HUMALOG MIX 50 PENFILL 3 ML

How HUMALOG MIX 50 PENFILL 3 ML Works

• HUMALOG MIX50 PENFILL 3 ML is a premixed insulin analog suspension containing 50% insulin lispro and 50% insulin lispro protamine suspension. This unique formulation combines the rapid onset of action of insulin lispro with the longer-lasting effect of insulin lispro protamine, providing comprehensive blood sugar control throughout the day. Insulin lispro is a rapid-acting insulin analog, meaning it is a modified form of human insulin that is absorbed much faster into the bloodstream. This rapid absorption allows for more flexibility in meal timing, as it can be injected shortly before or after eating. It mimics the natural insulin response of a healthy pancreas more closely than regular human insulin.
• The insulin lispro component of Humalog Mix50 works by binding to insulin receptors on cells throughout the body, particularly in muscle, fat, and liver tissues. This binding triggers a cascade of intracellular events that ultimately lead to the uptake of glucose from the bloodstream into these cells. In muscle and fat cells, glucose is stored as glycogen or triglycerides, respectively, providing a readily available energy source. In the liver, insulin promotes glucose storage as glycogen and inhibits the production of glucose from other sources (gluconeogenesis), further reducing blood sugar levels.
• The insulin lispro protamine suspension component is a modified form of insulin lispro that has been combined with protamine, a protein that slows down its absorption. This results in a longer duration of action, providing a basal level of insulin activity that helps to control blood sugar levels between meals and overnight. The protamine gradually releases the insulin lispro, allowing for a more sustained effect compared to insulin lispro alone. The combination of rapid-acting insulin lispro and intermediate-acting insulin lispro protamine in Humalog Mix50 provides a dual-action effect: the rapid-acting component quickly lowers blood sugar levels after meals, while the intermediate-acting component helps to maintain stable blood sugar levels between meals. This helps reduce the number of injections needed daily and can improve overall blood sugar control. By using Humalog Mix50, patients with diabetes can better manage their blood glucose levels, reducing the risk of both hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar).
• Essentially, HUMALOG MIX50 PENFILL 3 ML mimics the body’s natural insulin release pattern more effectively than traditional insulins. The rapid-acting component handles the glucose surge from meals, while the intermediate-acting component provides background insulin coverage. This combination helps patients achieve better glycemic control, leading to fewer long-term complications associated with diabetes. Always use HUMALOG MIX50 PENFILL 3 ML as prescribed by your healthcare provider to ensure safe and effective blood sugar management.

Like all medicines, Humalog Mix50 Penfill can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Severe hypoglycemia can lead to unconsciousness and, in very rare circumstances, be fatal. * Local allergy: Redness, swelling, or itching at the injection site. * Lipodystrophy: The skin under the injection site may either thicken or shrink. **Uncommon Side Effects (may affect up to 1 in 100 people):** * Systemic allergy: Generalized allergic reaction. **Rare Side Effects (may affect up to 1 in 1,000 people):** * None Reported **Other possible side effects:** * Edema (swelling), particularly of the feet ankles: Some cases of edema have been reported with Humalog Mix50 Penfill. **Important Information:** * If you experience any symptoms of a serious allergic reaction, such as difficulty breathing, wheezing, rapid heartbeat, sweating, or feeling faint, seek medical attention immediately. * Always monitor your blood sugar levels regularly, as directed by your doctor. * Rotate injection sites to help prevent lipodystrophy.

• If you miss a dose of Humalog Mix 50, take your next dose at the regularly scheduled time. Do not double your dose to make up for the forgotten dose. Be aware of how Humalog Mix 50 affects your blood sugar levels and watch for symptoms of high or low blood sugar.

• Keep HUMALOG MIX 50 PENFILL 3ML away from the reach of children and pets.
• Store HUMALOG MIX 50 PENFILL 3ML in a refrigerator (2 - 8°C). Do not freeze.

• Always store your Humalog Mix50 Penfill in the refrigerator (2-8°C or 36-46°F) before first use. Once in use, it can be stored at room temperature (below 30°C or 86°F) for up to 28 days. Discard any unused insulin after 28 days, even if there is insulin left in the penfill. This ensures the potency and effectiveness of the insulin.
• Before each injection, resuspend the insulin properly by gently rolling the pen between your hands 10 times and inverting it 10 times. This ensures that the insulin is uniformly mixed, which is essential for accurate dosing. Do not shake vigorously, as this can cause bubbles or frothing that may affect your dose.
• Administer Humalog Mix50 Penfill 15 minutes before a meal. This timing helps to control your blood sugar levels after eating. Work closely with your healthcare provider to determine the best timing for your injections based on your individual needs and meal plans. Regularly monitor your blood glucose levels to fine-tune the timing and dosage.
• Rotate your injection sites with each dose. Choose a different area within your abdomen, thigh, or upper arm each time you inject. This helps to prevent lipohypertrophy (thickening of the skin) or lipoatrophy (indentation of the skin), which can affect insulin absorption. Consistently rotating sites ensures optimal insulin absorption and reduces the risk of skin complications.
• If you experience any symptoms of hypoglycemia (low blood sugar), such as shakiness, sweating, dizziness, or confusion, immediately consume a fast-acting source of glucose, like juice, glucose tablets, or hard candy. Check your blood sugar level, and if it is still low after 15 minutes, repeat the treatment. Contact your healthcare provider if you experience frequent or severe episodes of hypoglycemia, as your insulin dose may need to be adjusted.

• It is important to have a meal within 15 minutes after injecting Humalog Mix 50 Penfill to avoid low blood sugar.
• The timing of your meal in relation to your injection is crucial for managing your blood sugar levels effectively.
• Consistent meal times and carbohydrate intake are important when using Humalog Mix 50 Penfill to maintain stable blood sugar control.
• Alcohol can affect your blood sugar levels. Consume alcohol cautiously and monitor your blood sugar levels frequently if you drink alcohol while using Humalog Mix 50 Penfill.
• Consult your healthcare provider for personalized advice on how your diet and lifestyle should be adjusted while using Humalog Mix 50 Penfill.