KOMBIGLYZE XR 5/1000MG TABLET 7'S

How KOMBIGLYZE XR 5/1000MG TABLET 7'S Works

• KOMBIGLYZE XR 5/1000MG TABLET 7'S is a combination medication containing two active ingredients: Metformin and Saxagliptin. These two medications work together through distinct mechanisms to help lower blood sugar levels in individuals with type 2 diabetes.
• Metformin, a biguanide, primarily works by reducing glucose production in the liver. The liver is a major source of glucose in the body, and Metformin helps to decrease the amount of glucose released into the bloodstream. Additionally, Metformin enhances insulin sensitivity in peripheral tissues, such as muscles. This means that the body's cells become more responsive to insulin, allowing them to take up glucose more effectively from the blood. Metformin may also slightly decrease glucose absorption in the intestines. It does not typically cause hypoglycemia (low blood sugar) when used alone because it does not stimulate insulin secretion directly.
• Saxagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, functions differently. DPP-4 is an enzyme that breaks down incretin hormones in the body. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), play a crucial role in regulating blood sugar levels. They stimulate insulin release from the pancreas in response to meals and also reduce glucagon secretion, which is a hormone that raises blood sugar. By inhibiting DPP-4, Saxagliptin increases the levels of active incretin hormones in the body. This leads to increased insulin release when blood sugar is high and decreased glucagon secretion. The overall effect is better blood sugar control, particularly after meals.
• In summary, KOMBIGLYZE XR combines the actions of Metformin, which reduces glucose production in the liver and improves insulin sensitivity, with Saxagliptin, which enhances the effects of incretin hormones to increase insulin release and reduce glucagon secretion. This dual mechanism of action provides a more comprehensive approach to managing blood sugar levels in individuals with type 2 diabetes compared to using either medication alone. The 'XR' in the name stands for extended release, meaning the medication is released slowly into the body over time, providing a more consistent effect.

Common side effects of KOMBIGLYZE XR 5/1000MG TABLET may include nausea, vomiting, diarrhea, stomach upset, metallic taste, and loss of appetite. Some individuals may experience hypoglycemia (low blood sugar), especially when taken with other diabetes medications. Symptoms of hypoglycemia can include shakiness, sweating, anxiety, blurred vision, rapid heartbeat, and confusion. Upper respiratory tract infection symptoms include cough, sneezing, and sore throat, headache, weakness, or fatigue. Serious side effects can include lactic acidosis (symptoms include muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, feeling dizzy, lightheaded, or very weak, stomach pain, nausea with vomiting, and slow or irregular heart rate), pancreatitis (severe pain in your upper stomach spreading to your back, nausea, and vomiting), and allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing). Changes in kidney function tests may also occur. This is not an exhaustive list; consult your doctor for complete information.

• If you miss a dose of KOMBIGLYZE XR 5/1000MG TABLET 7'S, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep KOMBIGLYZE XR 5/1000MG TAB 1X7 away from the reach of children and pets.
• Store KOMBIGLYZE XR 5/1000MG TAB 1X7 at room temperature.

• Take KOMBIGLYZE XR 5/1000MG TABLET 7'S exactly as prescribed by your doctor. Do not crush, chew, or break the tablet, swallow it whole with a full glass of water. Consistency is key, so take it at the same time each day to maintain stable blood sugar levels. This helps your body respond optimally to the medication.
• KOMBIGLYZE XR 5/1000MG TABLET 7'S is most effective when taken with meals. Food helps to regulate the absorption of the medication and minimizes potential gastrointestinal side effects. Discuss your diet with your healthcare provider or a registered dietitian to create a meal plan that complements your medication and supports overall blood sugar control. Consistent carbohydrate intake is also important.
• Stay well-hydrated throughout the day while taking KOMBIGLYZE XR 5/1000MG TABLET 7'S. Drinking plenty of water helps your kidneys function properly, which is essential for eliminating waste products and maintaining overall health. Proper hydration can also help prevent certain side effects associated with the medication. Aim for at least 8 glasses of water daily, adjusting for activity levels and climate.
• Monitor your blood sugar levels regularly as directed by your healthcare provider. Keeping a record of your blood sugar readings will help you and your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan. Be sure to share these readings during your regular check-ups.
• Be aware of the symptoms of hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar). KOMBIGLYZE XR 5/1000MG TABLET 7'S can affect your blood sugar levels, so it's important to recognize the signs of both conditions. Symptoms of hypoglycemia include shakiness, sweating, dizziness, and confusion. Hyperglycemia symptoms include increased thirst, frequent urination, and blurred vision. If you experience any of these symptoms, contact your doctor immediately.
• Inform all your healthcare providers that you are taking KOMBIGLYZE XR 5/1000MG TABLET 7'S before any surgery or medical procedure. This medication can interact with certain anesthetics and other medications, so it's important for your medical team to be aware of your complete medical history and current medications. This helps prevent any potential complications during the procedure.
• Maintain a healthy lifestyle by incorporating regular exercise into your routine. Physical activity can help improve insulin sensitivity, lower blood sugar levels, and promote overall well-being. Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Consult with your doctor before starting any new exercise program.

• KOMBIGLYZE XR 5/1000MG TABLET 7'S should be taken with food to decrease the chance of an upset stomach. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of lactic acidosis. Be consistent with your diet and inform your doctor about any significant changes in your eating habits.