NEBICARD H TABLET 15'S

How NEBICARD H TABLET 15'S Works

• NEBICARD H TABLET 15'S is a combination medication containing nebivolol and hydrochlorothiazide, designed to manage hypertension (high blood pressure). Each component works through different mechanisms to achieve a synergistic effect in lowering blood pressure.
• **Nebivolol's Mechanism of Action:** Nebivolol is a beta-1 selective adrenergic receptor blocker, often referred to as a beta-blocker. It primarily targets beta-1 receptors in the heart. By blocking these receptors, nebivolol reduces the heart rate and the force of heart contractions. This leads to a decrease in cardiac output, which is the amount of blood the heart pumps per minute. Lowering cardiac output directly contributes to reducing blood pressure. Additionally, nebivolol has a unique property compared to other beta-blockers: it stimulates the release of nitric oxide (NO) from the endothelial cells lining the blood vessels. Nitric oxide is a potent vasodilator, meaning it causes blood vessels to relax and widen. This vasodilation further lowers blood pressure by reducing peripheral vascular resistance – the resistance to blood flow in the arteries.
• **Hydrochlorothiazide's Mechanism of Action:** Hydrochlorothiazide is a thiazide diuretic, commonly known as a water pill. It works in the kidneys to reduce sodium and water reabsorption. Specifically, it inhibits the sodium-chloride symporter in the distal convoluted tubule of the nephron. This inhibition increases the excretion of sodium and chloride in the urine. As sodium and chloride are excreted, water follows osmotically, leading to increased urine volume. This reduces the overall blood volume, which subsequently lowers blood pressure. Furthermore, hydrochlorothiazide has a long-term effect on blood vessels, reducing their sensitivity to vasoconstrictors and further contributing to blood pressure reduction.
• **Synergistic Effect:** The combination of nebivolol and hydrochlorothiazide provides a dual approach to blood pressure management. Nebivolol reduces cardiac output and promotes vasodilation, while hydrochlorothiazide reduces blood volume. These complementary actions result in a more effective and sustained reduction in blood pressure compared to using either medication alone. The combination also helps to counteract potential side effects. For example, beta-blockers can sometimes cause fluid retention, which is mitigated by the diuretic effect of hydrochlorothiazide. Similarly, hydrochlorothiazide can lead to potassium loss, which may be less pronounced when combined with nebivolol.
• In summary, NEBICARD H TABLET 15'S effectively lowers blood pressure by combining a beta-1 selective adrenergic receptor blocker (nebivolol) that reduces cardiac output and promotes vasodilation with a thiazide diuretic (hydrochlorothiazide) that reduces blood volume. This dual mechanism makes it a valuable option for managing hypertension and reducing the risk of cardiovascular events.

Nebicard H Tablet may cause several side effects, although not everyone experiences them. Common side effects include: * Dizziness * Headache * Fatigue * Slow heartbeat * Low blood pressure * Diarrhea * Constipation * Nausea * Peripheral edema (swelling in the extremities) Less common but potentially serious side effects include: * Allergic reactions (rash, itching, swelling) * Heart failure (worsening of existing condition) * Bronchospasm (wheezing or difficulty breathing, especially in people with asthma or COPD) * Depression * Sleep disturbances * Impotence * Raynaud's phenomenon (numbness, tingling, and color changes in fingers and toes) * AV block (heart rhythm problem) This is not an exhaustive list. If you experience any unusual or severe side effects, stop taking Nebicard H and consult your doctor immediately.

• If you miss a dose of Nebicard H Tablet, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep NEBICARD H TAB 1X15 away from the reach of children and pets.
• Store NEBICARD H TAB 1X15 at room temperature.

• **Take as Prescribed:** Always take NEBICARD H TABLET 15'S exactly as your doctor has prescribed. Do not change the dosage or stop taking the medication without consulting your healthcare provider, as this can affect its effectiveness and potentially cause adverse effects. Consistent adherence ensures optimal management of your condition.
• **Monitor Blood Pressure Regularly:** While taking NEBICARD H TABLET 15'S, regularly monitor your blood pressure. Keep a record of your readings and share them with your doctor during follow-up appointments. This helps in assessing the medication's effectiveness and making necessary adjustments to your treatment plan. Regular monitoring empowers you to proactively manage your health.
• **Be Aware of Potential Side Effects:** NEBICARD H TABLET 15'S can cause side effects such as dizziness, fatigue, or slow heart rate. If you experience any persistent or bothersome side effects, inform your doctor immediately. Understanding potential side effects helps you to take prompt action and minimize discomfort. Don't ignore any new symptoms that arise.
• **Maintain a Healthy Lifestyle:** Complement the medication with a healthy lifestyle. This includes a balanced diet low in sodium, regular exercise (as advised by your doctor), and avoiding smoking and excessive alcohol consumption. A holistic approach combining medication and lifestyle modifications enhances overall cardiovascular health and well-being. Your active participation significantly contributes to the success of the treatment.
• **Avoid Abrupt Discontinuation:** Do not stop taking NEBICARD H TABLET 15'S suddenly, even if you feel better. Abrupt discontinuation can lead to a sudden increase in blood pressure or other withdrawal symptoms. Always consult your doctor before making any changes to your medication regimen. Gradual tapering of the dose, if needed, should be done under medical supervision to ensure safety.

• NEBICARD H TABLET 15'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent levels of the medication in your body. Avoid consuming high-fat meals before taking this medicine as it may delay the absorption.