METROHEX GEL 10 GM

How METROHEX GEL 10 GM Works

• METROHEX GEL 10 GM is a topical medication primarily used to treat bacterial infections, particularly those affecting the skin. Its effectiveness stems from the synergistic action of its two active ingredients: Metronidazole and Chlorhexidine Gluconate. Understanding how each component works is crucial to appreciating the gel's overall therapeutic effect.
• Metronidazole, a nitroimidazole antibiotic, is the primary antibacterial agent in METROHEX GEL. It works by targeting the DNA of anaerobic bacteria and certain protozoa. Anaerobic bacteria thrive in environments lacking oxygen, often contributing to skin infections, rosacea, and other dermatological conditions. When METROHEX GEL is applied, metronidazole diffuses into the bacterial cells. Once inside, it undergoes a reduction process, typically facilitated by enzymes present only in anaerobic organisms. This reduction generates reactive nitro radicals, which are highly toxic to the bacterial DNA. These radicals cause DNA strand breaks and disrupt DNA replication, effectively halting bacterial growth and leading to cell death. Because metronidazole requires this specific reduction process, it selectively targets anaerobic bacteria, minimizing harm to beneficial aerobic bacteria on the skin.
• Chlorhexidine Gluconate is an antiseptic and disinfectant that provides a broader spectrum of antimicrobial activity. Unlike metronidazole, chlorhexidine is effective against both gram-positive and gram-negative bacteria, as well as certain fungi and viruses. It works by disrupting the cell membranes of microorganisms. Chlorhexidine is a cationic molecule, meaning it carries a positive charge. Bacterial cell membranes, on the other hand, are generally negatively charged. This difference in charge leads to a strong attraction between chlorhexidine and the bacterial cell surface. Once attached, chlorhexidine disrupts the integrity of the cell membrane, causing it to become leaky. This leakage leads to the loss of essential cellular components, such as potassium ions and other vital molecules, ultimately leading to cell death. Chlorhexidine's broad-spectrum activity makes it a valuable addition to METROHEX GEL, helping to eliminate a wide range of potential pathogens.
• The combination of metronidazole and chlorhexidine gluconate in METROHEX GEL provides a dual-action approach to treating skin infections. Metronidazole specifically targets anaerobic bacteria by disrupting their DNA, while chlorhexidine gluconate provides broad-spectrum antimicrobial activity by disrupting cell membranes. This synergistic effect makes METROHEX GEL a powerful and effective treatment option for various skin conditions. The gel formulation allows for direct application to the affected area, ensuring that the active ingredients are concentrated where they are needed most. Furthermore, the gel base helps to keep the area moist, which can promote healing.
• In summary, METROHEX GEL works through a two-pronged mechanism: metronidazole targets anaerobic bacteria at the DNA level, while chlorhexidine gluconate disrupts the cell membranes of a broad range of microorganisms. This combination provides effective treatment for bacterial skin infections by halting bacterial growth, causing cell death, and promoting healing at the application site.

Common side effects of Metrohex Gel may include: Dryness, scaling, itching, burning sensation, skin irritation, redness, temporary darkening of the skin, and metallic taste. Less common side effects could involve allergic reactions like rash, hives, swelling, and difficulty breathing. Discontinue use and consult a doctor if these occur. This is not an exhaustive list; other side effects may occur. Report any unusual symptoms to your doctor.

• If you forget to apply Metrohex Gel, apply it as soon as you remember. However, if it is almost time for your next application, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for the missed one.

• Keep METROHEX GEL 10GM away from the reach of children and pets.
• Store METROHEX GEL 10GM at room temperature.

• METROHEX GEL 10 GM is for external use only and is unlikely to interact with food. However, it is always a good practice to inform your doctor about your diet and any existing medical conditions.