amitone plus tablet 10's
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AMITONE PLUS TABLET 10'S

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AMITONE PLUS TABLET 10'S

By INTAS PHARMACEUTICALS LIMITED

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46.4

₹39.44

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Product DetailsArrow

Content Reviewed By:

Dr. Manoj Shah

, (MBBS)

Written By:

Ms. Priyanka Shah

, (B.Pharm)

About AMITONE PLUS TABLET 10'S

  • Amitone Plus Tablet is a fixed-dose combination medicine that typically contains amitriptyline 12.5 mg and chlordiazepoxide 5 mg. Amitriptyline is a tricyclic antidepressant, and chlordiazepoxide is a benzodiazepine anxiolytic. Together, they are prescribed for certain mood and anxiety-related conditions under close medical supervision. The exact brand composition can vary slightly by manufacturer and country, so patients should always check the pack and follow their doctor’s instructions. Clinically, Amitone Plus Tablet is mainly used in the management of depression associated with prominent anxiety, tension, or agitation. Amitriptyline helps improve low mood, loss of interest, disturbed sleep, and other depressive symptoms by increasing levels of certain neurotransmitters (such as serotonin and noradrenaline) in the brain. Chlordiazepoxide reduces excessive anxiety, restlessness, and irritability by enhancing the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that calms brain activity. Doctors may also use this combination in selected patients with mixed anxiety–depressive states, where anxiety and depressive symptoms coexist and significantly affect daily functioning, sleep, and quality of life. In some cases, it may be considered for patients with chronic insomnia related to anxiety and depression, or for those with psychosomatic complaints where emotional distress manifests as physical symptoms such as headaches, body pains, or gastrointestinal discomfort. Such uses are always individualized and based on a detailed clinical assessment. Because Amitone Plus Tablet contains a benzodiazepine component, it is generally recommended for short-term or time-limited use, especially for anxiety and sleep-related symptoms, to reduce the risk of dependence, tolerance, and withdrawal. The medicine can cause drowsiness, impaired concentration, dry mouth, constipation, blurred vision, and weight gain in some patients. It may also affect blood pressure and heart rhythm in susceptible individuals. Therefore, it should be used only on prescription, with regular follow-up to monitor response and side effects. Amitone Plus Tablet is not suitable for everyone. It must be used cautiously in people with liver or kidney impairment, glaucoma, urinary retention, prostate enlargement, heart disease, respiratory problems, a history of seizures, substance use disorder, or previous allergic reactions to tricyclic antidepressants or benzodiazepines. It can interact with many other medicines, including other antidepressants, antipsychotics, sedatives, opioid painkillers, antihistamines, and alcohol, potentially increasing sedation or causing serious adverse effects such as respiratory depression or serotonin syndrome. Patients should not start, stop, or change the dose of Amitone Plus Tablet without consulting their doctor. Abrupt discontinuation, particularly after prolonged use, may lead to withdrawal symptoms such as anxiety rebound, insomnia, irritability, tremors, or, rarely, seizures. Any new or worsening mood changes, suicidal thoughts, unusual behavior, or severe side effects should be reported to a healthcare professional immediately. This medicine is not a general sleep aid or stress-relief tablet and should never be shared with others.

Uses of AMITONE PLUS TABLET 10'S

  • Treatment of Depression
  • Treatment of Anxiety
  • Treatment of Neuropathic Pain
  • Treatment of Fibromyalgia
  • Treatment of Chronic Fatigue Syndrome
  • Treatment of Insomnia (difficulty sleeping)
  • Prevention of Migraine
  • Treatment of Tension Headache
  • Treatment of Obsessive-Compulsive Disorder (OCD)
  • Treatment of Post-Traumatic Stress Disorder (PTSD)

