DERIPHYLLIN INJECTION 2 ML
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DERIPHYLLIN INJECTION 2 ML
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DERIPHYLLIN INJECTION 2 ML

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DERIPHYLLIN INJECTION 2 ML

By ZYDUS LIFESCIENCES LIMITED

MRP

10.21

₹8.68

14.99 % OFF

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Product DetailsArrow

Content Reviewed By:

Dr. Rajesh Sharma

, (MBBS)

Written By:

Ms. Priyanka Shah

, (B.Pharm)

About DERIPHYLLIN INJECTION 2 ML

  • Deriphyllin injection is a parenteral bronchodilator formulation that typically contains a fixed-dose combination of etofylline and theophylline, both belonging to the xanthine class of drugs. It is used under medical supervision for the management of acute episodes of reversible airway obstruction, such as acute exacerbations of bronchial asthma and chronic obstructive pulmonary disease (COPD), when rapid bronchodilation is required and oral therapy is not feasible or not effective. By relaxing the smooth muscles in the bronchial tree and improving airflow, Deriphyllin injection helps relieve symptoms like wheezing, chest tightness, and shortness of breath. The medicine acts mainly by inhibiting phosphodiesterase enzymes, leading to increased intracellular cyclic AMP levels and subsequent bronchodilation. It may also have mild diuretic, cardiac stimulant, and respiratory stimulant effects. Because theophylline has a narrow therapeutic index and its blood levels can be influenced by age, smoking status, liver function, concurrent illnesses, and interacting medicines, Deriphyllin injection must be used cautiously, usually in a hospital or monitored setting. Serum theophylline levels may be monitored where facilities are available, especially in patients at higher risk of toxicity. Deriphyllin injection is generally reserved for short-term use in acute situations rather than for long-term maintenance therapy. It may be used as an adjunct to inhaled bronchodilators and corticosteroids, not as a replacement for them. The decision to use this injection, the route of administration (intravenous or intramuscular), and the duration of therapy are determined by a qualified physician based on the severity of symptoms, previous response to bronchodilators, and the patient’s overall clinical status. Commonly reported adverse effects include nausea, vomiting, headache, restlessness, tremor, palpitations, and insomnia. At higher blood levels, more serious reactions such as severe vomiting, cardiac arrhythmias, seizures, and hypotension can occur. The risk of side effects is higher in elderly patients, those with liver or heart disease, and in patients receiving interacting drugs such as certain antibiotics, anti-epileptics, and anti-arrhythmics. Therefore, a detailed medical history, including current medications and comorbidities, is essential before starting therapy. Deriphyllin injection is contraindicated or used with extreme caution in patients with known hypersensitivity to xanthines, uncontrolled cardiac arrhythmias, severe hypotension, acute porphyria, or active peptic ulcer disease. Dose adjustments and close monitoring are usually required in patients with hepatic impairment, heart failure, thyroid disorders, fever, or viral infections, as these conditions can alter theophylline clearance. Smoking and certain foods or beverages containing caffeine or other xanthines may also influence drug levels and side-effect profile. Because of the potential for serious toxicity, Deriphyllin injection should never be self-administered. It must be given only by trained healthcare professionals in a setting where resuscitation facilities and monitoring equipment are available. Patients and caregivers should be educated about the purpose of treatment, possible side effects, and the importance of reporting symptoms such as persistent vomiting, severe headache, palpitations, chest pain, or seizures immediately. Deriphyllin injection is a prescription-only medicine and should be used strictly according to the treating physician’s instructions.

Uses of DERIPHYLLIN INJECTION 2 ML

  • Treatment of respiratory diseases
  • Management of asthma
  • Treatment of Chronic Obstructive Pulmonary Disease (COPD)
  • Relief from bronchospasm
  • Treatment of breathing difficulties
  • Treatment of shortness of breath
  • Treatment of wheezing
  • Treatment of chest tightness

