AMIFRU PLUS TABLET 10'S

How AMIFRU PLUS TABLET 10'S Works

• AMIFRU PLUS TABLET 10'S is a combination medicine designed to manage fluid retention (edema) and high blood pressure (hypertension). It combines the synergistic actions of three active ingredients: Amiloride, Furosemide, and Atenolol. Understanding how each component works is key to appreciating the overall effect of AMIFRU PLUS.
• Furosemide is a potent loop diuretic. It primarily works by inhibiting the reabsorption of sodium and chloride in the loop of Henle, a critical part of the nephron in the kidneys. By blocking the reabsorption of these electrolytes, Furosemide increases their excretion in the urine. Water follows these electrolytes, leading to increased urine production. This helps to reduce fluid volume in the body, alleviating edema and lowering blood pressure. The rapid and effective diuresis makes Furosemide particularly useful in cases of severe fluid overload.
• Amiloride is a potassium-sparing diuretic. Unlike Furosemide, which can lead to potassium loss, Amiloride works in the distal convoluted tubule and collecting ducts of the nephron. It blocks the epithelial sodium channels (ENaC), preventing sodium reabsorption. This action reduces the excretion of potassium, thus helping to maintain potassium levels in the body. By counteracting the potassium-wasting effect of Furosemide, Amiloride helps to prevent hypokalemia, a common side effect of loop diuretics. The combination of Furosemide and Amiloride provides effective diuresis while minimizing the risk of potassium imbalance.
• Atenolol is a beta-1 selective adrenergic blocker, often referred to as a beta-blocker. It primarily targets the beta-1 adrenergic receptors located in the heart. By blocking these receptors, Atenolol reduces the heart rate and force of contraction. This leads to a decrease in cardiac output, which in turn lowers blood pressure. Atenolol also reduces the release of renin, an enzyme produced by the kidneys that contributes to the regulation of blood pressure. By reducing renin levels, Atenolol further helps to lower blood pressure. The inclusion of Atenolol in AMIFRU PLUS provides an additional mechanism for blood pressure control, complementing the diuretic effects of Furosemide and Amiloride.
• In summary, AMIFRU PLUS TABLET 10'S works through a multi-pronged approach. Furosemide promotes fluid excretion, reducing edema and blood volume. Amiloride helps to maintain potassium balance, preventing hypokalemia. Atenolol lowers blood pressure by reducing heart rate and cardiac output. The combination of these three medications provides a comprehensive approach to managing edema and hypertension, addressing both fluid volume and blood pressure regulation. This makes AMIFRU PLUS an effective option for patients requiring comprehensive management of these conditions.

Common side effects of Amifru Plus Tablet may include nausea, vomiting, diarrhea, constipation, stomach upset, loss of appetite, dizziness, lightheadedness, headache, skin rash, itching, and changes in urine color. Less common but more serious side effects can include severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing), liver problems (yellowing of skin/eyes, dark urine, persistent nausea/vomiting), kidney problems (change in the amount of urine), muscle weakness, numbness/tingling, and easy bruising/bleeding. Other potential side effects are electrolyte imbalance (such as low potassium or sodium), dehydration, and blood disorders. This is not an exhaustive list, and it's important to consult with a doctor or pharmacist if you experience any unusual or bothersome symptoms.

• If you miss a dose of Amifru Plus Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep AMIFRU PLUS TAB 1X10 away from the reach of children and pets.
• Store AMIFRU PLUS TAB 1X10 at room temperature.

• AMIFRU PLUS TABLET 10'S can be taken with or without food, but it is important to take it at a consistent time each day to maintain a steady level of medication in your body.
• Avoid consuming large amounts of grapefruit or grapefruit juice while taking AMIFRU PLUS TABLET 10'S, as it can increase the levels of the medication in your blood and potentially increase the risk of side effects.
• If you experience any stomach upset while taking AMIFRU PLUS TABLET 10'S, try taking it with a small meal or snack.