GLYXAMBI 10/5MG TABLET 10'S
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GLYXAMBI 10/5MG TABLET 10'S
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GLYXAMBI 10/5MG TABLET 10'S

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GLYXAMBI 10/5MG TABLET 10'S

By BOEHRINGER INGELHEIM INDIA PVT LTD

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788

₹669.8

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About GLYXAMBI 10/5MG TABLET 10'S

  • GLYXAMBI 10/5MG TABLET is a prescription medication designed to help adults with type 2 diabetes manage their blood sugar levels. It combines two active ingredients: empagliflozin and linagliptin. Empagliflozin belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors, while linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. This dual-action approach helps to control blood sugar in multiple ways.
  • Empagliflozin works by preventing the kidneys from reabsorbing glucose back into the blood. Instead, the excess glucose is eliminated through urine. This process not only lowers blood sugar levels but can also lead to modest weight loss and blood pressure reduction. Linagliptin, on the other hand, works by increasing the levels of incretin hormones in the body. These hormones stimulate the release of insulin when blood sugar is high and reduce the amount of glucose produced by the liver.
  • GLYXAMBI is typically used in conjunction with diet and exercise to improve glycemic control in adults with type 2 diabetes. It is important to take GLYXAMBI exactly as prescribed by your doctor. The usual dosage is one tablet once daily, taken orally. It can be taken with or without food. Regular monitoring of blood sugar levels is necessary while taking this medication to ensure it is working effectively and to adjust the dosage if needed.
  • Before starting GLYXAMBI, inform your doctor about any other medical conditions you have, especially kidney problems, liver problems, heart problems, or a history of pancreatitis. Also, discuss all other medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, as drug interactions can occur. Common side effects of GLYXAMBI may include urinary tract infections, yeast infections, and increased urination. If you experience any severe side effects, such as symptoms of dehydration or ketoacidosis, seek medical attention immediately.

Uses of GLYXAMBI 10/5MG TABLET 10'S

  • Treatment of type 2 diabetes mellitus
  • Lowering high blood sugar levels
  • Improving blood sugar control
  • Reducing the risk of cardiovascular disease (in some patients)
  • Used in combination with diet and exercise

How GLYXAMBI 10/5MG TABLET 10'S Works

  • GLYXAMBI 10/5MG TABLET 10'S is a combination medication designed to manage blood sugar levels in adults with type 2 diabetes. It combines two active ingredients: empagliflozin and linagliptin, each working through different mechanisms to achieve better glycemic control. Empagliflozin belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors, while linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
  • Empagliflozin primarily works by preventing the kidneys from reabsorbing glucose back into the blood. In healthy individuals, the kidneys filter glucose from the blood, and nearly all of it is reabsorbed. However, in people with diabetes, this reabsorption process can contribute to elevated blood sugar levels. Empagliflozin blocks the SGLT2 protein in the kidneys, which is responsible for this reabsorption. As a result, more glucose is excreted in the urine, effectively lowering blood glucose levels. This mechanism is also associated with a modest reduction in blood pressure and body weight, offering additional benefits for many patients with type 2 diabetes. The excess glucose is eliminated through urine.
  • Linagliptin, on the other hand, works by enhancing the body's own ability to lower blood sugar. It inhibits the DPP-4 enzyme, which is responsible for breaking down incretin hormones. Incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), are released by the gut in response to food intake. These hormones stimulate insulin release from the pancreas and reduce glucagon secretion from the liver, both of which help to lower blood sugar levels. By inhibiting DPP-4, linagliptin increases the levels of active incretin hormones in the body, prolonging their effects and improving glucose control. Linagliptin helps in a glucose-dependent manner, meaning it primarily works when blood sugar levels are elevated, reducing the risk of hypoglycemia (low blood sugar).
  • The combination of empagliflozin and linagliptin in GLYXAMBI 10/5MG TABLET 10'S provides a dual approach to managing blood sugar levels. Empagliflozin reduces glucose reabsorption in the kidneys, while linagliptin enhances the action of incretin hormones. This synergistic effect can lead to better glycemic control compared to either drug used alone. This medication is typically used in conjunction with diet and exercise to improve blood sugar management in adults with type 2 diabetes. Always consult with your healthcare provider for personalized advice and to determine if GLYXAMBI 10/5MG TABLET 10'S is right for you.

