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Composition
Content Reviewed By:
Dr. Rajesh Sharma
, (MBBS)
Written By:
Ms. Priyanka Shah
, (B.Pharm)
Common side effects of Deriphyllin Injection may include nausea, vomiting, epigastric pain, headache, insomnia, dizziness, palpitations, and mild diuresis. Less common but more serious side effects can include allergic reactions (rash, itching, swelling), seizures, and cardiac arrhythmias. Rapid intravenous administration may cause flushing, hypotension, and anxiety. Rarely, it can cause liver problems or blood disorders. Consult your doctor if you experience any persistent or severe side effects.

Allergies
Contraindicated in hypersensitivityDeriphyllin injection is contraindicated in patients with known hypersensitivity to theophylline, etofylline, other xanthine derivatives, or any component of the formulation.
Deriphyllin injection is used for the short-term management of acute episodes of reversible airway obstruction, such as acute exacerbations of bronchial asthma and chronic obstructive pulmonary disease (COPD). It provides rapid bronchodilation when oral medicines or inhalers are insufficient, not tolerated, or cannot be used. It is usually administered in hospital or emergency settings under close medical supervision.
Deriphyllin injection contains etofylline and theophylline, which are xanthine derivatives. They inhibit phosphodiesterase enzymes, leading to increased levels of cyclic AMP in bronchial smooth muscle cells. This causes relaxation of the airway smooth muscles and bronchodilation, improving airflow and relieving symptoms like wheezing and breathlessness. Theophylline may also stimulate the respiratory center and have mild diuretic and cardiac stimulant effects.
No, Deriphyllin injection is not a steroid. It is a bronchodilator containing xanthine derivatives (etofylline and theophylline). While it helps open the airways, it does not have the anti-inflammatory properties of corticosteroids. In acute asthma or COPD exacerbations, it is often used in addition to inhaled or systemic corticosteroids, not as a substitute for them.
Deriphyllin injection is not intended for routine treatment of all types of cough or breathlessness. It is specifically used for reversible airway obstruction, such as in asthma or COPD exacerbations, and only when clinically indicated. Breathlessness due to heart failure, pneumonia, pulmonary embolism, or other non-obstructive causes requires different treatment. A doctor must evaluate the underlying cause before deciding whether Deriphyllin injection is appropriate.
Common side effects include nausea, vomiting, abdominal discomfort, headache, dizziness, restlessness, irritability, tremor, palpitations, and difficulty sleeping. Some patients may experience flushing or a feeling of warmth. These effects are often related to theophylline levels in the blood. If side effects are severe or persistent, or if symptoms such as severe vomiting, chest pain, rapid or irregular heartbeat, or seizures occur, urgent medical attention is required.
Deriphyllin injection should be avoided in patients with known hypersensitivity to theophylline, etofylline, or other xanthines, and in those with uncontrolled cardiac arrhythmias, severe hypotension, or active peptic ulcer disease, unless the potential benefit clearly outweighs the risk. It should be used with particular caution in elderly patients, those with liver impairment, heart failure, hyperthyroidism or hypothyroidism, fever, viral infections, seizure disorders, or a history of peptic ulcer, and in patients taking interacting medicines.
Deriphyllin injection should not be self-administered. Because theophylline has a narrow therapeutic index and can cause serious adverse effects, it must be given only by trained healthcare professionals, usually in a hospital or clinic where the patient can be monitored. Self-injection or unsupervised use can lead to overdose, severe arrhythmias, seizures, or other life-threatening complications.
Yes, Deriphyllin injection can interact with many medicines that either increase or decrease theophylline levels or enhance its side effects. Examples include certain antibiotics (such as some macrolides and fluoroquinolones), anti-epileptics, anti-arrhythmics, cimetidine, some antiviral agents, and drugs that induce or inhibit liver enzymes. Smoking, alcohol, and caffeine-containing products can also affect theophylline metabolism. Patients should inform their doctor about all prescription, over-the-counter, and herbal products they are using before receiving Deriphyllin injection.
Use of Deriphyllin injection during pregnancy or breastfeeding requires careful risk–benefit assessment by a physician. Theophylline crosses the placenta and is excreted into breast milk. In some situations, it may be used if the expected benefit to the mother outweighs potential risks to the fetus or infant, but close monitoring for maternal side effects and, where relevant, for irritability or feeding difficulties in the breastfed infant is advisable. Pregnant or breastfeeding women should not receive this medicine without explicit medical advice.
If you develop severe or unusual symptoms after receiving Deriphyllin injection, such as persistent or uncontrollable vomiting, severe headache, confusion, agitation, chest pain, very fast or irregular heartbeat, fainting, or seizures, seek emergency medical care immediately. These may indicate high theophylline levels or serious cardiovascular or neurological reactions. Do not wait for the symptoms to resolve on their own, and inform the treating team about all medicines and medical conditions you have.
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ZYDUS LIFESCIENCES LIMITED
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India

MRP
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