AMIFRU S TABLET 10'S

How AMIFRU S TABLET 10'S Works

• AMIFRU S Tablet is a combination medication designed to manage fluid retention (edema) and high blood pressure (hypertension). It contains two active ingredients: Amiloride and Furosemide, each working through different mechanisms to achieve the desired therapeutic effect. Understanding how each component works is crucial to appreciating the overall action of AMIFRU S Tablet.
• Furosemide is a loop diuretic, meaning it primarily acts on the loop of Henle in the kidneys. The loop of Henle is a crucial part of the nephron, the functional unit of the kidney responsible for filtering blood and producing urine. Furosemide inhibits the sodium-potassium-chloride (Na-K-Cl) cotransporter in the ascending limb of the loop of Henle. This cotransporter is responsible for reabsorbing these electrolytes back into the bloodstream. By blocking this transporter, Furosemide prevents the reabsorption of sodium, potassium, and chloride. This leads to increased excretion of these electrolytes in the urine. Water follows these electrolytes due to osmosis, resulting in increased urine production (diuresis). This increased fluid excretion helps reduce fluid volume in the body, thereby lowering blood pressure and reducing edema.
• Amiloride is a potassium-sparing diuretic. It works by directly blocking the epithelial sodium channels (ENaC) in the collecting tubules of the kidneys. These channels are responsible for the reabsorption of sodium from the urine back into the bloodstream. By blocking these channels, Amiloride prevents sodium reabsorption. This, in turn, reduces the driving force for potassium secretion into the urine. Unlike many other diuretics (like Furosemide), Amiloride helps to conserve potassium levels in the body. This is particularly beneficial because Furosemide can lead to potassium loss, potentially causing hypokalemia (low potassium levels), which can have serious consequences.
• The combination of Furosemide and Amiloride in AMIFRU S Tablet provides a synergistic effect. Furosemide effectively removes excess fluid and lowers blood pressure, while Amiloride helps to prevent potassium loss associated with Furosemide use. This combined action helps to manage edema and hypertension more effectively while minimizing the risk of electrolyte imbalances. The balanced diuretic action of AMIFRU S Tablet makes it a valuable tool in managing conditions where both fluid overload and potassium balance are concerns. Always use this medication as prescribed by your healthcare provider to ensure optimal results and minimize potential side effects. It is important to regularly monitor electrolyte levels, especially potassium, during treatment with AMIFRU S Tablet.

Possible side effects of AMIFRU S Tablet may include: Nausea, Vomiting, Diarrhea, Stomach upset, Loss of appetite, Headache, Dizziness, Weakness, Fatigue, Muscle cramps, Electrolyte imbalance (such as low potassium or sodium), Dehydration, Increased urination, Allergic reactions (rash, itching, swelling), Changes in blood sugar levels, Liver problems, Kidney problems, Confusion, and Constipation. This is not an exhaustive list, and it is important to consult your doctor or pharmacist for a complete list and medical advice.

• If you miss a dose of AMIFRU S Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep AMIFRU S TAB 1X10 away from the reach of children and pets.
• Store AMIFRU S TAB 1X10 at room temperature.

• Take AMIFRU S TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting your healthcare provider. This ensures optimal effectiveness and minimizes potential side effects.
• AMIFRU S TABLET 10'S is a combination medicine containing a diuretic (furosemide) and a potassium-sparing agent (amiloride). It helps in removing excess fluid from the body while conserving potassium levels. Use it consistently as directed to manage fluid retention and blood pressure.
• Inform your doctor about all other medications, supplements, and herbal products you are currently taking before starting AMIFRU S TABLET 10'S. Drug interactions can affect how the medication works and increase the risk of adverse effects. Pay special attention to medications affecting blood pressure or potassium levels.
• While taking AMIFRU S TABLET 10'S, monitor your blood pressure and potassium levels regularly, especially if you have pre-existing kidney problems, diabetes or cardiovascular conditions. Contact your doctor immediately if you experience any unusual symptoms like muscle cramps, weakness, nausea, or irregular heartbeat.
• Follow dietary guidelines recommended by your doctor or dietician while using AMIFRU S TABLET 10'S. This may include limiting your sodium intake and consuming potassium-rich foods (like bananas and oranges) unless otherwise advised due to the potassium-sparing effect of the medication. Staying hydrated is also important, but discuss fluid intake with your doctor.
• If you miss a dose of AMIFRU S TABLET 10'S, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this can increase the risk of adverse effects.
• Be cautious when engaging in activities that require alertness, such as driving or operating machinery, until you know how AMIFRU S TABLET 10'S affects you. This medication may cause dizziness or lightheadedness in some individuals, especially when starting treatment or after dosage adjustments. Stand up slowly from a sitting or lying position to minimize dizziness.
• Store AMIFRU S TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Properly dispose of any unused or expired medication according to local regulations or your pharmacist's instructions.

• AMIFRU S TABLET 10'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent blood levels. Avoid consuming large amounts of grapefruit or grapefruit juice while taking this medicine, as it may increase the drug's concentration in your body.