LEUCOVORIN CALCIUM 15MG/2ML INJECTION
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LEUCOVORIN CALCIUM 15MG/2ML INJECTION
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LEUCOVORIN CALCIUM 15MG/2ML INJECTION

By FRESENIUS KABI INDIA PVT LTD

MRP

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132.86

₹42

68.39 % OFF

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Product DetailsArrow

About LEUCOVORIN CALCIUM 15MG/2ML INJECTION

  • LEUCOVORIN CALCIUM 15MG/2ML INJECTION contains leucovorin calcium, a substance related to folic acid, a vital vitamin. It belongs to a class of medications known as folic acid analogs. This medication is primarily used to mitigate the adverse effects of methotrexate, a drug used in the treatment of certain cancers. It is also administered to patients who have experienced an accidental overdose of methotrexate or similar medications. Additionally, LEUCOVORIN CALCIUM 15MG/2ML INJECTION is used in conjunction with other anticancer drugs in the treatment of colorectal cancer, which originates in the colon or rectum. Beyond cancer treatment, it can also address anemia resulting from folic acid deficiency.
  • It is crucial to avoid LEUCOVORIN CALCIUM 15MG/2ML INJECTION if you have a known allergy to leucovorin calcium, calcium folinate, or any other components of this medicine. It's also contraindicated in individuals with specific types of anemia, such as pernicious anemia or megaloblastic anemia, particularly those stemming from vitamin B12 deficiency. Before starting treatment, inform your healthcare provider about any pre-existing conditions, including anemia, or kidney, heart, or liver issues. Furthermore, disclose any medications you are currently taking, especially those for seizure management. Promptly notify your physician if you experience any allergic reactions, such as wheezing, breathing difficulties, skin rashes, itching, hives, or swelling of the lips, face, or tongue. This medication can be a crucial part of cancer treatment and managing methotrexate toxicity, but it needs to be administered with careful consideration of potential risks and individual health factors.

Uses of LEUCOVORIN CALCIUM 15MG/2ML INJECTION

  • Addressing Methotrexate Overdose and Toxicity: Strategies for managing and mitigating the adverse effects of methotrexate overdose, including recognizing symptoms, implementing supportive care, and administering antidotes like LEUCOVORIN CALCIUM 15MG/2ML INJECTION to counteract its harmful effects.
  • Preventing the Harmful Effects of Methotrexate or Similar Medications: Taking proactive measures to minimize the potential side effects associated with methotrexate and related drugs. This includes appropriate dosage adjustments, monitoring for early signs of toxicity, and utilizing rescue medications such as LEUCOVORIN CALCIUM 15MG/2ML INJECTION to protect healthy cells.
  • Colorectal Cancer: Addressing colorectal cancer, focusing on treatment options that may involve LEUCOVORIN CALCIUM 15MG/2ML INJECTION in conjunction with other chemotherapeutic agents to target and eradicate cancerous cells within the colon and rectum.
  • Anemia: Managing anemia by addressing its underlying causes and utilizing LEUCOVORIN CALCIUM 15MG/2ML INJECTION in specific cases where folate deficiency contributes to the condition, supporting red blood cell production and overall blood health.

Side Effects of LEUCOVORIN CALCIUM 15MG/2ML INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. With LEUCOVORIN CALCIUM 15MG/2ML INJECTION, common side effects include diarrhea, nausea, vomiting, inflamed and sore mouth, and tiredness. Serious side effects may include allergic reactions.

  • Diarrhea
  • Nausea
  • Vomiting
  • Inflammmed and sore mouth
  • Tiredness
  • Allergic reactions

Safety Advice for LEUCOVORIN CALCIUM 15MG/2ML INJECTIONArrow

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Pregnancy

CONSULT YOUR DOCTOR

There is a limited number of studies on the safety of LEUCOVORIN CALCIUM 15MG/2ML INJECTION during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

Dosage of LEUCOVORIN CALCIUM 15MG/2ML INJECTIONArrow

  • LEUCOVORIN CALCIUM 15MG/2ML INJECTION will be administered to you by a trained healthcare professional, such as a physician or nurse, who specializes in cancer chemotherapy. The specific dosage and duration of your treatment will be determined by your doctor. This decision is carefully made based on several factors, including the type and stage of your cancer, its severity, your overall health condition, kidney function, and how well you respond to the medication.
  • The route of administration, whether intravenously (directly into a vein) or intramuscularly (directly into a muscle), will also be determined by your doctor based on your specific medical condition and the characteristics of the LEUCOVORIN CALCIUM 15MG/2ML INJECTION treatment protocol. Intravenous administration allows the medication to enter the bloodstream directly for rapid distribution throughout the body. Intramuscular administration allows for a slower, more sustained release of the medication.
  • It's crucial to adhere to the prescribed dosage schedule and attend all scheduled treatment appointments. Any concerns or side effects experienced during treatment should be promptly reported to your doctor or nurse.

