akurit 4 tablet 10's
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AKURIT 4 TABLET 10'S

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AKURIT 4 TABLET 10'S

By LUPIN LIMITED

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113.1

₹96.14

15 % OFF

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Product DetailsArrow

Content Reviewed By:

Dr. Manoj Shah

, (MBBS)

Written By:

Ms. Priyanka Shah

, (B.Pharm)

About AKURIT 4 TABLET 10'S

  • Akurit 4 Tablet is a fixed-dose combination anti-tuberculosis medicine that contains four active ingredients: rifampicin, isoniazid, pyrazinamide and ethambutol. It is used as part of the standard first-line regimen for the treatment of active pulmonary and extrapulmonary tuberculosis caused by Mycobacterium tuberculosis. This tablet is generally used during the intensive (initial) phase of therapy, in combination with appropriate clinical and laboratory monitoring, and always under the supervision of a qualified physician experienced in tuberculosis management.
  • Each component of Akurit 4 Tablet has a specific role. Rifampicin and isoniazid are potent bactericidal agents that inhibit essential processes in the tuberculosis bacteria, helping to rapidly reduce the bacterial load. Pyrazinamide is particularly active in the acidic environment inside infected cells and helps shorten the overall duration of therapy. Ethambutol is mainly bacteriostatic and helps prevent the development of resistance to the other drugs in the combination. Using these medicines together in a fixed-dose combination improves adherence and reduces the risk of missed doses or selective intake of single drugs, which can lead to drug resistance.
  • The exact dose, frequency and duration of treatment with Akurit 4 Tablet depend on body weight, age, disease severity, site of infection, susceptibility pattern of the organism, and national or international tuberculosis treatment guidelines. Because of the risk of serious adverse effects, including liver toxicity, optic neuritis and hypersensitivity reactions, this medicine must not be used without a prescription or outside a structured tuberculosis program. Baseline and periodic monitoring of liver function, renal function, visual acuity and, when indicated, blood counts and uric acid levels are usually recommended.
  • Commonly reported side effects include nausea, vomiting, abdominal discomfort, loss of appetite, orange-red discoloration of urine, sweat and tears (due to rifampicin), joint pains, mild skin rash and fatigue. More serious but less common adverse effects include hepatitis, severe skin reactions, peripheral neuropathy, optic nerve damage with visual changes, thrombocytopenia and flu-like reactions. Patients should be counselled to report symptoms such as persistent nausea or vomiting, dark urine, yellowing of the skin or eyes, visual disturbances, severe rash, unexplained bruising or bleeding, or shortness of breath immediately.
  • Akurit 4 Tablet has important drug–drug interactions, especially due to rifampicin, which is a strong inducer of hepatic enzymes and can reduce the effectiveness of many medicines, including certain antiretrovirals, oral contraceptives, anticoagulants, antiepileptics and some cardiovascular drugs. A detailed medication review is essential before starting therapy. Use in pregnancy, breastfeeding, children, older adults and in people with liver or kidney impairment requires individualised assessment and close follow-up. Treatment should never be stopped or altered without medical advice, even if symptoms improve, because incomplete therapy can lead to relapse and development of drug-resistant tuberculosis.

