GIBTULIO MET 12.5/500MG TABLET 10'S
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GIBTULIO MET 12.5/500MG TABLET 10'SGIBTULIO MET 12.5/500MG TABLET 10'SGIBTULIO MET 12.5/500MG TABLET 10'S
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GIBTULIO MET 12.5/500MG TABLET 10'S

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GIBTULIO MET 12.5/500MG TABLET 10'S

By LUPIN LIMITED

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125

₹106.25

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About GIBTULIO MET 12.5/500MG TABLET 10'S

  • Gibtulio Met 12.5/500mg Tablet is a combination medication designed to manage blood sugar levels in adults with type 2 diabetes mellitus. It combines two active ingredients: Empagliflozin and Metformin hydrochloride, working synergistically to improve glycemic control.
  • Empagliflozin belongs to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. It works by preventing the kidneys from reabsorbing glucose back into the blood. Instead, the excess glucose is excreted through urine, thereby lowering blood sugar levels. In addition to reducing blood sugar, empagliflozin can also lead to modest weight loss and blood pressure reduction, offering additional cardiovascular benefits.
  • Metformin is a biguanide that reduces glucose production in the liver and improves insulin sensitivity in the body's tissues, allowing cells to utilize glucose more effectively. It also slows down the absorption of glucose from the intestines.
  • This combination helps to maintain healthy blood sugar levels, especially when diet and exercise alone are not sufficient. It's typically taken once or twice daily with meals to minimize gastrointestinal side effects associated with metformin. Common side effects may include nausea, diarrhea, abdominal pain, and loss of appetite. It's important to stay hydrated while taking this medication, and to monitor kidney function regularly. Individuals with severe kidney problems should not take this medication.
  • Gibtulio Met is used along with diet and exercise to lower blood sugar levels in adults with type 2 diabetes. It helps the body better use insulin and reduces the amount of sugar absorbed by the body. Always use as directed by your healthcare provider.
  • Before taking Gibtulio Met, inform your doctor about any other medical conditions you have, especially kidney or liver problems, heart failure, or a history of diabetic ketoacidosis. Women who are pregnant or breastfeeding should consult their doctor before taking this medication.

Uses of GIBTULIO MET 12.5/500MG TABLET 10'S

  • Treatment of Type 2 Diabetes Mellitus
  • Controlling high blood sugar levels
  • Improving insulin sensitivity
  • May improve outcomes in Polycystic Ovary Syndrome (PCOS)

How GIBTULIO MET 12.5/500MG TABLET 10'S Works

  • GIBTULIO MET 12.5/500MG TABLET 10'S is a combination medication designed to manage type 2 diabetes effectively. It contains two active ingredients: Empagliflozin and Metformin hydrochloride. Each component works through different mechanisms to lower blood sugar levels and improve glycemic control.
  • Empagliflozin belongs to a class of drugs called Sodium-Glucose Co-transporter 2 (SGLT2) inhibitors. SGLT2 is a protein in the kidneys responsible for reabsorbing glucose back into the bloodstream. By inhibiting SGLT2, Empagliflozin reduces the reabsorption of glucose, causing excess glucose to be excreted in the urine. This process lowers blood glucose levels, helps in weight management by eliminating calories through urine, and provides cardiovascular benefits. Studies have shown that empagliflozin can reduce the risk of heart attack, stroke, and cardiovascular death in patients with type 2 diabetes and established cardiovascular disease.
  • Metformin hydrochloride is a biguanide that works primarily by decreasing glucose production in the liver. It reduces hepatic gluconeogenesis, the process by which the liver converts non-carbohydrate sources into glucose. Metformin also improves insulin sensitivity in peripheral tissues, such as muscles, allowing them to utilize glucose more efficiently. Additionally, it slows down the absorption of glucose from the intestines, further contributing to lower post-meal blood sugar spikes. Metformin is a well-established drug for type 2 diabetes, known for its efficacy, safety, and affordability. It does not typically cause hypoglycemia (low blood sugar) when used alone, which is an advantage.
  • When combined in GIBTULIO MET, Empagliflozin and Metformin work synergistically to provide comprehensive glycemic control. Empagliflozin helps to remove excess glucose from the body through the kidneys, while Metformin reduces glucose production in the liver and improves insulin sensitivity. This dual action effectively lowers both fasting and postprandial (after-meal) blood sugar levels. The combination is particularly beneficial for patients who require more than one medication to achieve their target blood sugar levels. It simplifies the treatment regimen by combining two medications into a single tablet, improving adherence and convenience.
  • Furthermore, GIBTULIO MET offers additional benefits beyond blood sugar control. Empagliflozin's cardiovascular benefits make it a favorable option for patients with or at high risk of cardiovascular disease. Metformin has been shown to have modest effects on weight loss and can improve lipid profiles. Together, these effects contribute to a more holistic approach to managing type 2 diabetes and reducing the risk of associated complications.
  • In summary, GIBTULIO MET 12.5/500MG TABLET 10'S works by combining the SGLT2 inhibition of Empagliflozin with the glucose-lowering and insulin-sensitizing effects of Metformin. This combination provides effective blood sugar control, cardiovascular benefits, and improved convenience for patients with type 2 diabetes.