How to store LEUCOVORIN CALCIUM 15MG/2ML INJECTION?Arrow

  • Keep LEUCOVORIN CALCIUM 15MG INJ 2ML away from the reach of children and pets.
  • Store LEUCOVORIN CALCIUM 15MG INJ 2ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of LEUCOVORIN CALCIUM 15MG/2ML INJECTIONArrow

  • LEUCOVORIN CALCIUM 15MG/2ML INJECTION serves as a vital countermeasure against medications like methotrexate, which inhibit the dihydrofolate reductase enzyme and interfere with folic acid's therapeutic effects. By providing the body with the necessary folic acid, this injection plays a crucial role in treating anemia, facilitating the production of healthy red blood cells and addressing folic acid deficiencies.
  • Furthermore, LEUCOVORIN CALCIUM 15MG/2ML INJECTION is utilized in the treatment of colorectal cancer, where it enhances the effectiveness of 5-fluorouracil, another anticancer drug. This synergistic effect can improve treatment outcomes for patients battling colorectal cancer.
  • The mechanism of action involves supplying a reduced form of folate that bypasses the blocked enzymatic step caused by folic acid antagonists. This rescue effect is essential in preventing severe toxicity associated with high-dose methotrexate therapy. Additionally, leucovorin is used in combination with 5-fluorouracil to modulate its activity, resulting in increased cytotoxicity against cancer cells. This dual functionality makes it a versatile medication in both hematological and oncological contexts.
  • In essence, LEUCOVORIN CALCIUM 15MG/2ML INJECTION acts as a protective agent against the harmful effects of certain medications while also playing a supportive role in cancer treatment and the management of anemia related to folic acid deficiency. It is a critical component in chemotherapy regimens and supportive care for patients undergoing treatment with folic acid antagonists.

How to use LEUCOVORIN CALCIUM 15MG/2ML INJECTIONArrow

  • LEUCOVORIN CALCIUM 15MG/2ML INJECTION will be administered to you by a qualified healthcare professional, such as a physician or nurse specializing in cancer chemotherapy. They have the expertise to handle the drug safely and effectively.
  • The dosage and duration of your treatment will be determined by your doctor, taking into account several factors. These include the specific type and stage of your cancer, the severity of your condition, your overall health, and how well your body responds to the medication. It's crucial to follow your doctor's instructions precisely.
  • The medicine is administered either intravenously (into a vein) or intramuscularly (into a muscle), depending on your specific medical condition and the treatment plan designed for you. The healthcare provider will choose the most appropriate method to ensure the medication is delivered effectively.
  • Before each injection, inform your doctor or nurse about any allergies you have or any other medications you are currently taking, including over-the-counter drugs and herbal supplements. This information is important to prevent potential drug interactions or allergic reactions.
  • During and after the injection, you will be closely monitored for any side effects or adverse reactions. Report any unusual symptoms or discomfort to your healthcare provider immediately. They can manage any side effects that may occur and ensure your safety throughout the treatment process.
  • It is important to adhere to the prescribed treatment schedule and attend all your appointments. Consistency in treatment is essential for the best possible outcome.

FAQs

Why is LEUCOVORIN CALCIUM 15MG/2ML INJECTION given 24 hours after methotrexate?Arrow

LEUCOVORIN CALCIUM 15MG/2ML INJECTION is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.

Can LEUCOVORIN CALCIUM 15MG/2ML INJECTION cause swelling?Arrow

LEUCOVORIN CALCIUM 15MG/2ML INJECTION may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

Can LEUCOVORIN CALCIUM 15MG/2ML INJECTION cause seizures?Arrow

There is no evidence that LEUCOVORIN CALCIUM 15MG/2ML INJECTION cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.

How long does it take for LEUCOVORIN CALCIUM 15MG/2ML INJECTION to work?Arrow

LEUCOVORIN CALCIUM 15MG/2ML INJECTION starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with LEUCOVORIN CALCIUM 15MG/2ML INJECTION?Arrow

A healthcare professional will monitor you during the treatment with this medicine. Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

Does LEUCOVORIN CALCIUM 15MG/2ML INJECTION interact with other drugs?Arrow

There is no known interaction of LEUCOVORIN CALCIUM 15MG/2ML INJECTION with other drugs.

What advice should I follow while taking LEUCOVORIN CALCIUM 15MG/2ML INJECTION?Arrow

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much LEUCOVORIN CALCIUM 15MG/2ML INJECTION. contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine.

What is LEUCOVORIN CALCIUM and why is it used for making LEUCOVORIN CALCIUM 15MG/2ML INJECTION?Arrow

LEUCOVORIN CALCIUM is a molecule/combination used for making LEUCOVORIN CALCIUM 15MG/2ML INJECTION.

For what type of ailments/diseases/conditions is LEUCOVORIN CALCIUM 15MG/2ML INJECTION prescribed?Arrow

LEUCOVORIN CALCIUM 15MG/2ML INJECTION is prescribed for {Oncology} ailments/diseases/conditions.

References

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Calcium Folinate 10 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. 2020. Available from:

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HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet]. Available from:

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Marketer / Manufacturer Details

FRESENIUS KABI INDIA PVT LTD

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LEUCOVORIN CALCIUM 15MG/2ML INJECTION

LEUCOVORIN CALCIUM 15MG/2ML INJECTION

MRP

₹

132.86

₹42

68.39 % OFF

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