AZFEX M TABLET 10'S

How AZFEX M TABLET 10'S Works

• AZFEX M Tablet 10'S is a combination medication containing two active ingredients: Alogliptin and Metformin. These components work synergistically to manage blood sugar levels in individuals with type 2 diabetes. Alogliptin belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors, while Metformin is a biguanide.
• Alogliptin enhances the incretin system, which is a natural mechanism in the body that helps regulate glucose. When blood sugar levels rise after a meal, the gut releases incretin hormones. These hormones stimulate the pancreas to release insulin and reduce the production of glucagon. Insulin helps cells absorb glucose from the blood, while glucagon signals the liver to release stored glucose. Alogliptin works by inhibiting the DPP-4 enzyme, which breaks down incretin hormones. By preventing the breakdown of incretins, Alogliptin prolongs their action, leading to increased insulin release and decreased glucagon secretion in a glucose-dependent manner.
• Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues, such as muscles. It reduces hepatic glucose output by suppressing gluconeogenesis (the process of creating glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, Metformin enhances insulin sensitivity, allowing cells to utilize glucose more effectively. It also slows down the absorption of glucose from the intestines after a meal.
• The combined action of Alogliptin and Metformin provides a dual approach to blood sugar control. Alogliptin boosts insulin secretion and reduces glucagon levels in response to elevated glucose, while Metformin reduces glucose production in the liver and improves insulin sensitivity. This synergistic effect helps lower both fasting and postprandial (after-meal) blood sugar levels, leading to better glycemic control in patients with type 2 diabetes. Regular monitoring of blood sugar levels and adherence to a healthy lifestyle, including diet and exercise, are essential for optimal management of diabetes with AZFEX M Tablet 10'S.
• In summary, AZFEX M Tablet 10'S works through a two-pronged approach: Alogliptin increases the activity of incretin hormones, leading to increased insulin release and decreased glucagon secretion when blood sugar is high. Metformin reduces glucose production in the liver and enhances the body's response to insulin. This combination helps to regulate blood sugar levels effectively in individuals with type 2 diabetes, improving overall glycemic control.

Like all medicines, AZFEX M TABLET 10'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Nausea * Vomiting * Diarrhea * Abdominal pain * Loss of appetite * Headache * Dizziness * Sleepiness * Fatigue **Uncommon Side Effects (may affect up to 1 in 100 people):** * Skin rash * Itching * Hives * Indigestion * Dry mouth * Thirst * Muscle pain * Joint pain * Anxiety * Nervousness * Insomnia (difficulty sleeping) * Increased sweating **Rare Side Effects (may affect up to 1 in 1,000 people):** * Allergic reaction (symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing) * Liver problems (symptoms may include yellowing of the skin or eyes, dark urine, pale stools) * Kidney problems (symptoms may include decreased urination, swelling of the ankles or feet) * Changes in blood sugar levels * Hair loss **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Severe skin reactions (symptoms may include blistering, peeling, or severe rash) * Blood disorders (symptoms may include easy bruising, bleeding gums, frequent infections) **If you experience any of these side effects, or any other unusual symptoms, stop taking AZFEX M TABLET 10'S and talk to your doctor or pharmacist immediately.**

• If you miss a dose of AZFEX M TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep AZFEX M TAB 1X10 away from the reach of children and pets.
• Store AZFEX M TAB 1X10 at room temperature.

• Take AZFEX M Tablet as prescribed by your doctor. It is typically taken once or twice daily, preferably with meals, to minimize stomach upset and ensure consistent absorption. Do not crush or chew the tablet; swallow it whole with a glass of water.
• AZFEX M Tablet combines two medications, metformin and a second drug (often a thiazolidinedione or a DPP-4 inhibitor), to help control blood sugar levels in adults with type 2 diabetes. It works by improving insulin sensitivity, reducing glucose production in the liver, and/or increasing insulin secretion, depending on the specific combination.
• Maintain a healthy lifestyle while taking AZFEX M Tablet. This includes following a balanced diet low in sugars and refined carbohydrates, engaging in regular physical activity (at least 30 minutes of moderate exercise most days of the week), and monitoring your blood sugar levels regularly as directed by your healthcare provider. Report any unusual readings to your doctor.
• Be aware of potential side effects. Common side effects of AZFEX M Tablet may include nausea, diarrhea, abdominal pain, and loss of appetite. More serious side effects are rare but can include lactic acidosis (a build-up of lactic acid in the blood) and liver problems. Contact your doctor immediately if you experience severe or persistent symptoms.
• Inform your doctor about all other medications, supplements, and medical conditions you have before starting AZFEX M Tablet. Certain medications and conditions can interact with AZFEX M Tablet, potentially affecting its efficacy or increasing the risk of side effects. This is especially important if you have kidney or liver problems, heart failure, or are planning to undergo surgery.

• AZFEX M TABLET 10'S does not have any known significant interactions with food. It can be taken with or without food. However, it's best to take it at a consistent time each day to maintain a steady level of medication in your body. If you experience stomach upset, taking it with food may help.