Side Effects of GLYXAMBI 10/5MG TABLET 10'SArrow

Common side effects of GLYXAMBI may include: Genital yeast infections (both male and female), Urinary tract infections, Increased urination, Upper respiratory tract infection, Headache, Nasopharyngitis (common cold), Nausea, Diarrhea, Constipation. Less common but potentially serious side effects can include: Ketoacidosis, Kidney problems, Pancreatitis, Hypoglycemia (low blood sugar, especially when taken with other diabetes medications like insulin or sulfonylureas), Allergic reactions (rash, itching, swelling), Dehydration, Dizziness or lightheadedness (related to blood pressure changes). This is not an exhaustive list; other side effects may occur. Consult your doctor for medical advice about side effects.

Safety Advice for GLYXAMBI 10/5MG TABLET 10'SArrow

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Allergies

Allergies

Do not use Glyxambi if you are allergic to it.

Dosage of GLYXAMBI 10/5MG TABLET 10'SArrow

  • The recommended dosage of GLYXAMBI 10/5MG TABLET 10'S is typically one tablet taken orally once daily. It's crucial to adhere strictly to your physician's prescribed dosage and timing. GLYXAMBI should be taken at the same time each day, ideally in the morning, with or without food. Consistent timing helps maintain stable blood glucose levels.
  • The specific dosage is determined by your doctor based on individual factors such as your blood sugar levels, kidney function, and other medications you may be taking. Do not adjust the dosage on your own without consulting your healthcare provider, as this can lead to undesirable side effects or ineffective blood sugar control.
  • If you miss a dose of GLYXAMBI, take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you have any questions or concerns about a missed dose, contact your doctor or pharmacist.
  • During treatment with GLYXAMBI, your doctor may monitor your kidney function periodically, especially if you are elderly or have pre-existing kidney problems. Dose adjustments may be necessary based on these monitoring results. Inform your doctor immediately if you experience any symptoms of kidney problems, such as decreased urination, swelling in your legs or ankles, or fatigue.
  • Take 'GLYXAMBI 10/5MG TABLET 10'S' only as per the prescription by your physician only

What if I miss my dose of GLYXAMBI 10/5MG TABLET 10'S?Arrow

  • If you miss a dose of GLYXAMBI 10/5MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How to store GLYXAMBI 10/5MG TABLET 10'S?Arrow

  • Keep GLYXAMBI 10/5MG TAB 1X10 away from the reach of children and pets.
  • Store GLYXAMBI 10/5MG TAB 1X10 at room temperature.

Benefits of GLYXAMBI 10/5MG TABLET 10'SArrow

  • GLYXAMBI 10/5MG TABLET 10'S is a combination medicine containing empagliflozin and linagliptin, designed to improve glycemic control in adults with type 2 diabetes mellitus. It works by reducing glucose reabsorption in the kidneys and increasing insulin secretion while decreasing glucagon secretion, addressing multiple pathways involved in blood sugar regulation.
  • One of the primary benefits of GLYXAMBI is its effectiveness in lowering HbA1c levels. HbA1c, or glycated hemoglobin, provides an average measure of blood sugar levels over the past 2-3 months. By consistently reducing HbA1c, GLYXAMBI helps patients achieve and maintain better long-term glycemic control, reducing the risk of diabetes-related complications.
  • GLYXAMBI offers a dual mechanism of action that targets different aspects of glucose metabolism. Empagliflozin, an SGLT2 inhibitor, promotes the excretion of glucose through the urine, while linagliptin, a DPP-4 inhibitor, enhances the body's own ability to lower blood sugar by increasing insulin release and decreasing glucagon secretion. This synergistic effect can lead to more significant improvements in blood sugar levels compared to either medication used alone.
  • Beyond glycemic control, GLYXAMBI has demonstrated cardiovascular benefits in clinical trials, particularly empagliflozin component. Studies have shown that empagliflozin can reduce the risk of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke in patients with type 2 diabetes and established cardiovascular disease. This makes GLYXAMBI a valuable option for patients with both diabetes and heart conditions.
  • GLYXAMBI can also contribute to weight management. Empagliflozin's mechanism of action leads to the excretion of excess glucose, resulting in a calorie loss that can support weight reduction. While not a primary weight loss medication, GLYXAMBI can be a beneficial option for patients who are also looking to manage their weight.
  • GLYXAMBI is generally well-tolerated, with a safety profile supported by clinical trials. However, like all medications, it can cause side effects. Common side effects may include urinary tract infections, genital infections, and increased urination. Patients should discuss potential side effects and contraindications with their healthcare provider before starting GLYXAMBI.
  • GLYXAMBI offers the convenience of a once-daily oral tablet, making it easier for patients to adhere to their treatment plan. Simplified dosing regimens can improve compliance and lead to better overall outcomes in managing type 2 diabetes. Always take the medication at the same time each day to maintain consistent blood levels.
  • GLYXAMBI can be used as part of a comprehensive diabetes management plan that includes diet and exercise. It is not a substitute for lifestyle modifications but rather an adjunct therapy to help patients achieve their blood sugar goals. Regular monitoring of blood sugar levels and adherence to a healthy lifestyle are essential for optimal results.
  • GLYXAMBI has shown promise in improving blood pressure control. Empagliflozin has a mild diuretic effect, which can help lower blood pressure in some patients. This can be particularly beneficial for individuals with both diabetes and hypertension, as managing blood pressure is crucial for reducing cardiovascular risk.
  • GLYXAMBI is available in different strengths, allowing healthcare providers to tailor the dosage to meet individual patient needs. The combination of 10mg of empagliflozin and 5mg of linagliptin offers a balanced approach to glycemic control, providing flexibility in treatment options.

