KNILONAT 200 CAPSULE 10'S
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KNILONAT 200 CAPSULE 10'S
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KNILONAT 200 CAPSULE 10'S

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KNILONAT 200 CAPSULE 10'S

By NATCO PHARMA LIMITED

MRP

1200

₹960

20 % OFF

₹96 Only /

CAPSULE

10

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Composition

Product DetailsArrow

About KNILONAT 200 CAPSULE 10'S

  • KNILONAT 200 CAPSULE 10'S contains Nilotinib, an antineoplastic drug belonging to the tyrosine kinase inhibitor class. It is prescribed for treating Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), a type of blood cancer characterized by an overproduction of white blood cells. This medication is suitable for adult and pediatric patients newly diagnosed with CML, as well as those experiencing adverse effects from prior treatments or who no longer respond to Imatinib.
  • Before taking KNILONAT 200 CAPSULE 10'S, inform your doctor if you are allergic to Nilotinib or any inactive ingredients in the capsule. Disclose any history of heart conditions, such as heart attack, abnormal electrical signals, chest pain, stroke, or claudication (reduced blood flow in the legs). Also, notify your doctor if you have liver or pancreas disorders, or if you experience low potassium or magnesium levels. It's crucial to discuss all current medications with your doctor, particularly those aimed at lowering blood cholesterol. Be sure to mention any pre-existing conditions, especially if you have a history of hepatitis B infection, as this medication can reactivate the virus, potentially leading to severe complications. Avoid grapefruit and grapefruit juice consumption during treatment. Inform your doctor if you have any sugar intolerances, as this medicine contains lactose.
  • During treatment with KNILONAT 200 CAPSULE 10'S, regular blood tests will be conducted to monitor your liver and pancreas function, blood cell counts (white blood cells, red blood cells, and platelets), heart condition (QT interval prolongation), electrolyte levels, and sugar and fat levels. These tests help assess how well you are tolerating the medication. If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor immediately. It is essential to use effective birth control methods while taking this medicine to prevent pregnancy. This medicine may cause serious harm to the fetus.

Uses of KNILONAT 200 CAPSULE 10'S

  • Treatment of blood cancer (Philadelphia chromosome-positive chronic myeloid leukemia) in adult and pediatric patients.

Side Effects of KNILONAT 200 CAPSULE 10'SArrow

Side effects are unwanted symptoms caused by medicines, though not everyone experiences them. **Serious** side effects include sudden weight gain, swelling in hands, feet, ankles, or face, chest pain, blood pressure changes (high and low), blue discoloration of tongue, lips, or skin, abnormal heart rhythm, hair loss, vision problems, stomach pain, vomiting blood or blood in stools, yellowing of skin/eyes and dark urine, high blood sugar, and light sensitivity. **Common** side effects include nausea, vomiting, diarrhea, headache, muscle pain, stomach pain, hair loss, tiredness, constipation, slowed growth in children, pneumonia, loss of appetite, sleeplessness, depression, anxiety, stomach discomfort like bloating and flatulence after meals, and musculoskeletal pain.

  • Sudden weight gain
  • Swelling in hands, feet, ankles, or face
  • Chest pain
  • Blood pressure (high and low)
  • Discoloration of tongue, lips, or skin (blue)
  • Abnormal heart (irregular heartbeat)
  • Hair loss
  • Vision problem
  • Stomach pain, vomiting of blood, blood in stools.
  • Yellowing of the skin, eyes, and dark urine.
  • High blood sugar levels.
  • Sensitivity to light
  • Nausea, vomiting, diarrhoea.
  • Headache, muscle pain, stomach pain.
  • Hair loss.
  • Tiredness.
  • Constipation.
  • Slowing of growth in children.
  • Pneumonia.
  • Loss of appetite.
  • Sleeplessness, depression, and anxiety.
  • Stomach discomforts like bloating and flatulence after meals.
  • musculoskeletal pain

Safety Advice for KNILONAT 200 CAPSULE 10'SArrow

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Pregnancy

UNSAFE

KNILONAT 200 CAPSULE 10'S is unsafe to use during pregnancy unless it is necessary. Report to your doctor if you are pregnant or think you may be pregnant, or planning for the pregnancy before starting the treatment; your doctor will tell you whether you can take this medicine during your pregnancy.

Dosage of KNILONAT 200 CAPSULE 10'SArrow

  • Take KNILONAT 200 CAPSULE 10'S exactly as your doctor has prescribed. It is important to adhere to their instructions regarding dosage and frequency. Generally, you should swallow the capsule whole with a glass of water. Avoid crushing, chewing, or breaking the capsule, as this could affect how the medication is released and absorbed by your body. The specific dosage and duration of treatment will be determined by your doctor, taking into account factors such as your age, body weight, and the severity of your medical condition. It's crucial to complete the full course of treatment, even if you start feeling better, unless your doctor specifically advises you to stop. Discontinuing the medication prematurely could lead to a recurrence of the infection or the development of antibiotic resistance. If you have any questions or concerns about how to take KNILONAT 200 CAPSULE 10'S, don't hesitate to ask your doctor or pharmacist for clarification.
  • Remember to maintain consistency in taking your medication to ensure optimal effectiveness. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one. If you have any concerns about a missed dose, consult with your healthcare provider.

How to store KNILONAT 200 CAPSULE 10'S?Arrow

  • Keep KNILONAT 200MG CAP 1X10 away from the reach of children and pets.
  • Store KNILONAT 200MG CAP 1X10 at room temperature.

