EPOFER 10000 INJECTION
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EPOFER 10000 INJECTION
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EPOFER 10000 INJECTION

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EPOFER 10000 INJECTION

By EMCURE PHARMACEUTICALS LIMITED

MRP

2144.22

₹2144.22

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About EPOFER 10000 INJECTION

  • EPOFER 10000 INJECTION is a vital medication primarily used to treat anemia, a condition characterized by a deficiency of red blood cells in the body. It contains erythropoietin, a glycoprotein that stimulates the bone marrow to produce more red blood cells. This is particularly beneficial for individuals with chronic kidney disease, cancer patients undergoing chemotherapy, and those with HIV taking zidovudine, all conditions that can significantly impair red blood cell production.
  • The active ingredient, erythropoietin, works by mimicking the natural erythropoietin hormone produced by the kidneys. When the kidneys are damaged or not functioning properly, as in chronic kidney disease, they may not produce enough of this hormone. EPOFER 10000 INJECTION steps in to fill this void, prompting the bone marrow to ramp up red blood cell production, thereby increasing hemoglobin levels and alleviating the symptoms of anemia such as fatigue, weakness, and shortness of breath.
  • EPOFER 10000 INJECTION is administered via subcutaneous (under the skin) or intravenous (into a vein) injection. The dosage and frequency of administration are determined by a healthcare professional based on individual patient factors such as the severity of anemia, kidney function, and other medical conditions. Regular monitoring of hemoglobin levels is crucial to ensure the medication is effective and to adjust the dosage as needed. While EPOFER 10000 INJECTION is generally safe, potential side effects can include high blood pressure, headache, joint pain, and in rare cases, blood clots. It is essential to consult with a doctor or healthcare provider to determine if EPOFER 10000 INJECTION is right for you and to discuss any potential risks and benefits.

Uses of EPOFER 10000 INJECTION

  • Treatment of anemia associated with chronic kidney disease
  • Treatment of anemia caused by chemotherapy
  • To reduce the need for red blood cell transfusion during or after surgery
  • Treatment of anemia in HIV-infected patients
  • Treatment of anemia in patients with certain types of cancers

How EPOFER 10000 INJECTION Works

  • EPOFER 10000 INJECTION is a medication primarily used to treat anemia, a condition characterized by a lower-than-normal number of red blood cells in the body. The active ingredient in EPOFER 10000 INJECTION is epoetin alfa, a synthetic form of erythropoietin. Erythropoietin is a naturally occurring hormone produced by the kidneys that plays a crucial role in stimulating the production of red blood cells in the bone marrow. When the kidneys are damaged or not functioning correctly, as in chronic kidney disease, they may not produce enough erythropoietin, leading to anemia.
  • EPOFER 10000 INJECTION works by mimicking the action of natural erythropoietin. Once injected, epoetin alfa travels through the bloodstream to the bone marrow, where it binds to erythropoietin receptors on the surface of red blood cell precursors (progenitor cells). This binding triggers a cascade of intracellular signaling pathways that promote the proliferation and differentiation of these progenitor cells into mature red blood cells (erythrocytes).
  • The stimulation of erythropoiesis (red blood cell production) by EPOFER 10000 INJECTION leads to an increase in the number of circulating red blood cells. This, in turn, increases the oxygen-carrying capacity of the blood, alleviating the symptoms of anemia, such as fatigue, weakness, and shortness of breath. The increased red blood cell count also helps to improve tissue oxygenation, which is essential for overall health and well-being.
  • EPOFER 10000 INJECTION helps in maturation of the reticulocytes to red blood cells. Reticulocytes are immature red blood cells that are released from the bone marrow into the bloodstream. Epoetin alfa promotes the maturation of reticulocytes into fully functional red blood cells, further contributing to the overall increase in red blood cell count and oxygen-carrying capacity.
  • It is important to note that EPOFER 10000 INJECTION is not a cure for the underlying condition causing anemia. Instead, it helps to manage the symptoms of anemia and improve the patient's quality of life. Regular monitoring of hemoglobin levels and other blood parameters is necessary to ensure that the dosage of EPOFER 10000 INJECTION is appropriately adjusted to maintain optimal red blood cell levels and minimize the risk of potential side effects.
  • In summary, EPOFER 10000 INJECTION works by supplementing the body's natural erythropoietin, stimulating red blood cell production in the bone marrow, and increasing the oxygen-carrying capacity of the blood, thereby alleviating the symptoms of anemia.