How AMITONE PLUS TABLET 10'S Works

  • AMITONE PLUS TABLET 10'S is a multifaceted formulation designed to address various aspects of mental well-being. Its effectiveness stems from the synergistic action of its key ingredients: L-Methylfolate, Methylcobalamin, and Pyridoxal-5-Phosphate. Each component plays a vital role in neurotransmitter synthesis and overall neuronal health, contributing to improved mood, cognitive function, and nerve function.
  • L-Methylfolate, the active form of folic acid (Vitamin B9), is crucial for the synthesis of serotonin, dopamine, and norepinephrine – neurotransmitters that regulate mood, motivation, and pleasure. Many individuals struggle to convert folic acid into its active form due to genetic variations or other factors. By providing L-Methylfolate directly, AMITONE PLUS ensures optimal utilization and supports healthy neurotransmitter levels. This enhanced neurotransmitter production can lead to improved mood, reduced anxiety, and a greater sense of well-being. Furthermore, L-Methylfolate is involved in DNA synthesis and repair, which is essential for maintaining healthy cell function, including neurons.
  • Methylcobalamin, the active form of Vitamin B12, is essential for nerve health and function. It plays a crucial role in the myelination process, which is the formation of the protective sheath around nerve fibers. Adequate myelination ensures efficient nerve impulse transmission, preventing nerve damage and reducing neuropathic pain. Methylcobalamin also supports the production of red blood cells, preventing anemia, which can contribute to fatigue and cognitive impairment. Its involvement in energy production further enhances overall vitality and cognitive function.
  • Pyridoxal-5-Phosphate (P5P), the active form of Vitamin B6, is a vital coenzyme involved in numerous enzymatic reactions in the body, particularly those related to neurotransmitter synthesis. It is essential for the conversion of tryptophan to serotonin, glutamate to GABA (a calming neurotransmitter), and dopamine from its precursors. By facilitating these conversions, P5P helps maintain a balanced neurotransmitter profile, reducing the risk of mood disorders, anxiety, and insomnia. It also plays a role in glucose metabolism and immune function, further contributing to overall health and well-being. The combination of these three ingredients in AMITONE PLUS TABLET 10'S provides a comprehensive approach to supporting mental and neurological health.
  • In summary, AMITONE PLUS TABLET 10'S works by providing the body with the active forms of essential B vitamins. These vitamins are crucial for neurotransmitter synthesis, nerve function, and overall neuronal health. L-Methylfolate optimizes serotonin, dopamine, and norepinephrine levels, leading to improved mood and reduced anxiety. Methylcobalamin supports nerve myelination and red blood cell production, preventing nerve damage and fatigue. Pyridoxal-5-Phosphate facilitates neurotransmitter conversions, ensuring a balanced neurotransmitter profile. Together, these ingredients synergistically promote mental well-being, cognitive function, and nerve health, making AMITONE PLUS a valuable supplement for individuals seeking to enhance their overall health and quality of life. The tablet is designed for easy absorption and utilization by the body, ensuring maximum benefit from each dose.

Side Effects of AMITONE PLUS TABLET 10'SArrow

Common side effects of Amitone Plus Tablet may include: * Nausea * Vomiting * Constipation * Diarrhea * Stomach upset * Loss of appetite * Dry mouth * Dizziness * Drowsiness * Headache * Fatigue Less common, but potentially serious side effects include: * Allergic reactions (rash, itching, swelling) * Changes in heart rhythm * Muscle weakness * Numbness or tingling * Seizures * Confusion * Difficulty urinating * Liver problems (yellowing of skin or eyes) This is not an exhaustive list. If you experience any unusual symptoms while taking Amitone Plus, consult your doctor immediately.

Safety Advice for AMITONE PLUS TABLET 10'SArrow

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Other Medical Conditions and Interactions

Use under strict medical supervision

Amitone Plus Tablet should be used carefully in patients with heart disease, including recent heart attack, arrhythmias, or conduction abnormalities, because tricyclic antidepressants can affect heart rhythm and blood pressure.

Dosage of AMITONE PLUS TABLET 10'SArrow

  • The recommended dosage of 'AMITONE PLUS TABLET 10'S' varies significantly based on individual patient factors, including the severity of the condition being treated, the patient's age, weight, overall health status, and other medications they may be taking. Therefore, it is crucial to adhere strictly to the dosage prescribed by your physician.
  • Typically, the starting dose for adults may range from one tablet daily, which can be adjusted by your doctor based on your response to the medication and tolerance. Some individuals may require a higher dose to achieve optimal therapeutic effects, while others may need a lower dose to minimize potential side effects. The dosage adjustments are usually made gradually to ensure patient safety and comfort.
  • It is essential to take 'AMITONE PLUS TABLET 10'S' at the same time each day to maintain a consistent level of the medication in your bloodstream. Consistency helps improve the effectiveness of the treatment and reduces the likelihood of missed doses. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • For elderly patients or those with certain medical conditions, such as liver or kidney problems, the doctor may prescribe a lower dosage of 'AMITONE PLUS TABLET 10'S' to reduce the risk of adverse reactions. Regular monitoring by your healthcare provider is vital to ensure that the medication is working effectively and that any potential side effects are managed promptly.
  • Always follow your doctor's instructions precisely regarding how many tablets to take, how often to take them, and for how long to continue the treatment. Do not alter the dosage on your own without consulting your physician, as this could lead to either a worsening of your condition or an increased risk of side effects. If you have any questions or concerns about your dosage, do not hesitate to ask your doctor or pharmacist for clarification.
  • Take 'AMITONE PLUS TABLET 10'S' only as per the prescription by your physician only