Side Effects of GIBTULIO MET 12.5/500MG TABLET 10'SArrow

Common side effects of GIBTULIO MET 12.5/500MG TABLET may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and metallic taste. Other possible side effects are hypoglycemia (low blood sugar), skin rash, itching, and upper respiratory tract infection. In rare cases, it can cause lactic acidosis, a serious metabolic complication. Allergic reactions such as angioedema and anaphylaxis are also possible, though uncommon. Consult your doctor if you experience persistent or severe side effects.

Safety Advice for GIBTULIO MET 12.5/500MG TABLET 10'SArrow

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Allergies

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Do not use this medicine if you are allergic to it.

Dosage of GIBTULIO MET 12.5/500MG TABLET 10'SArrow

  • The recommended dosage of 'GIBTULIO MET 12.5/500MG TABLET 10'S' varies depending on individual patient needs, existing medical conditions, and response to treatment. It is crucial to adhere strictly to your physician's instructions regarding dosage and administration. Typically, the starting dose is one tablet, once or twice daily, taken with meals to minimize gastrointestinal side effects. Your doctor may gradually increase the dosage based on your blood sugar levels and overall tolerance.
  • The maximum recommended daily dose should not exceed the limit prescribed by your doctor. Do not exceed the prescribed dose under any circumstances. Consistent timing of administration, preferably at the same time(s) each day, is important to maintain stable blood sugar levels. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one.
  • It's important to swallow the tablet whole with a glass of water and not to crush, chew, or break the tablet unless specifically instructed by your doctor. 'GIBTULIO MET 12.5/500MG TABLET 10'S' is usually prescribed as part of a comprehensive diabetes management plan that includes diet and exercise. Regular monitoring of blood sugar levels is essential to assess the effectiveness of the medication and to guide dosage adjustments. Take 'GIBTULIO MET 12.5/500MG TABLET 10'S' only as per the prescription by your physician only.

What if I miss my dose of GIBTULIO MET 12.5/500MG TABLET 10'S?Arrow

  • If you miss a dose of GIBTULIO MET 12.5/500MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How to store GIBTULIO MET 12.5/500MG TABLET 10'S?Arrow

  • Keep GIBTULIO MET 12.5/500MG TAB 1X10 away from the reach of children and pets.
  • Store GIBTULIO MET 12.5/500MG TAB 1X10 at room temperature.

