MACHALER INHALER

How MACHALER INHALER Works

• MACHALER Inhaler is a combination medicine containing Levosalbutamol, Ipratropium, and Beclometasone. It is used to relieve symptoms of chronic obstructive pulmonary disease (COPD) and asthma, such as wheezing, shortness of breath, chest tightness, and coughing. Understanding how each component of MACHALER Inhaler works is key to appreciating its overall effectiveness.
• Levosalbutamol is a short-acting beta-2 adrenergic receptor agonist. It works by selectively stimulating beta-2 receptors in the smooth muscle lining the airways. This stimulation causes the smooth muscle to relax, leading to bronchodilation, or widening of the airways. By opening up the airways, Levosalbutamol makes it easier to breathe and provides quick relief from acute bronchospasm (sudden constriction of the airways). Its effects are relatively rapid, making it an ideal component for addressing sudden breathing difficulties.
• Ipratropium Bromide is an anticholinergic bronchodilator. It works by blocking the action of acetylcholine, a neurotransmitter that causes the muscles in the airways to tighten. By blocking acetylcholine, Ipratropium helps to relax and widen the airways, making it easier to breathe. Unlike Levosalbutamol, Ipratropium's effects are longer-lasting and it helps to prevent bronchospasm rather than just treating acute symptoms. It reduces mucus production in the lungs, further easing breathing difficulties. This makes it particularly useful in managing COPD, where mucus hypersecretion is often a problem.
• Beclometasone Dipropionate is a corticosteroid. It works by reducing inflammation in the airways. When inhaled, Beclometasone suppresses the release of inflammatory substances in the lungs. This helps to reduce swelling and mucus production in the airways, making it easier to breathe and reducing the frequency of asthma or COPD exacerbations. The anti-inflammatory effect of beclometasone is crucial for long-term control of airway inflammation and preventing the worsening of respiratory conditions. Regular use helps to maintain open airways and reduce the risk of flare-ups.
• In summary, MACHALER Inhaler works through the combined action of its three active ingredients. Levosalbutamol provides quick relief by opening up the airways, Ipratropium offers sustained bronchodilation and reduces mucus production, and Beclometasone controls inflammation in the airways. Together, these components address both the immediate symptoms and the underlying causes of breathing difficulties in COPD and asthma.

Like all medicines, MACHALER INHALER can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Headache * Sore throat * Hoarseness * Cough * Oral thrush (a fungal infection in the mouth) **Uncommon side effects (may affect up to 1 in 100 people):** * Palpitations (feeling your heartbeat) * Muscle cramps * Anxiety * Restlessness * Sleep disturbances * Dizziness * Changes in taste * Nausea * Blurred vision * Increased sweating * Tremor * Skin rash * Itching * Urticaria * High blood sugar * Bronchospasm (tightening of the airways causing wheezing or difficulty breathing) - If this happens, stop using MACHALER INHALER and seek immediate medical attention. **Rare side effects (may affect up to 1 in 1,000 people):** * Angioedema (swelling of the face, lips, tongue, or throat) * Paradoxical bronchospasm (opposite of the intended effect, causing wheezing or difficulty breathing) - If this happens, stop using MACHALER INHALER and seek immediate medical attention. * Hypokalaemia (low potassium level in the blood) * Hyperglycemia (high blood sugar) **Very rare side effects (may affect up to 1 in 10,000 people):** * Arrhythmias (irregular heartbeat) * Decreased bone density * Cataracts * Glaucoma **Frequency not known (cannot be estimated from the available data):** * Depression * Aggression This is not a complete list of side effects, others may occur. If you experience any troublesome or persistent side effects, please consult your doctor or pharmacist.

• If you miss a dose of MACHALER Inhaler, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

• Keep MACHALER INHALER away from the reach of children and pets.
• Store MACHALER INHALER at room temperature.

• **Prime Your Inhaler:** If it's a new Machaler Inhaler or hasn't been used in a while (more than a week), prime it by releasing a test spray into the air. This ensures the inhaler delivers the correct dose. Usually, 2-3 sprays are sufficient. Avoid spraying towards your face.
• **Shake Well Before Use:** Always shake the Machaler Inhaler vigorously for a few seconds before each use. This mixes the medication properly, ensuring you get a consistent dose with every inhalation. Shaking distributes the drug evenly within the propellant.
• **Exhale Completely:** Before using the inhaler, breathe out fully, away from the inhaler. This empties your lungs, allowing you to take a deeper and more effective breath of the medication. A full exhale preps your lungs for optimal absorption.
• **Inhale Slowly and Deeply:** As you press down on the canister of the Machaler Inhaler, breathe in slowly and deeply through your mouth. This helps the medication reach deep into your lungs. Continue inhaling for as long as you comfortably can.
• **Hold Your Breath:** After inhaling, hold your breath for about 10 seconds, or as long as comfortable, before exhaling slowly. This allows the medication to settle in your lungs and be absorbed effectively. Holding your breath maximizes drug delivery to the airways.
• **Rinse Your Mouth:** After using the Machaler Inhaler, rinse your mouth with water and spit it out. This helps to prevent thrush (a fungal infection) and reduces any potential side effects from the medication. Oral hygiene is crucial after inhaler use, especially for corticosteroids.
• **Clean Your Inhaler Regularly:** Clean the mouthpiece of your Machaler Inhaler regularly with a clean, dry cloth. This prevents buildup of medication and keeps the inhaler hygienic. Do not wash the canister or put any part of the inhaler in water unless specifically instructed by your doctor or pharmacist.
• **Store Properly:** Store your Machaler Inhaler in a cool, dry place away from direct sunlight and heat. Extreme temperatures can affect the medication's effectiveness. Check the expiration date regularly and discard the inhaler if it's expired or if you've used the indicated number of actuations.
• **Keep Track of Doses:** Keep track of how many doses you have used from your Machaler Inhaler. This will help you to know when it is time for a refill. Many inhalers have a dose counter, but if yours doesn't, you can mark it on the packaging each time you use it. Knowing when to refill prevents running out of medication unexpectedly.
• **Consult Your Doctor:** Use Machaler Inhaler only as prescribed by your doctor. Do not increase or decrease the dose without consulting them. If your symptoms worsen or do not improve, seek medical advice promptly. Self-treating can be dangerous; always follow your doctor's guidance.
• **Understand Potential Side Effects:** Be aware of the potential side effects of Machaler Inhaler, such as throat irritation, cough, or headache. If you experience any severe or persistent side effects, consult your doctor immediately. Knowing the side effects helps in early identification and management.

• MACHALER INHALER is generally unaffected by food. It can be used regardless of meal times. There are no known food interactions with MACHALER INHALER. However, it is always advisable to follow your doctor's instructions regarding the use of this medication.