LAREGAB AT LS TABLET 10'S

How LAREGAB AT LS TABLET 10'S Works

• LAREGAB AT LS TABLET 10'S is a combination medication designed to address both neuropathic pain and anxiety. It achieves this through the synergistic action of its two active ingredients: Pregabalin and Nortriptyline.
• Pregabalin, an anticonvulsant and analgesic, plays a crucial role in modulating nerve activity. Specifically, it binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system. These calcium channels are vital for the release of neurotransmitters, which are chemical messengers that transmit signals between nerve cells. By binding to the α2δ subunit, Pregabalin reduces the influx of calcium into nerve terminals. This, in turn, decreases the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. These neurotransmitters are heavily involved in the transmission of pain signals and the amplification of anxiety. By reducing their release, Pregabalin effectively dampens the overactivity of nerves, thereby alleviating neuropathic pain and reducing anxiety.
• Nortriptyline, a tricyclic antidepressant (TCA), complements Pregabalin's action through a different mechanism. It primarily works by inhibiting the reuptake of serotonin and norepinephrine in the synaptic cleft – the space between nerve cells. Serotonin and norepinephrine are neurotransmitters that play a significant role in mood regulation, pain modulation, and the body's stress response. By blocking their reuptake, Nortriptyline increases the concentration of these neurotransmitters in the synaptic cleft, allowing them to bind to their receptors for a more extended period. This prolonged activation of serotonin and norepinephrine receptors leads to several beneficial effects, including improved mood, reduced anxiety, and decreased pain perception. Moreover, Nortriptyline also exhibits some anticholinergic properties, which can contribute to its therapeutic effects.
• The combined action of Pregabalin and Nortriptyline provides a comprehensive approach to managing neuropathic pain and anxiety. Pregabalin directly reduces the overactivity of nerves by modulating calcium channel activity and reducing the release of excitatory neurotransmitters, while Nortriptyline enhances the effects of mood-regulating neurotransmitters and provides additional pain relief. This dual mechanism helps to alleviate pain, reduce anxiety, and improve overall well-being in individuals suffering from these conditions. It's crucial to take LAREGAB AT LS TABLET 10'S as prescribed by your doctor, as they have determined the appropriate dosage and duration of treatment for your specific needs.

Common side effects of LAREGAB AT LS Tablet may include: Sleepiness, Dizziness, Headache, Fatigue, Nausea, Vomiting, Constipation, Diarrhea, Dry mouth, Blurred vision, Weight gain, Peripheral edema (swelling in the extremities), Muscle pain or cramps, Tremors, Memory problems, Difficulty concentrating, Anxiety, Nervousness, Insomnia, Increased appetite, Changes in libido, Balance disorder, Speech disorder, Confusion, Tingling or numbness, Skin rash or itching. Less common but potentially serious side effects include: Allergic reactions (hives, swelling, difficulty breathing), Liver problems (yellowing of skin or eyes, dark urine, abdominal pain), Suicidal thoughts or behavior, Severe muscle pain or weakness (rhabdomyolysis), Heart problems (chest pain, irregular heartbeat), Vision changes, Difficulty urinating.

• If you miss a dose of LAREGAB AT LS TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep LAREGAB AT LS TAB 1X10 away from the reach of children and pets.
• Store LAREGAB AT LS TAB 1X10 at room temperature.

• Take LAREGAB AT LS TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. This ensures optimal effectiveness and minimizes potential side effects. Consistency is key to managing your condition effectively.
• LAREGAB AT LS TABLET 10'S can be taken with or without food, but it's best to choose one method and stick to it. Taking it at the same time each day can also help you remember.
• Be aware of potential side effects, such as dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how LAREGAB AT LS TABLET 10'S affects you. If side effects persist or worsen, inform your doctor immediately.
• Inform your doctor about all other medications, supplements, and herbal remedies you are taking before starting LAREGAB AT LS TABLET 10'S. This prevents potential drug interactions that could reduce effectiveness or increase the risk of adverse effects.
• Do not stop taking LAREGAB AT LS TABLET 10'S abruptly, even if you feel better. Suddenly discontinuing the medication can lead to withdrawal symptoms or a worsening of your condition. Follow your doctor's instructions for gradually reducing the dosage if necessary.
• Store LAREGAB AT LS TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets to prevent accidental ingestion. Proper storage helps maintain the medication's efficacy.
• If you miss a dose of LAREGAB AT LS TABLET 10'S, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
• Regularly monitor your health and attend follow-up appointments with your doctor while taking LAREGAB AT LS TABLET 10'S. This allows your doctor to assess your progress, adjust the dosage if needed, and address any concerns you may have. This ensures you're getting the maximum benefit from the medication.
• Avoid alcohol consumption while taking LAREGAB AT LS TABLET 10'S, as it can exacerbate side effects such as drowsiness and dizziness. Alcohol can also interfere with the medication's effectiveness. Limiting or avoiding alcohol will help you remain safe and feel better.
• If you are planning to undergo any surgery or medical procedure, inform your doctor that you are taking LAREGAB AT LS TABLET 10'S. This is important because the medication may interact with anesthesia or other medications used during the procedure. This helps to prevent any complications during or after the procedure.

• LAREGAB AT LS TABLET 10'S does not typically have significant interactions with food. It can be taken with or without food. However, it is advisable to maintain a consistent routine with regards to meals to ensure optimal absorption and to minimize potential gastrointestinal discomfort.