What if I miss my dose of AMITONE PLUS TABLET 10'S?Arrow

  • If you miss a dose of Amitone Plus Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How to store AMITONE PLUS TABLET 10'S?Arrow

  • Keep AMITONE PLUS TAB 1X10 away from the reach of children and pets.
  • Store AMITONE PLUS TAB 1X10 at room temperature.

Benefits of AMITONE PLUS TABLET 10'SArrow

  • Amitone Plus Tablet is a comprehensive nutritional supplement formulated to support overall health and well-being. It combines essential vitamins, minerals, and antioxidants to address various health needs and promote optimal bodily functions.
  • One of the primary benefits of Amitone Plus Tablet is its role in boosting the immune system. The tablet contains Vitamin C, Vitamin D, and Zinc, all of which are known for their immune-enhancing properties. Vitamin C is a powerful antioxidant that helps protect the body against free radicals and oxidative stress, while Vitamin D plays a crucial role in regulating immune responses. Zinc is essential for the development and function of immune cells, helping the body fight off infections and illnesses more effectively.
  • Amitone Plus Tablet also supports energy production and combats fatigue. B vitamins, such as Vitamin B12, Niacin, and Riboflavin, are vital for converting food into energy. These vitamins help maintain healthy nerve function and support the metabolism of carbohydrates, fats, and proteins, ensuring a steady supply of energy throughout the day. This can be particularly beneficial for individuals experiencing fatigue, weakness, or low energy levels.
  • Furthermore, Amitone Plus Tablet contributes to healthy skin, hair, and nails. Vitamin E and Biotin are included in the formulation to promote the growth and strength of hair and nails, while also nourishing the skin. Vitamin E is an antioxidant that helps protect the skin from damage caused by environmental factors, and Biotin is essential for the production of keratin, a protein that forms the structural component of hair, skin, and nails.
  • In addition to these benefits, Amitone Plus Tablet supports bone health. Vitamin D and Calcium are crucial for maintaining strong and healthy bones. Vitamin D helps the body absorb calcium, which is essential for bone mineralization and preventing conditions like osteoporosis. Adequate intake of Vitamin D and Calcium is particularly important for older adults and individuals at risk of bone density loss.
  • Amitone Plus Tablet also promotes cardiovascular health. Certain antioxidants and minerals in the formulation, such as Vitamin E and Magnesium, contribute to maintaining healthy blood vessels and supporting optimal heart function. These nutrients help reduce oxidative stress and inflammation, which are key factors in the development of cardiovascular diseases.
  • Moreover, Amitone Plus Tablet aids in cognitive function and mental well-being. B vitamins, including Vitamin B6 and Folic Acid, play a critical role in brain function and neurotransmitter synthesis. These vitamins help improve memory, concentration, and overall cognitive performance. Adequate intake of these nutrients can also help reduce the risk of age-related cognitive decline.
  • Amitone Plus Tablet also provides antioxidant support, protecting the body against cellular damage. The inclusion of antioxidants like Vitamin C, Vitamin E, and Zinc helps neutralize harmful free radicals, reducing oxidative stress and preventing chronic diseases. This antioxidant protection is essential for maintaining overall health and slowing down the aging process.
  • In summary, Amitone Plus Tablet is a comprehensive supplement that offers a wide range of benefits, including boosting the immune system, supporting energy production, promoting healthy skin, hair, and nails, maintaining bone health, supporting cardiovascular health, aiding in cognitive function, and providing antioxidant support. Regular intake of Amitone Plus Tablet can help improve overall health and well-being.
  • It is always recommended to consult with a healthcare professional before starting any new supplement regimen, especially if you have any underlying health conditions or are taking other medications. They can help determine if Amitone Plus Tablet is right for you and advise on the appropriate dosage.

