PERINDOSYL AM 4/5MG TABLET 10'S

How PERINDOSYL AM 4/5MG TABLET 10'S Works

• PERINDOSYL AM 4/5MG TABLET is a combination medication containing perindopril arginine and amlodipine besilate. These two active ingredients work synergistically to manage hypertension (high blood pressure) and reduce the risk of cardiovascular events.
• Perindopril arginine belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. ACE inhibitors work by blocking the action of ACE, an enzyme that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, increasing blood pressure. By inhibiting ACE, perindopril arginine reduces the production of angiotensin II, leading to vasodilation (widening of blood vessels) and a decrease in blood pressure. Additionally, it reduces the breakdown of bradykinin, a vasodilator, further contributing to its blood pressure-lowering effect. This mechanism helps to reduce the workload on the heart and improve blood flow.
• Amlodipine besilate is a calcium channel blocker. Calcium channel blockers work by blocking the entry of calcium into the smooth muscle cells of the heart and blood vessels. Calcium is essential for muscle contraction. By blocking calcium entry, amlodipine relaxes and widens the blood vessels, which lowers blood pressure. It primarily affects the arteries, reducing peripheral vascular resistance. Amlodipine also increases the supply of oxygen to the heart, reducing the frequency of angina (chest pain) attacks. This dual action of vasodilation both reduces blood pressure and alleviates chest pain associated with reduced blood flow to the heart.
• The combination of perindopril arginine and amlodipine besilate provides a complementary approach to blood pressure control. Perindopril arginine addresses the hormonal (angiotensin II) component of blood pressure regulation, while amlodipine targets the vascular smooth muscle. This synergistic effect often results in greater blood pressure reduction than either drug could achieve alone. By reducing blood pressure, PERINDOSYL AM 4/5MG TABLET decreases the risk of stroke, heart attack, and kidney problems associated with hypertension. It's crucial to take this medication as prescribed by your doctor to ensure optimal blood pressure control and minimize potential side effects.
• In summary, PERINDOSYL AM 4/5MG TABLET works by combining an ACE inhibitor (perindopril arginine) that reduces the production of angiotensin II and a calcium channel blocker (amlodipine besilate) that relaxes blood vessels. This dual action lowers blood pressure, reduces the workload on the heart, and improves blood flow, thereby decreasing the risk of cardiovascular complications associated with hypertension.

Common side effects of PERINDOSYL AM 4/5MG TABLET may include: Headache, Dizziness, Lightheadedness, Cough, Fatigue, Nausea, Abdominal pain, Diarrhea, Constipation, Visual disturbances, Hypotension (low blood pressure), Peripheral edema (swelling in the extremities). Uncommon side effects may include: Mood changes, Sleep disorders, Urticaria (hives), Angioedema (swelling of the face, lips, tongue, or throat), Pruritus (itching), Muscle cramps, Renal impairment, Hyperkalemia (high potassium levels), Dry mouth. Rare side effects may include: Psoriasis, Acute renal failure, Confusion. Very rare side effects may include: Arrhythmia, Myocardial infarction, Stroke, Eosinophilic pneumonia. If you experience any severe or persistent side effects, discontinue use and consult your doctor immediately.

• If you miss a dose of PERINDOSYL AM 4/5MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep PERINDOSYL AM 4/5MG TAB 1X10 away from the reach of children and pets.
• Store PERINDOSYL AM 4/5MG TAB 1X10 at room temperature.

• **Take as Directed:** Always take PERINDOSYL AM 4/5MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting them, as this can affect its effectiveness and your health.
• **Timing Matters:** For consistent results, take this medication at the same time each day. It's often recommended to take it in the morning, but follow your doctor's specific instructions. Consistency helps maintain stable blood pressure levels throughout the day.
• **Monitor Blood Pressure Regularly:** While taking PERINDOSYL AM 4/5MG TABLET 10'S, regularly monitor your blood pressure. Keep a record of your readings and share them with your doctor during check-ups. This helps in assessing the medication's effectiveness and making any necessary adjustments.
• **Lifestyle Adjustments:** Complement the medication with healthy lifestyle choices. This includes a balanced diet low in sodium, regular exercise, maintaining a healthy weight, and limiting alcohol consumption. These changes can significantly enhance the effectiveness of the medication in controlling your blood pressure.
• **Be Aware of Side Effects:** Be aware of potential side effects such as dizziness, lightheadedness, cough, or swelling. If you experience any severe or persistent side effects, contact your doctor immediately. Understanding the possible side effects helps you manage them effectively and seek timely medical attention.
• **Stay Hydrated:** Drink plenty of water throughout the day. Staying hydrated helps maintain healthy blood volume and supports the medication's function. Dehydration can sometimes exacerbate side effects like dizziness.
• **Avoid Grapefruit:** Avoid consuming grapefruit or grapefruit juice while taking this medication, as it can interact with the drug and alter its effectiveness. This interaction can potentially lead to increased side effects or reduced therapeutic benefits.
• **Inform Your Doctor About Other Medications:** Inform your doctor about all other medications, supplements, and herbal products you are taking. This helps prevent potential drug interactions that could affect the efficacy of PERINDOSYL AM 4/5MG TABLET 10'S or increase the risk of side effects.

• PERINDOSYL AM 4/5MG TABLET 10'S can be taken with or without food. However, it is advisable to take it at the same time each day to maintain consistent blood levels.
• Avoid consuming high amounts of potassium-rich foods (e.g., bananas, spinach) or potassium supplements unless specifically directed by your doctor, as PERINDOSYL AM can increase potassium levels in the body.
• Be cautious with alcohol consumption while taking PERINDOSYL AM 4/5MG TABLET 10'S, as it may enhance the blood-pressure-lowering effect of the medication, potentially leading to dizziness or lightheadedness.