DIGIHALER SF 250 INHALER 120 MD

How DIGIHALER SF 250 INHALER 120 MD Works

• DIGIHALER SF 250 Inhaler is a combination medicine containing two active ingredients: Salmeterol and Fluticasone. These components work synergistically to alleviate the symptoms of asthma and chronic obstructive pulmonary disease (COPD).
• Salmeterol, a long-acting beta-adrenergic agonist (LABA), functions as a bronchodilator. It selectively stimulates beta-2 adrenergic receptors in the lungs, causing the smooth muscles lining the airways to relax. This relaxation widens the airways, making it easier to breathe. The effects of Salmeterol last for approximately 12 hours, providing long-term relief from bronchospasm.
• Fluticasone, a corticosteroid, acts as an anti-inflammatory agent. When inhaled, it reduces inflammation in the airways by suppressing the release of inflammatory mediators and cytokines. Fluticasone also inhibits the migration of inflammatory cells into the lungs and reduces mucus production. By reducing inflammation, Fluticasone helps to prevent asthma attacks and improve overall lung function.
• The combined action of Salmeterol and Fluticasone addresses both bronchoconstriction and inflammation, which are the two primary underlying causes of asthma and COPD symptoms. Salmeterol provides rapid relief from bronchospasm, while Fluticasone provides long-term control of inflammation. Regular use of DIGIHALER SF 250 Inhaler helps to improve lung function, reduce the frequency and severity of asthma attacks or COPD exacerbations, and improve overall quality of life.
• Specifically, after inhalation, Salmeterol binds to beta-2 receptors on airway smooth muscle. This binding activates adenylyl cyclase, which increases the production of cyclic AMP (cAMP). Increased cAMP levels lead to the relaxation of smooth muscle, resulting in bronchodilation. Simultaneously, Fluticasone enters the cells of the airway lining and binds to glucocorticoid receptors. This binding alters gene transcription, leading to decreased production of inflammatory proteins and mediators. The reduction in inflammation makes the airways less reactive to triggers and reduces swelling and mucus production.
• The DIGIHALER device ensures consistent and accurate dosing of the medication directly to the lungs. This targeted delivery maximizes the therapeutic effects of both Salmeterol and Fluticasone while minimizing systemic side effects. It is crucial to use the inhaler as prescribed by your healthcare provider to achieve optimal results. Consistent daily use is recommended, even when you feel well, to maintain control over your respiratory condition.

Like all medicines, DIGIHALER SF 250 INHALER 120 MD can cause side effects, although not everybody gets them. **Common Side Effects (May affect up to 1 in 10 people):** * Sore throat * Hoarseness * Fungal infection (thrush) in the mouth or throat. Rinse your mouth with water after each use to help prevent this. * Headache * Palpitations (fast or irregular heartbeat) * Tremor (shaking) **Uncommon Side Effects (May affect up to 1 in 100 people):** * Feeling anxious, nervous, or agitated * Disturbed sleep * Dizziness * Changes in taste * Cough * Dry mouth * Skin rash * Upset stomach or indigestion * Muscle cramps * Blurred vision * Increased sweating **Rare Side Effects (May affect up to 1 in 1,000 people):** * Wheezing or difficulty breathing (paradoxical bronchospasm). Stop using the inhaler and seek immediate medical help. * Swelling of the face, mouth, or throat (angioedema) * Irregular heartbeat (arrhythmia) * Decrease in bone density (with prolonged use) * Glaucoma * Cataracts **Very Rare Side Effects (May affect up to 1 in 10,000 people):** * Problems with adrenal gland function * Increased pressure in the eyes * Changes in blood sugar levels **Other Possible Side Effects (Frequency not known):** * Depression or feeling depressed * Aggression **Important Note:** This is not a complete list. Tell your doctor or pharmacist if you notice any other side effects.

• If you miss a dose, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

• Keep DIGIHALER SF 250 INHALER 120MD away from the reach of children and pets.
• Store DIGIHALER SF 250 INHALER 120MD at room temperature.

• **Prime the Inhaler:** Before using DIGIHALER SF 250 for the first time, or if it hasn't been used for a week or more, prime it by releasing 4 test sprays into the air away from your face. This ensures the inhaler delivers the correct dose. This is crucial for consistent medication delivery and effective symptom management.
• **Proper Inhalation Technique:** Breathe out fully, then place the mouthpiece in your mouth, creating a tight seal with your lips. As you start to inhale slowly and deeply, press down firmly on the canister to release the medication. Continue inhaling deeply to ensure the medication reaches your lungs. Hold your breath for about 10 seconds, then exhale slowly. This ensures optimal drug deposition in the airways.
• **Clean the Inhaler Regularly:** Wipe the mouthpiece with a clean, dry cloth after each use to remove any medication buildup. At least once a week, wash the mouthpiece with warm water and allow it to air dry completely before reassembling and using the inhaler. This prevents clogging and maintains hygiene.
• **Monitor Dosage and Refills:** Keep track of the number of inhalations you've used. DIGIHALER SF 250 contains 120 metered doses. When the counter approaches zero, refill your prescription promptly to avoid running out of medication. Always have a backup inhaler available, especially if you rely on it daily for asthma or COPD management.
• **Consult Your Doctor Regularly:** DIGIHALER SF 250 is typically prescribed for long-term management of respiratory conditions. Continue using it as directed by your doctor, even if you feel well. Regular check-ups are essential to monitor your condition and adjust your treatment plan if needed. Do not stop or alter the dosage without consulting your healthcare provider.

• DIGIHALER SF 250 Inhaler 120 MD is administered via inhalation, so it has minimal interaction with food. It is unlikely that food intake will affect the medication's absorption or effectiveness. You can use this inhaler regardless of when you eat.