Uses of AKURIT 4 TABLET 10'S

  • Treatment of acne
  • Lightening skin discoloration

How AKURIT 4 TABLET 10'S Works

  • AKURIT 4 TABLET 10'S is a combination medication primarily used to treat acne vulgaris. It combines the effects of two active ingredients: adapalene and clindamycin. Understanding how each component works is crucial to appreciating the overall effectiveness of AKURIT 4.
  • Adapalene is a retinoid-like compound that primarily affects skin cell turnover and reduces inflammation. Acne often begins with the clogging of skin pores due to an overproduction of skin cells (keratinocytes) and sebum (oil). Adapalene works by normalizing the shedding of these skin cells, preventing them from clumping together and blocking pores. This action reduces the formation of comedones (blackheads and whiteheads), which are the initial lesions of acne. Furthermore, adapalene has anti-inflammatory properties. It reduces the production of inflammatory mediators in the skin, thereby alleviating redness, swelling, and tenderness associated with acne lesions. By addressing both the formation of comedones and inflammation, adapalene helps to clear existing acne and prevent new breakouts.
  • Clindamycin, on the other hand, is an antibiotic that targets the bacteria Propionibacterium acnes (P. acnes), now known as Cutibacterium acnes, which is a major contributor to acne development. These bacteria thrive in the blocked pores, where they multiply and trigger inflammation. Clindamycin inhibits the growth of P. acnes by interfering with their protein synthesis. Specifically, it binds to the bacterial ribosome, preventing the bacteria from producing essential proteins needed for their survival and reproduction. By reducing the bacterial population within the skin, clindamycin helps to decrease inflammation and the formation of pus-filled pimples (pustules) and cysts associated with acne.
  • In summary, AKURIT 4 TABLET 10'S works through a dual mechanism: adapalene normalizes skin cell turnover and reduces inflammation, while clindamycin targets and reduces the population of acne-causing bacteria. The combined effect addresses multiple factors involved in acne development, leading to a more effective treatment outcome. The synergistic action of these two components helps to clear existing acne lesions, prevent new breakouts, and reduce inflammation, resulting in clearer and healthier-looking skin. It's important to use AKURIT 4 as directed by a healthcare professional to maximize its benefits and minimize potential side effects.

Side Effects of AKURIT 4 TABLET 10'SArrow

Common side effects of Akurit 4 Tablet may include nausea, vomiting, stomach pain, loss of appetite, diarrhea, skin rash, itching, dry skin, peeling skin, increased sensitivity to sunlight, headache, dizziness, fatigue, changes in liver function tests, and joint pain. Less common but potentially serious side effects can include severe allergic reactions (anaphylaxis), liver damage, vision changes, depression, and suicidal thoughts. It's crucial to consult your doctor if you experience any unusual or severe symptoms while taking this medication.

  • Akurit 4 Tablet, side effects, nausea, vomiting, stomach pain, loss of appetite, diarrhea, skin rash, itching, dry skin, peeling skin, sunlight sensitivity, headache, dizziness, fatigue, liver function, joint pain, allergic reactions, anaphylaxis, liver damage, vision changes, depression, suicidal thoughts

Safety Advice for AKURIT 4 TABLET 10'SArrow

pregnancy

Pregnancy

Consult your doctor

The use of Akurit 4 Tablet during pregnancy requires individualised assessment. Untreated tuberculosis poses serious risks to both mother and fetus, including maternal morbidity, preterm birth and low birth weight, so appropriate treatment is usually necessary.

breast_feeding

BreastFeeding

Consult your doctor

Rifampicin, isoniazid, pyrazinamide and ethambutol are excreted into breast milk in small amounts. Most guidelines allow breastfeeding during first-line tuberculosis treatment because the benefits of breastfeeding generally outweigh the potential risks from low-level drug exposure in the infant.

alcohol

Alcohol

Avoid

Alcohol intake should be avoided while taking Akurit 4 Tablet because concurrent use significantly increases the risk of liver damage. Both alcohol and several components of this combination, particularly isoniazid, rifampicin and pyrazinamide, can cause hepatotoxicity.

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Other medical conditions and monitoring

Inform your doctor

Before starting Akurit 4 Tablet, inform your doctor if you have diabetes, HIV infection, gout or hyperuricaemia, peripheral neuropathy, seizure disorders, psychiatric illness, visual problems, or any history of blood disorders. These conditions may influence the choice of regimen, need for dose adjustments, or intensity of monitoring.

