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Composition
Content Reviewed By:
Dr. Amit Patel
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Hydration, Electrolytes, and General Precautions
Essential for safe useStable fluid and salt intake are crucial for safe lithium therapy, as changes in sodium balance and hydration can significantly affect lithium levels.
It takes some time before you see improvement in your symptoms after taking LITHOSUN SR 400MG TABLET 10'S. Though it varies from person to person, it may take 1-3 weeks or longer for you to see the full benefits of LITHOSUN SR 400MG TABLET 10'S. Do not stop taking LITHOSUN SR 400MG TABLET 10'S if you feel you are not improving. Instead, discuss it with your doctor.
Yes, LITHOSUN SR 400MG TABLET 10'S can cause nervous system disorders like sleepiness and dizziness and feeling confused. It can also cause rapid eye movements, blurred vision, or blind spots in your eyesight. If you experience any of these symptoms, consult your doctor. In addition, avoid driving or operating heavy machinery as it can be hazardous for you.
Yes, LITHOSUN SR 400MG TABLET 10'S may cause kidney problems. LITHOSUN SR 400MG TABLET 10'S is not prescribed in patients who already have severe kidney impairment. The kidney problems may not be reversible and the symptoms include swollen ankles, passing a lot of urine and feeling thirsty. Before starting treatment with LITHOSUN SR 400MG TABLET 10'S, your doctor will get blood tests done to see if your kidney function is normal. During LITHOSUN SR 400MG TABLET 10'S therapy, any gradual or sudden changes in renal function, even within the normal range, may indicate the need for re-evaluation of treatment.
LITHOSUN SR 400MG TABLET 10'S can cause both weight gain or weight loss. You should keep a check on your weight during LITHOSUN SR 400MG TABLET 10'S therapy. If you feel you are gaining or losing too much weight, consult your doctor who will assess whether the change in weight is due to LITHOSUN SR 400MG TABLET 10'S or some other reason.
LITHOSUN SR 400MG TABLET 10'S therapy should only be started if adequate facilities for assessing LITHOSUN SR 400MG TABLET 10'S levels are available. This is because LITHOSUN SR 400MG TABLET 10'S toxicity is related to increased levels of LITHOSUN SR 400MG TABLET 10'S in blood. LITHOSUN SR 400MG TABLET 10'S toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your LITHOSUN SR 400MG TABLET 10'S levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Take LITHOSUN SR 400MG TABLET 10'S exactly as prescribed by your doctor. Check with your doctor if you are not sure. It is meant for oral administration and can be taken with or without food. However, if you start following a certain type of diet, talk to your doctor first. Any drastic changes in the amount of water you drink or amount of sodium (salt) in your diet may require more frequent monitoring of LITHOSUN SR 400MG TABLET 10'S levels.
You should inform your doctor about the medicines you are taking before starting LITHOSUN SR 400MG TABLET 10'S since many medicines interfere with the working of LITHOSUN SR 400MG TABLET 10'S. Some medicines decrease the levels of LITHOSUN SR 400MG TABLET 10'S in blood which means that it will not work well. These include theophylline (for asthma), caffeine, anything containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea used to treat skin conditions.
Lithosun SR is a sustained‑release tablet containing lithium carbonate, a mood stabilizing medicine. It is mainly used in the management of bipolar affective disorder to treat and prevent manic or hypomanic episodes and to help stabilize mood over the long term. It may also be used in certain other mood or psychiatric conditions at the discretion of a specialist, but its primary indication is bipolar disorder.
Lithosun SR contains lithium, which acts on several chemical signaling systems in the brain. It modulates neurotransmitters such as serotonin, norepinephrine, and dopamine, and influences intracellular second messengers and neuroprotective pathways. These combined effects help reduce abnormal mood swings, decrease the intensity and frequency of manic episodes, and support long‑term mood stabilization. The exact mechanism is complex and not fully understood, but lithium has a well‑established clinical benefit in bipolar disorder.
