RAMIPEN H 2.5MG TABLET 10'S

How RAMIPEN H 2.5MG TABLET 10'S Works

• RAMIPEN H 2.5MG TABLET 10'S is a combination medication containing ramipril and hydrochlorothiazide, designed to manage hypertension (high blood pressure). Each component works through different mechanisms to achieve a synergistic effect in lowering blood pressure.
• Ramipril belongs to a class of drugs called ACE inhibitors (Angiotensin-Converting Enzyme inhibitors). ACE is an enzyme in the body that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, leading to increased blood pressure. Ramipril inhibits ACE, thus reducing the production of angiotensin II. This results in vasodilation (widening of blood vessels), which lowers blood pressure. Additionally, angiotensin II stimulates the release of aldosterone, a hormone that causes the kidneys to retain sodium and water. By reducing angiotensin II levels, ramipril also decreases aldosterone release, promoting sodium and water excretion, further contributing to lower blood pressure.
• Hydrochlorothiazide is a thiazide diuretic, often referred to as a 'water pill.' It works by inhibiting the reabsorption of sodium and chloride in the kidneys. This action increases the excretion of sodium and water from the body, leading to a decrease in blood volume. Reduced blood volume translates to lower blood pressure. Hydrochlorothiazide primarily affects the distal convoluted tubule in the nephron, where it blocks the sodium-chloride symporter. This results in more sodium and water being excreted in the urine.
• The combination of ramipril and hydrochlorothiazide provides a dual approach to blood pressure management. Ramipril addresses the hormonal component of blood pressure regulation by inhibiting the renin-angiotensin-aldosterone system (RAAS), while hydrochlorothiazide targets the blood volume component by promoting sodium and water excretion. This combination often leads to more effective blood pressure control than either drug used alone.
• The overall effect of RAMIPEN H 2.5MG TABLET 10'S is to reduce the workload on the heart by lowering blood pressure, making it easier for the heart to pump blood. It also helps to prevent complications associated with high blood pressure, such as heart attack, stroke, and kidney disease. Regular monitoring by a healthcare professional is essential to ensure the medication is working effectively and to adjust the dosage if needed. Patients should also be aware of potential side effects and report any concerns to their doctor.

Like all medicines, RAMIPEN H 2.5MG TABLET 10'S can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Increased blood sugar levels (especially in patients with diabetes) * Headache * Feeling tired * Cough * Dizziness * Lightheadedness * Low blood pressure * Postural hypotension (dizziness when standing up) * Electrolyte imbalance (including hyponatremia, hypokalemia) * Kidney problems **Uncommon side effects (may affect up to 1 in 100 people):** * Muscle cramps * Sleep disturbances * Nervousness * Depression * Tingling or numbness * Vertigo * Taste disturbance * Visual disturbances * Dry mouth * Increased sweating * Skin reactions such as rash or itching * Hair loss * Impotence * Gout * Pancreatitis * Changes in blood count * Liver problems **Rare side effects (may affect up to 1 in 1,000 people):** * Confusion * Kidney failure * Allergic reactions, such as hives or angioedema (swelling of the face, lips, tongue or throat) * Decreased white blood cells, which makes infections more likely **Very rare side effects (may affect up to 1 in 10,000 people):** * Cardiac arrest * Severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis **Other possible side effects:** * Loss of appetite * Restlessness * Concentration problem * Swelling * Photosensitivity * Nausea * Constipation * Diarrhea * Stomach pain This is not an exhaustive list. If you experience any other unusual symptoms, consult your doctor or pharmacist.

• If you miss a dose of RAMIPEN H 2.5MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep RAMIPEN H 2.5MG TAB 1X10 away from the reach of children and pets.
• Store RAMIPEN H 2.5MG TAB 1X10 at room temperature.

• RAMIPEN H 2.5MG TABLET 10'S can be taken with or without food. However, it is advisable to take it at a consistent time each day to maintain a steady level of medication in your body. Avoid consuming excessive amounts of salt, as it can reduce the effectiveness of the medication. Consult your doctor for specific dietary recommendations.