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Composition
Content Reviewed By:
Dr. Manoj Shah
, (MBBS)
Written By:
Ms. Priyanka Shah
, (B.Pharm)
Common side effects of Amitone Plus Tablet may include: * Nausea * Vomiting * Constipation * Diarrhea * Stomach upset * Loss of appetite * Dry mouth * Dizziness * Drowsiness * Headache * Fatigue Less common, but potentially serious side effects include: * Allergic reactions (rash, itching, swelling) * Changes in heart rhythm * Muscle weakness * Numbness or tingling * Seizures * Confusion * Difficulty urinating * Liver problems (yellowing of skin or eyes) This is not an exhaustive list. If you experience any unusual symptoms while taking Amitone Plus, consult your doctor immediately.

Other Medical Conditions and Interactions
Use under strict medical supervisionAmitone Plus Tablet should be used carefully in patients with heart disease, including recent heart attack, arrhythmias, or conduction abnormalities, because tricyclic antidepressants can affect heart rhythm and blood pressure.
Amitone Plus Tablet 10's is a combination medicine used to treat anxiety and depression. It works by increasing the levels of chemical messengers in the brain that help regulate mood.
Amitone Plus Tablet 10's is used to treat anxiety, depression, and related symptoms such as sleep disturbances, loss of appetite, and fatigue.
Amitone Plus Tablet 10's works by increasing the amount of chemical messengers in the brain, such as serotonin and noradrenaline, which help improve mood and reduce anxiety.
The common side effects of Amitone Plus Tablet 10's include dry mouth, constipation, blurred vision, drowsiness, and dizziness.
Amitone Plus Tablet 10's is not addictive, but abruptly stopping it can cause withdrawal symptoms.
It is not recommended to drink alcohol with Amitone Plus Tablet 10's, as it can increase side effects such as drowsiness and dizziness.
Store Amitone Plus Tablet 10's at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.
If you miss a dose of Amitone Plus Tablet 10's, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
There is not enough information to say whether Amitone Plus Tablet 10's is safe for pregnant women. Therefore, it is important to consult a doctor before using it during pregnancy.
There is not enough information to say whether Amitone Plus Tablet 10's is safe for breastfeeding women. Therefore, it is important to consult a doctor before using it during breastfeeding.
Before starting Amitone Plus Tablet 10's, tell your doctor about all your medical conditions, allergies, and all the medications you are taking.
Yes, Amitone Plus Tablet 10's can interact with certain other medications. It is important to tell your doctor about all the medications you are taking so they can check for any potential interactions.
If you overdose on Amitone Plus Tablet 10's, seek immediate medical attention. Symptoms of an overdose may include drowsiness, confusion, irregular heartbeat, and seizures.
Alternatives to Amitone Plus Tablet 10's include other antidepressant medications, therapy, and lifestyle changes. Talk to your doctor about what the best option is for you.
Amitone Plus Tablet 10's contains a combination of Amitriptyline and Methylcobalamin. Amitriptyline is primarily used to treat depression. Amitone Plus Tablet 10's is one of many medications used for treating depression.
Amitone Plus Tablet is generally used for the treatment of depression associated with significant anxiety, tension, or agitation. It may also be prescribed for mixed anxiety–depressive states, where both anxiety and depressive symptoms are present together and interfere with daily life. In some patients, it can help improve sleep disturbances and psychosomatic symptoms related to anxiety and depression. Its use should always be based on a doctor’s assessment and prescription.
Amitone Plus Tablet contains amitriptyline, a tricyclic antidepressant, and chlordiazepoxide, a benzodiazepine. Amitriptyline increases the levels of certain neurotransmitters such as serotonin and noradrenaline in the brain, which helps improve mood, energy, and sleep patterns. Chlordiazepoxide enhances the effect of gamma-aminobutyric acid (GABA), a calming neurotransmitter, thereby reducing anxiety, restlessness, and tension. The combined effect helps relieve anxiety-depressive symptoms under medical supervision.