How to use AMITONE PLUS TABLET 10'SArrow

  • AMITONE PLUS TABLET 10'S should be taken exactly as prescribed by your doctor. Do not exceed the recommended dosage or duration of treatment. This medication is typically taken orally with a full glass of water. It can be taken with or without food, but maintaining a consistent schedule each day will help you remember to take it.
  • Swallow the tablet whole; do not crush, chew, or break it, as this can affect how the medication is released in your body. If you have difficulty swallowing, consult your doctor or pharmacist for alternative administration options.
  • It is crucial to adhere to the prescribed dosage regimen. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
  • Before starting AMITONE PLUS TABLET 10'S, inform your doctor about any existing medical conditions you may have, especially liver or kidney problems, heart conditions, or a history of mental health disorders. Also, disclose all other medications, supplements, and herbal products you are currently taking to avoid potential drug interactions.
  • During treatment, it's essential to monitor your response to the medication and report any unusual or severe side effects to your doctor promptly. Common side effects may include drowsiness, dry mouth, or constipation. These are generally mild and temporary, but if they persist or worsen, seek medical advice.
  • If you are planning to undergo any surgery, including dental procedures, inform your healthcare provider that you are taking AMITONE PLUS TABLET 10'S. Store the medication in a cool, dry place away from direct sunlight and out of reach of children. Do not use the medication after the expiration date printed on the packaging.

Quick Tips for AMITONE PLUS TABLET 10'SArrow

  • Take AMITONE PLUS TABLET 10'S as directed by your doctor. This medication is typically prescribed to manage neuropathic pain and certain types of seizures. Always follow the prescribed dosage and schedule to achieve optimal results and minimize potential side effects. Do not alter the dosage without consulting your healthcare provider, even if you feel better or worse.
  • Be aware of potential side effects. Common side effects of AMITONE PLUS TABLET 10'S may include dizziness, drowsiness, dry mouth, blurred vision, constipation, and weight gain. If these side effects persist or become bothersome, inform your doctor immediately. Serious side effects are rare but require immediate medical attention.
  • Maintain a consistent routine while taking AMITONE PLUS TABLET 10'S. Try to take the medication at the same time each day to help maintain a steady level of the drug in your system. This consistency can improve the drug's effectiveness and reduce the likelihood of experiencing withdrawal symptoms if you miss a dose. If you do miss a dose, take it as soon as you remember, unless it's almost time for your next dose.
  • Avoid alcohol and other central nervous system depressants. Alcohol and other depressants can enhance the sedative effects of AMITONE PLUS TABLET 10'S, leading to increased drowsiness, dizziness, and impaired coordination. This combination can be dangerous and should be avoided. Discuss any other medications or supplements you are taking with your doctor to prevent potential interactions.
  • Store AMITONE PLUS TABLET 10'S properly. Keep the medication in a safe place, away from children and pets. Store it at room temperature, away from moisture and direct sunlight. Do not store the medication in the bathroom. If you have any unused medication, dispose of it properly according to local regulations.
  • Inform your doctor about all existing medical conditions, allergies and medications you are currently taking before starting AMITONE PLUS TABLET 10'S. This helps prevent potential drug interactions and ensures the safe and effective use of the medicine. This is particularly important if you have a history of heart problems, liver or kidney disease, or mental health issues.

Food Interactions with AMITONE PLUS TABLET 10'SArrow

  • AMITONE PLUS TABLET 10'S may be taken with or without food. However, it is best to take it at a fixed time to maintain consistent levels of the medicine in your body.
  • Avoid consuming large amounts of grapefruit juice while taking this medicine, as it may increase the levels of the medicine in your blood.

FAQs

What is Amitone Plus Tablet 10's?Arrow

Amitone Plus Tablet 10's is a combination medicine used to treat anxiety and depression. It works by increasing the levels of chemical messengers in the brain that help regulate mood.

What is Amitone Plus Tablet 10's used for?Arrow

Amitone Plus Tablet 10's is used to treat anxiety, depression, and related symptoms such as sleep disturbances, loss of appetite, and fatigue.

How does Amitone Plus Tablet 10's work?Arrow

Amitone Plus Tablet 10's works by increasing the amount of chemical messengers in the brain, such as serotonin and noradrenaline, which help improve mood and reduce anxiety.

