FLUGESIC P TABLET 10'S

How FLUGESIC P TABLET 10'S Works

• FLUGESIC P TABLET 10'S is a combination medicine designed to alleviate pain and reduce fever. It contains two active ingredients: Flupirtine and Paracetamol. Understanding how each component works is crucial to appreciating the overall mechanism of action of this medication.
• Flupirtine is a centrally acting non-opioid analgesic. It primarily functions as a selective neuronal potassium channel opener. This means it helps to stabilize the resting membrane potential of neurons, making them less excitable. By opening these potassium channels, flupirtine promotes the efflux of potassium ions from the nerve cells. This hyperpolarization reduces the ability of nerve cells to transmit pain signals to the brain. It essentially interferes with the neuronal pathways responsible for pain perception. Furthermore, flupirtine also exhibits some NMDA receptor antagonism. NMDA receptors are involved in the amplification of pain signals, especially in chronic pain conditions. By blocking these receptors to some extent, flupirtine can further reduce the intensity of pain. Flupirtine also has muscle relaxant properties, which can be beneficial in relieving muscle spasms that often accompany pain.
• Paracetamol, also known as Acetaminophen, is a widely used analgesic and antipyretic (fever reducer). Its mechanism of action is complex and not fully understood, but it's believed to primarily work by inhibiting prostaglandin synthesis in the brain. Prostaglandins are substances that contribute to pain and inflammation. Paracetamol inhibits the cyclooxygenase (COX) enzymes, which are necessary for the production of prostaglandins. By reducing prostaglandin levels in the central nervous system, paracetamol helps to alleviate pain and reduce fever. Unlike NSAIDs (non-steroidal anti-inflammatory drugs), paracetamol has minimal anti-inflammatory effects in peripheral tissues. This is because it is readily inactivated in peripheral tissues.
• In summary, FLUGESIC P TABLET 10'S works through the combined actions of flupirtine and paracetamol. Flupirtine acts centrally to reduce the excitability of nerve cells and interfere with pain signal transmission, while paracetamol inhibits prostaglandin synthesis in the brain to alleviate pain and reduce fever. The synergistic effect of these two ingredients provides effective relief from various types of pain, including headaches, muscle aches, and fever-related discomfort. Always use this medication as directed by your healthcare provider.

Like all medicines, FLUGESIC P TABLET 10'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Nausea * Vomiting * Heartburn * Diarrhea * Constipation * Stomach pain * Drowsiness * Dizziness * Headache * Dry mouth **Uncommon Side Effects (may affect up to 1 in 100 people):** * Skin rash * Itching * Hives * Anxiety * Nervousness * Difficulty sleeping * Ringing in the ears (tinnitus) * Blurred vision **Rare Side Effects (may affect up to 1 in 1,000 people):** * Serious allergic reactions (anaphylaxis) with symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, and/or loss of consciousness. * Liver problems, including jaundice (yellowing of the skin or eyes) * Kidney problems * Blood disorders, such as a decrease in white blood cells (leukopenia) or platelets (thrombocytopenia), which can increase the risk of infection or bleeding. * Severe skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Hallucinations * Confusion **If you experience any of the following serious side effects, stop taking FLUGESIC P TABLET 10'S and seek medical attention immediately:** * Signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing. * Signs of liver problems, such as yellowing of the skin or eyes, dark urine, or abdominal pain. * Signs of kidney problems, such as decreased urination, swelling in the ankles or feet, or fatigue. * Unexplained bleeding or bruising. * Severe skin rash with blistering. This is not a complete list of side effects. If you experience any other unusual symptoms, talk to your doctor or pharmacist.

• If you miss a dose of Flugesic P Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep FLUGESIC P TAB 1X10 away from the reach of children and pets.
• Store FLUGESIC P TAB 1X10 at room temperature.

• **Take Flugesic P Tablet as Directed:** Always follow your doctor's prescribed dosage and schedule. Don't exceed the recommended dose, even if your pain or fever persists. Overuse can lead to serious side effects.
• **Manage Fever and Pain Effectively:** Flugesic P Tablet is formulated to alleviate fever and various types of pain, including headaches, muscle aches, and toothaches. It provides relief, allowing you to function more comfortably.
• **Be Aware of Potential Side Effects:** While generally safe, Flugesic P Tablet can cause side effects such as nausea, vomiting, or stomach upset in some individuals. If these effects persist or worsen, consult your doctor promptly. Discontinue use if you experience allergic reactions like skin rash or itching.
• **Avoid Alcohol Consumption:** It is advisable to avoid alcohol while taking Flugesic P Tablet, as alcohol can exacerbate potential side effects, especially liver-related issues. Combining them can increase the risk of liver damage and other complications.
• **Consult Your Doctor Before Combining with Other Medications:** Inform your doctor about all the medications you are currently taking, including over-the-counter drugs and herbal supplements, before starting Flugesic P Tablet. This helps prevent potential drug interactions that could reduce effectiveness or increase the risk of adverse effects.
• **Store Flugesic P Tablet Properly:** Keep Flugesic P Tablet in a cool, dry place away from direct sunlight and moisture. Ensure it is out of reach of children and pets. Proper storage helps maintain the drug's effectiveness and prevents accidental ingestion.
• **Stay Hydrated:** Drink plenty of water while taking Flugesic P Tablet. Staying hydrated helps your body process the medication effectively and minimizes the risk of certain side effects, such as kidney problems.

• FLUGESIC P TABLET 10'S can be taken with or without food. However, if you experience stomach upset, it's best to take it with food or milk. Avoid taking it on an empty stomach for prolonged periods.