DUPHIL M TABLET 10'S

How DUPHIL M TABLET 10'S Works

• DUPHIL M TABLET 10'S is a combination medication containing two active ingredients: Metformin and Vildagliptin. These components work synergistically to improve glycemic control in individuals with type 2 diabetes mellitus. Understanding how each ingredient functions individually and together is crucial to appreciating the therapeutic effect of DUPHIL M.
• Metformin, a biguanide, is the cornerstone of treatment for type 2 diabetes. It primarily works by reducing hepatic glucose production. The liver is a significant source of glucose in the body, especially during fasting states. Metformin inhibits gluconeogenesis, the process by which the liver generates glucose from non-carbohydrate sources like amino acids and glycerol. By suppressing this process, metformin effectively lowers the amount of glucose released into the bloodstream.
• In addition to its effects on hepatic glucose production, metformin also enhances insulin sensitivity in peripheral tissues, such as muscle and fat. Insulin is a hormone that facilitates the uptake of glucose from the blood into cells for energy utilization. In type 2 diabetes, cells often become resistant to insulin's effects, leading to elevated blood glucose levels. Metformin helps overcome this resistance, allowing cells to respond more effectively to insulin and absorb more glucose.
• Furthermore, metformin slows down the absorption of glucose from the intestines after a meal. This action helps to prevent sharp spikes in blood sugar levels following food intake, contributing to better postprandial glycemic control. Metformin's multifaceted approach – reducing hepatic glucose output, improving insulin sensitivity, and slowing intestinal glucose absorption – makes it a highly effective agent in managing blood sugar.
• Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, operates through a different mechanism. DPP-4 is an enzyme that breaks down incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These incretin hormones play a vital role in regulating blood glucose levels by stimulating insulin release from the pancreas and suppressing glucagon secretion.
• By inhibiting DPP-4, vildagliptin increases the levels of active incretin hormones in the body. This, in turn, leads to enhanced insulin secretion in response to meals and reduced glucagon secretion. The increased insulin helps cells take up more glucose from the blood, while the reduced glucagon prevents the liver from releasing excessive amounts of glucose. The net effect is a decrease in both fasting and postprandial blood glucose levels.
• The combination of metformin and vildagliptin in DUPHIL M provides a dual-pronged approach to glycemic control. Metformin addresses insulin resistance and excess glucose production, while vildagliptin enhances incretin activity and improves insulin secretion. This synergistic action often results in better blood sugar management compared to using either medication alone. This helps to achieve target HbA1c levels which reflects average blood sugar levels over the past 2-3 months, crucial for preventing long-term complications of diabetes.
• DUPHIL M is typically taken with meals to minimize gastrointestinal side effects associated with metformin. Common side effects may include nausea, diarrhea, and abdominal discomfort, but these are usually mild and transient. It is important to take DUPHIL M as prescribed by your doctor and to monitor blood glucose levels regularly to ensure optimal glycemic control and minimize the risk of complications.
• In summary, DUPHIL M TABLET 10'S works by combining the actions of metformin and vildagliptin to reduce hepatic glucose production, enhance insulin sensitivity, slow intestinal glucose absorption, and increase incretin hormone activity, ultimately leading to improved blood sugar control in individuals with type 2 diabetes.

Common side effects of Duphil M Tablet may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, drowsiness, fatigue, weakness, and skin rash. Less common side effects can include constipation, dry mouth, heartburn, indigestion, anxiety, confusion, depression, insomnia, nervousness, tremor, blurred vision, ringing in the ears (tinnitus), changes in taste, increased sweating, and hair loss. Rare but serious side effects may include liver problems (such as jaundice or hepatitis), blood disorders (such as anemia or low white blood cell count), severe allergic reactions (such as angioedema or anaphylaxis), and Stevens-Johnson syndrome. Consult your doctor immediately if you experience any severe or persistent side effects.

• If you miss a dose of Duphil M Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep DUPHIL M TAB 1X10 away from the reach of children and pets.
• Store DUPHIL M TAB 1X10 at room temperature.

• Take DUPHIL M TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. Consistency is key for optimal results in managing your condition.
• DUPHIL M TABLET 10'S is typically taken with or without food. However, taking it at the same time each day can help you remember to take it and maintain a steady level of medication in your system, which is important for its effectiveness.
• Be aware of potential side effects. Common side effects may include nausea, diarrhea, or stomach upset. If these side effects persist or worsen, inform your doctor promptly. Report any unusual or severe symptoms immediately.
• If you miss a dose of DUPHIL M TABLET 10'S, take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
• Inform your doctor about all other medications, supplements, and herbal remedies you are currently taking. DUPHIL M TABLET 10'S can interact with certain substances, potentially reducing its effectiveness or increasing the risk of side effects. A complete medication list helps your doctor ensure your safety.
• Store DUPHIL M TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. Proper storage helps maintain the medication's efficacy.
• Avoid alcohol consumption while taking DUPHIL M TABLET 10'S, as it can exacerbate potential side effects or interfere with the medication's effectiveness. Discuss any concerns about alcohol use with your doctor.
• If you have any pre-existing medical conditions, especially kidney or liver problems, inform your doctor before starting DUPHIL M TABLET 10'S. Dosage adjustments may be necessary based on your medical history.
• Attend all scheduled follow-up appointments with your doctor. Regular monitoring allows your doctor to assess your progress, adjust your treatment plan if needed, and address any concerns you may have.

• DUPHIL M TABLET 10'S is generally safe to take with food. However, it's best to follow your doctor's instructions regarding the timing of your dose in relation to meals. If you experience any stomach upset, taking it with food might help. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of side effects.