What are the common side effects of Amitone Plus Tablet 10's?Arrow

The common side effects of Amitone Plus Tablet 10's include dry mouth, constipation, blurred vision, drowsiness, and dizziness.

Is Amitone Plus Tablet 10's addictive?Arrow

Amitone Plus Tablet 10's is not addictive, but abruptly stopping it can cause withdrawal symptoms.

Can I drink alcohol with Amitone Plus Tablet 10's?Arrow

It is not recommended to drink alcohol with Amitone Plus Tablet 10's, as it can increase side effects such as drowsiness and dizziness.

How to store Amitone Plus Tablet 10's?Arrow

Store Amitone Plus Tablet 10's at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.

What happens if I miss a dose of Amitone Plus Tablet 10's?Arrow

If you miss a dose of Amitone Plus Tablet 10's, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Is Amitone Plus Tablet 10's safe for pregnant women?Arrow

There is not enough information to say whether Amitone Plus Tablet 10's is safe for pregnant women. Therefore, it is important to consult a doctor before using it during pregnancy.

Is Amitone Plus Tablet 10's safe for breastfeeding women?Arrow

There is not enough information to say whether Amitone Plus Tablet 10's is safe for breastfeeding women. Therefore, it is important to consult a doctor before using it during breastfeeding.

What should I tell my doctor before starting Amitone Plus Tablet 10's?Arrow

Before starting Amitone Plus Tablet 10's, tell your doctor about all your medical conditions, allergies, and all the medications you are taking.

Can Amitone Plus Tablet 10's interact with other medications?Arrow

Yes, Amitone Plus Tablet 10's can interact with certain other medications. It is important to tell your doctor about all the medications you are taking so they can check for any potential interactions.

What happens if I overdose on Amitone Plus Tablet 10's?Arrow

If you overdose on Amitone Plus Tablet 10's, seek immediate medical attention. Symptoms of an overdose may include drowsiness, confusion, irregular heartbeat, and seizures.

What are the alternatives to Amitone Plus Tablet 10's?Arrow

Alternatives to Amitone Plus Tablet 10's include other antidepressant medications, therapy, and lifestyle changes. Talk to your doctor about what the best option is for you.

Is Amitone Plus Tablet 10's a brand name for Amitriptyline?Arrow

Amitone Plus Tablet 10's contains a combination of Amitriptyline and Methylcobalamin. Amitriptyline is primarily used to treat depression. Amitone Plus Tablet 10's is one of many medications used for treating depression.

What is Amitone Plus Tablet used for?Arrow

Amitone Plus Tablet is generally used for the treatment of depression associated with significant anxiety, tension, or agitation. It may also be prescribed for mixed anxiety–depressive states, where both anxiety and depressive symptoms are present together and interfere with daily life. In some patients, it can help improve sleep disturbances and psychosomatic symptoms related to anxiety and depression. Its use should always be based on a doctor’s assessment and prescription.

How does Amitone Plus Tablet work in the body?Arrow

Amitone Plus Tablet contains amitriptyline, a tricyclic antidepressant, and chlordiazepoxide, a benzodiazepine. Amitriptyline increases the levels of certain neurotransmitters such as serotonin and noradrenaline in the brain, which helps improve mood, energy, and sleep patterns. Chlordiazepoxide enhances the effect of gamma-aminobutyric acid (GABA), a calming neurotransmitter, thereby reducing anxiety, restlessness, and tension. The combined effect helps relieve anxiety-depressive symptoms under medical supervision.

Is Amitone Plus Tablet a sleeping pill?Arrow

Amitone Plus Tablet is not primarily a sleeping pill, but it can cause drowsiness and may improve sleep in people whose insomnia is related to anxiety and depression. The chlordiazepoxide component has sedative and anxiolytic properties, and amitriptyline can also be sedating. However, it should not be used as a general-purpose sleep aid or for occasional insomnia without proper psychiatric evaluation and prescription, because of the risk of dependence, side effects, and interactions.

Can Amitone Plus Tablet be used for general stress or mild anxiety?Arrow

Amitone Plus Tablet is usually reserved for clinically significant anxiety associated with depressive symptoms, not for everyday stress or mild, self-limiting anxiety. Because it contains a benzodiazepine and a tricyclic antidepressant, it carries risks such as drowsiness, dependence, withdrawal, and interactions with other medicines. For mild stress or transient anxiety, non-pharmacological approaches and, if needed, safer short-term options are generally preferred. A healthcare professional should decide whether this medicine is appropriate.

