haemaccel injection 500 ml
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HAEMACCEL INJECTION 500 ML

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HAEMACCEL INJECTION 500 ML

By ABBOTT HEALTH CARE PRIVATE LIMITED

MRP

526.89

₹447.86

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Product DetailsArrow

Content Reviewed By:

Dr. Amit Patel

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About HAEMACCEL INJECTION 500 ML

  • Haemaccel is a plasma volume expander that contains polygeline, a modified fluid gelatin, used primarily for the treatment and prevention of hypovolemia (low blood volume) and shock due to blood or plasma loss. It is typically administered intravenously in hospital or clinical settings under close medical supervision. By increasing the circulating blood volume, Haemaccel helps improve blood pressure, tissue perfusion, and oxygen delivery to vital organs such as the brain, heart, kidneys, and liver. Haemaccel works by staying mainly within the blood vessels and exerting a colloid osmotic effect, drawing fluid into the circulation and thereby expanding plasma volume. It is often used in situations such as trauma, major surgery, burns, or severe dehydration where rapid restoration of intravascular volume is required. It may be used as part of a broader resuscitation strategy that can include crystalloids, blood products, and other supportive measures, depending on the patient’s condition and the treating physician’s judgment. Because Haemaccel contains polygeline and electrolytes (including calcium), it must be used cautiously in patients with certain medical conditions. These include severe heart failure, significant kidney impairment, hypervolemia (excess blood volume), severe electrolyte imbalances, or conditions where additional fluid load could be harmful, such as pulmonary edema. It is also important to consider potential interactions with blood products and other intravenous solutions, particularly those containing citrates, due to the calcium content. Allergic or anaphylactoid reactions can occur with Haemaccel, ranging from mild skin rashes and itching to severe reactions such as bronchospasm, hypotension, or anaphylactic shock. For this reason, patients are usually monitored closely during infusion, especially at the start and in those with a history of allergies or previous reactions to gelatin-based or colloid solutions. If any signs of hypersensitivity appear, the infusion must be stopped immediately and appropriate emergency treatment initiated. Use in pregnancy and breastfeeding requires careful risk–benefit assessment by a physician, as data in these populations may be limited. Haemaccel is not a substitute for blood or blood components when there is significant anemia or coagulation disorders; in such cases, specific blood products may be required. The dose, rate of infusion, and duration of therapy are individualized based on the patient’s clinical status, ongoing losses, and response to treatment, and must always be determined and adjusted by qualified healthcare professionals.

Uses of HAEMACCEL INJECTION 500 ML

  • Treatment of blood volume loss
  • Treatment of shock
  • Maintaining blood volume during surgery
  • Blood volume replacement in emergency situations
  • Plasma volume expansion
  • Treatment of hypovolemia
  • Maintaining blood pressure during hemodialysis
  • Management of acute blood loss

How HAEMACCEL INJECTION 500 ML Works

  • HAEMACCEL INJECTION 500 ML is a plasma volume expander used to treat and prevent hypovolemia. Hypovolemia is a condition where there is a decreased volume of circulating blood in the body. It contains a combination of electrolytes and colloids, specifically polygeline. Polygeline is a modified gelatin molecule that acts as a plasma substitute. It works by increasing the osmotic pressure of the blood, which helps to draw fluid from the interstitial space (the space between cells) into the bloodstream, thereby increasing the circulating blood volume.
  • The polygeline molecules in HAEMACCEL are large and remain in the bloodstream for a relatively long time, providing sustained volume expansion. This is crucial in situations where rapid restoration of blood volume is needed, such as in cases of severe bleeding, trauma, or surgery. The electrolytes present in the solution help to maintain the electrolyte balance in the body, which can be disrupted during hypovolemia.
  • When HAEMACCEL is administered intravenously, the polygeline component exerts an oncotic effect, meaning it attracts water into the circulatory system. This immediate increase in blood volume helps to improve blood pressure and cardiac output, ensuring adequate oxygen delivery to vital organs. The expanded blood volume also aids in improving microcirculation, ensuring that oxygen and nutrients reach the tissues effectively. Over time, the polygeline molecules are broken down and eliminated from the body via the kidneys. It is a temporary solution to restore and maintain circulating blood volume while addressing the underlying cause of hypovolemia is essential.
  • In essence, HAEMACCEL works by rapidly increasing the volume of fluid in your bloodstream. The polygeline within Haemaccel acts like a sponge, attracting water from other areas of the body into the circulation. This increased volume helps to improve blood pressure and ensures that vital organs receive the oxygen they need. Simultaneously, the balanced electrolyte solution within Haemaccel helps to correct any electrolyte imbalances that might accompany the fluid loss, contributing to overall stabilization of the patient's condition. The effect is temporary, providing crucial support while other treatments address the root cause of the hypovolemia.