How DERIPHYLLIN INJECTION 2 ML Works

  • DERIPHYLLIN INJECTION 2 ML is a bronchodilator and anti-inflammatory medication, primarily used to manage respiratory conditions like asthma, chronic bronchitis, and emphysema. Its effectiveness stems from the synergistic action of its two active ingredients: etofylline and theophylline.
  • Etofylline is a derivative of theophylline and functions as a bronchodilator. It works by relaxing the smooth muscles in the airways, which widens the bronchial passages. This widening, or bronchodilation, makes it easier for air to flow in and out of the lungs, relieving symptoms like wheezing, shortness of breath, and chest tightness. Etofylline achieves this bronchodilation primarily through the inhibition of phosphodiesterase (PDE) enzymes. PDE enzymes are responsible for breaking down cyclic AMP (cAMP), a crucial intracellular messenger that promotes smooth muscle relaxation. By inhibiting PDE, etofylline increases cAMP levels, leading to bronchodilation.
  • Theophylline also contributes to bronchodilation, enhancing the effects of etofylline. Additionally, theophylline possesses anti-inflammatory properties. It can suppress the release of inflammatory mediators from cells in the airways, reducing inflammation and mucus production. This dual action of bronchodilation and anti-inflammation is particularly beneficial in chronic respiratory conditions where both airway obstruction and inflammation contribute to the disease process.
  • The combined action of etofylline and theophylline in DERIPHYLLIN INJECTION 2 ML provides a comprehensive approach to managing respiratory symptoms. By relaxing airway muscles and reducing inflammation, it improves airflow, reduces breathlessness, and alleviates chest congestion. This makes breathing easier and enhances the overall quality of life for individuals with chronic respiratory diseases. The injectable form allows for rapid absorption and quicker relief of acute symptoms compared to oral medications.
  • It is important to note that DERIPHYLLIN INJECTION 2 ML should only be administered by healthcare professionals. The dosage and frequency of administration depend on individual patient factors, such as the severity of the condition, age, weight, and response to treatment. Regular monitoring may be necessary to ensure optimal therapeutic levels and minimize potential side effects.

Side Effects of DERIPHYLLIN INJECTION 2 MLArrow

Common side effects of Deriphyllin Injection may include nausea, vomiting, epigastric pain, headache, insomnia, dizziness, palpitations, and mild diuresis. Less common but more serious side effects can include allergic reactions (rash, itching, swelling), seizures, and cardiac arrhythmias. Rapid intravenous administration may cause flushing, hypotension, and anxiety. Rarely, it can cause liver problems or blood disorders. Consult your doctor if you experience any persistent or severe side effects.

Safety Advice for DERIPHYLLIN INJECTION 2 MLArrow

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Allergies

Contraindicated in hypersensitivity

Deriphyllin injection is contraindicated in patients with known hypersensitivity to theophylline, etofylline, other xanthine derivatives, or any component of the formulation.

Dosage of DERIPHYLLIN INJECTION 2 MLArrow

  • The recommended dosage of DERIPHYLLIN INJECTION 2 ML varies depending on the patient's age, weight, severity of the condition, and renal function. It is crucial to adhere strictly to the dosage prescribed by your physician. Typically, for adults, the intravenous dose ranges from 250 mg to 500 mg, administered slowly over 20-30 minutes. This may be repeated every 6 to 8 hours as needed, guided by the patient's response and clinical assessment.
  • For children, the dosage is carefully calculated based on body weight, usually ranging from 4mg to 6mg per kg of body weight, administered intravenously. Close monitoring is essential in pediatric patients to avoid potential adverse effects. Elderly patients and individuals with renal or hepatic impairment may require a reduced dosage to prevent accumulation of the drug and associated complications. The injection should be administered by a qualified healthcare professional in a controlled setting where respiratory and cardiovascular function can be closely monitored.
  • The duration of treatment with DERIPHYLLIN INJECTION 2 ML is also determined by the physician based on the patient's condition and response to therapy. It is important not to exceed the prescribed dosage or frequency of administration. Always inform your doctor about any other medications you are taking, as drug interactions can occur. In case of any adverse reactions, such as nausea, vomiting, palpitations, or seizures, seek immediate medical attention. The injection is usually diluted in normal saline or dextrose solution before administration.
  • Take 'DERIPHYLLIN INJECTION 2 ML' only as per the prescription by your physician only

What if I miss my dose of DERIPHYLLIN INJECTION 2 ML?Arrow

  • As this medication is administered by a healthcare professional, the likelihood of missing a dose is minimal. However, if you believe you have missed a scheduled dose, inform your healthcare provider immediately to determine the appropriate course of action. Do not attempt to self-administer a double dose to compensate.

How to store DERIPHYLLIN INJECTION 2 ML?Arrow

  • Keep DERIPHYLLIN INJ 2ML away from the reach of children and pets.
  • Store DERIPHYLLIN INJ 2ML at room temperature.