Amitone Plus Tablet is not primarily a sleeping pill, but it can cause drowsiness and may improve sleep in people whose insomnia is related to anxiety and depression. The chlordiazepoxide component has sedative and anxiolytic properties, and amitriptyline can also be sedating. However, it should not be used as a general-purpose sleep aid or for occasional insomnia without proper psychiatric evaluation and prescription, because of the risk of dependence, side effects, and interactions.
Amitone Plus Tablet is usually reserved for clinically significant anxiety associated with depressive symptoms, not for everyday stress or mild, self-limiting anxiety. Because it contains a benzodiazepine and a tricyclic antidepressant, it carries risks such as drowsiness, dependence, withdrawal, and interactions with other medicines. For mild stress or transient anxiety, non-pharmacological approaches and, if needed, safer short-term options are generally preferred. A healthcare professional should decide whether this medicine is appropriate.
The anxiolytic effect from chlordiazepoxide may appear within hours to a few days, leading to reduced anxiety and improved sleep. However, the full antidepressant effect of amitriptyline usually takes longer, often 2 to 4 weeks or more, to become evident. Response time varies between individuals. Patients should continue the medicine as prescribed and not stop early just because they do not feel immediate improvement, unless they experience troubling side effects and are advised by their doctor to discontinue.
Stopping Amitone Plus Tablet abruptly, especially after prolonged or high-dose use, is not recommended. Sudden discontinuation can lead to withdrawal symptoms such as rebound anxiety, insomnia, irritability, restlessness, sweating, tremors, and, rarely, seizures. The antidepressant component may also cause discontinuation symptoms like nausea, headache, and mood changes. Any decision to stop should be made with your doctor, who will usually advise a gradual dose reduction to minimize withdrawal and relapse risk.
Common side effects include drowsiness, dizziness, fatigue, dry mouth, constipation, blurred vision, increased appetite, weight gain, and difficulty concentrating. Some people may experience low blood pressure on standing (postural hypotension), palpitations, or changes in heart rate. Mood changes, confusion (especially in older adults), and sexual dysfunction can also occur. Not everyone experiences these effects, but any persistent, severe, or unusual symptoms should be reported to a healthcare professional promptly.
The chlordiazepoxide component of Amitone Plus Tablet is a benzodiazepine, which can be habit-forming if used for long periods, at high doses, or without proper medical supervision. Dependence and tolerance may develop, meaning higher doses are needed to achieve the same effect, and withdrawal symptoms can occur if the medicine is stopped suddenly. For this reason, doctors usually prescribe the lowest effective dose for the shortest possible duration and review the need for ongoing therapy regularly.
Combining Amitone Plus Tablet with other antidepressants, sedatives, opioid painkillers, antihistamines, or alcohol can increase the risk of excessive drowsiness, impaired breathing, confusion, falls, and other serious adverse effects. Certain antidepressant combinations may also raise the risk of serotonin syndrome or heart rhythm disturbances. Any concurrent medication, including over-the-counter products and herbal supplements, should be discussed with your doctor so that potential interactions can be assessed and avoided.
Amitone Plus Tablet is generally avoided in people with known allergy to amitriptyline, chlordiazepoxide, other tricyclic antidepressants, or benzodiazepines. It is usually contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or those who have recently stopped them, and in certain serious heart rhythm disorders. Caution or avoidance is advised in severe liver or kidney disease, narrow-angle glaucoma, urinary retention, prostate enlargement, severe respiratory insufficiency, history of substance use disorder, and in elderly or frail patients, unless the potential benefits clearly outweigh the risks and close monitoring is possible.
Amitone Plus Tablet is generally not a first-line option in children and adolescents because of limited safety data, risk of behavioral changes, and the need for very careful psychiatric assessment. In older adults, the medicine can cause pronounced drowsiness, confusion, falls, low blood pressure, and anticholinergic side effects such as urinary retention and constipation. If prescribed in these age groups, it should be used at the lowest effective dose with close monitoring and regular review of the ongoing need for therapy.
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INTAS PHARMACEUTICALS LIMITED
Country of Origin -
India
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