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Composition
Content Reviewed By:
Dr. Rajesh Sharma
, (MBBS)
Written By:
Ms. Priyanka Shah
, (B.Pharm)
Possible side effects of DEPSONIL DZ TABLET 10'S may include: Nausea, Vomiting, Diarrhea, Constipation, Dry mouth, Dizziness, Lightheadedness, Headache, Anxiety, Nervousness, Insomnia (trouble sleeping), Drowsiness, Fatigue, Weakness, Blurred vision, Changes in appetite, Weight gain or loss, Sweating, Tremors, Sexual dysfunction, Skin rash, Itching, Allergic reactions (swelling, hives, difficulty breathing), Changes in heart rate or blood pressure, Liver problems (jaundice, abdominal pain), Seizures, Serotonin syndrome (confusion, agitation, muscle stiffness), Suicidal thoughts or behavior.

Cardiovascular and Other Special Populations
Use with cautionImipramine can affect cardiac conduction and may prolong cardiac intervals, increasing the risk of arrhythmias, particularly in patients with pre‑existing heart disease, recent myocardial infarction, or electrolyte disturbances. Baseline and periodic ECG monitoring may be advisable in such patients.
DEPSONIL DZ TABLET 10'S is a medication used to treat mental disorders like depression and anxiety. It contains two active ingredients that help restore chemical balance in the brain.
It is used to treat conditions like depression, anxiety, obsessive-compulsive disorder (OCD), and panic disorder.
It works by increasing the levels of chemical messengers like serotonin and norepinephrine in the brain, which help in improving mood and reducing anxiety.
Common side effects include nausea, vomiting, diarrhea, constipation, dizziness, dry mouth, drowsiness, and changes in sexual desire.
It can be taken with or without food, but it's best to take it at the same time every day.
No, it's not recommended to drink alcohol while taking DEPSONIL DZ TABLET 10'S, as it can increase side effects.
The dosage depends on your condition and as directed by your doctor. Follow the dosage prescribed by the doctor.
No, DEPSONIL DZ TABLET 10'S should not be stopped suddenly. The doctor may gradually reduce the dose to avoid withdrawal symptoms.
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and follow your regular schedule.
Consult a doctor before using DEPSONIL DZ TABLET 10'S during pregnancy.
Consult a doctor before using DEPSONIL DZ TABLET 10'S while breastfeeding.
Store it at room temperature, away from direct sunlight and moisture. Keep it out of reach of children.
In case of an overdose, contact a doctor or the nearest hospital immediately.
DEPSONIL DZ TABLET 10'S can interact with certain other medications. Inform the doctor about all your medications.
Do not replace DEPSONIL DZ TABLET 10'S with any other medication without talking to your doctor.
Depsonil 10 is a brand name that generally refers to a low‑strength formulation of imipramine, a tricyclic antidepressant. In some markets, related products such as Depsonil DZ contain a combination of imipramine with diazepam. Imipramine is primarily used to treat depressive disorders and may also help with associated anxiety symptoms. In selected cases and under specialist supervision, imipramine can be used for other indications such as nocturnal enuresis (bed‑wetting) in children. Diazepam, when present, is used for short‑term relief of severe anxiety and for its sedative and muscle‑relaxant effects. The exact indication for your Depsonil 10 depends on your doctor’s prescription and the specific formulation you have.
Imipramine, the main active ingredient in Depsonil 10, belongs to the tricyclic antidepressant class. It works by inhibiting the reuptake of neurotransmitters such as noradrenaline and serotonin in the brain, thereby increasing their availability in the synaptic cleft. This modulation of neurotransmitter levels is believed to improve mood, energy, and emotional stability over time. If your product also contains diazepam, that component enhances the effect of gamma‑aminobutyric acid (GABA), an inhibitory neurotransmitter, leading to reduced anxiety, muscle relaxation, and sedation. The full antidepressant effect of imipramine usually develops over several weeks of regular use.
Some patients may notice partial improvement in sleep, appetite, or anxiety within 1 to 2 weeks of starting imipramine. However, the full antidepressant effect typically takes 3 to 6 weeks or longer. If diazepam is part of your Depsonil formulation, its anxiolytic and sedative effects can appear within hours of taking a dose, but this does not mean the underlying depression has resolved. It is important to continue the medicine exactly as prescribed and attend follow‑up appointments so your doctor can assess response and adjust treatment if needed.