Benefits of GIBTULIO MET 12.5/500MG TABLET 10'SArrow

  • GIBTULIO MET 12.5/500MG TABLET 10'S is a combination medicine used to effectively manage type 2 diabetes mellitus. This medication works through a dual mechanism of action, providing comprehensive glycemic control and addressing multiple aspects of the disease.
  • One of the primary benefits of GIBTULIO MET is its ability to lower blood sugar levels. It combines a DPP-4 inhibitor (like GIBTULIO i.e.,Glibomet) with Metformin, a biguanide. The DPP-4 inhibitor enhances the incretin system, which increases insulin release and decreases glucagon secretion in a glucose-dependent manner. Metformin reduces glucose production in the liver and improves insulin sensitivity in peripheral tissues, enhancing glucose uptake and utilization.
  • By improving insulin sensitivity, GIBTULIO MET enables the body to use insulin more effectively. This is particularly beneficial for individuals with insulin resistance, a common characteristic of type 2 diabetes. Improved insulin sensitivity helps to lower blood glucose levels and reduces the risk of hyperglycemia.
  • GIBTULIO MET helps in reducing hepatic glucose production, thereby addressing a key factor contributing to elevated blood sugar levels in type 2 diabetes. This action helps to control fasting blood glucose levels and reduces overall glucose spikes throughout the day.
  • This medicine improves glycemic control both after meals and during fasting periods. The DPP-4 inhibitor component helps regulate postprandial glucose levels by enhancing insulin secretion in response to food intake. Metformin contributes to maintaining stable fasting glucose levels, providing a more consistent and balanced glycemic profile.
  • Compared to using single-agent therapies, the combination of a DPP-4 inhibitor and Metformin in GIBTULIO MET often leads to better overall blood sugar control. The synergistic effect of the two medications allows for more effective management of blood glucose levels than either medication could achieve alone.
  • For many individuals, taking a single combination tablet like GIBTULIO MET is more convenient than taking multiple medications. This can improve adherence to the prescribed treatment plan, leading to better health outcomes. Improved adherence is crucial for effectively managing chronic conditions like type 2 diabetes.
  • GIBTULIO MET can also offer weight management benefits. While Metformin is generally weight-neutral, some individuals may experience modest weight loss. This can be an added advantage for patients with type 2 diabetes, as weight management is an important aspect of overall disease management.
  • By effectively managing blood sugar levels and improving insulin sensitivity, GIBTULIO MET helps to reduce the risk of long-term complications associated with diabetes. These complications can include cardiovascular disease, nerve damage (neuropathy), kidney damage (nephropathy), and eye damage (retinopathy).
  • GIBTULIO MET is often prescribed as part of a comprehensive diabetes management plan that includes diet and exercise. It complements lifestyle modifications, helping individuals achieve and maintain their target blood glucose levels more effectively. Regular monitoring of blood sugar levels and adherence to a healthy lifestyle are essential for optimizing the benefits of this medication.

How to use GIBTULIO MET 12.5/500MG TABLET 10'SArrow

  • GIBTULIO MET 12.5/500MG TABLET 10'S is a combination medicine containing two active ingredients, typically used to manage blood sugar levels in adults with type 2 diabetes. It is crucial to adhere to your doctor's instructions regarding dosage and timing. Generally, it is taken orally, once or twice daily, with meals to minimize the risk of stomach upset.
  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break it, as this can affect how the medication is released into your system. Taking it with food helps to prevent nausea and other gastrointestinal side effects associated with metformin, one of the components of this medication.
  • Consistency is key for effective blood sugar control. Try to take GIBTULIO MET 12.5/500MG TABLET 10'S at the same time(s) each day to maintain a steady level of medication in your body. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
  • This medication works best when combined with a healthy diet and regular exercise. Follow your doctor's recommendations for a balanced meal plan and physical activity. Regular monitoring of your blood sugar levels is also essential to assess how well the medication is working and to make any necessary adjustments to your treatment plan in consultation with your doctor.
  • Inform your doctor about all other medications, including over-the-counter drugs, herbal supplements, and vitamins, you are taking, as they may interact with GIBTULIO MET 12.5/500MG TABLET 10'S. Also, it is important to discuss any existing medical conditions, especially kidney or liver problems, heart failure, or a history of diabetic ketoacidosis, before starting this medication.
  • Regular check-ups with your doctor are necessary while taking this medication to monitor your overall health and to check for any potential side effects. If you experience any unusual symptoms, such as persistent nausea, vomiting, abdominal pain, or signs of an allergic reaction (rash, itching, swelling), seek medical attention immediately.
  • Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight and heat. Dispose of any unused medication properly, following the instructions provided by your pharmacist or local waste disposal company.

