METROGYL F SYRUP 60 ML

How METROGYL F SYRUP 60 ML Works

• METROGYL F SYRUP 60 ML is a combination medication primarily used to treat various bacterial and parasitic infections. It contains two active ingredients: Metronidazole and Diloxanide Furoate, each targeting different aspects of the infection.
• Metronidazole is a nitroimidazole antibiotic and antiprotozoal agent. Its mechanism of action involves the following steps: 1) Entry into the Microbial Cell: Metronidazole, in its inactive form, enters the bacterial or parasitic cell via diffusion. 2) Reduction of Nitro Group: Once inside the cell, Metronidazole's nitro group is reduced by microbial enzymes, particularly in anaerobic bacteria and protozoa. This reduction process is crucial for its activation. 3) Formation of Reactive Intermediates: The reduction of the nitro group results in the formation of highly reactive nitro radical intermediates. These intermediates are toxic to the microbial cell. 4) DNA Damage: The reactive intermediates interact with and damage the microbial DNA. They cause strand breaks and inhibit DNA synthesis, which is essential for the microorganism's survival and replication. 5) Cell Death: Ultimately, the DNA damage leads to cell death, effectively eradicating the infection.
• Diloxanide Furoate is an antiprotozoal agent specifically effective against Entamoeba histolytica, the parasite responsible for amoebic dysentery and other forms of amoebiasis. Its mechanism of action is as follows: 1) Conversion to Diloxanide: Diloxanide Furoate is a prodrug, meaning it's converted into its active form, Diloxanide, in the gastrointestinal tract after oral administration. 2) Action on Trophozoites: Diloxanide primarily acts on the trophozoite stage of Entamoeba histolytica, which is the active, feeding, and multiplying form of the parasite. 3) Interference with Protein Synthesis: Diloxanide is believed to interfere with protein synthesis in the trophozoites. It disrupts the normal functioning of the ribosomes, which are essential for protein production. 4) Impaired Metabolism: By inhibiting protein synthesis, Diloxanide impairs the metabolism and survival of the trophozoites. This leads to their death and reduces the parasitic load in the intestine. 5) Cyst Eradication: Diloxanide is particularly effective in eradicating cysts of Entamoeba histolytica, which are responsible for the transmission of the infection. By eliminating cysts, it helps prevent the spread of amoebiasis.
• In summary, METROGYL F SYRUP 60 ML works through the combined actions of Metronidazole and Diloxanide Furoate. Metronidazole targets anaerobic bacteria and protozoa by damaging their DNA, while Diloxanide Furoate inhibits protein synthesis in Entamoeba histolytica trophozoites and eliminates cysts. This dual-action approach makes it effective in treating mixed infections involving bacteria and parasites. The synergistic effect helps in comprehensively addressing the infection and reducing the chances of recurrence. Always complete the full course of the syrup as prescribed by your doctor to ensure complete eradication of the infection and to prevent the development of resistance.

Common side effects of Metrogyl F Syrup may include nausea, vomiting, diarrhea, abdominal pain, metallic taste in the mouth, loss of appetite, headache, and dizziness. Less common side effects can involve skin rash, itching, dark urine, furry tongue, and rarely, neurological problems such as seizures or peripheral neuropathy. In children, monitor for signs of central nervous system effects.

• If you miss a dose of METROGYL F SYRUP 60 ML, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the one you missed.

• Keep METROGYL F SYP 60ML away from the reach of children and pets.
• Store METROGYL F SYP 60ML at room temperature.

• Complete the Course: Even if your child feels better after a few doses of METROGYL F SYRUP 60 ML, it's vital to complete the entire prescribed course. Stopping early can allow the infection to return and may lead to antibiotic resistance.
• Administer as Directed: Always give METROGYL F SYRUP 60 ML exactly as prescribed by your doctor. The dosage and duration of treatment depend on the type and severity of the infection. Use a measuring spoon or cup to ensure accurate dosing. Do not estimate or use household spoons.
• Be Mindful of Side Effects: Common side effects of METROGYL F SYRUP 60 ML can include nausea, vomiting, stomach upset, metallic taste, and dark urine. Contact your doctor if these side effects persist or worsen. Allergic reactions are rare but serious; seek immediate medical attention if you notice signs like rash, itching, swelling, or difficulty breathing.
• Proper Storage: Store METROGYL F SYRUP 60 ML at room temperature, away from direct sunlight and moisture. Keep it out of reach of children. Do not use the medication if the color has changed or if there are any particles in the solution.
• Dietary Considerations: METROGYL F SYRUP 60 ML can interact with certain foods and drinks. Avoid alcohol consumption during treatment and for at least 24 hours after completing the course, as it can cause unpleasant side effects like nausea, vomiting, and headache. Consult your doctor about any specific dietary restrictions.
• Inform Your Doctor: Before starting METROGYL F SYRUP 60 ML, inform your doctor about any existing medical conditions, allergies, or medications your child is taking. This includes over-the-counter drugs, herbal remedies, and supplements. This information helps prevent potential drug interactions and ensures safe and effective treatment.

• METROGYL F SYRUP 60 ML should be taken as directed by your doctor. Generally, it is recommended to take this medication after food to avoid stomach upset. However, you should consult your doctor for specific instructions.
• Avoid alcohol consumption while taking METROGYL F SYRUP 60 ML, as it may cause adverse effects.