Benefits of DERIPHYLLIN INJECTION 2 MLArrow

  • DERIPHYLLIN INJECTION 2 ML is a bronchodilator and is primarily used to alleviate breathing difficulties associated with various respiratory conditions. It effectively widens the airways, making it easier for air to flow in and out of the lungs. This is particularly beneficial for individuals suffering from asthma, chronic bronchitis, and emphysema, where airway constriction is a major problem.
  • This injection provides rapid relief during acute asthma attacks or exacerbations of chronic obstructive pulmonary disease (COPD). Its fast-acting nature ensures that patients experiencing severe breathlessness receive timely intervention, preventing further complications and potential hospitalization. The medication works by relaxing the muscles surrounding the airways, opening them up for improved airflow.
  • DERIPHYLLIN INJECTION 2 ML helps reduce wheezing, shortness of breath, and chest tightness, which are common symptoms of respiratory distress. By improving airflow, it enables patients to breathe more comfortably and engage in daily activities with greater ease. This can significantly enhance their quality of life and overall well-being.
  • The medication contains both theophylline and etofylline, which work synergistically to provide enhanced bronchodilation. Theophylline relaxes the smooth muscles in the airways, while etofylline helps to reduce inflammation and further open the airways. This dual action makes DERIPHYLLIN INJECTION 2 ML a potent and effective treatment for respiratory conditions.
  • DERIPHYLLIN INJECTION 2 ML can be used as part of a comprehensive treatment plan for managing chronic respiratory conditions. It is often administered alongside other medications, such as inhaled corticosteroids and beta-agonists, to provide optimal control of symptoms and prevent future exacerbations. Regular use, as prescribed by a healthcare professional, can help patients maintain stable respiratory function and minimize the impact of their condition on their daily lives.
  • In cases of severe bronchospasm that are unresponsive to other treatments, DERIPHYLLIN INJECTION 2 ML can be a life-saving intervention. Its ability to quickly dilate the airways and improve oxygenation can prevent respiratory failure and other serious complications. Healthcare providers often rely on this medication to manage critical respiratory emergencies and stabilize patients in distress.
  • DERIPHYLLIN INJECTION 2 ML improves the ability to cough up mucus, helping to clear the airways of accumulated secretions. This is especially beneficial for patients with chronic bronchitis or other conditions that cause excessive mucus production. By facilitating mucus clearance, the injection reduces the risk of infection and further airway obstruction.

How to use DERIPHYLLIN INJECTION 2 MLArrow

  • DERIPHYLLIN INJECTION 2 ML is administered intravenously or intramuscularly by a healthcare professional. The dosage and frequency are determined by the patient's condition, weight, and response to the medication. The intravenous route is preferred for acute conditions requiring rapid bronchodilation.
  • For intravenous administration, DERIPHYLLIN INJECTION 2 ML is typically diluted in a compatible intravenous solution, such as normal saline or dextrose solution. The diluted solution is then infused slowly over a period of 20-30 minutes to minimize the risk of adverse effects such as hypotension or arrhythmias. The rate of infusion is carefully monitored by the healthcare provider.
  • Intramuscular injections are administered deep into a large muscle mass, such as the gluteus maximus. The injection site should be rotated with each subsequent dose to prevent local irritation or tissue damage. Patients should be advised to report any pain, redness, or swelling at the injection site.
  • Dosage adjustments may be necessary based on the patient's age, renal function, liver function, and concurrent medications. Elderly patients and those with impaired renal or liver function may require lower doses to avoid toxicity. Serum theophylline levels should be monitored periodically to ensure that the medication is within the therapeutic range. Regular monitoring helps in preventing both subtherapeutic levels and toxic concentrations.
  • Before administering DERIPHYLLIN INJECTION 2 ML, it is essential to assess the patient's medical history, including any history of heart disease, hypertension, seizures, or thyroid disorders. Patients with these conditions may be at increased risk of adverse effects. The medication should be used with caution in pregnant or breastfeeding women.
  • Patients should be educated about the potential side effects of DERIPHYLLIN INJECTION 2 ML, such as nausea, vomiting, headache, insomnia, and palpitations. They should be instructed to report any concerning symptoms to their healthcare provider promptly. It’s also important to inform them about potential interactions with other medications they may be taking, including over-the-counter drugs and herbal supplements.

Quick Tips for DERIPHYLLIN INJECTION 2 MLArrow

Food Interactions with DERIPHYLLIN INJECTION 2 MLArrow

  • While using Deriphyllin Injection 2 ML, it's generally advisable to avoid excessive consumption of caffeine-containing products like coffee, tea, and chocolate, as they may enhance the stimulant effects of the medication. Consult your doctor for personalized advice.

FAQs

What is Deriphyllin injection used for?Arrow

Deriphyllin injection is used for the short-term management of acute episodes of reversible airway obstruction, such as acute exacerbations of bronchial asthma and chronic obstructive pulmonary disease (COPD). It provides rapid bronchodilation when oral medicines or inhalers are insufficient, not tolerated, or cannot be used. It is usually administered in hospital or emergency settings under close medical supervision.

How does Deriphyllin injection work in the body?Arrow

Deriphyllin injection contains etofylline and theophylline, which are xanthine derivatives. They inhibit phosphodiesterase enzymes, leading to increased levels of cyclic AMP in bronchial smooth muscle cells. This causes relaxation of the airway smooth muscles and bronchodilation, improving airflow and relieving symptoms like wheezing and breathlessness. Theophylline may also stimulate the respiratory center and have mild diuretic and cardiac stimulant effects.

