FOSAVANCE 70MG/5600IU TABLET 4'S

How FOSAVANCE 70MG/5600IU TABLET 4'S Works

• FOSAVANCE 70MG/5600IU TABLET 4'S is a combination medication specifically designed to treat osteoporosis in individuals who are at risk of vitamin D deficiency. It contains two active ingredients: alendronate and cholecalciferol (vitamin D3). These components work synergistically to enhance bone density and reduce the risk of fractures.
• Alendronate, a bisphosphonate, is the primary agent responsible for preventing bone loss. It functions by inhibiting the activity of osteoclasts, which are cells that break down bone tissue. Osteoclasts normally resorb old or damaged bone, but in osteoporosis, their activity is excessive, leading to weakened and brittle bones. Alendronate selectively binds to bone surfaces, particularly in areas of active resorption. When osteoclasts attempt to break down the bone to which alendronate is attached, they are effectively poisoned, leading to their inactivation. This reduces the rate of bone resorption, allowing bone formation to catch up and ultimately increasing bone mineral density.
• Cholecalciferol (vitamin D3) plays a crucial role in calcium absorption from the gut and in maintaining adequate serum calcium levels. Calcium is a fundamental building block of bone, and sufficient calcium intake and absorption are essential for strong and healthy bones. Vitamin D3 is converted in the body to its active form, calcitriol, which regulates calcium absorption in the small intestine. It also affects bone remodeling by influencing the activity of osteoblasts (cells that build new bone) and osteoclasts. In individuals with vitamin D deficiency, calcium absorption is impaired, leading to decreased bone mineralization and increased risk of fractures. By providing an adequate dose of vitamin D3, FOSAVANCE ensures that calcium is properly absorbed and utilized for bone health.
• The combination of alendronate and cholecalciferol in FOSAVANCE addresses both the bone resorption aspect and the calcium absorption deficiency commonly seen in osteoporosis. Alendronate reduces bone breakdown, while cholecalciferol ensures sufficient calcium availability for bone building. This dual action helps to restore bone balance, increase bone density, and reduce the risk of fractures, particularly in the hip, spine, and wrist. Consistent use of FOSAVANCE, as prescribed by a healthcare professional, along with a healthy lifestyle including weight-bearing exercise and a balanced diet, is crucial for maximizing its benefits in preventing and treating osteoporosis.

- **Common Side Effects (may affect up to 1 in 10 people):** - Bone, muscle, or joint pain - Heartburn - Indigestion - Nausea - Stomach pain - **Uncommon Side Effects (may affect up to 1 in 100 people):** - Inflammation of the esophagus (the tube that connects your mouth with your stomach), causing difficulty swallowing, pain when swallowing, chest pain, or heartburn - Vomiting - Gastritis (inflammation of the lining of the stomach) - Black or tarry stools - Blurred vision - Pain or redness in the eye - Rash - Itching - **Rare Side Effects (may affect up to 1 in 1,000 people):** - Allergic reactions such as hives or swelling of the face, lips, tongue, and/or throat, possibly causing difficulty breathing or swallowing - Severe bone, muscle, and/or joint pain - Osteonecrosis of the jaw (bone problems in the jaw associated with delayed healing and infection, often following tooth extraction) - Atypical fractures of the thigh bone, particularly in patients on long-term treatment for osteoporosis. - Esophageal stricture (narrowing of the esophagus) - **Other Possible Side Effects (frequency not known):** - Flu-like symptoms - Swelling in the joints - Fatigue - Hair loss - Taste disturbance

• If you miss a dose of FOSAVANCE 70MG/5600IU TABLET 4'S, take it the next morning. Do not take two tablets on the same day to make up for the missed dose. Return to taking one tablet once a week, as originally scheduled.

• Keep FOSAVANCE 70MG/5600IU TAB 1X4 away from the reach of children and pets.
• Store FOSAVANCE 70MG/5600IU TAB 1X4 at room temperature.

• **Take FOSAVANCE exactly as prescribed:** Always follow your doctor's instructions regarding dosage and timing. Typically, FOSAVANCE is taken once a week. Do not deviate from the prescribed schedule without consulting your healthcare provider to ensure optimal absorption and effectiveness.
• **Take FOSAVANCE on an empty stomach:** To maximize absorption, take FOSAVANCE first thing in the morning, at least 30 minutes before your first food, beverage (other than plain water), or other medications. This helps the medication to be properly absorbed into your bloodstream.
• **Stay upright after taking FOSAVANCE:** After taking the tablet, remain upright (sitting or standing) for at least 30 minutes. Do not lie down during this time. This helps the tablet to reach your stomach quickly and reduces the risk of esophageal irritation.
• **Ensure adequate Calcium and Vitamin D intake:** While FOSAVANCE contains Vitamin D, it's important to ensure you're getting enough Calcium and Vitamin D through your diet or supplements. These nutrients are crucial for bone health and work synergistically with FOSAVANCE. Discuss your Calcium and Vitamin D levels with your doctor.
• **Report any unusual side effects to your doctor:** While FOSAVANCE is generally well-tolerated, be aware of potential side effects such as heartburn, difficulty swallowing, or bone, joint, or muscle pain. Report any persistent or severe side effects to your doctor promptly.
• **Maintain a bone-healthy lifestyle:** Incorporate weight-bearing exercises like walking, jogging, or dancing into your routine. Avoid smoking and excessive alcohol consumption, as these can negatively impact bone health. A healthy lifestyle supports the effectiveness of FOSAVANCE in strengthening your bones.

• FOSAVANCE 70MG/5600IU TABLET 4'S should be taken on an empty stomach, at least 30 minutes before the first food or drink of the day (other than plain water).
• Food and beverages (including mineral water), calcium supplements, and some medicines can interfere with the absorption of FOSAVANCE. Wait at least 30 minutes after taking FOSAVANCE before consuming anything other than plain water.
• Avoid taking FOSAVANCE at the same time as calcium-rich foods or supplements, as calcium can decrease the absorption of alendronate (a component of FOSAVANCE).