SACUHART 100MG TABLET 10'S

How SACUHART 100MG TABLET 10'S Works

• SACUHART 100MG TABLET 10'S is a combination medicine containing Sacubitril and Valsartan. It's primarily used to treat heart failure with reduced ejection fraction (HFrEF). To understand how it works, we need to look at each component individually:
• **Sacubitril:** Sacubitril belongs to a class of drugs called neprilysin inhibitors. Neprilysin is an enzyme in the body that breaks down several beneficial peptides, including natriuretic peptides. These peptides help regulate blood volume, blood pressure, and sodium excretion. By inhibiting neprilysin, Sacubitril increases the levels of these beneficial peptides.
• The increased levels of natriuretic peptides lead to several positive effects in heart failure patients: Increased sodium excretion reduces fluid overload, Vasodilation (widening of blood vessels) lowers blood pressure and improves blood flow, Reduced sympathetic nervous system activity lessens the 'fight-or-flight' response, which can strain the heart, and Inhibited fibrosis (scarring) in the heart muscle can improve its function.
• **Valsartan:** Valsartan is an angiotensin receptor blocker (ARB). Angiotensin II is a hormone that causes blood vessels to constrict, increasing blood pressure. It also stimulates the release of aldosterone, which leads to sodium and water retention. In heart failure, the renin-angiotensin-aldosterone system (RAAS) is often overactive, contributing to the worsening of the condition.
• Valsartan blocks the effects of angiotensin II by binding to the angiotensin II receptors. This results in Vasodilation (widening of blood vessels) and Lowered blood pressure. It also Reduces sodium and water retention, easing the workload on the heart. Furthermore, it Decreases the release of aldosterone, further contributing to blood pressure control and fluid balance.
• **Synergistic Effect:** The combination of Sacubitril and Valsartan provides a synergistic effect. By inhibiting neprilysin and blocking angiotensin II receptors, the medication addresses multiple pathways involved in heart failure. This dual action helps to: Reduce the strain on the heart, Improve heart function, Reduce hospitalizations for heart failure, and Prolong life expectancy in patients with HFrEF.
• In summary, SACUHART 100MG TABLET 10'S works by enhancing the beneficial effects of natriuretic peptides (through Sacubitril) and blocking the harmful effects of angiotensin II (through Valsartan), leading to improved cardiovascular function and outcomes in patients with heart failure with reduced ejection fraction.

Common side effects of Sacuhart 100mg Tablet may include nausea, vomiting, diarrhea, stomach pain, indigestion, heartburn, loss of appetite, headache, dizziness, drowsiness, fatigue, weakness, skin rash, itching, and sweating. Less common but potentially serious side effects include allergic reactions (such as hives, swelling of the face, lips, or tongue, difficulty breathing), liver problems (such as jaundice, dark urine, persistent fatigue), kidney problems (such as changes in urine output), and gastrointestinal bleeding (such as black, tarry stools, bloody vomit). Other rare side effects include changes in blood cell counts and severe skin reactions. Consult your doctor immediately if you experience any severe or persistent side effects.

• If you miss a dose of Sacuhart 100mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep SACUHART 100MG TAB 1X10 away from the reach of children and pets.
• Store SACUHART 100MG TAB 1X10 at room temperature.

• Take SACUHART 100MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or frequency without consulting them. Consistent adherence to the prescribed regimen ensures optimal therapeutic benefits and minimizes the risk of adverse effects. Setting a daily reminder can help maintain consistency.
• Inform your doctor about all other medications, supplements, and herbal remedies you are currently taking before starting SACUHART 100MG TABLET 10'S. This information helps prevent potential drug interactions that could reduce the effectiveness of SACUHART or increase the risk of side effects. Include both prescription and over-the-counter products in your disclosure.
• Store SACUHART 100MG TABLET 10'S in a cool, dry place, away from direct sunlight and moisture. Keep it out of reach of children and pets. Proper storage helps maintain the drug's efficacy and prevents accidental ingestion. Do not store in the bathroom due to humidity.
• If you experience any unusual or severe side effects while taking SACUHART 100MG TABLET 10'S, contact your doctor immediately. Common side effects might include mild nausea or headache, but severe reactions warrant immediate medical attention. Do not ignore persistent or worsening symptoms. Provide a detailed account of your symptoms to your healthcare provider.
• Maintain a healthy lifestyle while taking SACUHART 100MG TABLET 10'S, including a balanced diet and regular exercise. This can help improve your overall health and enhance the effectiveness of the medication. Avoid excessive alcohol consumption and smoking, as these can interfere with the drug's action and increase the risk of complications. Discuss specific dietary recommendations with your doctor or a registered dietitian.

• SACUHART 100MG TABLET 10'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent blood levels. If you experience stomach upset, taking it with food may help.