KOMBIGLYZE XR 5/500MG TABLET 7'S

How KOMBIGLYZE XR 5/500MG TABLET 7'S Works

• KOMBIGLYZE XR 5/500MG TABLET 7'S is a combination medication containing two active ingredients: saxagliptin and metformin hydrochloride. These two medications work together through different mechanisms to help lower blood sugar levels in individuals with type 2 diabetes. Let's explore how each component contributes to the overall effect:
• **Metformin Hydrochloride:** Metformin is a biguanide antidiabetic agent that primarily works by reducing glucose production in the liver. Specifically, it: * Decreases hepatic glucose production: Metformin suppresses gluconeogenesis, the process by which the liver produces glucose from non-carbohydrate sources. By inhibiting this process, metformin lowers the amount of glucose released into the bloodstream. * Increases insulin sensitivity: Metformin enhances the sensitivity of peripheral tissues (such as muscles) to insulin. This means that insulin can more effectively facilitate the uptake of glucose from the blood into these tissues, where it can be used for energy. * Slows down glucose absorption in the intestines: Metformin can slightly reduce the absorption of glucose from the small intestine into the bloodstream after a meal.
• **Saxagliptin:** Saxagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 inhibitors work by increasing the levels of incretin hormones in the body. Incretin hormones, such as glucagon-like peptide-1 (GLP-1), play a role in regulating blood sugar levels. Saxagliptin functions by: * Inhibiting DPP-4 enzyme: Saxagliptin inhibits the DPP-4 enzyme, which is responsible for breaking down incretin hormones. By inhibiting DPP-4, saxagliptin increases the levels of active incretin hormones in the body. * Enhancing insulin release: Increased levels of incretin hormones stimulate the pancreas to release more insulin in response to elevated blood glucose levels, particularly after meals. * Decreasing glucagon secretion: Incretin hormones also suppress the secretion of glucagon, a hormone that raises blood glucose levels. By reducing glucagon secretion, saxagliptin helps to further lower blood sugar levels.
• **Synergistic Effect:** When combined, metformin and saxagliptin provide a synergistic effect in managing blood sugar levels. Metformin reduces glucose production and improves insulin sensitivity, while saxagliptin enhances insulin release and reduces glucagon secretion. This combination helps to address multiple aspects of glucose control in type 2 diabetes.
• It's important to note that KOMBIGLYZE XR 5/500MG TABLET 7'S is typically used in conjunction with lifestyle modifications such as diet and exercise to achieve optimal blood sugar control. It is crucial to take this medication as prescribed by your healthcare provider and to follow their recommendations for diet, exercise, and blood sugar monitoring.

Common side effects of Kombiglyze XR 5/500mg Tablet may include nausea, vomiting, diarrhea, stomach upset, metallic taste, and loss of appetite. Some individuals might experience hypoglycemia (low blood sugar), especially when taken with other diabetes medications. Symptoms of hypoglycemia can include shakiness, sweating, anxiety, blurred vision, tingling lips, paleness, cold sweat, drowsiness. Upper respiratory tract infection, headache, and weakness are also reported. Less common but serious side effects can include lactic acidosis (symptoms like muscle cramps, difficulty breathing, abdominal pain, and weakness), pancreatitis, and allergic reactions (rash, itching, swelling). Kidney problems and liver problems, although rare, can also occur. Vitamin B12 deficiency may also occur with long-term use. It is important to consult your doctor if you experience any persistent or severe side effects.

• If you miss a dose of KOMBIGLYZE XR 5/500MG TABLET 7'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep KOMBIGLYZE XR 5/500MG TAB 1X7 away from the reach of children and pets.
• Store KOMBIGLYZE XR 5/500MG TAB 1X7 at room temperature.

• **Take KOMBIGLYZE XR consistently:** For optimal blood sugar control, take KOMBIGLYZE XR 5/500MG TABLET 7'S at the same time each day, preferably with your evening meal. This helps maintain steady levels of medication in your body and maximizes its effectiveness. Consistency is key to managing your blood sugar levels effectively. Don't skip doses, and if you do, take it as soon as you remember, unless it's almost time for your next dose.
• **Follow Dietary Guidelines:** Enhance the effects of KOMBIGLYZE XR by adhering to a balanced diet rich in fiber, fruits, and vegetables. Limit your intake of processed foods, sugary drinks, and saturated fats. Working with a registered dietitian or nutritionist can provide personalized meal plans that complement your medication and help you achieve better glycemic control. Remember, medication works best when combined with a healthy lifestyle.
• **Monitor Blood Sugar Regularly:** Regularly check your blood sugar levels as directed by your healthcare provider. This will help you understand how KOMBIGLYZE XR is working for you and whether any adjustments to your treatment plan are needed. Keep a log of your blood sugar readings to share with your doctor during your appointments. This data will enable them to make informed decisions about your medication and overall diabetes management.
• **Stay Active:** Incorporate regular physical activity into your daily routine. Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Exercise helps improve insulin sensitivity, lower blood sugar levels, and promote weight loss. Choose activities you enjoy, such as walking, swimming, or cycling, to make it easier to stick to your exercise plan. Consult your doctor before starting any new exercise program, especially if you have any underlying health conditions.
• **Be Aware of Potential Side Effects:** While KOMBIGLYZE XR is generally well-tolerated, be aware of potential side effects such as nausea, diarrhea, or hypoglycemia (low blood sugar). If you experience any persistent or bothersome side effects, contact your healthcare provider promptly. Carry a source of fast-acting glucose, such as glucose tablets or juice, with you in case you experience low blood sugar. Knowing how to recognize and manage side effects will help you stay safe and comfortable while taking this medication.

• KOMBIGLYZE XR 5/500MG TABLET 7'S should be taken with food to help reduce stomach upset. It is best to take it at the same time each day with your main meal. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of low blood sugar.
• High-fiber foods may affect the absorption of metformin, one of the active ingredients in KOMBIGLYZE XR. Consult your doctor or pharmacist about specific dietary recommendations.