LETHYROX 75MCG TABLET 120'S

How LETHYROX 75MCG TABLET 120'S Works

• LETHYROX 75MCG TABLET 120'S contains levothyroxine sodium, a synthetic form of thyroxine (T4), a hormone naturally produced by the thyroid gland. It is primarily used to treat hypothyroidism, a condition where the thyroid gland doesn't produce enough thyroid hormone.
• Here's how levothyroxine works step by step: 1. Supplementing Thyroid Hormone: Levothyroxine directly supplements the body's supply of T4. In individuals with hypothyroidism, the thyroid gland is unable to produce sufficient amounts of this crucial hormone. 2. Conversion to T3: Once ingested and absorbed into the bloodstream, levothyroxine (T4) undergoes conversion to triiodothyronine (T3). T3 is the more active form of the thyroid hormone. This conversion mainly occurs in the liver and kidneys, but also takes place in other tissues throughout the body.
• 3. Binding to Thyroid Receptors: T3 then enters cells and binds to thyroid hormone receptors located in the nucleus. These receptors are present in nearly every tissue in the body. 4. Gene Expression Regulation: The binding of T3 to its receptor triggers changes in gene expression. Thyroid hormones influence the transcription of various genes, ultimately affecting protein synthesis and cellular metabolism.
• 5. Metabolic Effects: Through its influence on gene expression, thyroid hormone plays a vital role in regulating numerous metabolic processes, including: a. Increasing Basal Metabolic Rate (BMR): Thyroid hormone stimulates oxygen consumption and energy expenditure, leading to an increase in BMR. This affects how quickly the body burns calories. b. Regulating Carbohydrate, Fat, and Protein Metabolism: Thyroid hormone influences the metabolism of all three macronutrients. It promotes glucose absorption in the gut, increases glycogenolysis (breakdown of glycogen to glucose) and gluconeogenesis (synthesis of glucose from non-carbohydrate sources), and enhances lipolysis (breakdown of fats) and protein synthesis and degradation. c. Cardiovascular Effects: Thyroid hormone increases heart rate, cardiac output, and blood flow. d. Nervous System Effects: Thyroid hormone is crucial for brain development and function. It affects neuronal growth, myelination, and neurotransmitter synthesis.
• 6. Symptom Relief: By restoring normal thyroid hormone levels, levothyroxine helps alleviate the symptoms of hypothyroidism, such as fatigue, weight gain, constipation, dry skin, hair loss, and cold intolerance. 7. Feedback Mechanism: The body has a feedback mechanism to regulate thyroid hormone production. When thyroid hormone levels are low, the hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to release thyroid-stimulating hormone (TSH). TSH then stimulates the thyroid gland to produce and release T4 and T3. When thyroid hormone levels are sufficient, TRH and TSH release are suppressed, preventing overproduction of thyroid hormones. Levothyroxine helps restore this balance.
• In summary, LETHYROX 75MCG TABLET 120'S provides a synthetic source of T4, which is converted to T3, the active form of thyroid hormone. T3 binds to receptors in cells throughout the body, influencing gene expression and regulating a wide range of metabolic processes. This helps restore normal thyroid function, alleviate symptoms of hypothyroidism, and maintain overall metabolic balance.

LETHYROX 75MCG TABLET, like all medications containing levothyroxine, can cause side effects if the dosage is too high or if an individual is particularly sensitive to the medication. Common side effects include: * **Cardiovascular:** Palpitations, rapid heartbeat (tachycardia), irregular heartbeat (arrhythmias), chest pain (angina). * **Neurological:** Anxiety, nervousness, insomnia, tremors, headache. * **Gastrointestinal:** Increased appetite, nausea, diarrhea. * **Endocrine:** Heat intolerance, excessive sweating. * **Musculoskeletal:** Muscle weakness, muscle cramps. * **Other:** Weight loss, hair loss (usually temporary), menstrual irregularities. Less common or rare side effects can include: * **Cardiovascular:** Heart failure. * **Endocrine:** Decreased bone mineral density (osteoporosis) in long-term use, especially in post-menopausal women. * **Dermatological:** Skin rash, itching, hives. * **Psychiatric:** Mood swings, irritability. * **Other:** Swelling (edema). It's crucial to consult a doctor if you experience any of these side effects or any other unusual symptoms while taking LETHYROX 75MCG TABLET. Dosage adjustments may be necessary.

• If you miss a dose of LETHYROX 75MCG TABLET 120'S, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Keep LETHYROX 75MCG TAB 1X120 away from the reach of children and pets.
• Store LETHYROX 75MCG TAB 1X120 at room temperature.

• Take LETHYROX 75MCG TABLET 120'S on an empty stomach, preferably first thing in the morning, at least 30 minutes to an hour before your first meal. This helps ensure optimal absorption of the medication, as food can interfere with how well your body utilizes the levothyroxine.
• Consistency is key! Take LETHYROX 75MCG TABLET 120'S at the same time every day. Establishing a routine will help maintain stable thyroid hormone levels in your blood, leading to more consistent symptom control and better overall well-being. Setting a daily alarm can serve as a helpful reminder.
• Avoid taking LETHYROX 75MCG TABLET 120'S at the same time as certain supplements and medications, such as calcium, iron, and antacids. These substances can bind to levothyroxine in the gut, reducing its absorption. If you need to take these, do so several hours before or after taking your thyroid medication.
• Regular monitoring of your thyroid hormone levels is crucial while taking LETHYROX 75MCG TABLET 120'S. Your doctor will schedule periodic blood tests to check your TSH (thyroid-stimulating hormone) levels and adjust your dosage as needed to ensure you're receiving the correct amount of thyroid hormone. Don't miss these appointments!
• Be aware of the symptoms of both hypothyroidism (underactive thyroid) and hyperthyroidism (overactive thyroid). Hypothyroidism symptoms include fatigue, weight gain, constipation, and dry skin, while hyperthyroidism symptoms include rapid heartbeat, weight loss, anxiety, and tremors. Report any significant changes in your symptoms to your doctor so they can adjust your dosage accordingly. Also, when you switch brands of levothyroxine, monitor and report any symptom changes to your doctor as the change in formulation may require dosage adjustments.
• Store LETHYROX 75MCG TABLET 120'S properly, away from moisture, heat, and direct sunlight. Keep it in a cool, dry place and out of reach of children. Improper storage can degrade the medication and affect its potency. Check the expiration date regularly and discard any expired medication properly.
• If you miss a dose of LETHYROX 75MCG TABLET 120'S, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one. If you frequently miss doses, discuss strategies with your doctor or pharmacist to help you remember.

• Take LETHYROX 75MCG TABLET 120'S on an empty stomach, preferably first thing in the morning, at least 30 minutes to an hour before food.
• Certain foods and medications can interfere with the absorption of levothyroxine. These include: Fiber-rich foods (like bran and high-fiber cereals), calcium, iron supplements, antacids containing aluminum or magnesium, and soy products.
• Maintain consistency in your diet and timing of medication. If you regularly consume any of the above-mentioned foods, do so consistently concerning the timing of your levothyroxine dose. Major dietary changes can affect thyroid hormone levels and necessitate dosage adjustments.
• Consult your doctor if you are taking any other medications or supplements, especially those listed above, to ensure they do not interfere with levothyroxine absorption.
• Avoid taking LETHYROX 75MCG TABLET 120'S simultaneously with food. Taking it on an empty stomach ensures optimal absorption.