LAREGAB M 300/500MG TABLET 10'S

How LAREGAB M 300/500MG TABLET 10'S Works

• LAREGAB M 300/500MG TABLET 10'S is a combination medication designed to manage neuropathic pain and improve overall nerve health. It contains two active ingredients: Pregabalin and Methylcobalamin (Vitamin B12). Each component works through distinct mechanisms to alleviate pain and promote nerve regeneration.
• Pregabalin, the first key ingredient, is an anticonvulsant and analgesic. Its primary function is to reduce the release of certain neurotransmitters in the brain and spinal cord that are responsible for transmitting pain signals. Specifically, Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels. By binding to this subunit, Pregabalin modulates calcium influx into nerve terminals. This reduction in calcium influx subsequently decreases the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. These neurotransmitters play a crucial role in the sensation of pain, and by reducing their release, Pregabalin effectively diminishes the intensity of pain signals perceived by the brain. Furthermore, Pregabalin's mechanism of action helps to stabilize nerve activity, reducing the erratic firing of neurons that contributes to neuropathic pain.
• Methylcobalamin, the second active ingredient, is a form of Vitamin B12 that is essential for nerve health and function. Unlike other forms of Vitamin B12, Methylcobalamin is the neurologically active form and can directly participate in reactions within the nervous system. Methylcobalamin plays a vital role in the synthesis of myelin, the protective sheath that surrounds nerve fibers. Adequate myelin is crucial for the efficient transmission of nerve impulses. Damage to the myelin sheath can lead to impaired nerve function and neuropathic pain. Methylcobalamin also supports nerve regeneration and repair by promoting the growth of nerve cells and enhancing their ability to recover from injury. In addition, it acts as a cofactor for methionine synthase, an enzyme involved in the conversion of homocysteine to methionine. By reducing homocysteine levels, Methylcobalamin helps prevent damage to blood vessels and nerves.
• In summary, LAREGAB M 300/500MG TABLET 10'S combines the pain-relieving effects of Pregabalin with the nerve-regenerating properties of Methylcobalamin. Pregabalin reduces the release of pain-signaling neurotransmitters, while Methylcobalamin supports myelin synthesis, nerve regeneration, and overall nerve health. This dual action helps to effectively manage neuropathic pain and improve the quality of life for individuals suffering from nerve-related conditions.

Common side effects of LAREGAB M 300/500MG TABLET may include: Dizziness, Sleepiness, Headache, Fatigue, Blurred vision, Dry mouth, Nausea, Vomiting, Constipation, Diarrhea, Increased appetite, Weight gain, Peripheral edema (swelling in hands and feet), Difficulty with coordination, Tremor, Memory problems, Confusion, Anxiety, Irritability, Depression, Sexual dysfunction. Less common or rare side effects may include: Muscle pain or weakness, Changes in blood pressure, Allergic reactions (rash, itching, swelling), Changes in blood sugar, Visual disturbances, Liver problems, Decreased platelet count, Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), Suicidal thoughts or behavior.

• If you miss a dose of LAREGAB M 300/500MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep LAREGAB M 300/500MG TAB 1X10 away from the reach of children and pets.
• Store LAREGAB M 300/500MG TAB 1X10 at room temperature.

• **Take LAREGAB M as Prescribed:** Always adhere to your doctor's prescribed dosage and schedule for LAREGAB M. Do not alter the dose or stop taking the medication without consulting your healthcare provider, as this could affect your condition and the medication's effectiveness. LAREGAB M is usually taken with food to minimize potential stomach upset. Maintain consistency in timing each day to optimize its therapeutic effect.
• **Monitor Blood Sugar Regularly:** LAREGAB M combines pregabalin and metformin, so it's crucial to monitor your blood sugar levels frequently, especially if you have diabetes. Keep a record of your blood sugar readings and share them with your doctor during check-ups. This helps in adjusting your diabetes management plan as needed. Watch out for signs of hypoglycemia (low blood sugar), such as sweating, shakiness, and confusion.
• **Be Aware of Potential Side Effects:** LAREGAB M may cause side effects such as dizziness, sleepiness, nausea, and peripheral edema (swelling in the extremities). Understand these potential side effects and discuss them with your doctor if they become bothersome or severe. Avoid activities requiring alertness, such as driving or operating machinery, until you know how the medication affects you. Report any unusual or severe side effects immediately.
• **Inform Your Doctor About Other Medications:** Before starting LAREGAB M, inform your doctor about all other medications, supplements, and herbal products you are taking. Drug interactions can affect how LAREGAB M works and increase the risk of side effects. Pay special attention to medications that also affect blood sugar levels or nerve function. Your doctor may need to adjust the dosages of your other medications or monitor you more closely.
• **Maintain a Healthy Lifestyle:** While taking LAREGAB M, complement your treatment with a healthy lifestyle. This includes eating a balanced diet, engaging in regular physical activity, and managing stress. A healthy lifestyle can improve your overall health and enhance the effectiveness of LAREGAB M in managing your condition. Avoid excessive alcohol consumption, as it can interfere with the medication's effects and increase the risk of side effects. Ensure adequate hydration and get sufficient sleep each night.
• **If you experience any signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing, seek immediate medical attention.**

• LAREGAB M 300/500MG TABLET 10'S can be taken with or without food. However, taking it at a consistent time each day is recommended for optimal absorption and to help you remember to take it.