KADCYLA 160MG INJECTION
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KADCYLA 160MG INJECTION
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KADCYLA 160MG INJECTION

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KADCYLA 160MG INJECTION

By ROCHE PRODUCTS INDIA PRIVATE LIMITED

MRP

275211

₹229270

16.69 % OFF

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Product Details
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About KADCYLA 160MG INJECTION

  • KADCYLA 160MG INJECTION contains the active medicine called Ado-Trastuzumab emtansine. This is a special kind of treatment used for breast cancer that is HER2-positive. HER2-positive means the cancer cells have too much of a protein called HER2 on their surface, which helps them grow. KADCYLA is typically used when the cancer has spread to other parts of the body (metastatic) or when other standard treatments haven't worked well.
  • KADCYLA works in a unique way. It combines two parts: trastuzumab, which is like a guide that finds the HER2 protein on cancer cells, and emtansine, which is a powerful chemotherapy drug. The trastuzumab part attaches to the HER2 protein, and this allows the emtansine part to enter the cancer cell directly. This way, the chemotherapy drug is delivered right to the cancer cell, helping to kill it while potentially causing less harm to healthy cells compared to traditional chemotherapy.
  • This medication is also used for patients who still have some cancer remaining (residual disease) after receiving surgery and standard treatments including chemotherapy and other HER2-targeted therapies. Having residual disease can mean the cancer might return, so KADCYLA is given to help reduce this risk. It's given as an infusion into a vein, usually every three weeks, but your doctor will decide the best schedule for you.
  • Like any medication, KADCYLA can cause side effects. It's very important to tell your doctor or nurse right away if you experience any serious symptoms, such as signs of an allergic reaction (rash, swelling, trouble breathing), unusual bleeding or bruising, or severe liver problems (yellowing of skin/eyes, dark urine, severe stomach pain). Less common but potential serious side effects can include heart problems or lung issues.
  • More common side effects are usually less severe and might include tiredness (fatigue), nausea, vomiting, diarrhea, constipation, headache, mouth sores, joint pain, and changes in liver function tests (shown in blood tests). Hair loss is possible but often less common or severe than with some other chemotherapy drugs. While the original content mentioned no kidney adverse effects, it's still crucial to monitor overall health during treatment. Always discuss any concerns with your healthcare team.

Uses of KADCYLA 160MG INJECTION

  • Advanced and metastatic breast cancer
  • Metastatic gastric cancer

Side Effects of KADCYLA 160MG INJECTION
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Side effects are unwanted symptoms caused by medicines. While all medicines can cause side effects, not everyone experiences them. KADCYLA 160MG INJECTION may cause the following side effects:

Safety Advice for KADCYLA 160MG INJECTION
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Pregnancy

Unsafe

Discuss with your physician before taking this KADCYLA 160MG INJECTION if you are pregnant or think you might be pregnant. Do not take this medicine during the pregnancy unless advised by the doctor to take as it may cause harm to the unborn baby.

Dosage of KADCYLA 160MG INJECTION
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  • KADCYLA 160MG INJECTION is a powerful medication that is always given by a trained healthcare professional, such as a doctor or nurse. You will receive this injection in a hospital or clinic setting where they can properly prepare and administer it, and also monitor you. The exact amount of KADCYLA 160MG INJECTION you receive, and how often you get it, is very carefully decided. It's not a one-size-fits-all dose. Your medical team will consider important things like your age, your body weight, your overall health condition, and precisely what type and how advanced your cancer is. This personalized approach helps ensure the treatment is as effective and safe as possible for you. It's crucial to stick to your scheduled appointments for this medication. However, sometimes life happens, and a dose might be missed. If you realize you've missed a dose, contact your healthcare provider as soon as possible. They will advise you on the best course of action. Generally, if it's soon after the missed dose, you might be able to receive it. But if it's very close to your next scheduled dose, they might tell you to skip the missed one and just continue with your regular schedule. It is very important not to take a double dose to catch up. Taking more than prescribed can be harmful and does not improve treatment outcomes. Always follow your healthcare team's instructions regarding your dosing schedule and missed doses.

How to store KADCYLA 160MG INJECTION?
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  • Keep KADCYLA 160MG INJ away from the reach of children and pets.
  • Store KADCYLA 160MG INJ in a refrigerator (2 - 8°C). Do not freeze.

Benefits of KADCYLA 160MG INJECTION
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  • KADCYLA 160MG INJECTION, also known as Ado-Trastuzumab emtansine, offers a highly targeted way to fight cancer, particularly in patients with HER2-positive tumours. Its unique design acts like a guided missile: the trastuzumab part is an antibody specifically engineered to find and attach itself to the HER2 protein found on the surface of certain cancer cells. Once it's locked onto the cancer cell, the entire drug complex is taken inside. Inside the cell, the chemotherapy drug emtansine, which was attached to trastuzumab, is released. This powerful drug then goes to work directly inside the cancer cell, disrupting its ability to grow and divide, ultimately leading to the cell's destruction. Because emtansine is primarily released *inside* the cancer cell that the trastuzumab targeted, less of the chemotherapy drug reaches healthy cells compared to traditional chemotherapy, potentially reducing some side effects while effectively shrinking tumours and helping patients live longer.