Side Effects of HAEMACCEL INJECTION 500 MLArrow

Like all medicines, Haemaccel can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Skin reactions, such as hives (urticaria), itching (pruritus), and flushing (redness of the skin). * Mild to moderate decrease in blood pressure (hypotension). * Slowing of the heart rate (bradycardia). **Uncommon Side Effects (may affect up to 1 in 100 people):** * Nausea, vomiting * Shortness of breath (dyspnea). **Rare Side Effects (may affect up to 1 in 1,000 people):** * Severe allergic reactions (anaphylactic reactions) with symptoms such as: * Difficulty breathing, wheezing * Swelling of the face, lips, tongue, or throat * Rapid heart rate * Loss of consciousness * Increase in body temperature (fever) * Shivering (chills) **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Cardiac arrest * Bronchospasm (narrowing of the airways) **Frequency not known (cannot be estimated from the available data):** * Disturbances of blood coagulation * Fluid overload (hypervolemia)

Safety Advice for HAEMACCEL INJECTION 500 MLArrow

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Allergies

Risk of hypersensitivity reactions

Haemaccel can cause allergic or anaphylactoid reactions, which may be serious and require immediate medical intervention.

Dosage of HAEMACCEL INJECTION 500 MLArrow

  • The dosage of HAEMACCEL INJECTION 500 ML is determined by several factors, including the patient's blood volume deficit, hemodynamic parameters, and overall clinical condition. It's crucial to individualize the dosage based on careful assessment and monitoring of the patient's response to therapy. The administration rate and total volume infused are guided by the patient’s physiological needs and should be continuously adjusted to maintain adequate circulatory volume. Rapid infusion may be necessary in acute situations, such as severe hypovolemia or shock, but should be carefully monitored to avoid potential complications like circulatory overload.
  • In adults, the initial dose typically ranges from 500 to 1000 ml, administered intravenously. However, larger volumes may be required in cases of significant blood loss or dehydration. The infusion rate should be adjusted to maintain stable blood pressure, heart rate, and urine output. Continuous monitoring of these parameters is essential throughout the infusion. In elderly patients or those with pre-existing cardiac or renal conditions, the infusion rate may need to be slower to prevent fluid overload.
  • For pediatric patients, the dosage is calculated based on body weight. A common initial dose is 10-20 ml/kg, administered intravenously. The infusion rate should be carefully controlled, and the patient should be closely monitored for signs of fluid overload. It's important to note that HAEMACCEL INJECTION 500 ML should be used with caution in children, and only under the direct supervision of a physician experienced in pediatric fluid resuscitation.
  • It is essential to remember that HAEMACCEL INJECTION 500 ML is a prescription medication and should only be administered by qualified healthcare professionals in a controlled clinical setting. The information provided here is for general knowledge and does not substitute for professional medical advice. Always consult with a physician or other qualified healthcare provider for any questions you may have regarding the appropriate use of HAEMACCEL INJECTION 500 ML. Take 'HAEMACCEL INJECTION 500 ML' only as per the prescription by your physician only.

What if I miss my dose of HAEMACCEL INJECTION 500 ML?Arrow

  • As HAEMACCEL INJECTION 500 ML is administered by a healthcare professional, the chances of missing a dose are low. However, if you believe you may have missed a dose, inform your doctor or healthcare provider immediately. Do not attempt to self-administer if you think a dose was missed.

How to store HAEMACCEL INJECTION 500 ML?Arrow

  • Keep HAEMACCEL INJ 500ML away from the reach of children and pets.
  • Store HAEMACCEL INJ 500ML at room temperature.

