DUOHALER INHALER

How DUOHALER INHALER Works

• DUOHALER INHALER is a combination medication meticulously crafted to manage and alleviate the symptoms of asthma and chronic obstructive pulmonary disease (COPD). It masterfully combines two active ingredients: a long-acting beta-agonist (LABA) and an inhaled corticosteroid (ICS). These components work synergistically to provide comprehensive relief and long-term control of respiratory conditions.
• The LABA component functions as a bronchodilator, directly targeting the smooth muscles lining the airways. Upon inhalation, it selectively binds to beta-2 adrenergic receptors present on these muscles. This interaction triggers a cascade of intracellular events, ultimately leading to the relaxation of the airway muscles. As the muscles relax, the airways widen, allowing for easier airflow in and out of the lungs. This bronchodilation effect helps to relieve symptoms such as wheezing, shortness of breath, and chest tightness, making breathing significantly more comfortable.
• The ICS component, on the other hand, functions as a potent anti-inflammatory agent. It works by suppressing the inflammatory response within the airways. In asthma and COPD, chronic inflammation plays a crucial role in narrowing the airways and exacerbating symptoms. The ICS reduces the production and release of inflammatory mediators, such as cytokines and chemokines, thereby diminishing airway inflammation. This reduction in inflammation helps to prevent future asthma attacks and COPD flare-ups, improving overall lung function over time.
• When DUOHALER INHALER is inhaled, the medication is delivered directly to the lungs, where it can exert its therapeutic effects. The LABA provides long-lasting bronchodilation, offering relief from symptoms for up to 12 hours. Meanwhile, the ICS works gradually to reduce inflammation and prevent future exacerbations. Regular and consistent use of DUOHALER INHALER, as prescribed by a healthcare professional, helps to maintain open airways, reduce inflammation, and control asthma or COPD symptoms effectively. It is important to use DUOHALER INHALER exactly as directed and to follow the healthcare provider's instructions regarding dosage and frequency of use for optimal management of the respiratory condition.
• In summary, DUOHALER INHALER works through the combined actions of a LABA and an ICS. The LABA relaxes airway muscles, opening up the airways for easier breathing, while the ICS reduces inflammation in the airways, preventing future exacerbations. This dual mechanism of action provides comprehensive relief and long-term control of asthma and COPD symptoms, allowing individuals to lead more active and fulfilling lives.

Like all medicines, DUOHALER INHALER can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Headache * Tremor * Palpitations (awareness of your heart beating faster or irregularly) * Cough * Sore throat * Hoarseness * Oral thrush (a fungal infection in the mouth) **Uncommon side effects (may affect up to 1 in 100 people):** * Muscle cramps * Nervousness * Restlessness * Sleep disturbances * Dizziness * Changes in taste * Nausea * Increased sweating * Skin rash * Itching * Urticaria (hives) * Increased heart rate * High blood pressure * Paradoxical bronchospasm (wheezing or difficulty breathing immediately after using the inhaler). **Rare side effects (may affect up to 1 in 1,000 people):** * Angina (chest pain) * Irregular heartbeat * Allergic reactions, including swelling of the face, lips, tongue, or throat. * Hypokalaemia (low potassium levels in the blood) **Very rare side effects (may affect up to 1 in 10,000 people):** * Hyperglycemia (high blood sugar levels) * Glaucoma (increased pressure in the eye) * Changes in bone density * Cataracts **Other possible side effects:** * Aggression * Depression * Anxiety * Changes in behavior, especially in children * Difficulty sleeping If you experience any of these side effects, or any other unusual symptoms, talk to your doctor or pharmacist.

• If you miss a dose of Duohaler Inhaler, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep DUOHALER INHALER away from the reach of children and pets.
• Store DUOHALER INHALER at room temperature.

• **Understand Your Inhaler:** Before using DUOHALER INHALER, carefully read the patient information leaflet. Understanding how to properly assemble, prime, and use the inhaler ensures you receive the correct dose of medication.
• **Prime Before First Use & After Long Storage:** If you're using a new DUOHALER INHALER or if it hasn't been used for more than a week, prime it by releasing a few test sprays into the air away from your face. This ensures the inhaler is working correctly and delivers an accurate dose. Typically 2-4 sprays are required.
• **Proper Inhalation Technique is Key:** To maximize the effectiveness of DUOHALER INHALER, use proper inhalation technique. Exhale completely, then place the mouthpiece in your mouth, creating a tight seal with your lips. As you begin to inhale slowly and deeply, press down on the canister to release the medication. Continue inhaling for as long as you can and hold your breath for about 10 seconds, then exhale slowly. This allows the medication to reach deep into your lungs.
• **Keep it Clean and Dry:** Clean your DUOHALER INHALER regularly to prevent clogging and ensure proper function. Remove the canister and wash the plastic mouthpiece with warm water and mild soap. Rinse thoroughly and allow it to air dry completely before reassembling. Avoid getting the metal canister wet.
• **Monitor Dosage & Refills:** Keep track of the number of doses you've used and refill your prescription before you run out. Many DUOHALER INHALERs have a dose counter. Consult your doctor or pharmacist to understand when you need a refill and never stop taking your medication without consulting your healthcare provider, even if you feel better.
• **Consult Healthcare provider:** DUOHALER INHALER is a prescription medicine and should only be used with guidance from a healthcare professional. Discuss with your doctor all other medications you are taking or other health concerns.

• DUOHALER INHALER is not known to interact with any specific food items. You can use the inhaler regardless of when you eat. However, it's always a good idea to maintain a balanced diet while using any medication.