How to use GLYXAMBI 10/5MG TABLET 10'SArrow

  • GLYXAMBI 10/5MG TABLET 10'S is an oral medication used to manage blood sugar levels in adults with type 2 diabetes. It contains two active ingredients: empagliflozin and linagliptin. Empagliflozin belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors, which work by helping the kidneys remove glucose from the bloodstream through urine. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which enhances the effects of incretin hormones, leading to increased insulin release and decreased glucagon secretion in a glucose-dependent manner.
  • Take GLYXAMBI exactly as prescribed by your doctor. The usual starting dose is one tablet once daily, preferably in the morning. You can take it with or without food. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • It is important to take GLYXAMBI at the same time each day to maintain consistent blood sugar control. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • While taking GLYXAMBI, it's crucial to adhere to a healthy diet and exercise regularly. This medication works best when combined with lifestyle modifications. Monitor your blood sugar levels regularly as directed by your healthcare provider. This will help you track how well the medication is working and make any necessary adjustments to your treatment plan.
  • Stay hydrated by drinking plenty of water throughout the day. Empagliflozin can increase urination, so adequate fluid intake is essential to prevent dehydration. Be aware of potential side effects, such as urinary tract infections and genital infections, and promptly report any unusual symptoms to your doctor.
  • Before starting GLYXAMBI, inform your doctor about any pre-existing medical conditions, especially kidney problems, liver problems, heart problems, or a history of pancreatitis. Also, tell your doctor about all other medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements.
  • Regularly follow up with your doctor to monitor your condition and discuss any concerns or side effects you may be experiencing. Your doctor may adjust your dosage or treatment plan as needed to optimize your blood sugar control.

Quick Tips for GLYXAMBI 10/5MG TABLET 10'SArrow

  • Take GLYXAMBI 10/5MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider. Consistent adherence to the prescribed regimen optimizes its effectiveness in managing your blood sugar levels.
  • It is recommended to take GLYXAMBI 10/5MG TABLET 10'S with food, preferably at the same time each day. Taking it with food can help reduce the risk of stomach upset and improve absorption. Consistent timing helps maintain stable blood sugar levels throughout the day.
  • Regularly monitor your blood sugar levels as directed by your doctor or diabetes educator. Keep a record of your readings and share them with your healthcare team. This information is crucial for assessing how well the medication is working and making necessary adjustments to your treatment plan.
  • Stay hydrated by drinking plenty of water throughout the day. Adequate hydration supports kidney function, which is important as GLYXAMBI can affect kidney function in some individuals. Aim for at least 8 glasses of water daily, unless your doctor advises otherwise.
  • Be aware of the symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, dizziness, and confusion. Carry a source of fast-acting sugar with you, such as glucose tablets or juice, to treat hypoglycemia promptly. Inform your family and friends about these symptoms and how to help you if needed. Also, be mindful of symptoms of high blood sugar (hyperglycemia) such as increased thirst, frequent urination, and blurred vision, and contact your healthcare provider if you experience these.
  • Inform your doctor about all other medications, supplements, and herbal products you are taking. GLYXAMBI can interact with other substances, potentially affecting its efficacy or increasing the risk of side effects. A comprehensive medication review ensures your safety and optimal treatment outcomes.