Benefits of HAEMACCEL INJECTION 500 MLArrow

  • HAEMACCEL INJECTION 500 ML is a plasma volume expander used to treat and prevent hypovolemia, a condition characterized by a decreased volume of circulating blood in the body. This can occur due to various reasons, including surgery, trauma, burns, infections, and other medical conditions that lead to fluid loss. By increasing the circulating blood volume, HAEMACCEL helps to maintain adequate blood pressure and ensures sufficient oxygen delivery to vital organs.
  • One of the primary benefits of HAEMACCEL is its rapid action in restoring blood volume. When administered intravenously, it quickly expands the plasma volume, leading to improved hemodynamic stability. This is particularly crucial in emergency situations where immediate volume replacement is necessary to prevent organ damage or failure.
  • HAEMACCEL is composed of modified fluid gelatin, which is a synthetic colloid. This composition offers several advantages over other volume expanders. Unlike blood transfusions, HAEMACCEL eliminates the risk of blood-borne infections and transfusion reactions. It is also readily available and does not require blood typing or cross-matching, making it a convenient option in urgent situations.
  • HAEMACCEL supports cardiovascular function by maintaining adequate preload and cardiac output. By increasing the circulating volume, it ensures that the heart has enough blood to pump, thereby improving cardiac efficiency and tissue perfusion. This is particularly important in patients with compromised cardiac function or those undergoing major surgical procedures.
  • The use of HAEMACCEL can reduce the need for allogeneic blood transfusions. By effectively expanding the plasma volume, it minimizes the reliance on donor blood, which can carry risks such as infections and immune reactions. This is especially beneficial for patients who are at high risk of complications from blood transfusions or those who prefer to avoid them for personal or religious reasons.
  • HAEMACCEL has a relatively short half-life compared to other colloids, which means it is cleared from the body more quickly. This can be advantageous in certain clinical situations where prolonged volume expansion is not desired. The shorter duration of action allows for better control over fluid balance and reduces the risk of fluid overload.
  • HAEMACCEL is generally well-tolerated, with a low incidence of adverse reactions. Common side effects are usually mild and transient, such as skin reactions or mild changes in heart rate. Serious allergic reactions are rare, but healthcare providers should monitor patients closely during and after administration.
  • In surgical settings, HAEMACCEL is used to maintain blood volume during and after procedures, especially those involving significant blood loss. It helps to stabilize blood pressure, prevent hypovolemic shock, and ensure adequate oxygen delivery to tissues, thereby promoting faster recovery.
  • HAEMACCEL can also be used in the treatment of dehydration and electrolyte imbalances. By expanding the intravascular volume, it helps to restore fluid balance and improve electrolyte distribution, which is essential for proper cellular function and overall physiological stability.
  • The use of HAEMACCEL is supported by extensive clinical evidence and guidelines. It is a well-established treatment option for hypovolemia and is recommended by various medical organizations for use in appropriate clinical settings. Healthcare providers can rely on its efficacy and safety profile when making treatment decisions.
  • HAEMACCEL comes in a convenient 500 ML infusion bag, which is easy to administer and allows for controlled volume replacement. The packaging ensures sterility and stability of the solution, maintaining its quality and efficacy until the time of use. This makes it a practical choice for hospitals, emergency rooms, and other healthcare facilities.
  • The cost-effectiveness of HAEMACCEL is another significant benefit. Compared to other volume expanders like albumin, HAEMACCEL is generally more affordable. This makes it a valuable option for healthcare providers looking to manage hypovolemia efficiently without incurring excessive costs.

