GLUCRETA L 5/10 TABLET 10'S

How GLUCRETA L 5/10 TABLET 10'S Works

• GLUCRETA L 5/10 Tablet is a combination medication designed to manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients: Metformin and Linagliptin, each working through different mechanisms to achieve optimal glycemic control.
• Metformin, a biguanide, is the cornerstone of type 2 diabetes treatment. It primarily works by reducing glucose production in the liver. The liver is a key player in glucose metabolism, and in individuals with diabetes, it often produces excessive glucose. Metformin inhibits this process, thereby lowering the amount of glucose released into the bloodstream. Secondly, Metformin enhances insulin sensitivity in peripheral tissues like muscles. This means that the body's cells become more responsive to insulin, allowing them to absorb glucose more effectively from the blood. Lastly, Metformin slows down the absorption of glucose from the intestines, further contributing to lower post-meal blood sugar spikes. It's important to note that Metformin does not stimulate insulin secretion, so it carries a lower risk of hypoglycemia (low blood sugar) compared to some other diabetes medications.
• Linagliptin belongs to a class of drugs called DPP-4 inhibitors. DPP-4 (dipeptidyl peptidase-4) is an enzyme that breaks down incretin hormones in the body. Incretins, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), play a crucial role in regulating blood sugar. They stimulate insulin release from the pancreas when blood sugar levels are high and suppress glucagon secretion (a hormone that raises blood sugar) when blood sugar levels are low. By inhibiting DPP-4, Linagliptin increases the levels of active incretin hormones in the body. This, in turn, enhances insulin secretion in a glucose-dependent manner (meaning insulin is released only when blood sugar is high) and reduces glucagon secretion, ultimately leading to improved blood sugar control.
• In summary, GLUCRETA L 5/10 Tablet combines the complementary actions of Metformin and Linagliptin to effectively manage blood sugar levels in type 2 diabetes. Metformin reduces glucose production in the liver, enhances insulin sensitivity, and slows down glucose absorption, while Linagliptin increases incretin hormone levels, leading to increased insulin secretion and reduced glucagon secretion. This dual mechanism helps to lower both fasting and post-meal blood sugar levels, providing comprehensive glycemic control.

Common side effects of GLUCRETA L 5/10 Tablet may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and hypoglycemia (low blood sugar). Some patients may experience headache, dizziness, fatigue, or weakness. Less common but potentially serious side effects include lactic acidosis (accumulation of lactic acid in the body), allergic reactions (rash, itching, swelling), liver problems (jaundice, dark urine, abdominal pain), and vitamin B12 deficiency. In rare cases, it may cause pancreatitis or blood disorders. Contact your doctor immediately if you experience any severe or persistent side effects.

• If you miss a dose of GLUCRETA L 5/10 TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep GLUCRETA L 5/5MG TAB 1X10 away from the reach of children and pets.
• Store GLUCRETA L 5/5MG TAB 1X10 at room temperature.

• **Take GLUCRETA L 5/10 Tablet as prescribed by your doctor:** Always adhere to the dosage and timing instructions provided by your healthcare professional. Do not self-adjust the dosage or discontinue the medication without consulting them, as this could affect your blood sugar control and overall health. Consistency is key for optimal results.
• **Monitor your blood sugar levels regularly:** GLUCRETA L 5/10 Tablet helps manage blood sugar, but regular monitoring is crucial to assess its effectiveness. Keep a log of your readings and share it with your doctor during check-ups. This allows for timely adjustments to your treatment plan if needed. Consistent blood sugar monitoring helps you understand how the medication and your lifestyle choices are working together.
• **Follow a healthy diet and exercise plan:** GLUCRETA L 5/10 Tablet works best when combined with a balanced diet and regular physical activity. Focus on whole grains, lean proteins, fruits, and vegetables while limiting sugary and processed foods. Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Discuss your diet and exercise plans with your doctor or a registered dietitian for personalized guidance.
• **Be aware of potential side effects:** Like all medications, GLUCRETA L 5/10 Tablet may cause side effects. Common side effects can include nausea, diarrhea, or headache. More serious side effects are rare, but it's essential to be aware of them. Contact your doctor immediately if you experience any unusual or severe symptoms, such as severe abdominal pain, persistent vomiting, or signs of an allergic reaction (rash, itching, swelling). Informing your doctor promptly helps in managing potential adverse effects effectively.
• **Store GLUCRETA L 5/10 Tablet properly:** Store your medication in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. Check the expiration date on the packaging and dispose of any expired medication safely. Proper storage ensures the medication remains effective and safe for use.

• GLUCRETA L 5/10 TABLET 10'S is generally safe to take with or without food. However, it is advisable to take it at a fixed time to maintain consistent blood sugar levels. Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of side effects.