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CLADRIM 10MG/10ML INJECTION
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CLADRIM 10MG/10ML INJECTION
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CLADRIM 10MG/10ML INJECTION

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CLADRIM 10MG/10ML INJECTION

By FRESENIUS KABI INDIA PVT LTD

MRP

₹

11244.43

₹8995.54

20 % OFF

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Composition

CLADRIBINE 10 MG

Product DetailsArrow

About CLADRIM 10MG/10ML INJECTION

  • CLADRIM 10MG/10ML INJECTION contains the active ingredient Cladribine and belongs to a class of medications known as purine analogs and is an antineoplastic drug. It is prescribed for the treatment of Multiple Sclerosis, an autoimmune condition affecting the nervous system. Additionally, it is used in the treatment of Hairy cell leukemia, a cancer affecting white blood cells. This medication works by interfering with the growth of cancer cells and suppressing the immune system in multiple sclerosis.
  • CLADRIM 10MG/10ML INJECTION is not suitable for individuals with existing malignancies, ongoing chronic infections such as tuberculosis or hepatitis, or a history of hypersensitivity reactions to Cladribine. It's important to be aware that high doses of this medication have been linked to irreversible neurologic toxicity, including paraparesis or quadriparesis, acute nephrotoxicity, and severe bone marrow suppression leading to neutropenia, anemia, and thrombocytopenia. Regular monitoring by healthcare providers is essential to detect any signs of neurological impairment, such as numbness or tingling in the extremities, weakness, or loss of bowel or bladder control. Prompt medical attention is necessary if these symptoms arise to prevent further neurological damage. Before starting CLADRIM 10MG/10ML INJECTION, inform your doctor if you have a history of bleeding disorders, liver or kidney disease, or if you are taking any other medications, including over-the-counter drugs, supplements, or herbal remedies. The use of live vaccines should be avoided during and after treatment with CLADRIM 10MG/10ML INJECTION while white blood cell counts are not within normal limits, due to the increased risk of infection.
  • If you are pregnant, planning to conceive, or breastfeeding, consult your doctor before using CLADRIM 10MG/10ML INJECTION. This medication is not recommended during pregnancy as it may pose a risk of fetal harm. A pregnancy test will be conducted before initiating treatment. It may cause birth defects if either partner uses it during conception or pregnancy. Therefore, male patients with female partners of reproductive potential should use effective contraception during treatment and for 3 months after the last dose. Do not breastfeed during treatment and for 10 days after the last dose. It's crucial to adhere to these guidelines to minimize potential risks to the developing fetus or infant. Discuss any concerns with your doctor to make informed decisions about your treatment and reproductive health. Follow all instructions provided by your healthcare team to ensure safe and effective use of CLADRIM 10MG/10ML INJECTION.

Uses of CLADRIM 10MG/10ML INJECTION

  • Multiple sclerosis: This medication helps in treating multiple sclerosis, an autoimmune disease affecting the brain and spinal cord.
  • Hairy cell leukaemia: This medication is also useful for treating hairy cell leukaemia, a type of blood cancer. CLADRIM 10MG/10ML INJECTION helps by targeting and destroying the cancerous cells.

Side Effects of CLADRIM 10MG/10ML INJECTIONArrow

Side effects are unwanted symptoms caused by medicines, though not everyone experiences them. CLADRIM 10MG/10ML INJECTION can cause side effects.

  • Septic shock (infection throughout the body)
  • Malignancies
  • Anemia
  • Renal failure
  • Bleeding
  • Depressed level of consciousness
  • Neurotoxicity
  • Infection
  • Low white blood cells
  • Allergic reactions
  • Administration site reaction
  • Confusion, Anxiety, Insomnia
  • Headache, dizziness
  • Eye infection
  • Abnormal heart rate
  • Cough, abnormal breath sounds
  • Nausea, vomiting
  • Abdominal pain, constipation, diarrhea
  • Buildup of gas
  • Rash, itchiness
  • Chills
  • Loss of appetite
  • Pain, joint pain
  • Fatigue, muscle weakness
  • Swelling in the hands and feet
  • Inflammation of vein

Safety Advice for CLADRIM 10MG/10ML INJECTIONArrow

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Pregnancy

UNSAFE

CLADRIM 10MG/10ML INJECTION is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.

Dosage of CLADRIM 10MG/10ML INJECTIONArrow

  • CLADRIM 10MG/10ML INJECTION should only be administered by a qualified healthcare professional, such as a trained doctor or nurse, who has experience in administering chemotherapy. This ensures the safe and effective delivery of the medication.
  • This medication offers flexibility in its administration, as it can be given either as an intravenous (IV) infusion or as a subcutaneous injection. The choice of method depends on various factors, including patient preference and the specific treatment protocol.
  • When administered as an IV infusion, CLADRIM 10MG/10ML INJECTION is delivered directly into a vein over a period of two hours, allowing for a controlled and consistent absorption of the drug into the bloodstream.
  • Alternatively, when given as a subcutaneous injection, CLADRIM 10MG/10ML INJECTION is injected under the skin using a small needle. This method offers a potentially more convenient option for some patients.
  • It is crucial to remember that CLADRIM 10MG/10ML INJECTION should never be self-administered. The injection must be given by a healthcare professional. Your doctor will determine the appropriate dose and duration of treatment based on the severity of your condition, your overall health, and other relevant factors. Following your doctor's instructions carefully is essential for the best possible outcome.
  • The dosage and frequency of CLADRIM 10MG/10ML INJECTION administration will be tailored to your individual needs. Regular monitoring and adjustments to the treatment plan may be necessary based on your response to the medication.

