ESAM AT TABLET 10'S

How ESAM AT TABLET 10'S Works

• ESAM AT TABLET 10'S is a combination medication designed to manage hypertension (high blood pressure) and reduce the risk of cardiovascular events such as heart attack and stroke. It combines two active ingredients: Esamolol and Amlodipine, each working through different mechanisms to achieve its therapeutic effect.
• **Esamolol:** Esamolol is a beta-blocker, specifically a beta-1 selective adrenergic receptor blocker. Beta-1 receptors are primarily located in the heart. When Esamolol binds to these receptors, it blocks the effects of adrenaline and noradrenaline (natural chemicals in the body that stimulate the heart). This leads to several beneficial effects for managing hypertension and heart conditions. Firstly, it decreases heart rate by slowing down the sinoatrial (SA) node firing rate, which is the heart's natural pacemaker. Secondly, it reduces the force of heart muscle contraction (contractility), which lowers the amount of blood the heart pumps out with each beat (cardiac output). Thirdly, it relaxes the blood vessels. All these effects contribute to lowering blood pressure. In addition to lowering blood pressure, Esamolol also helps to reduce chest pain (angina) and control irregular heart rhythms (arrhythmias).
• **Amlodipine:** Amlodipine is a calcium channel blocker, specifically a dihydropyridine calcium channel blocker. It works by blocking the entry of calcium into the smooth muscle cells of the blood vessel walls. Calcium is essential for muscle contraction. By blocking calcium entry, Amlodipine causes the smooth muscles to relax, leading to vasodilation (widening of blood vessels). This vasodilation reduces the resistance against which the heart has to pump, thus lowering blood pressure. Amlodipine primarily affects the arteries and arterioles (small arteries). Its effect is more pronounced in the peripheral blood vessels, contributing to a decrease in systemic vascular resistance. It also increases the supply of oxygen to the heart, which helps in reducing chest pain.
• **Synergistic Effect:** The combination of Esamolol and Amlodipine provides a synergistic effect in managing hypertension. Esamolol reduces heart rate and contractility, while Amlodipine reduces peripheral vascular resistance. Together, they offer a comprehensive approach to lowering blood pressure. The beta-blocking action of Esamolol can counteract the reflex tachycardia (increased heart rate) that can sometimes occur with Amlodipine, while Amlodipine can help to counter the vasoconstriction that can sometimes occur with beta-blockers. This combination helps to provide more consistent and effective blood pressure control than either drug used alone.
• In summary, ESAM AT TABLET 10'S effectively manages hypertension by combining a beta-blocker (Esamolol) that reduces heart rate and contractility with a calcium channel blocker (Amlodipine) that dilates blood vessels. This dual mechanism helps lower blood pressure, reduce the workload on the heart, and decrease the risk of cardiovascular events.

Common side effects of Esam AT Tablet may include: Headache, Dizziness, Fatigue, Sleepiness, Nausea, Vomiting, Abdominal pain, Diarrhea, Constipation, Flushing (sense of warmth in the face, ears, neck and trunk), Palpitations, Cold extremities, Orthostatic hypotension (sudden lowering of blood pressure on standing), Peripheral edema (swelling of the extremities). Uncommon side effects may include: Muscle cramps, Joint pain, Back pain, Blurred vision, Dry mouth, Increased sweating, Hair loss, Erectile dysfunction, Depression, Sleep disturbances, Shortness of breath, Worsening of asthma, Changes in blood sugar levels, Changes in liver function tests, Allergic reactions (rash, itching, hives). This is not an exhaustive list, and other side effects may occur. Consult your doctor if you experience any troublesome symptoms.

• If you miss a dose of ESAM AT Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep ESAM AT TAB 1X10 away from the reach of children and pets.
• Store ESAM AT TAB 1X10 at room temperature.

• Take ESAM AT TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them, as this can affect its effectiveness and increase the risk of side effects. Consistency is key for optimal results in managing your blood pressure and heart condition.
• It's crucial to monitor your blood pressure regularly while taking ESAM AT TABLET 10'S. Keep a record of your readings and share them with your doctor during check-ups. This helps in assessing the medication's effectiveness and making necessary adjustments to your treatment plan. Regular monitoring empowers you to actively participate in your healthcare.
• Inform your doctor about all other medications, supplements, or herbal remedies you are currently taking before starting ESAM AT TABLET 10'S. Drug interactions can occur and may impact how ESAM AT works or increase the risk of adverse effects. Transparency ensures your doctor can make informed decisions about your treatment.
• Adopt a healthy lifestyle alongside taking ESAM AT TABLET 10'S. This includes following a balanced diet low in sodium and saturated fats, engaging in regular physical activity, maintaining a healthy weight, and avoiding smoking. These lifestyle changes can significantly enhance the benefits of the medication and improve your overall cardiovascular health. Lifestyle modifications are integral for long-term well-being.
• Be aware of potential side effects of ESAM AT TABLET 10'S, such as dizziness, lightheadedness, or fatigue. If you experience any persistent or bothersome side effects, notify your doctor promptly. They can provide guidance on managing these effects or adjust your medication if necessary. Proactive communication ensures your comfort and safety during treatment.

• ESAM AT TABLET 10'S does not typically have significant interactions with food. It can be taken with or without food. However, it's advisable to maintain consistency in your daily routine. If you usually take it with food, continue doing so, and if you take it on an empty stomach, maintain that pattern. Consult your doctor if you have specific concerns about food interactions.
• Avoid grapefruit or grapefruit juice while taking ESAM AT TABLET 10'S as it may increase the levels of amlodipine in your blood, potentially increasing the risk of side effects.