occur, especially at the start of treatment. * Skin reactions: Rash, itching, hives, and redness. **Rare side effects (may affect up to 1 in 1,000 people):** * Blood disorders: Decrease in the number of blood cells (e.g., platelets, white blood cells, red blood cells), which can cause bleeding, bruising, infections, or fatigue. These are generally reversible upon discontinuation of the drug. * Liver problems: Elevated liver enzymes, hepatitis (inflammation of the liver). In isolated cases, liver failure has been reported. **Very rare side effects (may affect up to 1 in 10,000 people):** * Allergic reactions: Severe allergic reactions (anaphylaxis) can occur, including swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, and a drop in blood pressure. Seek immediate medical attention if you experience any of these symptoms. * Other: Decreased sodium levels in the blood (hyponatremia). **If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed here.**

• If you miss a dose of GLICLATUS XR 60MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep GLICLATUS XR 60MG TAB 1X10 away from the reach of children and pets.
• Store GLICLATUS XR 60MG TAB 1X10 at room temperature.

• Take GLICLATUS XR 60MG TABLET 10'S exactly as prescribed by your doctor. Do not crush, chew, or break the tablet. Swallow it whole with a glass of water. Usually, it's taken once daily, preferably with breakfast, to coincide with your body's natural insulin release patterns and help manage blood sugar levels throughout the day. Consistent timing optimizes the medication's effectiveness.
• Even while taking GLICLATUS XR 60MG TABLET 10'S, it's essential to adhere to a healthy diet and exercise regularly. Focus on a balanced meal plan rich in fiber, lean protein, and whole grains. Limit your intake of sugary foods and processed carbohydrates. Regular physical activity, such as brisk walking, jogging, or swimming, can significantly improve your body's response to the medication and help in better blood sugar control. Consult with a registered dietitian or certified diabetes educator for personalized guidance.
• Regularly monitor your blood sugar levels as directed by your healthcare provider while taking GLICLATUS XR 60MG TABLET 10'S. Keeping a log of your readings can help you and your doctor understand how the medication and your lifestyle are affecting your blood sugar control. Report any significant fluctuations or concerning trends to your doctor promptly. This allows for timely adjustments to your treatment plan.
• Be aware of the signs and symptoms of hypoglycemia (low blood sugar) while taking GLICLATUS XR 60MG TABLET 10'S. These can include shakiness, sweating, dizziness, confusion, rapid heartbeat, and hunger. Always carry a source of fast-acting sugar with you, such as glucose tablets, hard candy, or fruit juice, to quickly raise your blood sugar levels if hypoglycemia occurs. Inform your family and friends about the symptoms of hypoglycemia and how to assist you if needed.
• Inform your doctor about all other medications, supplements, and herbal remedies you are taking before starting GLICLATUS XR 60MG TABLET 10'S. Certain medications can interact with gliclazide, affecting its effectiveness or increasing the risk of side effects. Pay particular attention to medications that affect blood sugar levels, such as other diabetes medications, corticosteroids, and certain diuretics. Also, notify your doctor if you have any kidney or liver problems, as these conditions can affect how your body processes the medication.

• GLICLATUS XR 60MG TABLET 10'S is generally recommended to be taken with food to help reduce the risk of stomach upset. However, it's important to maintain a consistent dietary pattern while taking this medication. Avoid skipping meals, and be mindful of your carbohydrate intake. Consult your doctor or pharmacist for specific dietary advice tailored to your individual needs.