How long does it take for Amitone Plus Tablet to show benefit?Arrow

The anxiolytic effect from chlordiazepoxide may appear within hours to a few days, leading to reduced anxiety and improved sleep. However, the full antidepressant effect of amitriptyline usually takes longer, often 2 to 4 weeks or more, to become evident. Response time varies between individuals. Patients should continue the medicine as prescribed and not stop early just because they do not feel immediate improvement, unless they experience troubling side effects and are advised by their doctor to discontinue.

Can I stop Amitone Plus Tablet suddenly if I feel better?Arrow

Stopping Amitone Plus Tablet abruptly, especially after prolonged or high-dose use, is not recommended. Sudden discontinuation can lead to withdrawal symptoms such as rebound anxiety, insomnia, irritability, restlessness, sweating, tremors, and, rarely, seizures. The antidepressant component may also cause discontinuation symptoms like nausea, headache, and mood changes. Any decision to stop should be made with your doctor, who will usually advise a gradual dose reduction to minimize withdrawal and relapse risk.

What are the common side effects of Amitone Plus Tablet?Arrow

Common side effects include drowsiness, dizziness, fatigue, dry mouth, constipation, blurred vision, increased appetite, weight gain, and difficulty concentrating. Some people may experience low blood pressure on standing (postural hypotension), palpitations, or changes in heart rate. Mood changes, confusion (especially in older adults), and sexual dysfunction can also occur. Not everyone experiences these effects, but any persistent, severe, or unusual symptoms should be reported to a healthcare professional promptly.

Is Amitone Plus Tablet habit-forming?Arrow

The chlordiazepoxide component of Amitone Plus Tablet is a benzodiazepine, which can be habit-forming if used for long periods, at high doses, or without proper medical supervision. Dependence and tolerance may develop, meaning higher doses are needed to achieve the same effect, and withdrawal symptoms can occur if the medicine is stopped suddenly. For this reason, doctors usually prescribe the lowest effective dose for the shortest possible duration and review the need for ongoing therapy regularly.

Can Amitone Plus Tablet be taken with other antidepressants or sedatives?Arrow

Combining Amitone Plus Tablet with other antidepressants, sedatives, opioid painkillers, antihistamines, or alcohol can increase the risk of excessive drowsiness, impaired breathing, confusion, falls, and other serious adverse effects. Certain antidepressant combinations may also raise the risk of serotonin syndrome or heart rhythm disturbances. Any concurrent medication, including over-the-counter products and herbal supplements, should be discussed with your doctor so that potential interactions can be assessed and avoided.

Who should avoid taking Amitone Plus Tablet?Arrow

Amitone Plus Tablet is generally avoided in people with known allergy to amitriptyline, chlordiazepoxide, other tricyclic antidepressants, or benzodiazepines. It is usually contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or those who have recently stopped them, and in certain serious heart rhythm disorders. Caution or avoidance is advised in severe liver or kidney disease, narrow-angle glaucoma, urinary retention, prostate enlargement, severe respiratory insufficiency, history of substance use disorder, and in elderly or frail patients, unless the potential benefits clearly outweigh the risks and close monitoring is possible.

Can Amitone Plus Tablet be used in children or older adults?Arrow

Amitone Plus Tablet is generally not a first-line option in children and adolescents because of limited safety data, risk of behavioral changes, and the need for very careful psychiatric assessment. In older adults, the medicine can cause pronounced drowsiness, confusion, falls, low blood pressure, and anticholinergic side effects such as urinary retention and constipation. If prescribed in these age groups, it should be used at the lowest effective dose with close monitoring and regular review of the ongoing need for therapy.

References

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Amitriptyline - Compound Summary. National Center for Biotechnology Information.

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Amitriptyline. DrugBank.

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Amitriptyline Hydrochloride Tablets, USP. FDA Label.

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Amitriptyline-induced changes in cerebral blood flow in patients with chronic tension-type headache. Journal of Headache and Pain.

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Amitriptyline - an overview. ScienceDirect.

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Methylcobalamin - Compound Summary. National Center for Biotechnology Information.

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METHYLCOBALAMIN injection solution. FDA Label.

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Methylcobalamin (Injection Route). Mayo Clinic.

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