Lithosun SR should be taken exactly as prescribed by your doctor. The sustained‑release tablets are usually swallowed whole with water and should not be crushed or chewed, as this can alter the release profile and increase the risk of side effects. It is generally taken at the same time each day, with or without food, according to your doctor’s instructions. Never change the dose, frequency, or timing on your own; any adjustments must be guided by your clinician based on clinical response and blood lithium levels.
Because lithium has a narrow therapeutic range, regular monitoring is essential. Your doctor will arrange periodic blood tests to measure serum lithium levels, usually after steady state is reached and then at intervals or when doses change, when new interacting medicines are started, or if you develop symptoms suggestive of toxicity. Kidney function (serum creatinine, estimated glomerular filtration rate) and thyroid function (TSH, and sometimes free T4) are also monitored periodically. Additional tests, such as electrolytes or an ECG, may be requested based on your age, comorbidities, and other medicines.
Common side effects include fine tremor of the hands, increased thirst (polydipsia), increased urination (polyuria), mild nausea, diarrhea or stomach discomfort, weight gain, and a feeling of tiredness or mild cognitive slowing. Some people may experience dry mouth, acne, or mild swelling. These effects are often dose‑related and may improve as the body adjusts or after dose modification. However, any persistent, troublesome, or worsening symptoms should be discussed with your doctor.
Signs of possible lithium toxicity include worsening or coarse tremor, unsteady gait or difficulty walking (ataxia), slurred speech, marked drowsiness, confusion, agitation, muscle twitching, blurred or double vision, severe nausea, vomiting, diarrhea, and, in severe cases, seizures or loss of consciousness. If you develop any of these symptoms, especially if more than one is present, you should seek urgent medical attention and inform healthcare providers that you are taking lithium.
Alcohol is generally not recommended while taking Lithosun SR. Alcohol can worsen drowsiness, impair judgment, and increase the risk of falls or accidents. It may also contribute to dehydration, which can raise lithium levels and increase the risk of toxicity. If you consume alcohol, it should be only after discussing with your doctor, in limited amounts if permitted, and you should be alert to any change in mood, coordination, or alertness.
Lithium use during pregnancy requires careful individual risk–benefit assessment. Lithium has been associated with certain fetal cardiac malformations when used in early pregnancy, although the absolute risk is relatively low. Untreated severe bipolar disorder also carries significant risks for both mother and fetus. Decisions about continuing, stopping, or adjusting Lithosun SR in pregnancy must be made jointly with a psychiatrist and obstetrician. Women who are pregnant or planning pregnancy should not stop lithium abruptly on their own but should seek specialist advice promptly.
Lithium passes into breast milk in clinically significant amounts, and infants are sensitive to its effects. Because of the potential risk of lithium toxicity in the breastfed infant, breastfeeding is usually not recommended while the mother is taking Lithosun SR. In some specialized settings, breastfeeding may be considered with very close monitoring of the infant’s lithium levels, kidney and thyroid function, but this requires expert supervision. Discuss feeding options with your psychiatrist and pediatrician before making a decision.
Several medicines and medical conditions can affect lithium levels or increase the risk of side effects. Common interacting medicines include certain diuretics (especially thiazides), ACE inhibitors, angiotensin receptor blockers, non‑steroidal anti‑inflammatory drugs (NSAIDs), and some other psychotropic agents. Dehydration, low sodium intake, vomiting, diarrhea, fever, and kidney impairment can all raise lithium levels. Always inform every healthcare provider and pharmacist that you are taking lithium, and do not start or stop any prescription, over‑the‑counter medicine, or herbal supplement without checking for interactions.
If you miss a dose and remember within a relatively short time, take it as soon as you remember unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects or toxicity. If you frequently forget doses, discuss strategies with your doctor to improve adherence.
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SUN PHARMACEUTICAL INDUSTRIES LTD
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India

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