MEXT F 7.5MG TABLET 28'S

How MEXT F 7.5MG TABLET 28'S Works

• MEXT F 7.5MG TABLET 28'S is a combination medication containing methotrexate and folic acid (also known as folate or vitamin B9). It is primarily used to manage rheumatoid arthritis, psoriasis, and certain types of cancer. Understanding how each component works is key to appreciating the therapeutic effect of this medication.
• **Methotrexate: The Disease-Modifying Agent** Methotrexate functions as a disease-modifying antirheumatic drug (DMARD) and an antimetabolite. Its mechanism of action is complex and multifaceted: * **Inhibiting Folate Metabolism:** Methotrexate primarily works by inhibiting dihydrofolate reductase (DHFR), an enzyme crucial for converting dihydrofolate to tetrahydrofolate. Tetrahydrofolate is essential for synthesizing purines and pyrimidines, which are building blocks for DNA and RNA. By inhibiting DHFR, methotrexate reduces the availability of these building blocks, slowing down cell division and proliferation. This is particularly important in rapidly dividing cells, such as those found in tumors, psoriatic skin, and the immune system in autoimmune diseases.
• * **Anti-inflammatory Effects:** In rheumatoid arthritis and psoriasis, methotrexate reduces inflammation by affecting the immune system. It inhibits the production of inflammatory cytokines (such as TNF-alpha, IL-1, and IL-6) and interferes with the activation and proliferation of immune cells, including T cells and B cells. This helps to reduce joint inflammation, pain, and skin lesions associated with these conditions.
• * **Adenosine Release:** Methotrexate can also stimulate the release of adenosine, an anti-inflammatory molecule. Adenosine can further suppress immune cell activity and reduce inflammation.
• **Folic Acid: Mitigating Methotrexate's Side Effects** While methotrexate is effective, it can also cause side effects due to its interference with folate metabolism. These side effects can include: * **Mouth Sores and Gastrointestinal Issues:** Folate deficiency can lead to mouth ulcers, nausea, abdominal pain, and diarrhea.
• * **Blood Cell Abnormalities:** Reduced folate can affect the production of red blood cells, white blood cells, and platelets, potentially leading to anemia, increased risk of infection, and bleeding problems.
• * **Liver Problems:** Long-term methotrexate use can sometimes cause liver damage.
• Folic acid supplementation helps to counteract these side effects by providing an alternative source of folate. It does not interfere with methotrexate's therapeutic effects but ensures that the body has enough folate to carry out essential functions, thus reducing the severity of side effects.
• **In Summary** MEXT F 7.5MG TABLET 28'S works through the combined actions of methotrexate and folic acid. Methotrexate reduces inflammation and slows down cell proliferation by inhibiting folate metabolism and affecting the immune system. Folic acid helps to minimize the side effects associated with methotrexate by providing a supplemental source of folate. This combination allows for effective disease management while improving patient tolerance and quality of life. Regular monitoring and consultation with a healthcare provider are essential to optimize treatment and manage any potential side effects.

Common side effects of MEXT F 7.5MG TABLET may include nausea, vomiting, diarrhea, constipation, abdominal pain, loss of appetite, headache, dizziness, fatigue, weakness, skin rash, itching, hair loss, mouth ulcers, and changes in liver function tests. Uncommon side effects may include infections, anemia, low white blood cell count, bleeding problems, allergic reactions, depression, anxiety, insomnia, nerve damage, lung problems, kidney problems, and vision changes. Serious side effects require immediate medical attention.

• If you miss a dose of MEXT F 7.5MG TABLET 28'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep MEXT F 7.5MG TAB 1X28 away from the reach of children and pets.
• Store MEXT F 7.5MG TAB 1X28 at room temperature.

• **Take MEXT F 7.5MG TABLET 28'S as Prescribed:** Always adhere to your doctor's instructions regarding dosage and timing. Do not alter the dose or stop taking the medication without consulting your healthcare provider, as this could affect the effectiveness of the treatment and potentially worsen your condition. MEXT F 7.5MG is typically used to manage conditions like rheumatoid arthritis or psoriasis, and consistent adherence is key for optimal results.
• **Stay Hydrated:** Drink plenty of water throughout the day while taking MEXT F 7.5MG TABLET 28'S. This helps to support kidney function and can minimize potential side effects associated with the medication. Aim for at least eight glasses of water daily, unless your doctor advises otherwise due to other health conditions.
• **Monitor for Side Effects:** Be vigilant about monitoring for any side effects. Common side effects may include nausea, fatigue, loss of appetite, or mouth sores. More serious side effects, though less common, can include liver problems or lung issues. Report any unusual or concerning symptoms to your doctor immediately. Early detection and management of side effects can prevent complications.
• **Avoid Alcohol:** It's generally recommended to avoid alcohol while taking MEXT F 7.5MG TABLET 28'S. Alcohol can increase the risk of liver damage, especially when combined with this medication. Consult your doctor to understand the specific risks in your situation and to determine a safe course of action. This precaution helps safeguard your liver health during treatment.
• **Regular Check-ups are Essential:** Schedule and attend regular check-ups with your doctor. These appointments allow your healthcare provider to monitor your response to the medication, assess for any potential side effects, and make necessary adjustments to your treatment plan. Blood tests are often required to monitor liver function and blood cell counts. Regular monitoring ensures the medication is working effectively and safely.

• MEXT F 7.5MG TABLET 28'S can be taken with or without food. However, taking it at the same time each day will help you to remember to take it.