Yes. Imipramine can cause drowsiness, dizziness, blurred vision, and slowed reaction time, especially when treatment is initiated or doses are changed. If your formulation also contains diazepam, the sedative effect is stronger and may significantly impair alertness and coordination. You should not drive, operate machinery, or perform tasks that require full mental alertness until you know how Depsonil 10 affects you. If you continue to feel excessively sleepy or unsteady, inform your doctor; a dose adjustment or alternative treatment may be required.
Common side effects of imipramine include dry mouth, constipation, blurred vision, drowsiness, dizziness, increased sweating, weight gain, nausea, and difficulty passing urine. Some people may experience changes in heart rate, low blood pressure on standing (orthostatic hypotension), or sexual dysfunction. If diazepam is present, additional effects such as pronounced drowsiness, muscle weakness, impaired coordination, and confusion (particularly in older adults) may occur. Many side effects are mild and may lessen as your body adjusts, but persistent or troublesome symptoms should be discussed with your doctor.
Yes, although serious adverse effects are less common, they can occur and require urgent medical attention. These include severe allergic reactions (rash, swelling of the face or throat, difficulty breathing), chest pain, palpitations, fainting, seizures, severe constipation with abdominal pain, difficulty or inability to pass urine, sudden mood changes, agitation, or emergence of suicidal thoughts, particularly in younger patients. Imipramine can affect heart rhythm and may cause arrhythmias, especially in people with pre‑existing heart disease, electrolyte disturbances, or those taking other medicines that prolong the QT interval. Overdose of tricyclic antidepressants is dangerous and potentially life‑threatening. If you suspect overdose or severe reaction, seek emergency care immediately.
Alcohol should generally be avoided while taking Depsonil 10. Both imipramine and diazepam (if present) act on the central nervous system, and alcohol can significantly enhance their sedative effects. This combination increases the risk of excessive drowsiness, impaired judgment, slowed breathing, falls, and accidents. In some individuals, alcohol can also worsen depression and anxiety, counteracting the benefits of treatment. If you consume alcohol, discuss this with your doctor so that appropriate guidance can be provided.
Use of Depsonil 10 during pregnancy or breastfeeding requires careful, individualized assessment by a specialist. Imipramine crosses the placenta and is excreted in breast milk. Potential risks to the fetus or nursing infant must be weighed against the risks of untreated maternal depression. Diazepam, if present, also crosses the placenta and appears in breast milk; prolonged use in late pregnancy may lead to neonatal respiratory depression, hypotonia (floppiness), or withdrawal symptoms in the newborn. Breastfed infants may experience sedation or feeding difficulties. Do not start, stop, or change the dose of Depsonil 10 during pregnancy or lactation without consulting your obstetrician and psychiatrist.
Depsonil 10 should not be stopped abruptly unless your doctor specifically instructs you to do so in an emergency. Sudden discontinuation of imipramine can lead to withdrawal‑like symptoms such as nausea, headache, irritability, sleep disturbance, and a rapid return or worsening of depressive or anxiety symptoms. If diazepam is part of your regimen, abrupt cessation after prolonged use can cause significant withdrawal, including anxiety, restlessness, tremor, and, in severe cases, seizures. Your doctor will usually recommend a gradual dose reduction over weeks or longer, tailored to your clinical situation.
Depsonil 10 can interact with several medicines and medical conditions. It must not be used together with monoamine oxidase inhibitors (MAOIs) or within the recommended washout period before or after MAOIs, due to the risk of serious reactions such as hypertensive crisis or serotonin‑related toxicity. Caution is required with other antidepressants, antipsychotics, antiarrhythmics, certain antibiotics, antihistamines, and medicines that prolong the QT interval or depress the central nervous system. Imipramine may also interact with drugs that affect liver enzymes, leading to altered blood levels. Pre‑existing heart disease, seizure disorders, glaucoma, urinary retention, thyroid disease, liver or kidney impairment, and a history of substance‑use disorder can influence the safety and dosing of Depsonil 10. Always provide your doctor with a complete list of your medicines and medical history before starting treatment.
Imipramine itself is not considered habit‑forming in the way that benzodiazepines or opioids are, but stopping it suddenly can cause withdrawal‑like symptoms and relapse of depression, which may give the impression of dependence. If your Depsonil product also contains diazepam, that component can be habit‑forming, especially with prolonged use or higher doses. Diazepam carries a recognized risk of tolerance, psychological dependence, and withdrawal symptoms. For this reason, benzodiazepine‑containing combinations are usually prescribed for the shortest duration necessary, and any dose reduction or discontinuation should be supervised by a healthcare professional.
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ABBOTT HEALTH CARE PRIVATE LIMITED
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India
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