Quick Tips for GIBTULIO MET 12.5/500MG TABLET 10'SArrow

  • Take GIBTULIO MET 12.5/500MG TABLET 10'S as prescribed by your doctor. It is typically taken once or twice daily with meals to minimize stomach upset. Follow your doctor's instructions carefully regarding dosage and timing.
  • Consistent timing is key! Take GIBTULIO MET 12.5/500MG TABLET 10'S at the same time(s) each day to maintain stable blood sugar levels and maximize its effectiveness. Setting a daily reminder can be helpful.
  • Be mindful of potential side effects. Common side effects may include nausea, diarrhea, and abdominal discomfort. If these persist or worsen, consult your doctor. Rare but serious side effects include lactic acidosis, so report any unusual symptoms like muscle pain, weakness, or difficulty breathing immediately.
  • Monitor your blood sugar regularly as directed by your healthcare provider. This will help you track how well the medication is working and make any necessary adjustments to your diet or exercise plan. Keep a record of your blood sugar levels to share with your doctor during appointments.
  • Inform your doctor about all other medications, supplements, and herbal remedies you are taking. GIBTULIO MET 12.5/500MG TABLET 10'S can interact with certain medications, potentially affecting its efficacy or increasing the risk of side effects. A complete medication list helps your doctor make informed decisions about your treatment.
  • Maintain a healthy lifestyle. GIBTULIO MET 12.5/500MG TABLET 10'S works best when combined with a balanced diet and regular exercise. Focus on consuming whole grains, lean proteins, fruits, and vegetables, and aim for at least 30 minutes of moderate-intensity exercise most days of the week. Discuss specific diet and exercise recommendations with your doctor or a registered dietitian.
  • Stay hydrated! Drink plenty of water throughout the day to help your kidneys function properly and prevent dehydration, especially if you experience diarrhea as a side effect of the medication. Aim for at least 8 glasses of water per day, unless otherwise directed by your doctor.
  • Do not crush or chew the tablets. GIBTULIO MET 12.5/500MG TABLET 10'S should be swallowed whole with a glass of water. Crushing or chewing the tablets can affect how the medication is released and may increase the risk of side effects.

Food Interactions with GIBTULIO MET 12.5/500MG TABLET 10'SArrow

  • To maximize the effectiveness of GIBTULIO MET 12.5/500MG TABLET 10'S and minimize potential gastrointestinal side effects, it is recommended to take this medication with food. Taking it with meals helps to slow down the absorption of metformin, which can reduce the likelihood of stomach upset, nausea, and diarrhea. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of lactic acidosis, a rare but serious side effect.

FAQs

What is GIBTULIO MET 12.5/500MG TABLET used for?Arrow

GIBTULIO MET 12.5/500MG TABLET is used to treat type 2 diabetes mellitus when diet and exercise alone are not enough to control blood sugar levels.

How does GIBTULIO MET 12.5/500MG TABLET work?Arrow

GIBTULIO MET 12.5/500MG TABLET is a combination of two medicines, metformin and a gliptin. Metformin works by decreasing glucose production in the liver and improving insulin sensitivity. The gliptin works by increasing insulin secretion and decreasing glucose production.

What are the common side effects of GIBTULIO MET 12.5/500MG TABLET?Arrow

Common side effects of GIBTULIO MET 12.5/500MG TABLET include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.

Is GIBTULIO MET 12.5/500MG TABLET safe during pregnancy?Arrow

The safety of GIBTULIO MET 12.5/500MG TABLET during pregnancy has not been established. Therefore, it is important to consult a doctor before using it during pregnancy.