How to use HAEMACCEL INJECTION 500 MLArrow

  • HAEMACCEL INJECTION 500 ML is administered intravenously (IV) by a healthcare professional in a controlled clinical setting. It's crucial that this medication is not self-administered. The dosage and infusion rate are determined by the patient's condition, blood loss, and individual response to treatment. Prior to administration, visually inspect the solution for particulate matter and discoloration. Do not use if the solution is not clear or the container is damaged.
  • Before starting the infusion, ensure that the patient is adequately hydrated. Monitor vital signs, including blood pressure, heart rate, and respiratory rate, throughout the infusion. HAEMACCEL should be warmed to body temperature before administration to minimize the risk of discomfort or complications. Use a dedicated IV line for HAEMACCEL administration, avoiding mixing it with other medications unless compatibility is confirmed.
  • The infusion rate should be carefully controlled, especially in patients with cardiac or pulmonary conditions. Rapid infusion can lead to circulatory overload. The recommended initial infusion rate is slow, gradually increasing as tolerated by the patient. Closely observe the patient for any signs of adverse reactions, such as allergic reactions, flushing, or difficulty breathing. If any adverse reactions occur, discontinue the infusion immediately and initiate appropriate medical management.
  • After the infusion, continue to monitor the patient's vital signs and overall condition. Ensure that the patient remains adequately hydrated. The healthcare provider will assess the effectiveness of the treatment based on the patient's clinical response and laboratory values. Proper documentation of the infusion, including the date, time, dosage, and patient response, is essential.
  • Always follow the specific instructions provided by your doctor or healthcare provider regarding the use of HAEMACCEL INJECTION 500 ML. If you have any questions or concerns, consult with them. This medication is intended for use in hospitals or clinical settings where appropriate monitoring and support are available.

Quick Tips for HAEMACCEL INJECTION 500 MLArrow

  • **Maintain Adequate Hydration:** HAEMACCEL INJECTION 500 ML is often administered to restore blood volume. Ensure you maintain adequate hydration by drinking plenty of fluids as advised by your healthcare provider, especially after the infusion, to support optimal recovery and prevent dehydration-related complications. Staying well-hydrated helps your body adjust to the increased blood volume and promotes overall well-being.
  • **Monitor for Allergic Reactions:** Although rare, allergic reactions can occur with HAEMACCEL INJECTION 500 ML. Watch closely for any signs of allergic reaction such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. Report any such symptoms to your healthcare provider immediately. Prompt medical attention is crucial to manage allergic reactions effectively and prevent serious complications.
  • **Follow Post-Infusion Instructions Carefully:** Your healthcare provider will provide specific instructions to follow after receiving HAEMACCEL INJECTION 500 ML. Adhere to these instructions meticulously, which may include monitoring your blood pressure, heart rate, and urine output. These parameters help assess your response to the treatment and identify any potential issues early on. Regular follow-up appointments are also important to ensure continued monitoring and optimal outcomes.
  • **Understand Potential Side Effects:** Be aware of potential side effects associated with HAEMACCEL INJECTION 500 ML, such as fever, chills, nausea, or headache. While most side effects are mild and transient, it's important to be informed and recognize when medical attention may be necessary. Discuss any concerns or unexpected symptoms with your doctor or nurse promptly. They can provide guidance on managing side effects and ensuring your comfort.
  • **Inform Your Healthcare Provider About Existing Conditions and Medications:** Before receiving HAEMACCEL INJECTION 500 ML, inform your healthcare provider about all existing medical conditions, especially heart, kidney, or lung problems, as well as any medications you are currently taking, including over-the-counter drugs and herbal supplements. This information is crucial for your healthcare provider to assess potential risks and interactions and ensure the safe and effective administration of HAEMACCEL INJECTION 500 ML. This will help in personalizing your treatment plan and maximizing its benefits.

Food Interactions with HAEMACCEL INJECTION 500 MLArrow

  • HAEMACCEL INJECTION 500 ML is generally administered by a healthcare professional and is unlikely to be affected by food intake. No specific food interactions have been identified. Patients can maintain their regular diet unless otherwise advised by their doctor.

FAQs

What is Haemaccel Injection 500ml?Arrow

Haemaccel Injection 500ml is a plasma volume expander used to replace blood volume lost due to surgery, accident, or burns.

What is the active ingredient in Haemaccel Injection 500ml?Arrow

The active ingredient in Haemaccel Injection 500ml is Polygeline.

What is Haemaccel Injection 500ml used for?Arrow

Haemaccel Injection 500ml is used to treat hypovolemia (decreased blood volume), which can be caused by hemorrhage, dehydration, or other medical conditions.

How is Haemaccel Injection 500ml administered?Arrow

Haemaccel Injection 500ml is administered intravenously (IV) by a healthcare professional.