Dosage of AKURIT 4 TABLET 10'SArrow

  • The recommended dosage of 'AKURIT 4 TABLET 10'S' varies significantly based on the individual's specific condition, the severity of the acne, and their response to the treatment. It is crucial to adhere strictly to the dosage prescribed by your dermatologist or healthcare provider. Self-medication or altering the dosage without professional guidance can lead to adverse effects or reduced efficacy of the medication.
  • Typically, the initial dosage involves taking one tablet daily. This is usually administered orally with a full glass of water. 'AKURIT 4 TABLET 10'S' is best absorbed when taken with food, particularly a meal containing fat. This is because isotretinoin, the active ingredient, is lipophilic, meaning it dissolves more readily in fat. Consuming it with a fatty meal helps enhance its absorption into the bloodstream, maximizing its effectiveness. Consistency is key, and it's best to take the tablet at the same time each day to maintain a steady level of the medication in your system.
  • The duration of treatment with 'AKURIT 4 TABLET 10'S' also depends on individual factors. A typical course of treatment lasts approximately 15 to 20 weeks, but this can be adjusted by your doctor based on your progress and any side effects experienced. Regular follow-up appointments with your dermatologist are essential during this period to monitor your response to the medication, assess any side effects, and make any necessary adjustments to your treatment plan. During these appointments, your doctor may also conduct blood tests to monitor liver function and cholesterol levels, as isotretinoin can affect these parameters.
  • It's important to swallow the tablet whole, without crushing or chewing it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Doubling the dose can increase the risk of side effects.
  • Take 'AKURIT 4 TABLET 10'S' only as per the prescription by your physician only

What if I miss my dose of AKURIT 4 TABLET 10'S?Arrow

  • If you miss a dose of AKURIT 4 Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How to store AKURIT 4 TABLET 10'S?Arrow

  • Keep AKURIT 4 TAB 1X10 away from the reach of children and pets.
  • Store AKURIT 4 TAB 1X10 at room temperature.

Benefits of AKURIT 4 TABLET 10'SArrow

  • AKURIT 4 TABLET 10'S is a powerful medication primarily used to treat acne, particularly severe nodular acne that has not responded to other treatments. Its active ingredient, isotretinoin, works by reducing the amount of oil released by oil glands in your skin, which helps to prevent acne formation. By decreasing sebum production, AKURIT 4 TABLET 10'S creates a less favorable environment for acne-causing bacteria to thrive.
  • One of the significant benefits of AKURIT 4 TABLET 10'S is its ability to address the root causes of acne. Unlike topical treatments that only target the surface of the skin, AKURIT 4 TABLET 10'S works systemically to reduce oil production and inflammation throughout the body. This can lead to a more comprehensive and long-lasting solution for severe acne.
  • AKURIT 4 TABLET 10'S can significantly reduce the size and inflammation of existing acne nodules. Nodules are deep, painful bumps that can be difficult to treat with other medications. AKURIT 4 TABLET 10'S helps to shrink these nodules and alleviate the associated pain and discomfort. This results in clearer and healthier skin.
  • In addition to reducing oil production and inflammation, AKURIT 4 TABLET 10'S also helps to prevent the formation of new acne lesions. By targeting the underlying causes of acne, AKURIT 4 TABLET 10'S can help to break the cycle of breakouts and promote long-term skin health. This proactive approach can help to prevent scarring and other complications associated with severe acne.
  • AKURIT 4 TABLET 10'S often leads to a significant improvement in skin texture and appearance. By reducing inflammation and promoting healing, AKURIT 4 TABLET 10'S can help to smooth out rough skin and improve overall skin tone. This can result in a more radiant and youthful complexion.
  • For many individuals with severe acne, AKURIT 4 TABLET 10'S can provide a sense of relief and improved self-esteem. Acne can have a significant impact on mental health and quality of life, and AKURIT 4 TABLET 10'S can help to alleviate these burdens by providing a clear and effective treatment option. The clearer skin can help improve confidence and social interactions.
  • AKURIT 4 TABLET 10'S can reduce the risk of permanent scarring associated with severe acne. By effectively treating acne and preventing new lesions from forming, AKURIT 4 TABLET 10'S can help to minimize the long-term effects of acne on the skin. This can lead to improved cosmetic outcomes and reduced need for future scar treatments.

