DAPAVEL GM 10/1/500 TABLET 10'S
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DAPAVEL GM 10/1/500 TABLET 10'S
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DAPAVEL GM 10/1/500 TABLET 10'S

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DAPAVEL GM 10/1/500 TABLET 10'S

By INTAS PHARMACEUTICALS LIMITED

MRP

130

₹110.5

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About DAPAVEL GM 10/1/500 TABLET 10'S

  • DAPAVEL GM 10/1/500 Tablet is a combination medicine used to treat type 2 diabetes mellitus. It improves blood sugar control in adults when used along with diet and exercise. This medication combines three active ingredients: Dapagliflozin, Glimepiride and Metformin. Dapagliflozin works by helping the kidneys remove glucose from the bloodstream. Glimepiride stimulates the pancreas to release insulin, which helps lower blood sugar. Metformin reduces glucose production in the liver and improves insulin sensitivity.
  • DAPAVEL GM 10/1/500 Tablet is typically taken once daily, preferably with a meal, to minimize gastrointestinal side effects. The dosage is determined by your doctor based on your blood sugar levels, response to treatment, and other medications you may be taking. It is crucial to follow your doctor's instructions carefully and not to adjust the dose without consulting them.
  • This medication is beneficial in managing blood sugar levels, but it is not a substitute for a healthy lifestyle. Continue to follow your diet and exercise plan as directed by your healthcare provider. Regular monitoring of blood sugar levels is essential while taking DAPAVEL GM 10/1/500 Tablet to ensure optimal control and detect any potential complications. Common side effects may include nausea, diarrhea, and headache. Report any persistent or severe side effects to your doctor.
  • Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, promotes the excretion of glucose through urine, thereby lowering blood sugar levels. Glimepiride, a sulfonylurea, stimulates the release of insulin from the beta cells of the pancreas. Metformin, a biguanide, decreases hepatic glucose production and enhances insulin sensitivity in peripheral tissues. The synergistic action of these three components makes DAPAVEL GM 10/1/500 Tablet an effective option for managing type 2 diabetes.
  • Before taking DAPAVEL GM 10/1/500 Tablet, inform your doctor about any pre-existing medical conditions, especially kidney or liver problems, heart disease, or diabetic ketoacidosis. Also, disclose all other medications you are taking, including herbal supplements and over-the-counter drugs, to avoid potential drug interactions. Regular check-ups with your doctor are necessary to monitor your overall health and the effectiveness of the treatment.

Uses of DAPAVEL GM 10/1/500 TABLET 10'S

  • Treatment of type 2 diabetes mellitus
  • Lowering high blood sugar levels
  • Improvement in glycemic control
  • Reducing cardiovascular risk (in some patients)
  • Increasing insulin sensitivity
  • Managing insulin resistance associated with polycystic ovary syndrome (PCOS)