What are the common side effects of Haemaccel Injection 500ml?Arrow

Common side effects of Haemaccel Injection 500ml may include nausea, vomiting, chills, and fever.

Is Haemaccel Injection 500ml safe for pregnant women?Arrow

Limited data is available on the use of Haemaccel Injection 500ml during pregnancy. It should only be used if clearly needed and under medical supervision.

How should Haemaccel Injection 500ml be stored?Arrow

Haemaccel Injection 500ml should be stored at room temperature, away from direct sunlight and heat.

What happens if I overdose on Haemaccel Injection 500ml?Arrow

Overdosing on Haemaccel Injection 500ml can lead to an increase in blood volume, which may cause symptoms such as high blood pressure, difficulty breathing, and heart failure. Seek immediate medical attention if you suspect an overdose.

Can Haemaccel Injection 500ml interact with other medications?Arrow

Haemaccel Injection 500ml can interact with other medications, especially those that affect blood clotting or increase blood pressure. It is important to inform your doctor about all medications you are taking.

Are there any contraindications for the use of Haemaccel Injection 500ml?Arrow

Haemaccel Injection 500ml is contraindicated in individuals with a known allergy to Polygeline or any component of the product, as well as in people with severe heart failure or pulmonary edema.

Can Haemaccel Injection 500ml be used for children?Arrow

Haemaccel Injection 500ml can be used in children, but the dosage should be adjusted based on the child's weight and clinical condition.

What is the brand name for Haemaccel Injection 500ml?Arrow

Haemaccel Injection 500ml is available under the brand name Haemaccel.

Are there any long-term risks associated with the use of Haemaccel Injection 500ml?Arrow

There are no known long-term risks associated with the use of Haemaccel Injection 500ml when used as directed.

Can I administer Haemaccel Injection 500ml myself?Arrow

No, Haemaccel Injection 500ml should only be administered by a healthcare professional.

What should I do if I experience a reaction?Arrow

If you experience symptoms of an allergic reaction after receiving Haemaccel Injection 500ml, such as hives, difficulty breathing, or swelling of the face or throat, seek immediate medical attention.

What is Haemaccel used for?Arrow

Haemaccel is used as a plasma volume expander to treat or prevent low blood volume (hypovolemia) and shock, typically due to blood or plasma loss from trauma, surgery, burns, or severe dehydration. It helps restore and maintain adequate blood pressure and organ perfusion until the underlying cause is addressed and, when necessary, blood products are given.

How does Haemaccel work in the body?Arrow

Haemaccel contains polygeline, a colloid that remains mainly within the blood vessels and exerts an oncotic (osmotic) effect. This draws fluid into the circulation and expands plasma volume, which helps increase blood pressure and improve blood flow to vital organs. It does not replace red blood cells or clotting factors, so it is not a substitute for blood transfusion when those are specifically needed.

Is Haemaccel safe for the liver?Arrow

In patients with normal liver function, Haemaccel is generally considered safe when used under medical supervision. However, in people with significant liver disease, fluid balance, protein metabolism, and coagulation can be altered, so the use of any volume expander, including Haemaccel, requires caution. The doctor will carefully monitor liver function tests, fluid status, and coagulation parameters and may adjust treatment or choose alternative fluids if there is a risk of worsening liver-related complications.

Can Haemaccel affect the kidneys?Arrow

Yes, kidney function is an important consideration when using Haemaccel. Adequate plasma volume can help support kidney perfusion and function, but excessive or inappropriate use may contribute to fluid overload, which can strain the kidneys, especially in patients with pre-existing kidney impairment. In moderate to severe renal dysfunction, Haemaccel should be used with great caution or may be avoided, and kidney function, urine output, and electrolyte levels must be closely monitored during therapy.

Is Haemaccel safe during pregnancy?Arrow

Use of Haemaccel during pregnancy should be based on a careful assessment of risks and benefits by the treating physician. Data in pregnant women are limited, so it is generally reserved for situations where restoring blood volume is clearly necessary for the health of the mother and fetus, such as in significant blood or fluid loss. The lowest effective amount is used, and the mother and fetus are monitored closely. It should not be used routinely in pregnancy without a clear medical indication.