FAQs

What is GLYXAMBI 10/5MG TABLET 10'S?Arrow

GLYXAMBI 10/5MG TABLET 10'S is a medication containing a combination of empagliflozin and linagliptin. It is used to control blood sugar levels in adults with type 2 diabetes.

What is GLYXAMBI 10/5MG TABLET 10'S used for?Arrow

GLYXAMBI 10/5MG TABLET 10'S is used to improve blood sugar levels in people with type 2 diabetes, along with diet and exercise.

How does GLYXAMBI 10/5MG TABLET 10'S work?Arrow

GLYXAMBI 10/5MG TABLET 10'S works in two ways: empagliflozin reduces reabsorption of sugar from the kidneys, and linagliptin increases insulin production and decreases glucose the liver makes.

What are the common side effects of GLYXAMBI 10/5MG TABLET 10'S?Arrow

Common side effects of GLYXAMBI 10/5MG TABLET 10'S include urinary tract infections, infections of the nose and throat, and low blood sugar.

Can GLYXAMBI 10/5MG TABLET 10'S cause kidney problems?Arrow

GLYXAMBI 10/5MG TABLET 10'S should be used with caution in people with kidney problems, as it may worsen kidney function.

Can GLYXAMBI 10/5MG TABLET 10'S be taken with or without food?Arrow

GLYXAMBI 10/5MG TABLET 10'S can be taken with or without food. It is best to take it at the same time each day.

What happens if I miss a dose of GLYXAMBI 10/5MG TABLET 10'S?Arrow

If you miss a dose of GLYXAMBI 10/5MG TABLET 10'S, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Can GLYXAMBI 10/5MG TABLET 10'S interact with other medications?Arrow

GLYXAMBI 10/5MG TABLET 10'S can interact with certain other medications, such as insulin and sulfonylureas. It is important to tell your doctor about all the medications you are taking.

How should I store GLYXAMBI 10/5MG TABLET 10'S?Arrow

Store GLYXAMBI 10/5MG TABLET 10'S at room temperature, away from heat and moisture.

Can pregnant or breastfeeding women take GLYXAMBI 10/5MG TABLET 10'S?Arrow

Pregnant or breastfeeding women should talk to their doctor before taking GLYXAMBI 10/5MG TABLET 10'S.

Can GLYXAMBI 10/5MG TABLET 10'S be used in children?Arrow

GLYXAMBI 10/5MG TABLET 10'S is not recommended for use in children.

How long should I take GLYXAMBI 10/5MG TABLET 10'S?Arrow

How long you should take GLYXAMBI 10/5MG TABLET 10'S will be determined by your doctor. Continue taking it for as long as they tell you to.

Does GLYXAMBI 10/5MG TABLET 10'S cause weight gain?Arrow

GLYXAMBI 10/5MG TABLET 10'S does not typically cause weight gain. However, some individuals may experience it.

Does GLYXAMBI 10/5MG TABLET 10'S cause dizziness?Arrow

GLYXAMBI 10/5MG TABLET 10'S can cause dizziness, especially when you first start taking it.

Are there other brands that also have a combination of empagliflozin and linagliptin?Arrow

Yes, the combination of empagliflozin and linagliptin may be available under other brands. Check with your doctor or pharmacist.

References

Book Icon

GLYXAMBI (empagliflozin and linagliptin) tablets, for oral use. Full Prescribing Information. Initial U.S. Approval: 2015. Highlights of Prescribing Information.

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Rachael A Moses, Alice Y Y Cheng, and Lawrence A Leiter. Combination therapy with linagliptin and empagliflozin: targeting complementary mechanisms to improve glycemic control in patients with type 2 diabetes mellitus. Postgraduate Medicine. 2016; 128(8): 757–767.

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GLYXAMBI : EPAR - Product Information. European Medicines Agency.

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GLYXAMBI- empagliflozin and linagliptin tablet, film coated. National Library of Medicine, DailyMed.

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Lewin A, et al. Empagliflozin as add-on to linagliptin in type 2 diabetes: a randomised, double-blind, placebo-controlled trial. Diabetologia. 2016 Jan;59(4):672-82. doi: 10.1007/s00125-015-3843-x. Epub 2015 Dec 18.

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Glyxambi (Empagliflozin and Linagliptin) Drug Information: Description, Clinical Pharmacology - RxList

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