NICOMNOL 4MG TABLET 10'S

How NICOMNOL 4MG TABLET 10'S Works

• NICOMNOL 4MG TABLET 10'S contains Nicorandil as its active ingredient. Nicorandil is a unique antianginal medication that works through a dual mechanism to alleviate chest pain (angina) and improve blood flow to the heart. Its actions involve both nitrate-like effects and the opening of ATP-sensitive potassium channels (KATP channels).
• Firstly, Nicorandil possesses a nitrate-like effect. It gets converted into nitric oxide (NO) within the body. Nitric oxide is a potent vasodilator, meaning it causes the blood vessels to relax and widen. This vasodilation has several beneficial effects for individuals with angina. It reduces the workload on the heart by decreasing both preload (the amount of blood returning to the heart) and afterload (the resistance the heart must pump against). The reduced workload translates to less oxygen demand by the heart muscle.
• Secondly, Nicorandil acts as a KATP channel opener. ATP-sensitive potassium channels are present in the smooth muscle cells of blood vessels and in cardiac muscle cells. When Nicorandil opens these channels, it causes potassium ions to flow out of the cells, leading to hyperpolarization (a change in the cell's electrical potential). In vascular smooth muscle, this hyperpolarization results in relaxation and vasodilation, further contributing to improved blood flow to the heart.
• The combined effect of nitrate-like action and KATP channel opening results in several benefits. It dilates both the large epicardial coronary arteries and the smaller resistance vessels, improving overall coronary blood flow. It also provides a degree of cardioprotection by mimicking the effects of ischemic preconditioning, making the heart more resistant to subsequent episodes of ischemia (reduced blood flow).
• Furthermore, the vasodilation induced by Nicorandil helps to reduce coronary artery spasm, a common cause of angina, especially in variant angina (Prinzmetal's angina). By preventing or alleviating these spasms, Nicorandil can effectively reduce the frequency and severity of angina attacks.
• In summary, NICOMNOL 4MG TABLET 10'S works by relaxing blood vessels and improving blood flow to the heart muscle. This reduces the heart's workload and oxygen demand, preventing chest pain (angina). The dual mechanism of action, involving nitric oxide release and KATP channel opening, provides comprehensive protection against angina and its associated symptoms.

Common side effects of Nicomnool 4mg Tablet may include: * Nausea * Vomiting * Diarrhea * Abdominal pain * Headache * Dizziness * Fatigue * Dry mouth * Insomnia (difficulty sleeping) * Increased sweating Less common, but more serious side effects that require immediate medical attention: * Severe allergic reactions (rash, itching, swelling, difficulty breathing) * Irregular heartbeat * Seizures * Unexplained muscle weakness or pain * Changes in vision This is not an exhaustive list. If you experience any unusual symptoms while taking Nicomnool 4mg Tablet, consult your doctor.

• If you miss a dose of Nicomnool 4mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep NICOMNOL 4MG TAB 1X10 away from the reach of children and pets.
• Store NICOMNOL 4MG TAB 1X10 at room temperature.

• Take NICOMNOL 4MG TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. Consistency is key for optimal results in managing your condition.
• NICOMNOL 4MG TABLET 10'S can be taken with or without food, but try to take it at the same time each day to maintain a steady level of medication in your system. This helps in better symptom control and reduces the likelihood of missed doses.
• If you miss a dose of NICOMNOL 4MG TABLET 10'S, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
• Inform your doctor about all other medications, supplements, or herbal products you are currently taking before starting NICOMNOL 4MG TABLET 10'S. Drug interactions can affect how NICOMNOL works or increase the risk of side effects. It is crucial to provide a complete medication history.
• Store NICOMNOL 4MG TABLET 10'S at room temperature, away from direct sunlight, heat, and moisture. Keep it out of reach of children and pets. Proper storage ensures the medication remains effective and safe for use. Do not store in the bathroom.

• While taking NICOMNOL 4MG TABLET 10'S, there are no specific food restrictions. You can continue your normal diet unless your doctor advises you otherwise. It's always a good idea to maintain a balanced diet while on medication for overall health and well-being.
• Avoid taking NICOMNOL 4MG TABLET 10'S with grapefruit or grapefruit juice, as it may increase the drug levels in your body and the risk of side effects. Consult your doctor if you have any concerns.