How to use KADCYLA 160MG INJECTION
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  • KADCYLA 160MG INJECTION is a powerful medicine given directly into a vein. This injection is always administered by a trained healthcare professional, usually in a hospital or clinic setting. You won't administer this medication yourself.
  • Your doctor will carefully determine the right dose and how often you receive KADCYLA 160MG INJECTION. This decision is personal and depends on many things, such as your age, weight, overall health condition, and importantly, the specific type and stage of the cancer being treated. They will create a treatment plan tailored just for you.
  • It's very important to stick to your scheduled appointments for this injection. However, if you happen to miss a scheduled dose, contact your healthcare team immediately. They will advise you on what to do. Generally, if you remember soon after the missed appointment, they might schedule you to receive it as soon as possible. But if it's almost time for your next scheduled dose, you will likely be told to skip the missed one and just continue with your regular schedule. Never double up on doses to catch up, as this could be harmful. Your healthcare provider is the best person to guide you on managing missed doses safely within your treatment plan.

FAQs

Can KADCYLA 160MG INJECTION cause nerve damage?

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KADCYLA 160MG INJECTION can cause peripheral neuropathy, a type of nerve damage that can cause tingling, numbness, or weakness in the hands and feet. If you experience these symptoms during treatment, discuss them with your healthcare provider.

Does KADCYLA 160MG INJECTION cause infertility?

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KADCYLA 160MG INJECTION can cause temporary infertility in some patients, particularly women. If fertility preservation is a concern for you, discuss this with your healthcare provider before starting treatment.

How is KADCYLA 160MG INJECTION different from traditional chemotherapy?

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KADCYLA 160MG INJECTION is a type of chemotherapy, but it is designed to target HER2-positive cancer cells specifically, which may result in fewer side effects than traditional chemotherapy. Additionally, it is given as a single medication, rather than as a combination of drugs.

Can KADCYLA 160MG INJECTION be used in combination with other cancer treatments?

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KADCYLA 160MG INJECTION may be used in combination with other cancer treatments, such as chemotherapy or targeted therapies. Your healthcare provider can help determine the best treatment plan for you based on your individual needs and medical history.

Can I take KADCYLA 160MG INJECTION if I have tuberculosis?

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The use of KADCYLA 160MG INJECTION in patients with active tuberculosis (TB) is not recommended due to the risk of worsening the TB infection. This medication can suppress the immune system, making it harder for the body to fight off infections such as TB. Before starting treatment, your healthcare provider will perform a thorough evaluation of your medical history, including screening for TB.

Can KADCYLA 160MG INJECTION cause heart problems?

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KADCYLA 160MG INJECTION can cause heart problems, particularly in patients with preexisting heart conditions or risk factors. Your healthcare provider will monitor your heart function closely during the treatment.

Does KADCYLA 160MG INJECTION interact with other medicines?

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KADCYLA 160MG INJECTION may interact with other medicines. It is important to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements, to avoid potential interactions.

What important advice should I follow while taking KADCYLA 160MG INJECTION?

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If you are receiving KADCYLA 160MG INJECTION, it's important to be proactive in managing your treatment and monitoring your symptoms. Keep communication with your healthcare provider and report any concerns or side effects as soon as possible. Avoid getting pregnant and breastfeeding during treatment. Use effective birth control during the treatment and at least 7 weeks after the last dose. Immediately contact your healthcare provider in case of any worsening of symptoms or infusion reactions. Take steps to care for yourself physically and emotionally during treatment, and seek support from loved ones and professionals as needed. Maintain a healthy and balanced diet during treatment to support your overall health and well-being. Being informed and engaged in your treatment can help ensure the best possible outcomes and manage potential risks or complications.

What is KADCYLA 160MG INJECTION made of?

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KADCYLA 160MG INJECTION is made using the molecule/combination called ADO-TRASTUZUMAB EMTANSINE.

What is KADCYLA 160MG INJECTION prescribed for?

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KADCYLA 160MG INJECTION is prescribed for treating certain types of cancer (anti-cancer).

How does KADCYLA 160MG INJECTION work against cancer?

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KADCYLA 160MG INJECTION is designed to target specific cancer cells to help treat the disease.

References

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Roche Products Limited, Electronic Medicines Compendium (EMC)

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Gunter von Minckwitz et al., Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer, N Engl J Med 2019; 380:617-628

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Barok et al., Trastuzumab emtansine: mechanisms of action and drug resistance, Breast Cancer Research 2014, 16:209

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Genentech, Inc. U.S Food and Drug Administration (FDA)

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Marketer / Manufacturer Details

ROCHE PRODUCTS INDIA PRIVATE LIMITED

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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