Can Haemaccel be used while breastfeeding?Arrow

Information on the excretion of polygeline into breast milk is limited. Because Haemaccel is given in acute or hospital settings and is largely confined to the intravascular space and then eliminated, it is not expected to pose a major risk to a breastfed infant when used appropriately. However, the decision to use Haemaccel in a breastfeeding woman should be made by the physician, who will weigh the clinical need for volume expansion against any theoretical risks and may advise monitoring the infant for any unusual symptoms.

Can I drive after receiving Haemaccel?Arrow

Haemaccel itself is not known to directly impair the ability to drive or operate machinery. However, the conditions for which it is given—such as shock, major blood loss, or serious illness—as well as associated medications (for example, sedatives, painkillers, or anesthetics) can significantly affect alertness, blood pressure, and coordination. You should not drive or operate machinery until your doctor confirms that your overall condition is stable and it is safe for you to do so.

Is it safe to consume alcohol after Haemaccel infusion?Arrow

There is no specific documented interaction between Haemaccel and alcohol, but alcohol can affect blood pressure, hydration status, liver function, and recovery from illness or surgery. Because Haemaccel is usually given in acute or serious clinical situations, alcohol consumption is generally discouraged during the recovery period. Follow your doctor’s advice, and avoid alcohol until you are fully stable and have been medically cleared to resume normal activities, including drinking alcohol if appropriate.

What allergic reactions can occur with Haemaccel?Arrow

Haemaccel can cause allergic or anaphylactoid reactions in some patients. Symptoms may include skin rash, itching, flushing, hives, swelling of the face or throat, difficulty breathing, wheezing, chest tightness, rapid or weak pulse, low blood pressure, nausea, or vomiting. Severe reactions can progress to anaphylactic shock, which is life-threatening. For this reason, Haemaccel is administered under close medical supervision, usually with monitoring of vital signs, and emergency treatment must be available. If any signs of allergy appear, the infusion is stopped immediately and appropriate therapy is given.

Who should not receive Haemaccel?Arrow

Haemaccel is generally contraindicated in patients with known hypersensitivity to polygeline or any component of the solution, in those with severe fluid overload states such as marked heart failure or pulmonary edema, and in certain severe kidney disorders where fluid excretion is markedly impaired. It should also be avoided or used with extreme caution in patients with severe electrolyte imbalances, uncontrolled bleeding disorders, or conditions where additional volume expansion could be dangerous. The treating physician will evaluate your medical history, current condition, and laboratory results before deciding whether Haemaccel is appropriate.

Does Haemaccel replace the need for a blood transfusion?Arrow

No, Haemaccel does not replace the need for a blood transfusion when there is significant anemia or loss of red blood cells. It expands plasma volume and helps stabilize blood pressure, but it does not provide red blood cells, platelets, or clotting factors. In cases of major blood loss, Haemaccel may be used as part of initial resuscitation, but blood and blood components may still be required to restore oxygen-carrying capacity and correct coagulation abnormalities, as determined by the treating physician.

References

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FDA - Hextend (hetastarch) Label. While not Haemaccel, Hextend contains hetastarch, a similar colloid volume expander. This label provides detailed information on hetastarch including clinical pharmacology, indications, contraindications, warnings, precautions, adverse reactions, and dosage and administration.

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PubMed - Search for 'hetastarch' or 'pentastarch'. PubMed provides access to numerous research articles and studies on hetastarch and pentastarch, the active ingredient in Haemaccel. Search results can provide information on its pharmacology, efficacy, and safety.

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European Medicines Agency (EMA). Search for 'hetastarch' or related terms. EMA provides information on the regulation and approval of medicines in Europe, including scientific guidelines and assessment reports on hetastarch-containing products.

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UpToDate - Search for 'colloid solutions' or 'hetastarch'. UpToDate is a subscription-based resource that provides comprehensive clinical information, including the use of colloid solutions like hetastarch for volume expansion.

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NCBI Bookshelf - 'Intravenous Fluid Therapy'. NCBI Bookshelf contains textbooks and other resources on various medical topics, including intravenous fluid therapy and the use of colloid solutions.

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Ratings & Review

Geniune medicines available at good discounts

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Very good service and discount

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(5/5)


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HAEMACCEL INJECTION 500 ML

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