How DAPAVEL GM 10/1/500 TABLET 10'S Works

  • DAPAVEL GM 10/1/500 Tablet is a combination medication designed to manage type 2 diabetes effectively. It combines three active ingredients: Dapagliflozin, Glimepiride, and Metformin Hydrochloride. Each component works through a different mechanism to lower blood sugar levels and improve glycemic control.
  • Dapagliflozin belongs to a class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. SGLT2 inhibitors work in the kidneys by blocking the reabsorption of glucose back into the bloodstream. This allows excess glucose to be excreted in the urine, thereby lowering blood sugar levels. This mechanism is insulin-independent, meaning it works regardless of insulin availability or sensitivity. By reducing glucose reabsorption, Dapagliflozin not only lowers blood sugar but can also lead to modest weight loss and blood pressure reduction in some patients.
  • Glimepiride is a sulfonylurea, which stimulates the pancreas to release more insulin. Insulin is a hormone that helps glucose enter cells for energy. By increasing insulin secretion, Glimepiride helps to lower blood sugar levels, particularly after meals. Sulfonylureas like Glimepiride have been used for many years to treat type 2 diabetes and are known for their effectiveness in lowering blood sugar.
  • Metformin Hydrochloride is a biguanide that works in several ways to lower blood sugar. Primarily, it reduces glucose production in the liver, decreasing the amount of glucose released into the bloodstream. Metformin also improves insulin sensitivity, allowing the body's cells to use insulin more effectively. Additionally, it slightly reduces glucose absorption in the intestines. Metformin is often the first-line treatment for type 2 diabetes due to its efficacy, safety profile, and potential benefits for weight management and cardiovascular health.
  • In combination, these three drugs provide a comprehensive approach to managing blood sugar levels. Dapagliflozin helps remove excess glucose through the kidneys, Glimepiride stimulates insulin release, and Metformin reduces glucose production and improves insulin sensitivity. This multi-pronged approach can be particularly effective for patients who need more than one medication to achieve their target blood sugar levels. However, it's essential to use DAPAVEL GM 10/1/500 Tablet as directed by a healthcare professional, as it may not be suitable for everyone, and potential side effects and interactions with other medications should be considered.

Side Effects of DAPAVEL GM 10/1/500 TABLET 10'SArrow

DAPAVEL GM 10/1/500 TABLET 10'S may cause several side effects, although not everyone experiences them. Common side effects include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and hypoglycemia (low blood sugar), which can manifest as sweating, dizziness, tremors, rapid heartbeat, and confusion. You might also experience headache, weakness, fatigue, and upper respiratory tract infections. Less common but potentially serious side effects include lactic acidosis (symptoms: deep and rapid breathing, nausea, vomiting, stomach pain), allergic reactions (rash, itching, swelling), and liver problems (yellowing of skin/eyes, dark urine, persistent fatigue). In rare cases, it can lead to diabetic ketoacidosis (symptoms: excessive thirst, frequent urination, nausea, vomiting, fatigue) or pancreatitis (severe abdominal pain radiating to the back). Kidney problems are also possible. This is not an exhaustive list, and it's crucial to consult your doctor if you experience any unusual or severe symptoms while taking DAPAVEL GM 10/1/500 TABLET 10'S.

Safety Advice for DAPAVEL GM 10/1/500 TABLET 10'SArrow

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Allergies

Allergies

Do not use DAPAVEL GM 10/1/500 TABLET 10'S if you are allergic to it.

Dosage of DAPAVEL GM 10/1/500 TABLET 10'SArrow

  • The recommended dosage of 'DAPAVEL GM 10/1/500 TABLET 10'S' is individualized and depends on several factors, including the patient's glycemic control, overall health, other medications, and response to treatment. Your physician will determine the appropriate dosage based on these factors.
  • Typically, 'DAPAVEL GM 10/1/500 TABLET 10'S' is taken orally, usually once or twice daily with meals to minimize gastrointestinal side effects. The 'GM' in the medicine name refers to Glimepiride and Metformin combination along with Dapagliflozin, and the dosage may be adjusted depending on individual needs. It's crucial to adhere to the prescribed dosage schedule to maintain optimal blood sugar levels.
  • It is important to swallow the tablet whole with a glass of water and avoid crushing or chewing it. Crushing or chewing the tablet can lead to rapid release of the medication, which may increase the risk of side effects.
  • If you miss a dose of 'DAPAVEL GM 10/1/500 TABLET 10'S', take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one.
  • Regular monitoring of blood glucose levels is essential while taking 'DAPAVEL GM 10/1/500 TABLET 10'S'. This will help your doctor assess the effectiveness of the medication and make any necessary adjustments to your treatment plan. It is important to follow your doctor's instructions regarding blood glucose monitoring and to keep them informed of your blood sugar readings.
  • Take 'DAPAVEL GM 10/1/500 TABLET 10'S' only as per the prescription by your physician only.