Side Effects of EPOFER 10000 INJECTIONArrow

Possible side effects of EPOFER 10000 INJECTION include: * **Common:** Fever, chills, headache, bone pain, muscle aches, joint pain, nausea, vomiting, diarrhea, cough, skin rash, injection site reactions (pain, redness, swelling), high blood pressure. * **Less Common:** Blood clots (especially in dialysis patients), seizures, allergic reactions (hives, itching, difficulty breathing, swelling of the face/tongue/throat), pure red cell aplasia (PRCA - a severe form of anemia), increased risk of tumor progression (in some cancer patients), stroke, heart attack, fluid retention (edema). * **Rare:** Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), kidney problems worsening. This is not a complete list. Tell your doctor about any side effect you experience while taking EPOFER 10000 INJECTION.

Safety Advice for EPOFER 10000 INJECTIONArrow

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Allergies

Allergies

Do not use this medicine if you are allergic to it.

Dosage of EPOFER 10000 INJECTIONArrow

  • The dosage of EPOFER 10000 INJECTION varies significantly depending on the specific condition being treated, the severity of anemia, the patient's overall health, and their response to the medication. It is crucial to adhere strictly to your physician's prescribed dosage and schedule. Self-adjusting the dosage can lead to ineffective treatment or potentially serious side effects.
  • For patients with chronic kidney disease (CKD) related anemia, the initial recommended dose is typically 50 to 100 Units/kg administered intravenously or subcutaneously three times per week. Your doctor will monitor your hemoglobin levels regularly and adjust the dosage accordingly to achieve and maintain a target hemoglobin level. The goal is to avoid exceeding a hemoglobin level of 11 g/dL to minimize the risk of cardiovascular events.
  • In patients undergoing chemotherapy, the dosage is also individualized. A common starting dose is 150 Units/kg administered subcutaneously three times per week, or 40,000 Units subcutaneously once weekly. Dosage adjustments are made based on hemoglobin levels and individual response. Therapy should be continued until one month following the end of chemotherapy.
  • For patients undergoing elective, noncardiac, nonvascular surgery, the recommended dose is 300 Units/kg per day subcutaneously for 10 days before surgery, on the day of surgery, and for 4 days after surgery. Alternatively, a dose of 600 Units/kg subcutaneously once weekly for 3 weeks prior to surgery and on the day of surgery may be administered.
  • It is essential to have regular blood tests to monitor your hemoglobin levels, iron levels, and other relevant parameters while on EPOFER 10000 INJECTION therapy. Iron supplementation may be necessary to ensure optimal response to the medication. Never share your medication with others, even if they have similar symptoms.
  • Take 'EPOFER 10000 INJECTION' only as per the prescription by your physician only

What if I miss my dose of EPOFER 10000 INJECTION?Arrow

  • If you miss a dose of EPOFER 10000 INJECTION, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. Contact your doctor if you are unsure about what to do.

How to store EPOFER 10000 INJECTION?Arrow

  • Keep EPOFER 10000IU INJ 1ML away from the reach of children and pets.
  • Store EPOFER 10000IU INJ 1ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of EPOFER 10000 INJECTIONArrow

  • EPOFER 10000 INJECTION is a synthetic form of erythropoietin, a hormone naturally produced by the kidneys. Its primary function is to stimulate the bone marrow to produce more red blood cells. This makes it invaluable in treating various conditions characterized by anemia, or a deficiency of red blood cells. One of the most common applications of EPOFER 10000 INJECTION is in patients with chronic kidney disease (CKD). As kidney function declines, the production of erythropoietin decreases, leading to anemia. EPOFER effectively addresses this by supplementing the body's natural hormone, thus boosting red blood cell production and alleviating symptoms like fatigue, weakness, and shortness of breath. This improvement in red blood cell count translates to enhanced energy levels and an overall better quality of life for CKD patients.
  • Another significant benefit of EPOFER 10000 INJECTION is its use in patients undergoing chemotherapy. Chemotherapy drugs often damage the bone marrow, suppressing red blood cell production and causing anemia. EPOFER helps counteract this effect by stimulating the bone marrow to produce red blood cells despite the suppressive effects of chemotherapy. This reduces the need for blood transfusions, which can carry risks of complications and infections. By maintaining adequate red blood cell levels, EPOFER allows patients to better tolerate chemotherapy and maintain their treatment schedules, leading to potentially better outcomes.
  • EPOFER 10000 INJECTION is also used in patients scheduled for major surgery. Pre-operative treatment with EPOFER can increase red blood cell levels, reducing the likelihood of needing a blood transfusion during or after the surgery. Avoiding transfusions minimizes the risk of transfusion-related complications and can shorten recovery times. Furthermore, EPOFER can be beneficial in treating anemia caused by other conditions such as certain medications or autoimmune disorders. Its ability to stimulate red blood cell production makes it a versatile tool in managing various types of anemia.
  • Beyond its direct effect on red blood cell production, EPOFER 10000 INJECTION can also improve cardiovascular function. By increasing the oxygen-carrying capacity of the blood, it reduces the strain on the heart and improves overall circulation. This can be particularly beneficial for patients with pre-existing heart conditions. The use of EPOFER is carefully monitored by healthcare professionals to ensure optimal dosage and minimize potential side effects. Regular blood tests are conducted to track red blood cell levels and adjust the dosage as needed. While EPOFER is generally safe and effective, it is essential to discuss any potential risks and benefits with a doctor before starting treatment. In summary, EPOFER 10000 INJECTION offers a wide range of benefits for patients with anemia due to various causes, improving their energy levels, quality of life, and overall health.