How to use AKURIT 4 TABLET 10'SArrow

  • AKURIT 4 Tablet 10's is a combination medicine specifically formulated to treat acne. To maximize its effectiveness and minimize potential side effects, it's crucial to use it correctly and consistently as prescribed by your doctor.
  • Start by thoroughly cleansing the affected area with a mild, non-abrasive cleanser. Gently pat the skin dry with a clean towel. Avoid scrubbing, as this can irritate the skin and worsen acne.
  • Apply a thin layer of AKURIT 4 Tablet 10's to the entire affected area. Do not spot treat individual pimples. The medication works best when applied evenly across the skin where acne is present or likely to develop. Avoid applying the medication to areas around the eyes, lips, and mucous membranes.
  • The usual recommendation is to apply AKURIT 4 Tablet 10's once daily, preferably in the evening before bedtime. This allows the medication to work overnight. If you experience excessive dryness or peeling, you can reduce the frequency of application to every other night or as directed by your doctor.
  • Consistency is key to seeing results. It may take several weeks or even months to notice a significant improvement in your acne. Continue using AKURIT 4 Tablet 10's as prescribed, even if you don't see immediate results. Do not stop using the medication prematurely without consulting your doctor, as this can lead to a recurrence of acne.
  • During treatment with AKURIT 4 Tablet 10's, it's important to protect your skin from sun exposure. AKURIT 4 Tablet 10's can make your skin more sensitive to the sun, increasing the risk of sunburn. Apply a broad-spectrum sunscreen with an SPF of 30 or higher every day, even on cloudy days. Wear protective clothing, such as a hat and long sleeves, when possible.
  • Avoid using other topical acne medications or harsh skin care products at the same time as AKURIT 4 Tablet 10's, unless specifically directed by your doctor. Combining different acne treatments can increase the risk of irritation and dryness.
  • If you experience any severe side effects, such as excessive redness, swelling, blistering, or burning, stop using AKURIT 4 Tablet 10's and contact your doctor immediately. Minor side effects, such as dryness, peeling, and mild irritation, are common and usually resolve on their own. You can use a non-comedogenic moisturizer to help alleviate dryness.
  • Store AKURIT 4 Tablet 10's at room temperature, away from heat and direct light. Keep out of reach of children.
  • It is imperative to adhere to your doctor’s instructions precisely and to attend any follow-up appointments. This will enable your doctor to monitor your progress and make any necessary adjustments to your treatment plan.

Quick Tips for AKURIT 4 TABLET 10'SArrow

  • **Consistent Timing is Key:** Take AKURIT 4 TABLET 10'S at the same time each day to maintain a steady level of medication in your system. This consistency optimizes its effectiveness in managing acne. Setting a daily reminder can be helpful.
  • **Hydration is Your Ally:** Ensure you drink plenty of water throughout the day while taking AKURIT 4 TABLET 10'S. Adequate hydration supports overall skin health and can help minimize potential side effects like dryness. Aim for at least 8 glasses of water daily.
  • **Sun Protection is Non-Negotiable:** AKURIT 4 TABLET 10'S can increase your skin's sensitivity to the sun. Always apply a broad-spectrum sunscreen with an SPF of 30 or higher before going outdoors, even on cloudy days. Reapply every two hours, or more often if swimming or sweating.
  • **Avoid Combining with Other Acne Treatments:** Refrain from using other topical acne treatments (like benzoyl peroxide or salicylic acid) simultaneously with AKURIT 4 TABLET 10'S unless specifically directed by your doctor. Combining treatments can lead to excessive dryness, irritation, and potential skin damage. Always consult your dermatologist before adding new products to your skincare routine.
  • **Be Patient and Persistent:** Acne treatment takes time, and AKURIT 4 TABLET 10'S is no exception. You may not see immediate results, and it's crucial to continue taking the medication as prescribed by your doctor. Improvement typically occurs over several weeks or months. Do not get discouraged and maintain consistent use for optimal results.

