PREGANZA D 50MG/20MG CAPSULE 10'S

How PREGANZA D 50MG/20MG CAPSULE 10'S Works

• PREGANZA D 50MG/20MG CAPSULE is a combination medication designed to alleviate neuropathic pain and discomfort associated with nerve damage. It contains two active ingredients: Pregabalin and Duloxetine, each working through distinct mechanisms to provide comprehensive pain relief.
• Pregabalin, a structural analogue of gamma-aminobutyric acid (GABA), primarily functions by binding to the α2δ subunit of voltage-gated calcium channels in the central nervous system. This binding modulates calcium influx at nerve terminals, subsequently reducing the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. By decreasing the levels of these neurotransmitters, Pregabalin effectively calms overactive nerve signals, thereby reducing pain transmission. It is particularly effective in managing conditions like fibromyalgia, diabetic neuropathy, and postherpetic neuralgia.
• Duloxetine, on the other hand, is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It works by preventing the reabsorption of serotonin and norepinephrine in the brain and spinal cord, increasing their levels in the synaptic cleft. These neurotransmitters play a crucial role in modulating pain pathways. By enhancing their availability, Duloxetine helps to reduce the perception of pain and improve mood. It is commonly used in treating conditions such as diabetic peripheral neuropathy, chronic musculoskeletal pain, and major depressive disorder, often co-existing with chronic pain conditions.
• When combined, Pregabalin and Duloxetine offer synergistic benefits. Pregabalin targets the neuronal excitability directly, while Duloxetine modulates the descending pain pathways in the central nervous system. This dual action provides more effective pain management compared to using either drug alone. The combination addresses both the physical and psychological aspects of chronic pain, offering patients a more comprehensive approach to managing their condition.
• The synergistic action helps in reducing the overall pain intensity, improving functional abilities, and enhancing the quality of life for individuals suffering from neuropathic pain. It's crucial to use PREGANZA D 50MG/20MG CAPSULE exactly as prescribed by a healthcare professional to maximize its benefits and minimize potential side effects. Always consult with your doctor regarding dosage adjustments and any concerns about the medication.

Common side effects of PREGANZA D 50MG/20MG CAPSULE may include: Dizziness, Sleepiness, Fatigue, Loss of coordination, Blurred vision, Dry mouth, Weight gain, Swelling of the extremities, Constipation, Increased appetite. Less common side effects may include: Mood changes, Memory problems, Difficulty concentrating, Tremors, Speech problems, Tingling or numbness, Muscle cramps, Erectile dysfunction, Decreased libido, Nausea, Vomiting, Diarrhea, Abdominal pain, Heartburn, Increased sweating, Skin rash, Itching. Rare but serious side effects: Allergic reactions (swelling of the face, lips, tongue, or throat, difficulty breathing), Suicidal thoughts, Severe muscle pain or weakness, Vision changes, Liver problems (yellowing of the skin or eyes, dark urine, abdominal pain), Pancreatitis (severe abdominal pain radiating to the back).

• If you miss a dose of PREGANZA D 50MG/20MG CAPSULE 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep PREGANZA D 50/20MG CAP 1X10 away from the reach of children and pets.
• Store PREGANZA D 50/20MG CAP 1X10 at room temperature.

• Take PREGANZA D 50MG/20MG CAPSULE 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. Consistency is key for optimal results in managing nerve pain and related conditions.
• PREGANZA D 50MG/20MG CAPSULE 10'S can be taken with or without food. However, taking it at the same time each day can help you remember to take it regularly and maintain a steady level of medication in your system. If you experience stomach upset, try taking it with food.
• Be aware that PREGANZA D 50MG/20MG CAPSULE 10'S may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you. Your safety is paramount, so take necessary precautions.
• If you miss a dose of PREGANZA D 50MG/20MG CAPSULE 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this can increase the risk of side effects. Adhering to the prescribed schedule is essential.
• Inform your doctor about all other medications, supplements, or herbal remedies you are taking before starting PREGANZA D 50MG/20MG CAPSULE 10'S. This helps prevent potential drug interactions that could affect the medication's effectiveness or increase the risk of adverse effects. Always keep your healthcare provider informed about your complete medication list.
• Store PREGANZA D 50MG/20MG CAPSULE 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets to prevent accidental ingestion. Proper storage ensures the medication remains effective and safe for use.
• Do not abruptly stop taking PREGANZA D 50MG/20MG CAPSULE 10'S without consulting your doctor. Sudden discontinuation can lead to withdrawal symptoms or a worsening of your condition. Your doctor will guide you on how to gradually reduce the dosage if necessary.
• Pay attention to any side effects you experience while taking PREGANZA D 50MG/20MG CAPSULE 10'S and report them to your doctor. Common side effects may include dizziness, drowsiness, dry mouth, or weight gain. Prompt reporting allows for timely management and adjustments to your treatment plan if needed.

• PREGANZA D 50MG/20MG CAPSULE 10'S may be taken with or without food, but it is important to take it consistently, either always with food or always without food, to maintain consistent absorption.
• Avoid consuming large amounts of alcohol while taking this medication, as it may increase the risk of side effects.