How to use EPOFER 10000 INJECTIONArrow

  • EPOFER 10000 Injection should be administered under the guidance of a healthcare professional. It is typically injected subcutaneously (under the skin) or intravenously (into a vein). The specific route, dosage, and frequency will be determined by your doctor based on your medical condition, kidney function, hemoglobin levels, and other factors. Never self-administer EPOFER 10000 Injection without proper training and instruction from a healthcare provider.
  • Before using EPOFER 10000 Injection, visually inspect the solution for particulate matter and discoloration. Do not use if the solution is cloudy, discolored, or contains particles. Use a new needle and syringe for each injection. Follow strict aseptic techniques to prevent contamination. Clean the injection site with an antiseptic swab before administering the injection.
  • If administering subcutaneously, choose an injection site on the abdomen, thigh, or upper arm. Rotate injection sites to avoid lipodystrophy (localized changes in fat tissue). Pinch up the skin and inject the needle at a 45- to 90-degree angle. Inject the medication slowly and steadily. Do not rub the injection site after injecting.
  • If administering intravenously, the injection should be given slowly over one to five minutes, according to your doctor's instructions. EPOFER 10000 Injection should not be mixed with other medications in the same syringe or infusion.
  • During EPOFER 10000 Injection therapy, your doctor will regularly monitor your hemoglobin levels, blood pressure, and other blood parameters. It is important to attend all scheduled appointments and undergo the necessary blood tests. Dosage adjustments may be necessary based on your response to treatment. Iron supplementation may also be required to support red blood cell production. Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements, as they may interact with EPOFER 10000 Injection.
  • Proper storage of EPOFER 10000 Injection is crucial. Store it in the refrigerator between 2°C and 8°C (36°F and 46°F). Protect it from light. Do not freeze. Keep out of reach of children. Dispose of used needles and syringes safely in a sharps container. Do not reuse needles or syringes.

Quick Tips for EPOFER 10000 INJECTIONArrow

  • **Understanding EPOFER 10000 INJECTION:** EPOFER 10000 INJECTION is a medication containing erythropoietin, a protein that stimulates red blood cell production. It's primarily used to treat anemia, a condition where the body doesn't have enough red blood cells, often caused by chronic kidney disease, chemotherapy, or certain medications. Always consult your doctor to understand if EPOFER is right for you and to determine the appropriate dosage based on your specific condition and medical history.
  • **Administration Matters:** EPOFER 10000 INJECTION is administered via subcutaneous (under the skin) or intravenous (into a vein) injection. Your healthcare provider will determine the best route for you. It's crucial to follow their instructions carefully regarding injection technique, frequency, and dosage. If you're administering the injection at home, ensure you've received proper training and understand the correct procedures for handling and disposing of needles and syringes safely. Rotate injection sites to prevent skin irritation.
  • **Monitoring and Regular Check-ups:** While using EPOFER, regular blood tests are essential to monitor your red blood cell count, hemoglobin levels, and iron levels. These tests help your doctor adjust your dosage to achieve optimal results and minimize potential side effects. It’s important to attend all scheduled appointments and promptly report any unusual symptoms or concerns to your healthcare provider. Iron supplementation might be necessary to ensure EPOFER is effective.
  • **Potential Side Effects and Precautions:** Like all medications, EPOFER can cause side effects. Common side effects include high blood pressure, headache, muscle aches, and injection site reactions. More serious side effects, although less common, can include blood clots, stroke, and allergic reactions. Be vigilant for symptoms such as chest pain, shortness of breath, sudden numbness or weakness, swelling, or signs of an allergic reaction (rash, itching, swelling). Immediately seek medical attention if you experience any of these symptoms. Discuss any pre-existing conditions, allergies, and all medications you're taking with your doctor before starting EPOFER.
  • **Lifestyle Considerations and Optimizing Treatment:** While EPOFER addresses the underlying issue of red blood cell production, adopting a healthy lifestyle can further support your treatment. This includes maintaining a balanced diet rich in iron-rich foods (such as leafy green vegetables, red meat, and fortified cereals), getting regular moderate exercise (as tolerated), and avoiding smoking. Staying hydrated is also important. Discuss any lifestyle modifications with your doctor to ensure they complement your EPOFER treatment plan. Store EPOFER according to the instructions provided, typically in the refrigerator, and protect it from light.