How to store CLADRIM 10MG/10ML INJECTION?Arrow

  • Keep CLADRIM 10MG INJ 10ML away from the reach of children and pets.
  • Store CLADRIM 10MG INJ 10ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of CLADRIM 10MG/10ML INJECTIONArrow

  • CLADRIM 10MG/10ML INJECTION is a type of medication known as a purine analog. This means its chemical structure closely resembles purines, which are essential components of DNA. Because of this similarity, CLADRIM 10MG/10ML INJECTION can integrate itself into the DNA of cancer cells.
  • Once incorporated, CLADRIM 10MG/10ML INJECTION disrupts the normal processes of DNA synthesis and repair. DNA synthesis is crucial for cell division and growth, while DNA repair mechanisms correct any damage that occurs to the DNA. By interfering with these processes, CLADRIM 10MG/10ML INJECTION causes the accumulation of damaged DNA within the cancer cells.
  • This buildup of DNA damage ultimately triggers a process called apoptosis, or programmed cell death. In essence, the cancer cells are forced to self-destruct due to the overwhelming amount of irreparable damage. This mechanism of action makes CLADRIM 10MG/10ML INJECTION an effective treatment option for certain types of cancer by selectively targeting and eliminating cancerous cells while minimizing harm to healthy cells. CLADRIM 10MG/10ML INJECTION's impact on DNA replication is a key factor in its effectiveness.

How to use CLADRIM 10MG/10ML INJECTIONArrow

  • CLADRIM 10MG/10ML INJECTION should only be administered by a trained doctor or nurse who has experience in giving chemotherapy. This ensures the medication is given safely and effectively.
  • This medication can be given in two ways: either directly into a vein (intravenous or IV infusion) or as a subcutaneous injection (under the skin).
  • If administered as an IV infusion, the CLADRIM 10MG/10ML INJECTION is given slowly over two hours. This allows for careful monitoring and helps to minimize potential side effects.
  • When given as a subcutaneous injection, a small needle is used to inject the medication under the skin. This method is often more convenient for patients. It is crucial that you do not attempt to self-administer the injection. This must be done by a trained healthcare professional.
  • Your doctor will determine the correct dose and how long you need to receive treatment. This decision will be based on how severe your condition is, your overall health, and how well you respond to the medication. It’s very important to follow your doctor’s instructions precisely.
  • During treatment, your doctor will monitor you closely for any side effects and make adjustments to your treatment plan as needed. Be sure to tell your doctor about any other medications you are taking, including over-the-counter drugs and supplements.

FAQs

<p style=\"text-align:justify;\"><strong>Who cannot take CLADRIM 10MG/10ML INJECTION?</strong></p>Arrow

CLADRIM 10MG/10ML INJECTION is primarily eliminated from the body through the kidneys. People with severe kidney impairment may not be able to eliminate the drug effectively, which can increase the risk of side effects. Therefore, those who have kidney disease should talk with your doctor before taking this tablet.

<p style=\"text-align:justify;\"><strong>What are the warnings of CLADRIM 10MG/10ML INJECTION?</strong></p>Arrow

Patients with severe kidney impairment may not be able to eliminate the drug effectively, which can increase the risk of side effects. Dose adjustments may be necessary for patients with kidney impairment.

<p style=\"text-align:justify;\"><strong>Whether CLADRIM 10MG/10ML INJECTION causes any neurologic events?</strong></p>Arrow

Yes, CLADRIM 10MG/10ML INJECTION can cause neurologic events, such as seizures and neuropathy. Patients should be monitored for signs of neurologic events and inform their healthcare provider if they experience any.

<p style=\"text-align:justify;\"><strong>What is the dosing frequency for CLADRIM 10MG/10ML INJECTION?</strong></p>Arrow

The recommended dosing of CLADRIM 10MG/10ML INJECTION is usually 0.09 mg/kg given over a 2-hour intravenous infusion on days 1 and 2 of a 7-day treatment cycle, with cycles repeated every 4 weeks for a total of 6 cycles.

<p style=\"text-align:justify;\"><strong>How do you store CLADRIM 10MG/10ML INJECTION?</strong></p>Arrow

CLADRIM 10MG/10ML INJECTION should be stored in a refrigerator at a temperature of 2°C to 8°C. Do not freeze the medication.

NULL interaction of CLADRIM 10MG/10ML INJECTION with other drungsArrow

NULL interaction of CLADRIM 10MG/10ML INJECTION with other drungs

<p style="text-align:justify;">Avoid contact with people who have infections, especially during the time when you are taking the medication.</p>Arrow

Avoid contact with people who have infections, especially during the time when you are taking the medication. Limit direct skin contact with the tablets, and wash exposed areas thoroughly. Your doctor will perform regular blood tests during treatment with this drug to monitor the blood cell counts and kidney function. Let your doctor know about any other medications you are taking, including over-the-counter drugs, supplements, or herbal remedies.

CLADRIBINE is molecule/combination used for making CLADRIM 10MG/10ML INJECTION.Arrow

CLADRIBINE is molecule/combination used for making CLADRIM 10MG/10ML INJECTION.

For which ailments/diseases/conditions CLADRIM 10MG/10ML INJECTION is prescribed?Arrow

CLADRIM 10MG/10ML INJECTION is prescribed for Oncology related ailments/diseases/conditions.

References

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Merck See Ltd, Electronic medicines compendium (emc)

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Highlights of prescribing information ... - food and drug administration

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Ema (2022) Mavenclad, European Medicines Agency

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SAHPRA Medicines

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Cladribine injection warnings - pfizer

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Marketer / Manufacturer Details

FRESENIUS KABI INDIA PVT LTD

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CLADRIM 10MG/10ML INJECTION

CLADRIM 10MG/10ML INJECTION

MRP

₹

11244.43

₹8995.54

20 % OFF

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