Is GIBTULIO MET 12.5/500MG TABLET safe during breastfeeding?Arrow

It is not known whether GIBTULIO MET 12.5/500MG TABLET is excreted in breast milk. Therefore, it is important to consult a doctor before using it during breastfeeding.

How should I take GIBTULIO MET 12.5/500MG TABLET?Arrow

GIBTULIO MET 12.5/500MG TABLET should be taken as prescribed by the doctor. It is best to take it with food.

What happens if I miss a dose of GIBTULIO MET 12.5/500MG TABLET?Arrow

If you miss a dose of GIBTULIO MET 12.5/500MG TABLET, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.

How to store GIBTULIO MET 12.5/500MG TABLET?Arrow

Store GIBTULIO MET 12.5/500MG TABLET at room temperature, away from heat and moisture. Keep it out of reach of children.

Does GIBTULIO MET 12.5/500MG TABLET cause weight gain?Arrow

GIBTULIO MET 12.5/500MG TABLET is not likely to cause weight gain. In fact, some people may experience weight loss with it.

Can I drink alcohol with GIBTULIO MET 12.5/500MG TABLET?Arrow

Avoid drinking alcohol with GIBTULIO MET 12.5/500MG TABLET, as it can lower blood sugar levels and cause other side effects.

Is GIBTULIO MET 12.5/500MG TABLET safe for kidneys?Arrow

Talk to your doctor before taking GIBTULIO MET 12.5/500MG TABLET if you have kidney problems, as it can worsen kidney problems.

Is GIBTULIO MET 12.5/500MG TABLET safe for the heart?Arrow

GIBTULIO MET 12.5/500MG TABLET may be safe for the heart by reducing some risk factors for heart disease. However, talk to your doctor before taking it if you have heart problems.

Can GIBTULIO MET 12.5/500MG TABLET interact with other medications?Arrow

GIBTULIO MET 12.5/500MG TABLET can interact with certain other medications, such as insulin, sulfonylureas, and some antibiotics. Tell your doctor if you are taking any other medications.

Can GIBTULIO MET 12.5/500MG TABLET be taken on an empty stomach?Arrow

It is best to take GIBTULIO MET 12.5/500MG TABLET with food. Taking it on an empty stomach may cause stomach upset.

What are the symptoms of an overdose of GIBTULIO MET 12.5/500MG TABLET?Arrow

Symptoms of an overdose of GIBTULIO MET 12.5/500MG TABLET include nausea, vomiting, diarrhea, abdominal pain, dizziness, and fainting.

What to do if I have an allergic reaction to GIBTULIO MET 12.5/500MG TABLET?Arrow

If you have an allergic reaction to GIBTULIO MET 12.5/500MG TABLET, stop taking the medication immediately and seek medical advice. Symptoms of an allergic reaction may include skin rash, itching, swelling, and difficulty breathing.

References

Book Icon

DrugBank: Glibenclamide and Metformin Combination. This entry provides comprehensive information on the drug combination, including its pharmacology, mechanism of action, and potential drug interactions. It is a widely recognized and reliable source for drug information.

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National Center for Biotechnology Information (NCBI): Efficacy and safety of metformin/glibenclamide in comparison with metformin/gliptin for type 2 diabetes: A systematic review and meta-analysis. This research article compares the effectiveness and safety of metformin/glibenclamide combination with other treatments for type 2 diabetes.

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FDA (Food and Drug Administration) Label for Metformin. This is the official prescribing information for metformin, including details about its indications, dosage, contraindications, and adverse effects.

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European Medicines Agency (EMA) - Glibenclamide/Metformin. Public assessment reports and scientific discussion regarding Glibenclamide/Metformin combination.

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ScienceDirect - Glibenclamide. Overview of Glibenclamide mechanism of action, usage and pharmacology.

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GIBTULIO MET 12.5/500MG TABLET 10'S

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