COMBIGAN EYE DROPS 5 ML

How COMBIGAN EYE DROPS 5 ML Works

• COMBIGAN EYE DROPS 5 ML is a dual-action medication specifically formulated to manage elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. It combines two active ingredients, brimonidine tartrate and timolol maleate, each working through distinct mechanisms to lower IOP and protect the optic nerve from damage.
• Brimonidine tartrate is an alpha-2 adrenergic receptor agonist. When administered topically to the eye, brimonidine selectively binds to alpha-2 adrenergic receptors located on nerve terminals and certain cells within the eye. This binding action triggers several beneficial effects. Firstly, it reduces the production of aqueous humor, the fluid that fills the space between the lens and the cornea. By decreasing the inflow of aqueous humor, the overall pressure inside the eye is reduced. Secondly, brimonidine enhances the outflow of aqueous humor through an alternative pathway known as the uveoscleral pathway. This dual action of reducing production and increasing outflow contributes to a significant decrease in IOP.
• Timolol maleate, on the other hand, is a non-selective beta-adrenergic receptor blocker. It primarily works by reducing the production of aqueous humor. Beta-adrenergic receptors are found in the ciliary epithelium, the tissue responsible for producing aqueous humor. Timolol blocks these receptors, leading to a decrease in the rate of aqueous humor formation. Unlike brimonidine, timolol does not significantly affect the outflow of aqueous humor.
• The synergistic effect of brimonidine and timolol is what makes COMBIGAN EYE DROPS 5 ML so effective. Brimonidine reduces aqueous humor production and increases outflow, while timolol primarily reduces production. By targeting both inflow and outflow mechanisms, COMBIGAN provides a more comprehensive approach to IOP control than either medication could achieve alone. This combined action results in a greater overall reduction in IOP compared to using either medication individually.
• By effectively lowering intraocular pressure, COMBIGAN EYE DROPS 5 ML helps to prevent or slow down the progression of optic nerve damage, which is the hallmark of glaucoma. The optic nerve transmits visual information from the eye to the brain, and elevated IOP can damage the nerve fibers, leading to irreversible vision loss. COMBIGAN helps to protect the optic nerve by maintaining a healthy IOP range.
• In summary, COMBIGAN EYE DROPS 5 ML works through a dual mechanism. Brimonidine reduces aqueous humor production and enhances outflow, while timolol reduces aqueous humor production. This synergistic action effectively lowers intraocular pressure, protecting the optic nerve and helping to manage glaucoma and ocular hypertension. Patients should use this medication as prescribed by their ophthalmologist for optimal results.

Like all medicines, Combigan eye drops can cause side effects, although not everybody gets them. **Very Common (may affect more than 1 in 10 people):** * Eye redness **Common (may affect up to 1 in 10 people):** * Burning sensation in the eyes * Stinging in the eyes * Allergic reaction in the eye * Blurred vision * Itching in the eye * Foreign body sensation in the eye * Conjunctivitis * Conjunctival follicles * Headache * Dry mouth * Drowsiness * Dizziness * Symptoms of a cold **Uncommon (may affect up to 1 in 100 people):** * Erosion of the cornea * Inflammation of the iris * Swollen eyelids * Fatigue * General allergic reaction * Irregular heart rate * Depression * Dry nose * Taste perversion **Rare (may affect up to 1 in 1,000 people):** * Shortness of breath **Not Known (frequency cannot be estimated from the available data):** * Eye irritation * Watering eyes * Abnormal vision * Eyelid disorder * Decreased blood pressure * Heart failure * Nervousness * Insomnia * Fainting * Skin reactions (including redness, rash, itching) Some side effects, such as blurred vision, drowsiness, and dizziness, could affect your ability to drive or operate machinery. If you experience these, do not drive or operate machinery until the effect has worn off.

• If you miss a dose of COMBIGAN EYE DROPS 5 ML, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose to catch up.

• Keep COMBIGAN EYE DROPS 5ML away from the reach of children and pets.
• Store COMBIGAN EYE DROPS 5ML at room temperature.

• **Use as Prescribed:** Always use COMBIGAN EYE DROPS 5 ML exactly as your doctor has instructed. Do not alter the dosage or frequency without consulting them. Adhering to the prescribed regimen is crucial for optimal results and minimizing potential side effects.Consistency is key.
• **Proper Instillation Technique:** Tilt your head back slightly, pull down your lower eyelid to create a small pocket, and gently squeeze one drop into the pocket. Avoid touching the dropper tip to your eye or any other surface to prevent contamination. Close your eye gently for 1-2 minutes, applying slight pressure to the inner corner of your eye to prevent the medication from draining away. If you wear contact lenses, remove them before instilling the drops and wait at least 15 minutes before reinserting them. This allows the medication to be fully absorbed and prevents any interaction with the lens material.
• **Storage Matters:** Store COMBIGAN EYE DROPS 5 ML at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed when not in use to prevent contamination and maintain the medication's efficacy. Do not store the drops in the bathroom, as the humidity can degrade the medication. Keep out of reach of children.
• **Be Aware of Side Effects:** Common side effects of COMBIGAN EYE DROPS 5 ML may include temporary blurred vision, stinging or burning sensation, dry eyes, or eye redness. If these side effects persist or worsen, consult your doctor immediately. More serious side effects, such as allergic reactions or significant changes in vision, require immediate medical attention. If you experience chest pain, difficulty breathing, or swelling of the face, lips, or tongue, seek emergency medical assistance. This medicine might cause drowsiness, use caution when driving or operating machinery. Consult with your healthcare provider.
• **Maintain Regular Check-ups:** Regular eye examinations are essential while using COMBIGAN EYE DROPS 5 ML to monitor your condition and assess the medication's effectiveness. Your doctor may adjust the dosage or treatment plan based on your progress. Do not discontinue the medication without consulting your doctor, as this could lead to a worsening of your condition. Report any changes in your vision or any new symptoms to your doctor promptly. Inform all healthcare providers about all medications, supplements, or herbal products you are taking. This will help prevent drug interactions.

• COMBIGAN EYE DROPS 5 ML is a topical medication, and its absorption into the bloodstream is minimal. Therefore, it is unlikely to have any significant interactions with food. You can use COMBIGAN EYE DROPS 5 ML regardless of your food intake.