What if I miss my dose of DAPAVEL GM 10/1/500 TABLET 10'S?Arrow

  • If you miss a dose of DAPAVEL GM 10/1/500 Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How to store DAPAVEL GM 10/1/500 TABLET 10'S?Arrow

  • Keep DAPAVEL GM 10/1/500MG TAB 1X10 away from the reach of children and pets.
  • Store DAPAVEL GM 10/1/500MG TAB 1X10 at room temperature.

Benefits of DAPAVEL GM 10/1/500 TABLET 10'SArrow

  • DAPAVEL GM 10/1/500 Tablet 10's is a combination medication meticulously formulated to manage type 2 diabetes mellitus effectively. It synergistically combines three active ingredients – dapagliflozin, glimepiride, and metformin – each contributing uniquely to glycemic control.
  • Dapagliflozin, an SGLT2 inhibitor, works primarily by preventing the kidneys from reabsorbing glucose back into the bloodstream. This mechanism results in excess glucose being excreted through urine, thereby lowering blood sugar levels. This reduction not only aids in managing hyperglycemia but also offers additional benefits such as weight management and blood pressure control.
  • Glimepiride, a sulfonylurea, stimulates the pancreas to release more insulin. Insulin is crucial for facilitating glucose uptake by cells for energy, effectively lowering blood glucose levels. Glimepiride's action complements dapagliflozin's mechanism, providing a dual approach to reducing blood sugar.
  • Metformin, a biguanide, reduces glucose production in the liver and enhances insulin sensitivity in peripheral tissues. This allows cells to utilize insulin more effectively, lowering blood glucose levels. Metformin also has a beneficial impact on lipid profiles and can aid in weight management, making it a cornerstone in type 2 diabetes treatment.
  • The combined action of these three medications offers comprehensive glycemic control. By targeting different pathways involved in glucose regulation, DAPAVEL GM 10/1/500 effectively manages blood sugar levels, reducing the risk of diabetes-related complications.
  • Beyond glycemic control, DAPAVEL GM 10/1/500 offers a multifaceted approach to improving overall health in individuals with type 2 diabetes. Dapagliflozin's diuretic effect can contribute to blood pressure reduction and potential cardiovascular benefits. Metformin's impact on lipid profiles can reduce the risk of cardiovascular events. Glimepiride ensures adequate insulin secretion, preventing drastic glucose spikes.
  • DAPAVEL GM 10/1/500 has shown promise in reducing the risk of cardiovascular events in patients with type 2 diabetes. By improving blood sugar control, blood pressure, and lipid profiles, it collectively contributes to a healthier cardiovascular system.
  • The convenience of a single tablet containing three different medications improves patient compliance. This simplifies the treatment regimen, making it easier for individuals to adhere to their prescribed medication schedule. Improved compliance translates to better glycemic control and reduced risk of complications.
  • The combination of dapagliflozin and metformin can lead to modest weight loss in some individuals. This can be particularly beneficial for overweight or obese patients with type 2 diabetes. Weight management further improves insulin sensitivity and overall metabolic health.
  • Regular monitoring of kidney function is essential while taking DAPAVEL GM 10/1/500, as dapagliflozin affects kidney function. Dosage adjustments may be necessary based on individual kidney function and response to the medication.
  • DAPAVEL GM 10/1/500 should be used as part of a comprehensive diabetes management plan, including lifestyle modifications such as diet and exercise. A healthy diet, regular physical activity, and adherence to the medication regimen contribute to optimal glycemic control and overall well-being.
  • In summary, DAPAVEL GM 10/1/500 Tablet 10's offers a comprehensive and convenient approach to managing type 2 diabetes. Its triple-action mechanism provides effective glycemic control, reduces cardiovascular risk, aids in weight management, and improves patient compliance, ultimately leading to better health outcomes.