Is Deriphyllin injection a steroid?Arrow

No, Deriphyllin injection is not a steroid. It is a bronchodilator containing xanthine derivatives (etofylline and theophylline). While it helps open the airways, it does not have the anti-inflammatory properties of corticosteroids. In acute asthma or COPD exacerbations, it is often used in addition to inhaled or systemic corticosteroids, not as a substitute for them.

Can Deriphyllin injection be used for all types of cough or breathlessness?Arrow

Deriphyllin injection is not intended for routine treatment of all types of cough or breathlessness. It is specifically used for reversible airway obstruction, such as in asthma or COPD exacerbations, and only when clinically indicated. Breathlessness due to heart failure, pneumonia, pulmonary embolism, or other non-obstructive causes requires different treatment. A doctor must evaluate the underlying cause before deciding whether Deriphyllin injection is appropriate.

What are the common side effects of Deriphyllin injection?Arrow

Common side effects include nausea, vomiting, abdominal discomfort, headache, dizziness, restlessness, irritability, tremor, palpitations, and difficulty sleeping. Some patients may experience flushing or a feeling of warmth. These effects are often related to theophylline levels in the blood. If side effects are severe or persistent, or if symptoms such as severe vomiting, chest pain, rapid or irregular heartbeat, or seizures occur, urgent medical attention is required.

Who should avoid or use Deriphyllin injection with caution?Arrow

Deriphyllin injection should be avoided in patients with known hypersensitivity to theophylline, etofylline, or other xanthines, and in those with uncontrolled cardiac arrhythmias, severe hypotension, or active peptic ulcer disease, unless the potential benefit clearly outweighs the risk. It should be used with particular caution in elderly patients, those with liver impairment, heart failure, hyperthyroidism or hypothyroidism, fever, viral infections, seizure disorders, or a history of peptic ulcer, and in patients taking interacting medicines.

Can Deriphyllin injection be self-administered at home?Arrow

Deriphyllin injection should not be self-administered. Because theophylline has a narrow therapeutic index and can cause serious adverse effects, it must be given only by trained healthcare professionals, usually in a hospital or clinic where the patient can be monitored. Self-injection or unsupervised use can lead to overdose, severe arrhythmias, seizures, or other life-threatening complications.

Does Deriphyllin injection interact with other medicines?Arrow

Yes, Deriphyllin injection can interact with many medicines that either increase or decrease theophylline levels or enhance its side effects. Examples include certain antibiotics (such as some macrolides and fluoroquinolones), anti-epileptics, anti-arrhythmics, cimetidine, some antiviral agents, and drugs that induce or inhibit liver enzymes. Smoking, alcohol, and caffeine-containing products can also affect theophylline metabolism. Patients should inform their doctor about all prescription, over-the-counter, and herbal products they are using before receiving Deriphyllin injection.

Is Deriphyllin injection safe during pregnancy and breastfeeding?Arrow

Use of Deriphyllin injection during pregnancy or breastfeeding requires careful risk–benefit assessment by a physician. Theophylline crosses the placenta and is excreted into breast milk. In some situations, it may be used if the expected benefit to the mother outweighs potential risks to the fetus or infant, but close monitoring for maternal side effects and, where relevant, for irritability or feeding difficulties in the breastfed infant is advisable. Pregnant or breastfeeding women should not receive this medicine without explicit medical advice.

What should I do if I experience severe side effects after Deriphyllin injection?Arrow

If you develop severe or unusual symptoms after receiving Deriphyllin injection, such as persistent or uncontrollable vomiting, severe headache, confusion, agitation, chest pain, very fast or irregular heartbeat, fainting, or seizures, seek emergency medical care immediately. These may indicate high theophylline levels or serious cardiovascular or neurological reactions. Do not wait for the symptoms to resolve on their own, and inform the treating team about all medicines and medical conditions you have.

References

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DrugBank: Etamiphylline. Provides chemical structure, properties, pharmacology, and interactions of etamiphylline, a component of Deriphyllin.

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PubChem: Theophylline. Provides chemical information, safety data, and related scientific literature for theophylline, another component of Deriphyllin.

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PubMed Central (PMC). A free archive of biomedical and life sciences literature. Search for research articles related to etamiphylline and theophylline.

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European Medicines Agency (EMA). Search for scientific information and regulatory documents related to Deriphyllin or its components if marketed in Europe.

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FDA's Drugs@FDA. Search for information on drugs approved by the FDA, though Deriphyllin may not be approved in the US.

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ScienceDirect. A comprehensive database for scientific, technical, and medical research. Search for articles related to the pharmacology and clinical use of etamiphylline and theophylline.

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UpToDate. A clinical decision support resource that may contain information on the use of theophylline in respiratory conditions (subscription required).

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Marketer / Manufacturer Details

ZYDUS LIFESCIENCES LIMITED

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DERIPHYLLIN INJECTION 2 ML

DERIPHYLLIN INJECTION 2 ML

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