Food Interactions with EPOFER 10000 INJECTIONArrow

  • EPOFER 10000 INJECTION does not typically have direct interactions with food. It can be administered without regard to meals. However, maintaining a balanced diet rich in iron and other essential nutrients is important for overall health and to support the effectiveness of EPOFER 10000 INJECTION in stimulating red blood cell production. Consult your doctor for specific dietary recommendations.

FAQs

What is EPOFER 10000 Injection and what is it used for?

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EPOFER 10000 Injection is an erythropoiesis-stimulating agent (ESA) used to treat anemia (low red blood cell count) caused by kidney disease, chemotherapy, or certain other medical conditions. It works by stimulating the bone marrow to produce more red blood cells.

How is EPOFER 10000 Injection administered?

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EPOFER 10000 Injection is usually administered by a healthcare professional as an intravenous (into a vein) or subcutaneous (under the skin) injection. The dosage and frequency will depend on your medical condition and response to treatment.

What are the common side effects of EPOFER 10000 Injection?

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Common side effects of EPOFER 10000 Injection may include joint pain, muscle pain, fever, dizziness, nausea, and injection site reactions. Inform your doctor if any of these side effects persist or worsen.

How should EPOFER 10000 Injection be stored?

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Store EPOFER 10000 Injection in the refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze it. Keep it in the original carton to protect from light.

Is EPOFER 10000 Injection safe for pregnant or breastfeeding women?

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There is limited information available on the use of EPOFER 10000 Injection during pregnancy or breastfeeding. Consult your doctor to determine if it is safe for you.

Can EPOFER 10000 Injection interact with other medications?

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EPOFER 10000 Injection can interact with certain medications, such as immunosuppressants and blood thinners. Tell your doctor about all the medications you are taking, including over-the-counter drugs and herbal supplements.

What are the symptoms of an EPOFER 10000 Injection overdose?

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Symptoms of an EPOFER 10000 Injection overdose may include severe high blood pressure, headache, and seizures. Seek immediate medical attention if you suspect you have overdosed.

What precautions should be followed during treatment with EPOFER 10000 Injection?

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During treatment with EPOFER 10000 Injection, monitor your blood pressure regularly, drink plenty of fluids, and inform your doctor about any new or worsening symptoms.

What are the alternatives to EPOFER 10000 Injection?

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Alternatives to EPOFER 10000 Injection may include other erythropoiesis-stimulating agents (ESAs), blood transfusions, and treating the underlying condition that is causing the anemia. Discuss the best treatment option for you with your doctor.

Can EPOFER 10000 Injection be used to enhance athletic performance?

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EPOFER 10000 Injection should not be used to enhance athletic performance. It is only used for treating anemia for medical reasons. Using it to enhance athletic performance can be dangerous and is considered doping.

What is the difference between EPOFER and Erythropoietin?

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EPOFER is a brand name for Erythropoietin. Erythropoietin is a hormone that stimulates the production of red blood cells.

Does EPOFER 10000 Injection cause hair loss?

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Hair loss is not a common side effect of EPOFER 10000 Injection, though it is possible in some cases. Consult your doctor if you experience this side effect.

Is there a specific diet to follow before taking EPOFER 10000 Injection?

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There is generally no specific diet to follow before taking EPOFER 10000 Injection. However, it is important to maintain a healthy diet and ensure adequate iron intake.

Is it safe to drive after taking EPOFER 10000 Injection?

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EPOFER 10000 Injection can cause dizziness or fatigue in some individuals. If you experience these side effects, it may not be safe to drive or operate machinery.

How long does it take to see results from EPOFER 10000 Injection?

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It may take several weeks to see results from EPOFER 10000 Injection. It typically takes 2 to 6 weeks to see an improvement in red blood cell count.

References

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EPO tablets (epoetin alfa) product label from FDA. (Dosage and Administration)

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Epoetin alfa hexal, assessment report, European Medicines Agency (EMA)

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Epoetin Alfa DrugBank Online. Contains chemical structure, uses, and pharmacology

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The past, present and future of erythropoiesis-stimulating agents (ESA): A review. Expert Opinion on Drug Safety.

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Epoetin Alfa British National Formulary. Contains indications, dose, contra-indications, side effects, precautions, and interactions

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Erythropoietin. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases.

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