How to use DAPAVEL GM 10/1/500 TABLET 10'SArrow

  • DAPAVEL GM 10/1/500 Tablet 10'S is a combination medicine prescribed for the management of type 2 diabetes mellitus. It contains dapagliflozin, glimepiride and metformin as active ingredients. It is crucial to adhere to your doctor's instructions regarding dosage and duration of treatment. Typically, it is taken orally once daily, preferably with your first main meal to minimize gastrointestinal discomfort. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
  • Consistency is key for optimal results. Try to take DAPAVEL GM at the same time each day to maintain a steady level of medication in your bloodstream. If you miss a dose, take it as soon as you remember unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
  • While taking DAPAVEL GM, it's essential to monitor your blood sugar levels regularly, as directed by your healthcare provider. This will help you and your doctor track how well the medication is working and adjust your treatment plan if needed. Also, inform your doctor about all other medications, supplements, or herbal products you are taking to avoid potential drug interactions.
  • DAPAVEL GM works best when combined with a healthy lifestyle. Follow a balanced diet, engage in regular physical activity, and maintain a healthy weight. These lifestyle modifications can significantly improve your blood sugar control and overall health. If you experience any unusual side effects, such as persistent nausea, vomiting, abdominal pain, or signs of dehydration, contact your doctor immediately.

Quick Tips for DAPAVEL GM 10/1/500 TABLET 10'SArrow

  • Take DAPAVEL GM 10/1/500 Tablet as prescribed by your doctor, usually once daily. Consistency in timing helps maintain stable blood sugar levels. It's crucial to adhere to the prescribed dosage and schedule to maximize its effectiveness in managing type 2 diabetes. Never self-adjust the dosage without consulting your healthcare provider.
  • DAPAVEL GM contains three active ingredients: dapagliflozin, glimepiride, and metformin. Dapagliflozin helps the kidneys remove glucose from your bloodstream, glimepiride stimulates the pancreas to release insulin, and metformin reduces glucose production in the liver and improves insulin sensitivity. Understanding these mechanisms can help you appreciate how the medication works synergistically to control your blood sugar.
  • Monitor your blood sugar levels regularly, as advised by your doctor. This is essential to track how well DAPAVEL GM is working and to make any necessary adjustments to your diet or exercise regimen. Keep a log of your readings to share with your healthcare provider during check-ups. Regular monitoring helps in the early detection of any fluctuations or potential complications.
  • Inform your doctor about all other medications, supplements, and herbal products you are taking. This is crucial to avoid potential drug interactions that could affect the efficacy of DAPAVEL GM or increase the risk of side effects. Pay special attention to medications that affect blood sugar, kidney function, or heart health. A comprehensive medication review ensures your safety and optimizes treatment outcomes.
  • Be aware of the potential side effects, such as hypoglycemia (low blood sugar), gastrointestinal issues (nausea, diarrhea), and urinary tract infections. Learn to recognize the symptoms of hypoglycemia (shaking, sweating, confusion) and carry a source of fast-acting sugar with you. Report any persistent or severe side effects to your doctor promptly. Early intervention can prevent complications and improve your quality of life.

Food Interactions with DAPAVEL GM 10/1/500 TABLET 10'SArrow

  • DAPAVEL GM 10/1/500 TABLET 10'S can be taken with or without food, but it is best to take it at the same time each day for consistent results.
  • Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of side effects such as low blood sugar (hypoglycemia).
  • There are no specific food restrictions while taking DAPAVEL GM 10/1/500 TABLET 10'S, but maintaining a balanced diet is recommended for overall health and diabetes management.

FAQs

What is DAPAVEL GM 10/1/500 TABLET 10'S?

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DAPAVEL GM 10/1/500 TABLET 10'S is a medication used to treat type 2 diabetes. It contains three medicines: Dapagliflozin, Glimepiride, and Metformin.

What is DAPAVEL GM 10/1/500 TABLET 10'S used for?

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DAPAVEL GM 10/1/500 TABLET 10'S is used to control blood sugar levels in people with type 2 diabetes.

How does DAPAVEL GM 10/1/500 TABLET 10'S work?

