METROGYL P 2% OINTMENT 125 GM

How METROGYL P 2% OINTMENT 125 GM Works

• METROGYL P 2% OINTMENT 125 GM is a topical medication primarily used to treat skin conditions such as rosacea and bacterial vaginosis when applied externally to the affected area. Its effectiveness stems from the combined action of its active ingredients, metronidazole and an emollient base that aids in drug delivery and skin soothing.
• Metronidazole, the primary active ingredient, is an antibiotic and antiprotozoal medication. It works by targeting anaerobic bacteria and certain protozoa. These microorganisms thrive in environments with little to no oxygen. In the context of rosacea, while the exact cause isn't fully understood, Demodex mites and bacteria on the skin's surface play a significant role. Metronidazole inhibits the growth of these bacteria by interfering with their DNA and other essential cellular processes. Specifically, once metronidazole enters the bacterial cell, it's reduced into reactive cytotoxic products that bind to DNA and other biomolecules, causing DNA strand breakage and ultimately leading to cell death. This reduction process occurs only in anaerobic conditions, which is why metronidazole is selective for anaerobic bacteria and protozoa.
• In bacterial vaginosis, anaerobic bacteria like Gardnerella vaginalis overgrow the normal vaginal flora. Topical metronidazole application helps to reduce the population of these harmful bacteria, restoring the balance of the vaginal microbiome. The ointment's formulation ensures that the metronidazole is delivered directly to the affected area, maximizing its local effect while minimizing systemic absorption and potential side effects.
• The emollient base in METROGYL P 2% OINTMENT plays a crucial role in several ways. It helps to hydrate and soften the skin, reducing dryness and irritation often associated with skin conditions like rosacea. By creating a protective barrier on the skin's surface, the emollient also helps to prevent moisture loss, further soothing and protecting the affected area. Moreover, the emollient facilitates the absorption of metronidazole into the skin, ensuring that the active ingredient reaches the target site effectively. This enhanced penetration improves the overall efficacy of the treatment.
• Therefore, METROGYL P 2% OINTMENT works by directly targeting and killing anaerobic bacteria and protozoa responsible for the infection or inflammation. Simultaneously, the emollient base hydrates, soothes, and protects the skin, promoting healing and reducing discomfort. The combined action of these components makes it an effective treatment for managing conditions like rosacea and bacterial vaginosis when used as directed by a healthcare professional.

Common side effects of Metrogy P ointment may include: * Skin irritation (redness, burning, stinging, itching) * Dryness or scaling of the skin * Contact dermatitis * Temporary darkening of the skin Less common side effects may include: * Allergic reactions (rash, hives, swelling) * Numbness or tingling of the extremities * Unpleasant metallic taste (if a significant amount of the medication is absorbed systemically) * Headache * Nausea Rare side effects: * Severe allergic reaction which includes difficulty in breathing. **Note:** This is not an exhaustive list. If you experience any other unusual symptoms, discontinue use and consult your doctor.

• If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for the missed one.

• Keep METROGYL P 2% OINTMENT 125GM away from the reach of children and pets.
• Store METROGYL P 2% OINTMENT 125GM at room temperature.

• Always wash your hands thoroughly with soap and water before and after applying METROGYL P 2% OINTMENT 125 GM. This helps prevent the spread of infection and keeps the affected area clean.
• Apply a thin layer of METROGYL P 2% OINTMENT 125 GM to the affected area as directed by your doctor, usually once or twice daily. Avoid applying too much ointment, as this won't make it work faster and might cause irritation. Ensure the area is clean and dry before application for optimal absorption.
• Avoid getting METROGYL P 2% OINTMENT 125 GM in your eyes, nose, or mouth. If accidental contact occurs, rinse immediately with plenty of water. If irritation persists, seek medical advice. Be cautious when applying near these sensitive areas.
• Continue using METROGYL P 2% OINTMENT 125 GM for the full course of treatment, even if your symptoms improve. Stopping the medication prematurely can lead to the infection returning or becoming resistant to treatment. Follow your doctor's instructions precisely.
• Inform your doctor about any other medications you are taking, including over-the-counter drugs, herbal remedies, and supplements, before starting METROGYL P 2% OINTMENT 125 GM. This will help prevent potential drug interactions. Also, disclose any allergies you have, especially to metronidazole or other nitroimidazole derivatives.

• METROGYL P 2% OINTMENT 125 GM is for external use only and is unlikely to interact with food. However, it is always best to consult your doctor or pharmacist if you have any concerns about potential interactions.