INSUPEN EZ

How INSUPEN EZ Works

• InsuPen EZ is designed for subcutaneous injection of insulin, offering a convenient and precise way to manage blood sugar levels. Its mechanism of action is directly linked to the type of insulin it delivers. Insulin, whether rapid-acting, short-acting, intermediate-acting, or long-acting, essentially replaces or supplements the insulin that the pancreas should be producing.
• Here's how insulin, delivered via InsuPen EZ, works at a cellular level: Insulin binds to receptors on the surface of cells, primarily muscle and fat cells. This binding triggers a cascade of intracellular events, most importantly, the translocation of GLUT4 (glucose transporter type 4) to the cell membrane. GLUT4 acts like a revolving door, facilitating the entry of glucose from the bloodstream into the cell.
• Once inside the cell, glucose is either used immediately for energy production through glycolysis and the Krebs cycle (cellular respiration), or it is stored as glycogen (in the liver and muscles) or as triglycerides (in fat cells). This process lowers blood glucose levels, bringing them back into the normal range. In individuals with diabetes, this process is impaired either due to insufficient insulin production (Type 1 diabetes) or insulin resistance (Type 2 diabetes), making external insulin administration necessary.
• The InsuPen EZ ensures accurate dosing, a critical factor in insulin therapy. By delivering precise units of insulin, it helps prevent hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar). The pen's ease of use also promotes better adherence to the prescribed insulin regimen, leading to improved glycemic control over time.
• Furthermore, different types of insulin have different onset, peak, and duration of action. Rapid-acting insulin works quickly to cover mealtime carbohydrate intake. Short-acting insulin also covers meals, but takes longer to start working. Intermediate-acting insulin provides a basal level of insulin, lasting for about 12-18 hours. Long-acting insulin provides a steady, basal level of insulin for 24 hours or longer. The choice of insulin type and the timing of injections are determined by a healthcare professional based on individual needs and blood glucose monitoring results. InsuPen EZ is compatible with various insulin cartridges, making it a versatile tool for diabetes management.

Like all medicines, INSUPEN EZ can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms may include sweating, shaking, anxiety, blurred vision, rapid heartbeat, dizziness, and hunger. Severe hypoglycemia can lead to unconsciousness and, in very rare cases, can be fatal. * Local injection site reactions: Redness, swelling, itching, or pain at the injection site. * Lipodystrophy: This refers to changes in the fatty tissue under the skin, which can occur at the injection site. It includes lipoatrophy (thinning of the fat) and lipohypertrophy (thickening of the fat). Rotating injection sites can help prevent these changes. **Uncommon side effects (may affect up to 1 in 100 people):** * Allergic reactions: These can include skin rash, itching, hives, and swelling of the face, lips, tongue, or throat. Severe allergic reactions (anaphylaxis) are very rare but can be life-threatening. * Edema: Swelling of the ankles and feet may occur temporarily when starting insulin therapy. **Rare side effects (may affect up to 1 in 1,000 people):** * Systemic allergic reaction: whole body rash with feeling faint **Very rare side effects (may affect up to 1 in 10,000 people):** * Visual impairment: A change in insulin therapy can cause temporary visual impairment, but this is usually short-lived. **Other possible side effects:** * Weight gain: Insulin can cause weight gain. * Peripheral neuropathy: Insulin can cause nerve damage, resulting in pain, numbness, or tingling. **Important Information:** * If you experience any side effects, especially severe allergic reactions or signs of low blood sugar, seek immediate medical attention. * Talk to your doctor or pharmacist if you are concerned about any side effects.

• If you miss a dose of INSUPEN EZ, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of hypoglycemia (low blood sugar).

• Keep INSUPEN EZ 1 away from the reach of children and pets.
• Store INSUPEN EZ 1 at room temperature.

• **Understanding INSUPEN EZ:** INSUPEN EZ is a pre-filled insulin pen designed for convenient and accurate insulin delivery. Familiarize yourself with its components, including the insulin cartridge, dose window, and injection needle.
• **Proper Storage:** Store your INSUPEN EZ in the refrigerator (2°C to 8°C) before first use. Once in use, it can be stored at room temperature (below 30°C) for a specified period (usually 28-30 days), as indicated by the manufacturer. Always protect it from direct sunlight and heat.
• **Priming the Pen:** Before each injection, prime the INSUPEN EZ by dialing 2 units and injecting into the air until a drop of insulin appears. This ensures that the pen is working correctly and delivers an accurate dose. Repeat if necessary until a drop is visible.
• **Choosing the Right Needle:** Use a new needle for each injection to prevent contamination, infection, and lipohypertrophy (thickening of the skin). Consult your healthcare provider for the appropriate needle length and gauge for your needs.
• **Injection Technique:** Inject insulin into the subcutaneous tissue (the layer of fat just under the skin). Rotate injection sites within the same area (e.g., abdomen, thigh, or arm) to prevent lipohypertrophy. Pinch the skin gently before injecting, insert the needle at a 90-degree angle (or 45-degree angle if using a shorter needle), and inject the insulin slowly and steadily. Count to 10 before removing the needle to ensure the full dose is delivered.
• **Dose Accuracy:** Always double-check the dose displayed in the dose window before injecting. If you have any doubts about the accuracy of the dose, do not inject it. Consult your healthcare provider or pharmacist for assistance.
• **Safe Disposal:** Dispose of used needles and INSUPEN EZ pens safely in a sharps container. Do not throw them in the regular trash. Contact your local pharmacy or healthcare provider for information on sharps disposal programs in your area.

• INSUPEN EZ should be administered approximately 15 minutes before or soon after starting a meal. The timing of insulin administration should be coordinated with meal intake to help manage blood sugar levels effectively.
• Consistent meal timing and carbohydrate intake are important when using INSUPEN EZ to avoid fluctuations in blood sugar. Consult your healthcare provider for personalized advice on meal planning and insulin dosage.
• Be cautious about consuming alcohol while using INSUPEN EZ, as alcohol can affect blood sugar levels. It may initially cause hyperglycemia and later lead to hypoglycemia. Monitor your blood sugar levels closely if you consume alcohol.