Benefits of KNILONAT 200 CAPSULE 10'SArrow

  • In Chronic Myelogenous Leukemia (CML), the BCR-ABL tyrosine kinase protein drives the excessive and uncontrolled proliferation of cells. KNILONAT 200 CAPSULE 10'S works by precisely targeting this aberrant protein. It acts as a tyrosine kinase inhibitor, specifically disrupting the signaling pathways that BCR-ABL utilizes to stimulate cell growth and division. By blocking these signals, KNILONAT 200 CAPSULE 10'S effectively halts the runaway growth of cancerous cells characteristic of CML.
  • Specifically, KNILONAT 200 CAPSULE 10'S binds to the ATP-binding site on the BCR-ABL protein. ATP (adenosine triphosphate) is the energy source that fuels the kinase activity. By occupying this site, KNILONAT 200 CAPSULE 10'S prevents ATP from binding and thus inhibits the BCR-ABL protein's ability to phosphorylate its target proteins. This phosphorylation is a crucial step in the signaling cascade that leads to uncontrolled cell growth.
  • Ultimately, by disrupting the BCR-ABL signaling pathway, KNILONAT 200 CAPSULE 10'S induces apoptosis (programmed cell death) in CML cells and reduces the spread of cancer. This mechanism of action makes it a vital treatment option for individuals diagnosed with CML, helping to improve their prognosis and quality of life.

How to use KNILONAT 200 CAPSULE 10'SArrow

  • Always take KNILONAT 200 CAPSULE 10'S exactly as your doctor has instructed. It's crucial to adhere to their guidance on dosage and timing for the best possible outcome. Typically, you'll swallow the capsule whole with a glass of water.
  • Avoid crushing, chewing, or opening the capsule, as this could affect how the medication is released and absorbed by your body. The capsule is designed for a specific release mechanism, and altering it can change the drug's effectiveness.
  • The dosage and duration of treatment will be determined by your doctor, considering factors such as your age, body weight, and the specific condition being treated. It is essential to follow their prescribed regimen precisely.
  • Do not stop taking KNILONAT 200 CAPSULE 10'S prematurely, even if you start feeling better. Completing the full course of treatment is essential to fully address the underlying medical issue. If you have any concerns or wish to discontinue the medication, consult your doctor for guidance.

FAQs

Can KNILONAT 200 CAPSULE 10'S cause liver damage?Arrow

KNILONAT 200 CAPSULE 10'S may cause liver function abnormalities, which may indicate liver damage. It is important to have regular blood tests to monitor your liver function while taking KNILONAT 200 CAPSULE 10'S. If you experience symptoms of liver damage, such as jaundice or abdominal pain, you should contact your doctor immediately.

How does KNILONAT 200 CAPSULE 10'S differ from other medications used to treat chronic myeloid leukemia, such as Imatinib?Arrow

Imatinib, in its selectivity and potency. KNILONAT 200 CAPSULE 10'S is more selective for the BCR-ABL protein that drives the growth of cancer cells, and it is more potent in inhibiting the activity of this protein. Kylonib 200mg has also been shown to be effective in patients who have developed resistance to Imatinib.

What are the potential long-term effects of KNILONAT 200 CAPSULE 10'S on the body?Arrow

The potential long-term effects of KNILONAT 200 CAPSULE 10'S on the body include cardiovascular events, such as hypertension, arrhythmias, and heart failure, as well as liver dysfunction, pancreatic enzyme elevation, and fluid retention. These side effects are generally rare, but they can occur in some patients.

How to monitor the effects of KNILONAT 200 CAPSULE 10'S over the course of treatment?Arrow

It is monitored through regular blood tests, electrocardiograms, and imaging studies. Blood tests can assess liver and kidney function, blood counts, and electrolyte levels. ECG can detect any changes in heart rhythm or function. Imaging studies, such as echocardiograms and chest X-rays, can evaluate the heart and lungs for any signs of damage or fluid accumulation.

Who should not take KNILONAT 200 CAPSULE 10'S?Arrow

KNILONAT 200 CAPSULE 10'S should not be taken by pregnant or breastfeeding women, or by people with certain medical conditions such as severe liver or kidney disease, a history of pancreatitis, or a prolonged QT interval.

Is there any interaction of KNILONAT 200 CAPSULE 10'S with other drugs?Arrow

NULL interaction of KNILONAT 200 CAPSULE 10'S with other drugs

What is the advice for taking KNILONAT 200 CAPSULE 10'S?Arrow

Based on your condition your doctor may prescribe a lower dose. KNILONAT 200 CAPSULE 10'S can be used by people aged 65 years and over with the same dose as other adults. Tell your doctor if you experience any irregular heartbeats or any signs of a heart condition because this can lead to serious complications like sudden death. Inform your physician if you have kidney problems. Your physician will decide whether you may receive this medication after monitoring your kidney functions. Some children and adolescents taking this medicine may have slower than normal growth. So, your doctor will regularly monitor your growth. Report to your doctor if you have had a history of heart failure or hepatitis infection. Discuss effective contraceptive options with your healthcare provider.

Which molecule/combination is used for making KNILONAT 200 CAPSULE 10'S?Arrow

NILOTINIB is molecule/combination used for making KNILONAT 200 CAPSULE 10'S.

For what ailments/diseases/conditions is KNILONAT 200 CAPSULE 10'S prescribed?Arrow

KNILONAT 200 CAPSULE 10'S is prescribed for ailments/diseases/conditions related to Oncology.

References

Book Icon

Robert J. Thomson; Majid Moshirfar; Yasmyne Ronquillo; Tyrosine Kinase Inhibitors

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Novartis Pharmaceuticals UK Ltd, Electronic Medicines Compendium (EMC)

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Novartis, US Food & Drug Administration

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Marketer / Manufacturer Details

NATCO PHARMA LIMITED

Country of Origin -

India

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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