ZUVIRAB INJECTION

How ZUVIRAB INJECTION Works

• ZUVIRAB INJECTION contains Rabies Immunoglobulin (Human), a vital component derived from human plasma specifically selected for its high concentration of rabies antibodies. When administered, ZUVIRAB works by providing passive immunization against the rabies virus. This means that instead of your body having to develop its own antibodies to fight the virus, ZUVIRAB provides you with ready-made antibodies that can immediately start working to neutralize the rabies virus.
• Here's a detailed breakdown of how ZUVIRAB INJECTION works:
• 1. **Neutralization of the Rabies Virus:** The rabies antibodies in ZUVIRAB bind directly to the rabies virus. This binding action prevents the virus from attaching to and entering your nerve cells. By neutralizing the virus in the peripheral tissues (outside the central nervous system), ZUVIRAB prevents the virus from traveling along the nerves to the brain and spinal cord, where it can cause fatal encephalitis (inflammation of the brain).
• 2. **Passive Immunity:** ZUVIRAB provides immediate, but temporary, protection against rabies. This is because the antibodies are 'borrowed' from another source (human plasma) and are not produced by your own body. This passive immunity gives your body time to begin producing its own antibodies in response to the rabies vaccine, which is typically administered concurrently with ZUVIRAB.
• 3. **Local Action at the Wound Site:** A significant portion of the ZUVIRAB dose is infiltrated directly into and around the wound site. This ensures a high concentration of antibodies at the point of entry of the virus. This local action is critical for neutralizing the virus before it can begin its journey to the central nervous system.
• 4. **Complementary Action with Rabies Vaccine:** ZUVIRAB is always administered in conjunction with a rabies vaccine. The vaccine stimulates your body to produce its own long-lasting antibodies against the rabies virus. ZUVIRAB provides immediate protection while the vaccine works to develop this active immunity. The combination of ZUVIRAB and the rabies vaccine provides the best possible protection against rabies infection.
• In summary, ZUVIRAB INJECTION provides immediate, passive immunity by directly neutralizing the rabies virus at the wound site and in the surrounding tissues, preventing it from reaching the central nervous system. This temporary protection bridges the gap until the rabies vaccine can stimulate your body to produce its own long-lasting antibodies, offering comprehensive protection against this deadly disease.

ZUVIRAB INJECTION, like all medications, can cause side effects. While not everyone experiences them, it's important to be aware of potential issues. Common side effects may include nausea, vomiting, diarrhea, headache, dizziness, and injection site reactions like pain, swelling, or redness. Less common but more serious side effects can include kidney problems, liver problems, nervous system disorders (such as confusion, seizures, or hallucinations), and severe skin reactions. Allergic reactions, though rare, can occur and may involve rash, itching, swelling, severe dizziness, or difficulty breathing. Changes in blood counts are also possible. Contact your doctor immediately if you experience any unusual or severe symptoms.

• If you miss a dose of ZUVIRAB INJECTION, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep ZUVIRAB INJ away from the reach of children and pets.
• Store ZUVIRAB INJ in a refrigerator (2 - 8°C). Do not freeze.

• Zuvirab Injection is primarily used to treat and manage acute viral infections such as Herpes simplex virus (HSV) infections including genital herpes, herpes labialis (cold sores), herpes zoster (shingles), and varicella (chickenpox). It can also be used in the management of herpes simplex encephalitis.
• Zuvirab should be administered by a healthcare professional via intravenous infusion. The dosage and duration of treatment will depend on the type and severity of the infection, as well as the patient's kidney function and overall health status. Follow the prescribed regimen strictly.
• Ensure adequate hydration during Zuvirab treatment. Drink plenty of fluids unless otherwise instructed by your doctor, as it helps to reduce the risk of kidney-related side effects. Monitor urine output and report any significant changes to your healthcare provider.
• Inform your doctor about any pre-existing kidney problems or other medical conditions before starting Zuvirab. The drug may affect kidney function, and dosage adjustments might be necessary. Regular monitoring of kidney function is recommended during treatment.
• Be aware of potential side effects such as nausea, vomiting, headache, and skin rash. If you experience any severe or persistent side effects, contact your healthcare provider immediately. Rarely, more serious side effects like neurological symptoms or kidney damage may occur, requiring immediate medical attention.

• ZUVIRAB INJECTION does not typically have significant interactions with food. It can be administered without regard to meals. However, it's essential to maintain a balanced diet to support overall health during treatment.