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DAPAVEL GM 10/1/500 TABLET 10'S works in three ways: Dapagliflozin reduces reabsorption of glucose by the kidneys, Glimepiride increases the release of insulin from the pancreas, and Metformin decreases glucose production by the liver and increases the body's sensitivity to insulin.

What are the common side effects of DAPAVEL GM 10/1/500 TABLET 10'S?

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Common side effects of DAPAVEL GM 10/1/500 TABLET 10'S include nausea, vomiting, diarrhea, stomach pain, and headache.

How should I store DAPAVEL GM 10/1/500 TABLET 10'S?

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Store DAPAVEL GM 10/1/500 TABLET 10'S at room temperature, away from heat and moisture.

Is DAPAVEL GM 10/1/500 TABLET 10'S safe during pregnancy?

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The safety of DAPAVEL GM 10/1/500 TABLET 10'S during pregnancy is not known. Talk to your doctor if you are pregnant or planning to become pregnant.

Is DAPAVEL GM 10/1/500 TABLET 10'S safe during breastfeeding?

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It is not known if DAPAVEL GM 10/1/500 TABLET 10'S passes into breast milk. Talk to your doctor if you are breastfeeding.

Should DAPAVEL GM 10/1/500 TABLET 10'S be taken on an empty stomach or with food?

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DAPAVEL GM 10/1/500 TABLET 10'S should be taken with food.

What happens if I miss a dose of DAPAVEL GM 10/1/500 TABLET 10'S?

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If you miss a dose of DAPAVEL GM 10/1/500 TABLET 10'S, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Can DAPAVEL GM 10/1/500 TABLET 10'S interact with other medications?

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DAPAVEL GM 10/1/500 TABLET 10'S can interact with certain other medications. Tell your doctor about all the medicines you are taking, including over-the-counter medicines and herbal supplements.

What are other brands of Dapagliflozin?

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Some other brands of Dapagliflozin include Forxiga and Qtern.

What are other brands of Glimepiride?

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Some other brands of Glimepiride include Amaryl and Glimestar.

What are other brands of Metformin?

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Some other brands of Metformin include Glucophage and Glycomet.

What should I avoid while taking DAPAVEL GM 10/1/500 TABLET 10'S?

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Avoid drinking alcohol while taking DAPAVEL GM 10/1/500 TABLET 10'S, as it can lower blood sugar levels.

What happens if I overdose on DAPAVEL GM 10/1/500 TABLET 10'S?

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If you overdose on DAPAVEL GM 10/1/500 TABLET 10'S, contact a doctor or go to the emergency room immediately. Symptoms of an overdose may include low blood sugar, nausea, vomiting, and stomach pain.

References

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Dapagliflozin (Farxiga) US Prescribing Information. This document provides detailed information on the drug's mechanism of action, pharmacokinetics, clinical trials, and safety profile. While it doesn't directly cover a combination product, it offers substantial data on dapagliflozin itself.

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Xigduo (dapagliflozin/metformin) European Medicines Agency assessment report. This provides extensive details on the combination of dapagliflozin and metformin, including clinical trial data, pharmacokinetics, and safety assessments.

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DrugBank entry for Dapagliflozin. Provides chemical structure, pharmacology, mechanism of action, and drug interactions.

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DrugBank entry for Metformin. Provides chemical structure, pharmacology, mechanism of action, and drug interactions.

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PubMed Central. A free archive of biomedical and life sciences literature. Search for articles on dapagliflozin, metformin, and combination therapies for type 2 diabetes.

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UpToDate. A subscription-based resource that provides detailed clinical information on various medical topics. Search for information on diabetes management, dapagliflozin, and metformin.

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American Heart Association Journals. Search for research articles on the cardiovascular effects of SGLT2 inhibitors like dapagliflozin.

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Kidney International. Search for research articles on the renal effects of SGLT2 inhibitors like dapagliflozin.

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INTAS PHARMACEUTICALS LIMITED

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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