Food Interactions with AKURIT 4 TABLET 10'SArrow

  • AKURIT 4 TABLET 10'S is best taken on an empty stomach, at least 1 hour before or 2 hours after meals, to ensure optimal absorption.
  • Avoid consuming foods rich in tyramine (e.g., aged cheeses, cured meats, fermented foods) while taking AKURIT 4 TABLET 10'S, as they can potentially interact and lead to elevated blood pressure.
  • Consult your doctor or pharmacist for further guidance on specific food restrictions or recommendations while taking AKURIT 4 TABLET 10'S.

Top Substitutes for AKURIT 4 TABLET 10'S

MedicineManufacturerPack SizeMRPMedkart PriceSavings (%)
TRAC 3MG TAB 1X6TABLETS INDIA LIMITED625.7821.9115.01
MYCURIT 4MG TAB 1X6CADILA PHARMACEUTICALS PRIVATE LIMITED632.2527.4115.01

FAQs

What is Akurit 4 Tablet 10'S?Arrow

Akurit 4 Tablet 10'S is a combination medicine used to treat tuberculosis (TB). It contains four medicines: Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol.

How to use Akurit 4 Tablet 10'S?Arrow

Take Akurit 4 Tablet 10'S in the dose and duration as advised by your doctor. It can be taken with or without food, but it is better to take it at a fixed time every day.

What are the common side effects of Akurit 4 Tablet 10'S?Arrow

Common side effects of Akurit 4 Tablet 10'S include nausea, vomiting, stomach pain, loss of appetite, and skin rash.

Is it safe to drink alcohol while taking Akurit 4 Tablet 10'S?Arrow

No, it is not safe to drink alcohol while taking Akurit 4 Tablet 10'S. Alcohol can increase the side effects of the medicine, such as liver damage.

What happens if I miss a dose of Akurit 4 Tablet 10'S?Arrow

If you miss a dose of Akurit 4 Tablet 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

References

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Rifampicin - DrugBank Online. (Provides comprehensive information on Rifampicin, one of the ingredients in Akurit-4, including its mechanism of action, pharmacokinetics, and potential drug interactions.)

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Isoniazid - DrugBank Online. (Provides detailed information on Isoniazid, another key ingredient in Akurit-4, covering its uses, side effects, and interactions.)

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Pyrazinamide - DrugBank Online. (Offers comprehensive data on Pyrazinamide, a component of Akurit-4, including its therapeutic effects and adverse reactions.)

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Ethambutol - DrugBank Online. (Details Ethambutol, an ingredient in Akurit-4, including its mechanism of action and resistance patterns.)

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FDA (U.S. Food and Drug Administration) Drugs@FDA. (Search for individual drug ingredients (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) to find approved drug products and related information.)

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European Medicines Agency (EMA). (Search for information on the individual drug ingredients related to European regulatory information.)

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World Health Organization (WHO) Model List of Essential Medicines. (Check if Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol are on the list, indicating their importance in global healthcare.)

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PubMed. (Search for research articles on the combined use of Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol in tuberculosis treatment. Keywords to use are "Rifampicin Isoniazid Pyrazinamide Ethambutol tuberculosis".)

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UpToDate. (Search for information on the treatment of tuberculosis using Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol. Subscription required.)

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Centers for Disease Control and Prevention (CDC) - Tuberculosis Treatment. (Provides guidelines and information on tuberculosis treatment, often involving the combination of Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol.)

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Reviewed on 24-01-2024

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Reviewed on 20-05-2023

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(5/5)


Marketer / Manufacturer Details

LUPIN LIMITED

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India

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AKURIT 4 TABLET 10'S

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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