AXINERVE NP TABLET 10'S

How AXINERVE NP TABLET 10'S Works

• AXINERVE NP Tablet is a combination medication designed to alleviate neuropathic pain and manage certain types of seizures. It combines the synergistic actions of Pregabalin and Nortriptyline to provide comprehensive relief. Pregabalin, an anticonvulsant and analgesic, primarily works by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates calcium influx at nerve terminals, subsequently reducing the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. By decreasing the release of these neurotransmitters, Pregabalin helps to calm overactive nerves, thereby reducing the sensation of pain and controlling seizures. It is particularly effective in managing conditions like fibromyalgia, diabetic neuropathy, and postherpetic neuralgia, where nerve damage causes persistent and often debilitating pain signals.
• Nortriptyline, on the other hand, is a tricyclic antidepressant (TCA) that primarily functions by inhibiting the reuptake of norepinephrine and serotonin in the synaptic cleft. By blocking the reuptake of these neurotransmitters, Nortriptyline increases their concentration in the synaptic space, allowing them to bind to their receptors for a more extended period. This action enhances neurotransmission, which can improve mood and reduce the perception of pain. Additionally, Nortriptyline has analgesic properties, independent of its antidepressant effects, that contribute to its effectiveness in managing neuropathic pain. It helps in modulating pain pathways and reducing the overall sensation of pain. TCAs like Nortriptyline also possess anticholinergic properties, which can contribute to their therapeutic effects but may also lead to certain side effects.
• The combined action of Pregabalin and Nortriptyline in AXINERVE NP Tablet provides a dual mechanism of action that targets both the underlying causes of neuropathic pain and the pain signals themselves. Pregabalin calms overexcited nerves and reduces the release of pain-inducing neurotransmitters, while Nortriptyline enhances neurotransmission and modulates pain pathways. This synergistic effect results in a more effective and comprehensive approach to managing neuropathic pain compared to using either medication alone. It is crucial to use AXINERVE NP Tablet as prescribed by a healthcare professional to ensure optimal benefits and minimize potential side effects. The dosage and duration of treatment are tailored to the individual's specific condition and response to therapy.

Possible side effects of AXINERVE NP Tablet may include: * **Common:** Drowsiness, dizziness, headache, nausea, vomiting, constipation, dry mouth, blurred vision, difficulty concentrating, weight gain, increased appetite, swelling in the extremities. * **Uncommon:** Changes in sexual desire or function, sleep disturbances, anxiety, restlessness, confusion, memory problems, speech problems, muscle pain or weakness, tremors, uncoordinated movements, skin rash, itching, allergic reactions (hives, swelling of the face, tongue, or throat), changes in blood pressure, irregular heartbeat, suicidal thoughts, seizures. * **Rare:** Neuroleptic Malignant Syndrome (NMS), Tardive Dyskinesia, Serotonin Syndrome, severe allergic reaction (anaphylaxis), liver problems (jaundice), blood disorders (agranulocytosis, thrombocytopenia), angle-closure glaucoma, urinary retention. This is not an exhaustive list. If you experience any unusual or severe side effects, it is crucial to contact your doctor immediately.

• If you miss a dose of Axinerve NP Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep AXINERVE NP TAB 1X10 away from the reach of children and pets.
• Store AXINERVE NP TAB 1X10 at room temperature.

• Take AXINERVE NP TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. This ensures optimal effectiveness and minimizes potential side effects. The usual dose is once or twice daily, depending on your condition and response to treatment.
• AXINERVE NP TABLET 10'S can be taken with or without food, but consistency is key. Choose a method and stick to it. Taking it with food may help reduce stomach upset if you experience any. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Be patient and consistent with your AXINERVE NP TABLET 10'S regimen. It may take several weeks to experience the full benefits, such as reduced nerve pain and improved mood. Do not get discouraged if you don't see immediate results. Continue taking the medication as prescribed, and communicate any concerns with your healthcare provider.
• Inform your doctor about all other medications, supplements, and herbal remedies you are taking before starting AXINERVE NP TABLET 10'S. This includes over-the-counter drugs. Certain substances can interact with AXINERVE NP, potentially affecting its efficacy or increasing the risk of side effects. Common interactions can occur with other antidepressants, pain relievers, and certain heart medications. Always keep your doctor informed about your complete medication list.
• Store AXINERVE NP TABLET 10'S at room temperature, away from direct sunlight, heat, and moisture. Keep it out of reach of children and pets. Proper storage ensures the medication remains effective and safe to use. Do not store it in the bathroom, as the humidity can degrade the tablet. Always check the expiration date before use, and dispose of any expired medication properly according to local guidelines.

• Consumption of Axinerve NP Tablet 10's does not have any known interactions with food. This medicine can be taken with or without food. However, it is important to follow your doctor's instructions regarding dosage and timing.