INTAGESIC MR TABLET 10'S

How INTAGESIC MR TABLET 10'S Works

• INTAGESIC MR TABLET 10'S is a combination medicine designed to alleviate pain and muscle spasms. It contains three active ingredients: Aceclofenac, Paracetamol, and Chlorzoxazone, each contributing uniquely to its therapeutic effect.
• Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain, inflammation, and fever. By reducing prostaglandin synthesis, Aceclofenac helps to alleviate pain and inflammation at the site of injury or inflammation. Specifically, it blocks the cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are responsible for prostaglandin production. While both COX-1 and COX-2 are inhibited, the anti-inflammatory effects are primarily attributed to COX-2 inhibition. This targeted inhibition helps reduce inflammation and pain associated with musculoskeletal conditions.
• Paracetamol, also known as acetaminophen, is an analgesic and antipyretic (fever reducer). Its mechanism of action is not fully understood, but it is believed to primarily work by inhibiting prostaglandin synthesis in the central nervous system (brain and spinal cord). Unlike NSAIDs, Paracetamol has minimal anti-inflammatory effects. It mainly reduces pain and fever by affecting the pain threshold and regulating body temperature. Paracetamol is particularly effective in managing mild to moderate pain and is often used in combination with NSAIDs to provide enhanced pain relief.
• Chlorzoxazone is a muscle relaxant that acts on the central nervous system to relieve muscle spasms and stiffness. Its exact mechanism of action is not completely understood, but it is thought to work by depressing reflexes within the spinal cord and subcortical areas of the brain. By reducing nerve impulses that cause muscle contractions, Chlorzoxazone helps to relax muscles and relieve associated pain and discomfort. This muscle-relaxing effect is particularly beneficial in conditions involving muscle spasms, such as back pain, neck pain, and muscle strains.
• In summary, INTAGESIC MR TABLET 10'S works through the combined actions of Aceclofenac, Paracetamol, and Chlorzoxazone. Aceclofenac reduces pain and inflammation by inhibiting prostaglandin synthesis. Paracetamol alleviates pain and fever by acting on the central nervous system. Chlorzoxazone relaxes muscles by depressing reflexes in the spinal cord and brain. Together, these ingredients provide comprehensive relief from pain, inflammation, and muscle spasms, making INTAGESIC MR TABLET 10'S an effective treatment for various musculoskeletal conditions.

Common side effects of INTAGESIC MR Tablet may include nausea, vomiting, stomach pain, heartburn, diarrhea, loss of appetite, drowsiness, dizziness, headache, and dry mouth. Less common side effects could involve allergic reactions (rash, itching, swelling), increased sweating, muscle weakness, blurred vision, difficulty sleeping, nervousness, confusion, anxiety, and ringing in the ears (tinnitus). In rare cases, serious side effects such as liver problems (dark urine, yellowing of skin/eyes), kidney issues (change in urine amount), stomach ulcers, bleeding, or severe allergic reactions (anaphylaxis) may occur. Consult your doctor if you experience any persistent or severe side effects.

• If you miss a dose of Intagesic MR Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep INTAGESIC MR TAB 1X10 away from the reach of children and pets.
• Store INTAGESIC MR TAB 1X10 at room temperature.

• Take INTAGESIC MR TABLET 10'S exactly as prescribed by your doctor. Do not exceed the recommended dosage or frequency, as this can increase the risk of side effects. It's generally advised to take it after food to minimize stomach upset.
• INTAGESIC MR contains a muscle relaxant. Avoid activities requiring alertness, such as driving or operating machinery, until you know how the medicine affects you. Drowsiness or dizziness are common side effects, especially when starting treatment.
• Inform your doctor about all other medications, including over-the-counter drugs, herbal remedies, and supplements, you are currently taking. INTAGESIC MR can interact with other medicines, potentially altering their effects or increasing the risk of adverse reactions. Especially mention if you are taking any other pain relievers or muscle relaxants.
• If you experience any unusual or severe side effects while taking INTAGESIC MR, such as allergic reactions (rash, itching, swelling), severe stomach pain, or changes in bowel habits, consult your doctor immediately. Do not ignore persistent or worsening symptoms.
• Store INTAGESIC MR at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets. Properly dispose of any unused medication; do not flush it down the toilet or pour it down the drain. Contact your pharmacist for guidance on safe disposal methods.

• While taking INTAGESIC MR TABLET 10'S, be mindful of your diet. It's generally best to take this medication after meals to minimize any potential stomach upset. Avoid consuming large amounts of alcohol, as it can increase the risk of liver problems and intensify drowsiness. If you have any specific dietary concerns or conditions, consult your doctor or pharmacist for personalized advice.